openSNP | rs1801274

Links to SNPedia

Title	Summary
rs1801274 C/C	Normal risk for cancer progression
rs1801274 C/T	Complex; generally greater risk for cancer progression
rs1801274 T/T	Complex; generally greater risk for cancer progression

Note: For some SNPs, testing providers detect the genotype from the opposite strand of DNA, so that the genotypes listed on openSNP don't appear here. In those cases, please replace "A" by "T" or "G" by "C" (and vice-versa).

Publications on this SNP on the Public Library of Science:

First Author	Title	Year of Publication	# of readers
Kimberly E. Taylor	Risk Alleles for Systemic Lupus Erythematosus in a Large Case-Control Collection and Associations with Clinical Subphenotypes	2011	10364
Bhawna Poonia	High Affinity Allele for the Gene of FCGR3A Is Risk Factor for HIV Infection and Progression	2010	1774
Sharon A. Chung	Differential Genetic Associations for Systemic Lupus Erythematosus Based on Anti–dsDNA Autoantibody Production	2011	12000
Sebastian Okser	Genetic Variants and Their Interactions in the Prediction of Increased Pre-Clinical Carotid Atherosclerosis: The Cardiovascular Risk in Young Finns Study	2010	8490
Bright Adu	Fc Gamma Receptor IIIB (FcγRIIIB) Polymorphisms Are Associated with Clinical Malaria in Ghanaian Children	2012	2915
Jacques Fellay	Common Genetic Variation and the Control of HIV-1 in Humans	2009	20820
Jiayu Duan	A Genetic Variant rs1801274 in FCGR2A as a Potential Risk Marker for Kawasaki Disease: A Case-Control Study and Meta-Analysis	2014	1648
Elisa Alonso-Perez	Further Evidence of Subphenotype Association with Systemic Lupus Erythematosus Susceptibility Loci: A European Cases Only Study	2012	3326
Lee R. Machado	Copy Number Variation of Fc Gamma Receptor Genes in HIV-Infected and HIV-Tuberculosis Co-Infected Individuals in Sub-Saharan Africa	2013	1898
Jianming Wu	Functional Fcgamma Receptor Polymorphisms Are Associated with Human Allergy	2014	2495
Charlotte J. Houldcroft	Host Genetic Variants and Gene Expression Patterns Associated with Epstein-Barr Virus Copy Number in Lymphoblastoid Cell Lines	2014	2724
Ousmane Toure	Candidate Polymorphisms and Severe Malaria in a Malian Population	2012	3484
Daniel Nilsson	Poor Reproducibility of Allergic Rhinitis SNP Associations	2013	2183
Rohina Rubicz	A Genome-Wide Integrative Genomic Study Localizes Genetic Factors Influencing Antibodies against Epstein-Barr Virus Nuclear Antigen 1 (EBNA-1)	2013	9845
Xiu-Ping Hu	Association of Fcγ Receptor IIB Polymorphism with Cryptococcal Meningitis in HIV-Uninfected Chinese Patients	2012	2148
Gabriela Avila-Pedretti	Variation at FCGR2A and Functionally Related Genes Is Associated with the Response to Anti-TNF Therapy in Rheumatoid Arthritis	2015	2597
Chantal E. Hargreaves	Evaluation of High-Throughput Genomic Assays for the Fc Gamma Receptor Locus	2015	858
Kaspar René Nielsen	Inherited Inflammatory Response Genes Are Associated with B-Cell Non-Hodgkin’s Lymphoma Risk and Survival	2015	1434
Martijn van de Bunt	Evaluating the Performance of Fine-Mapping Strategies at Common Variant GWAS Loci	2015	4261
Rob N. de Jong	A Novel Platform for the Potentiation of Therapeutic Antibodies Based on Antigen-Dependent Formation of IgG Hexamers at the Cell Surface	2016	4766
Xinxia Peng	FCGR2C Polymorphisms Associated with HIV-1 Vaccine Protection Are Linked to Altered Gene Expression of Fc-γ Receptors in Human B Cells	2016	1330
Ho-Chang Kuo	Genome-Wide Association Study Identifies Novel Susceptibility Genes Associated with Coronary Artery Aneurysm Formation in Kawasaki Disease	2016	2418

