openSNP | rs2032582

SNP rs2032582

Basic Information

Name	rs2032582
Chromosome	7
Position	87531302
Weight of evidence	170

Links to SNPedia

Title	Summary
rs2032582 T/T	6.7x higher risk for lung cancer.
rs2032582 G/G	Normal. better response to atorvastatin. greater severity of delusions in male schizophrenics.
rs2032582 A/A	Rare genotype, on a triallelic snp

Note: For some SNPs, testing providers detect the genotype from the opposite strand of DNA, so that the genotypes listed on openSNP don't appear here. In those cases, please replace "A" by "T" or "G" by "C" (and vice-versa).

Publications on this SNP on the Public Library of Science:

First Author	Title	Year of Publication	# of readers
Géraldine Dessilly	ABCB1 1199G>A Genetic Polymorphism (Rs2229109) Influences the Intracellular Accumulation of Tacrolimus in HEK293 and K562 Recombinant Cell Lines	2014	2750
Soobitha Subenthiran	Linkage Disequilibrium between Polymorphisms of ABCB1 and ABCC2 to Predict the Treatment Outcome of Malaysians with Complex Partial Seizures on Treatment with Carbamazepine Mono-Therapy at the Kuala Lumpur Hospital	2013	2615
Beate Beer	Association of Polymorphisms in Pharmacogenetic Candidate Genes (OPRD1, GAL, ABCB1, OPRM1) with Opioid Dependence in European Population: A Case-Control Study	2013	3561
Yi-kuan Chen	Personalized Tacrolimus Dose Requirement by CYP3A5 but Not ABCB1 or ACE Genotyping in Both Recipient and Donor after Pediatric Liver Transplantation	2014	2691
Eugenia Ulzurrun	Selected ABCB1, ABCB4 and ABCC2 Polymorphisms Do Not Enhance the Risk of Drug-Induced Hepatotoxicity in a Spanish Cohort	2014	2314
Chin-Chuan Hung	Functional Impact of ABCB1 Variants on Interactions between P-Glycoprotein and Methadone	2013	3408
Xiaobo Yu	Association of MDR1 Gene SNPs and Haplotypes with the Tacrolimus Dose Requirements in Han Chinese Liver Transplant Recipients	2011	4636
Huai Liu	Genetic Variations in Radiation and Chemotherapy Drug Action Pathways and Survival in locoregionally Advanced Nasopharyngeal Carcinoma Treated with Chemoradiotherapy	2013	2035
Sabrina Llop	Polymorphisms in ABC Transporter Genes and Concentrations of Mercury in Newborns – Evidence from Two Mediterranean Birth Cohorts	2014	2617
Shabeesh Balan	Genetic Association Analysis of ATP Binding Cassette Protein Family Reveals a Novel Association of ABCB1 Genetic Variants with Epilepsy Risk, but Not with Drug-Resistance	2014	3784
Dong-Yi Chen	Paraoxonase-1 Is Not a Major Determinant of Stent Thrombosis in a Taiwanese Population	2012	2329
Weihua Shou	Gene-Wide Characterization of Common Quantitative Trait Loci for ABCB1 mRNA Expression in Normal Liver Tissues in the Chinese Population	2012	1970
Lauren E. Kelly	A Clinical Tool for Reducing Central Nervous System Depression among Neonates Exposed to Codeine through Breast Milk	2013	3965
Onkar Singh	SLC22A1-ABCB1 Haplotype Profiles Predict Imatinib Pharmacokinetics in Asian Patients with Chronic Myeloid Leukemia	2012	4078