Publications on this SNP on Mendeley

First Author	Title	Pub. Year	# of Readers	DOI
K Asano	A genome-wide association study identifies three new susceptibility loci for ulcerative colitis in the Japanese population	2009	2	ng.482 [pii]\r10.1038/ng.482
3 Kouichi Asano1, 2, 3, Tomonaga Matsushita1, 2, Junji Umeno1, 2, Naoya Hosono1, Atsushi Takahashi4, Takahisa Kawaguchi5, Takayuki Matsumoto2, Toshiyuki Matsui6, Yoichi Kakuta7, Yoshitaka Kinouchi7, Tooru Shimosegawa7, Masayo Hosokawa8, Yoshiaki Arimura8, Y	A genome-wide association study identifies three new susceptibility loci for ulcerative colitis in the Japanese population	2009	1
Chiea Chuen Khor	Genome-wide association study identifies FCGR2A as a susceptibility locus for Kawasaki disease.	2011	21	10.1038/ng.981
J Zuniga	Genetic variants associated with severe pneumonia in A/H1N1 influenza infection	2011	1	10.1183/09031936.00020611
C Barnett	Fcgamma receptor polymorphisms do not predict response to intravenous immunoglobulin in myasthenia gravis	2012	1	10.1097/CND.0b013e31825c566b 00131402-201209000-00001
Cristian A. Galv??n	Genetic profiling of GSTP1, DPYD, FCGR2A, FCGR3A and CCND1 genes in an Argentinian population	2011	5	10.1016/j.clinbiochem.2011.06.080
Gwan Gyu Song	Associations between FCGR2A rs1801274, FCGR3A rs396991, FCGR3B NA1/NA2 polymorphisms and periodontitis: a meta-analysis.	2013	1	10.1007/s11033-013-2599-y
Yoshiaki Arimura	A genome-wide association study identifies three new susceptibility loci for ulcerative colitis in the Japanese population	2009	1	10.1038/ng.482
Jordi Solé-Violán	The Fcγ receptor IIA-H/H131 genotype is associated with bacteremia in pneumococcal community-acquired pneumonia.	2011	9	10.1097/CCM.0b013e31820eda74
T Qidwai	DNA Sequence Variation and Regulation of Genes Involved in Pathogenesis of Pulmonary Tuberculosis	2012	8	10.1111/j.1365-3083.2012.02696.x
a H Omar	The rs150311303 polymorphism in FcγRIIa enhances IgG binding capacity.	2012	5	10.1111/j.1365-3083.2012.02715.x
Khalid Sadki	Analysis of MIF, FCGR2A and FCGR3A gene polymorphisms with susceptibility to pulmonary tuberculosis in Moroccan population.	2010	9	10.1016/S1673-8527(09)60044-8
José A Lopez-Escamez	Polymorphisms of CD16A and CD32 Fc gamma receptors and circulating immune complexes in Meniere's disease: a case-control study	2011	2	10.1186/1471-2350-12-2
B K Flesch	The FCGR2A--Arg131 variant is no major mortality factor in the elderly--evidence from a German centenarian study.	2006	5	10.1111/j.1744-313X.2006.00613.x
Hong-Zhen Xia	E-selectin rs5361 and FCGR2A rs1801274 variants were associated with increased risk of gastric cancer in a Chinese population.	2012	1	10.1002/mc.20828
C C Khor	Genome-wide association study identifies FCGR2A as a susceptibility locus for Kawasaki disease	2011	1	10.1038/ng.981
Adriana H. Tremoulet	Calcineurin inhibitor treatment of intravenous immunoglobulin-resistant Kawasaki disease	2012	12	10.1016/j.jpeds.2012.02.048
Sophia S Wang	Common genetic variants in proinflammatory and other immunoregulatory genes and risk for non-Hodgkin lymphoma.	2006	11	10.1158/0008-5472.CAN-06-0324
Y Yan	Combined analysis of genome-wide-linked susceptibility loci to Kawasaki disease in Han Chinese	2013	3	-
Huadan Ye	Genetic associations with coronary heart disease: Meta-analyses of 12 candidate genetic variants	2013	6	10.1016/j.gene.2013.07.029