Konrad J. Karczewski	Chapter 7: Pharmacogenomics	2012	25648
George Fountzilas	Ixabepilone Administered Weekly or Every Three Weeks in HER2-Negative Metastatic Breast Cancer Patients; A Randomized Non-Comparative Phase II Trial	2013	2636
Ji-Ye Yin	Meta-Analysis on Pharmacogenetics of Platinum-Based Chemotherapy in Non Small Cell Lung Cancer (NSCLC) Patients	2012	5268
Orsolya Lautner-Csorba	Roles of Genetic Polymorphisms in the Folate Pathway in Childhood Acute Lymphoblastic Leukemia Evaluated by Bayesian Relevance and Effect Size Analysis	2013	3555
Pawel Gaj	Pooled Sample-Based GWAS: A Cost-Effective Alternative for Identifying Colorectal and Prostate Cancer Risk Variants in the Polish Population	2012	4915
Daniela Caronia	Effect of ABCB1 and ABCC3 Polymorphisms on Osteosarcoma Survival after Chemotherapy: A Pharmacogenetic Study	2011	4951
Peng Zhu	ABCB1 Variation and Treatment Response in AIDS Patients: Initial Results of the Henan Cohort	2013	2742
Pascaline Boudou-Rouquette	Early Sorafenib-Induced Toxicity Is Associated with Drug Exposure and UGTIA9 Genetic Polymorphism in Patients with Solid Tumors: A Preliminary Study	2012	5028
Daniele Campa	A Comprehensive Investigation on Common Polymorphisms in the MDR1/ABCB1 Transporter Gene and Susceptibility to Colorectal Cancer	2012	3627
Takeshi Nishijima	Drug Transporter Genetic Variants Are Not Associated with TDF-Related Renal Dysfunction in Patients with HIV-1 Infection: A Pharmacogenetic Study	2015	1448
Ying-Hsia Chu	Association of ABCB1 and FLT3 Polymorphisms with Toxicities and Survival in Asian Patients Receiving Sunitinib for Renal Cell Carcinoma	2015	1769
Hui Li	The Roles of Variants in Human Multidrug Resistance (MDR1) Gene and Their Haplotypes on Antiepileptic Drugs Response: A Meta-Analysis of 57 Studies	2015	1866
Seung Seok Han	Monitoring the Intracellular Tacrolimus Concentration in Kidney Transplant Recipients with Stable Graft Function	2016	2419
Himanshu Gupta	Genetic and epigenetic changes in host ABCB1 influences malaria susceptibility to Plasmodium falciparum	2017	1846
Tomas Pascual	Polymorphisms associated with everolimus pharmacokinetics, toxicity and survival in metastatic breast cancer	2017	1608
Lit Yeen Tan	Superior Multiplexing Capacity of PlexPrimers Enables Sensitive and Specific Detection of SNPs and Clustered Mutations in qPCR	2017	1822
Dragana Mijac	MDR1 gene polymorphisms are associated with ulcerative colitis in a cohort of Serbian patients with inflammatory bowel disease	2018	374
Si Sun	Prognostic Value and Implication for Chemotherapy Treatment of ABCB1 in Epithelial Ovarian Cancer: A Meta-Analysis	2016	2004
Catharina Scholl	Population nutrikinetics of green tea extract	2018	439
Haifa Jmel	Pharmacogenetic landscape of Metabolic Syndrome components drug response in Tunisia and comparison with worldwide populations	2018	67
Kalluri Thishya	Artificial neural network model for predicting the bioavailability of tacrolimus in patients with renal transplantation	2018	235

Publications on this SNP on Mendeley

First Author	Title	Pub. Year	# of Readers	DOI
Keh-Ming Lin	ABCB1 gene polymorphisms are associated with the severity of major depressive disorder and its response to escitalopram treatment.	2011	18	-
Luciene T. Lima	ABCB1 haplotype is associated with major molecular response in chronic myeloid leukemia patients treated with standard-dose of imatinib	2012	7	10.1016/j.bcmd.2011.11.001
Jessica L Mega	Identification of genetic variants associated with response to statin therapy	2009	3	10.1161/ATVBAHA.109.188474
M Onizuka	Cytochrome P450 genetic polymorphisms influence the serum concentration of calcineurin inhibitors in allogeneic hematopoietic SCT recipients.	2011	5	10.1038/bmt.2010.273
J F Thompson	An association study of 43 SNPs in 16 candidate genes with atorvastatin response.	2005	11	10.1038/sj.tpj.6500328
Takashi Fujii	Association between the functional polymorphism (C3435T) of the gene encoding P-glycoprotein (ABCB1) and major depressive disorder in the Japanese population.	2012	1	10.1016/j.jpsychires.2012.01.012
Elena Osswald	Association of MDR1 genotypes with susceptibility to colorectal cancer in older non-smokers.	2007	1	-
B Qi	Genetic variations in radiation and chemotherapy drug action pathways predict clinical outcomes in locoregionally advanced nasopharyngeal carcinoma	2010	1
J L Mega	Identification of genetic variants associated with response to statin therapy	2009	1
K Y Urayama	MDR1 gene variants, indoor insecticide exposure, and the risk of childhood acute lymphoblastic leukemia	2007	1	16/6/1172 [pii]\r10.1158/1055-9965.EPI-07-0007
M Kato	ABCB1 (MDR1) gene polymorphisms are associated with the clinical response to paroxetine in patients with major depressive disorder	2008	1
Sahoko Ichihara	Association of a polymorphism of ABCB1 with obesity in Japanese individuals	2008	7	10.1016/j.ygeno.2008.03.004
Y Koh	Polymorphisms in genes that regulate cyclosporine metabolism affect cyclosporine blood levels and clinical outcomes in patients who receive allogeneic hematopoietic stem cell transplantation	2012	1	S1083-8791(11)00366-1 [pii]\r10.1016/j.bbmt.2011.08.019
Nicolás Saavedra	Identification of pharmacogenetic predictors of lipid-lowering response to atorvastatin in Chilean subjects with hypercholesterolemia	2012	5	10.1016/j.cca.2011.11.003
Margherita Maffioli	Correlation between genetic polymorphisms of the hOCT1 and MDR1 genes and the response to imatinib in patients newly diagnosed with chronic-phase chronic myeloid leukemia	2011	11	10.1016/j.leukres.2010.12.004
Masaki Kato	ABCB1 (MDR1) gene polymorphisms are associated with the clinical response to paroxetine in patients with major depressive disorder	2008	0	10.1016/j.pnpbp.2007.09.003
Sahoko Ichihara	Association of a polymorphism of ABCB1 with obesity in Japanese individuals.	2008	4	-
Sheng Yan	Association of MDR1 Gene SNPs and Haplotypes with the Tacrolimus Dose Requirements in Han Chinese Liver Transplant Recipients	2011	3	10.1371/journal.pone.0025933
Peng Zhu	ABCB1 Variation and Treatment Response in AIDS Patients: Initial Results of the Henan Cohort	2013	2	10.1371/journal.pone.0055197
Sahoko Ichihara	Association of a polymorphism of ABCB1 with obesity in Japanese individuals.	2008	5	10.1016/j.ygeno.2008.03.004
Darinka Todorova Petrova	No association between MDR1 (ABCB1) 2677G>T and 3435C>T polymorphism and sporadic colorectal cancer among Bulgarian patients.	2008	1	10.1007/s00432-007-0279-9
Dyah a Perwitasari	Association of ABCB1, 5-HT3B receptor and CYP2D6 genetic polymorphisms with ondansetron and metoclopramide antiemetic response in Indonesian cancer patients treated with highly emetogenic chemotherapy.	2011	12	10.1093/jjco/hyr117
Youngil Koh	Polymorphisms in genes that regulate cyclosporine metabolism affect cyclosporine blood levels and clinical outcomes in patients who receive allogeneic hematopoietic stem cell transplantation.	2012	1	10.1016/j.bbmt.2011.08.019
Y Lu	Host genetic variants of ABCB1 and IL15 influence treatment outcome in paediatric acute lymphoblastic leukaemia.	2014	2	10.1038/bjc.2014.7
R Lakhan	No association of ABCB1 polymorphisms with drug-refractory epilepsy in a north Indian population.	2009	9	10.1016/j.yebeh.2008.08.019
Christoph Grimm	Two multidrug-resistance (ABCB1) gene polymorphisms as prognostic parameters in women with ovarian cancer.	2010	1
Kevin Y Urayama	MDR1 gene variants, indoor insecticide exposure, and the risk of childhood acute lymphoblastic leukemia.	2007	2	10.1158/1055-9965.EPI-07-0007
Jessica L Mega	Identification of genetic variants associated with response to statin therapy.	2009	6	10.1161/ATVBAHA.109.188474
Xiaobo Yu	Association of MDR1 gene SNPs and haplotypes with the tacrolimus dose requirements in Han Chinese liver transplant recipients	2011	4	10.1371/journal.pone.0025933
M L Lozano	Influence of genetic polymorphisms in CYP2C8 and ABCB1 on the mobilization ability and toxicity of paclitaxel	2011	1	-
M C Rosenhagen	The clinical impact of ABCB1 polymorphisms on the treatment of psychiatric diseases	2011	5
C Brasch-Andersen	Focused Conference Group: PW12 - Experimental pain methods in development and validation of analgesics the pharmacogenomics of escitalopram in the treatment of neuropathic pain	2010	1
Christine E Staatz	Effect of CYP3A and ABCB1 single nucleotide polymorphisms on the pharmacokinetics and pharmacodynamics of calcineurin inhibitors: Part II.	2010	22	10.2165/11317550-000000000-00000
Neetha N Vijayan	Antipsychotic drug dosage and therapeutic response in schizophrenia is influenced by ABCB1 genotypes: a study from a south Indian perspective.	2012	5	10.2217/pgs.12.86
M Kato	ABCB1 (MDR1) gene polymorphisms are associated with the clinical response to paroxetine in patients with major depressive disorder	2008	1
Douglas Vivona	ABCB1 haplotype is associated with major molecular response in chronic myeloid leukemia patients treated with standard-dose of imatinib.	2012	4	10.1016/j.bcmd.2011.11.001
Peng Zhu	ABCB1 variation and treatment response in AIDS patients: initial results of the Henan cohort.	2013	2	10.1371/journal.pone.0055197
Ardeshir Omoumi	Fetal polymorphisms at the ABCB1-transporter gene locus are associated with susceptibility to non-syndromic oral cleft malformations.	2013	2	10.1038/ejhg.2013.25
Mark M Pomerantz Yuksel Urun, Kathryn P. Gray, Sabina Signoretti, David F. McDermott, Michael B. Atkins, Megan E. Lampron, Matthew Freedman, Toni K. Choueiri	Pharmacogenetics as predictor of sunitinib and mTOR inhibitors toxicity in patients with metastatic renal cell carcinoma (mRCC).	2013	2
V Hlavac	Expression profile of ABC transporter genes in breast carcinoma	2011	1
Arnaud G L'Huillier	ABCB1 polymorphisms and neuropsychiatric adverse events in oseltamivir-treated children during influenza H1N1/09 pandemia.	2011	3	-
Abhijit Das	Corpora amylacea deposition in the hippocampus of patients with mesial temporal lobe epilepsy: A new role for an old gene?	2011	1	-
Georg Nikisch	Cytochrome P450 and ABCB1 genetics: association with quetiapine and norquetiapine plasma and cerebrospinal fluid concentrations and with clinical response in patients suffering from schizophrenia. A pilot study.	2011	6	10.1177/0269881110389208
Michael J Bly	P-glycoprotein (PGP) polymorphisms and sexual dysfunction in female patients with depression and SSRI-associated sexual side effects.	2013	4	10.1080/0092623X.2011.615896
Kotaro Hattori	Association between the functional polymorphism (C3435T) of the gene encoding P-glycoprotein (ABCB1) and major depressive disorder in the Japanese population	2012	4	10.1016/j.jpsychires.2012.01.012
Elena Osswald	Association of MDR1 genotypes with susceptibility to colorectal cancer in older non-smokers.	2007	2	10.1007/s00228-006-0225-9
A B Singh	ABCB1 polymorphism predicts escitalopram dose needed for remission in major depression	2012	16	10.1038/tp.2012.115
Mary B. Drake	Multidrug resistance gene expression and ABCB1 SNPs in plasma cell myeloma	2011	3	10.1016/j.leukres.2011.05.033
M C Rosenhagen	The clinical impact of ABCB1 polymorphisms on the treatment of psychiatric diseases	2011	1	-
Yanqiong Zhang	Genetic association of the P-glycoprotein gene ABCB1 polymorphisms with the risk for steroid-induced osteonecrosis of the femoral head in Chinese population.	2014	1	10.1007/s11033-014-3173-y
Margherita Maffioli	Correlation between genetic polymorphisms of the hOCT1 and MDR1 genes and the response to imatinib in patients newly diagnosed with chronic-phase chronic myeloid leukemia.	2011	10	10.1016/j.leukres.2010.12.004
N N Vijayan	Antipsychotic drug dosage and therapeutic response in schizophrenia is influenced by ABCB1 genotypes: A study from a south Indian perspective	2012	3
Huai Liu	Genetic variations in radiation and chemotherapy drug action pathways and survival in locoregionally advanced nasopharyngeal carcinoma treated with chemoradiotherapy	2013	3	10.1371/journal.pone.0082750
M C Rosenhagen	The clinical impact of ABCB1 polymorphisms on the treatment of psychiatric diseases	2011	1	-
M Kato	ABCB1 (MDR1) gene polymorphisms are associated with the clinical response to paroxetine in patients with major depressive disorder	2008	2	10.1016/j.pnpbp.2007.09.003
So Won Kim	ABCB1 c.2677G>T variation is associated with adverse reactions of OROS-methylphenidate in children and adolescents with ADHD.	2013	2	10.1097/JCP.0b013e3182905a8d
Elena De Mattia	Pharmacogenetics of ABC and SLC transporters in metastatic colorectal cancer patients receiving first-line FOLFIRI treatment.	2013	3	10.1097/FPC.0b013e328364b6cf
Hairong Qiu	The single nucleotide polymorphism and haplotype analysis of MDR1 in Jiangsu Han population of China	2012	2	10.1016/j.biopha.2012.03.007
S. Oudard	7115 POSTER DISCUSSION ABCB-1 and VEGFR-3 Single Nucleotide Polymorphisms (SNPs) and Outcome on Sunitinib (SUN) Treatment in Metastatic Clear Cell Renal Cell Carcinoma (RCC)	2011	1	10.1016/S0959-8049(11)72030-5
Jeong-Hyun Kim	Different transport activity of human triallelic MDR1 893Ala/Ser/Thr variant and its association with herb extracts.	2011	2	10.1002/ptr.3405
Hege Edvardsen	Detection of frequent ABCB1 polymorphisms by high-resolution melting curve analysis and their effect on breast carcinoma prognosis	2012	2	10.1515/cclm-2012-0103
Masaki Kato	ABCB1 (MDR1) gene polymorphisms are associated with the clinical response to paroxetine in patients with major depressive disorder.	2008	16	10.1016/j.pnpbp.2007.09.003
Hyun Jin Choi	Polymorphisms of the MDR1 and MIF genes in children with nephrotic syndrome	2011	3	10.1007/s00467-011-1903-0
J F Thompson	An association study of 43 SNPs in 16 candidate genes with atorvastatin response.	2005	9	-
R. Lakhan	No association of ABCB1 polymorphisms with drug-refractory epilepsy in a north Indian population	2009	12	10.1016/j.yebeh.2008.08.019
Orna Levran	ABCB1 (MDR1) genetic variants are associated with methadone doses required for effective treatment of heroin dependence.	2008	24	10.1093/hmg/ddn122
Javier Puente	Single nucleotide polymorphism associations with response and toxic effects in patients with advanced renal-cell carcinoma treated with first-line sunitinib: a multicentre, observational, prospective study	2011	25	10.1016/S1470-2045(11)70266-2
Edna Efrati Irit Avivi Tsila Zuckerman Norberto Krivoy	Genetic Polymorphisms Predicting Methotrexate Blood Levels and Toxicity in Adult Non-Hodgkin's Lymphoma	2013	1	-
Jessica L Mega	Identification of genetic variants associated with response to statin therapy.	2009	3	-
Ingolf Cascorbi	Association of ATP-binding cassette transporter variants with the risk of Alzheimer's disease.	2013	1	10.2217/pgs.13.18
a B Singh	ABCB1 polymorphism predicts escitalopram dose needed for remission in major depression.	2012	12	10.1038/tp.2012.115
Jeong-Hyun Kim	Different transport activity of human triallelic MDR1 893Ala/Ser/Thr variant and its association with herb extracts.	2011	1	10.1002/ptr.3405
Stephen Drain	Multidrug resistance gene expression and ABCB1 SNPs in plasma cell myeloma	2011	6	10.1016/j.leukres.2011.05.033
Ana Santoro	Pharmacogenetics of calcineurin inhibitors in Brazilian renal transplant patients.	2011	5	10.2217/pgs.11.70
Masaki Kato	ABCB1 (MDR1) gene polymorphisms are associated with the clinical response to paroxetine in patients with major depressive disorder.	2008	12	-
Sharon E Johnatty	ABCB1 (MDR1) polymorphisms and ovarian cancer progression and survival: A comprehensive analysis from the Ovarian Cancer Association Consortium and The Cancer Genome Atlas.	2013	2	10.1016/j.ygyno.2013.07.107
Orna Levran	ABCB1 (MDR1) genetic variants are associated with methadone doses required for effective treatment of heroin dependence.	2008	22	10.1093/hmg/ddn122
Abhijit Das	Corpora amylacea deposition in the hippocampus of patients with mesial temporal lobe epilepsy: A new role for an old gene?	2011	1	-
M C Rosenhagen	The clinical impact of ABCB1 polymorphisms on the treatment of psychiatric diseases	2011	1	-
J L Mega	Identification of genetic variants associated with response to statin therapy	2009	2	ATVBAHA.109.188474 [pii]\n10.1161/ATVBAHA.109.188474
Kourong Miao	The single nucleotide polymorphism and haplotype analysis of MDR1 in Jiangsu Han population of China	2012	1	10.1016/j.biopha.2012.03.007
Sharon E. Johnatty	ABCB1 (MDR1) polymorphisms and ovarian cancer progression and survival: A comprehensive analysis from the Ovarian Cancer Association Consortium and the Cancer Genome Atlas	2013	7	10.1016/j.ygyno.2013.07.107
M Kato	ABCB1 (MDR1) gene polymorphisms are associated with the clinical response to paroxetine in patients with major depressive disorder	2008	1
P Garcia Alfonso	Association of single nucleotide polymorphisms (SNP) in the ABCB1 gene with neutropenia and diarrhea protection in capecitabine and 5-fluorouracil-treated colorectal cancer patients respectively	2010	1
Kevin Y Urayama	MDR1 gene variants, indoor insecticide exposure, and the risk of childhood acute lymphoblastic leukemia.	2007	1	10.1158/1055-9965.EPI-07-0007

Evidence compiled by the Personal Genome Project

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Publications listed by Genome.gov

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Users who share this SNP:

Lucie Franklin Leduc

10.07.2018 15:30

j'ai AC que ce la signifie ?

SNP rs2032582

Basic Information

Genotype Frequency

Allele Frequency

Additional Information