Niki L Dimou	Fcgamma receptor polymorphisms and their association with periodontal disease: a meta-analysis.	2010	7	10.1111/j.1600-051X.2009.01530.x
J Zúñiga	Genetic variants associated with severe pneumonia in A/H1N1 influenza infection.	2012	6	10.1183/09031936.00020611
Xu-Jie Zhou	FCGR2B gene polymorphism rather than FCGR2A, FCGR3A and FCGR3B is associated with anti-GBM disease in Chinese.	2010	2	10.1093/ndt/gfp374
I Sareneva	Linkage and association study of FcgammaR polymorphisms in celiac disease.	2009	4	10.1111/j.1399-0039.2008.01179.x
Niki L Dimou	Fc γ receptor polymorphisms and their association with periodontal disease: a meta-analysis.	2010	1
Hong-Zhen Xia	E-selectin rs5361 and FCGR2A rs1801274 variants were associated with increased risk of gastric cancer in a Chinese population.	2012	1	10.1002/mc.20828
Hiroyuki Moriya	Single‑nucleotide polymorphisms and copy number variations of the FCGR2A and FCGR3A genes in healthy Japanese subjects	2013	2	10.3892/br.2013.210
Lopez-Escamez J.A.	Polymorphisms of CD16A and CD32 Fc receptors and circulating immune complexes in Meniere's disease: A case-control study	2011	1	10.1186/1471-2350-12-2
J Zuniga	Genetic variants associated with severe pneumonia in A/H1N1 influenza infection.	2012	1
Elizabeth E Brown	Common variants in genes that mediate immunity and risk of multiple myeloma.	2007	2	-
Stylianos Bournazos	Association of FcγRIIa R131H polymorphism with idiopathic pulmonary fibrosis severity and progression.	2010	5	10.1186/1471-2466-10-51
C C Khor	Genome-wide association study identifies FCGR2A as a susceptibility locus for Kawasaki disease	2011	1	10.1038/ng.981
Leonardo Terranova	Role of polymorphisms of toll-like receptor (TLR) 4, TLR9, toll-interleukin 1 receptor domain containing adaptor protein (TIRAP) and FCGR2A genes in malaria susceptibility and severity in Burundian children	2012	14	10.1186/1475-2875-11-196
Huadan Ye	Genetic associations with coronary heart disease: Meta-analyses of 12 candidate genetic variants.	2013	2	10.1016/j.gene.2013.07.029
Kouichi Asano	A genome-wide association study identifies three new susceptibility loci for ulcerative colitis in the Japanese population.	2009	48	10.1038/ng.482
Kouichi Asano	A genome-wide association study identifies three new susceptibility loci for ulcerative colitis in the Japanese population.	2009	53	-
Y Yan	Combined analysis of genome-wide-linked susceptibility loci to Kawasaki disease in Han Chinese	2013	6	10.1007/s00439-013-1279-2
Gwan Gyu Song	Associations between FCGR2A rs1801274, FCGR3A rs396991, FCGR3B NA1/NA2 polymorphisms and periodontitis: a meta-analysis.	2013	0	10.1007/s11033-013-2599-y
Yoshihiro Onouchi	A genome-wide association study identifies three new risk loci for Kawasaki disease.	2012	18	10.1038/ng.2220
Stylianos Bournazos	Association of FcγRIIa R131H polymorphism with idiopathic pulmonary fibrosis severity and progression	2010	2	10.1186/1471-2466-10-51
J Zúñiga	Genetic variants associated with severe pneumonia in A/H1N1 influenza infection.	2012	2	10.1183/09031936.00020611
Niki L Dimou	Fcgamma receptor polymorphisms and their association with periodontal disease: a meta-analysis.	2010	7	-
Jordi Solé-Violán	The Fcγ receptor IIA-H/H131 genotype is associated with bacteremia in pneumococcal community-acquired pneumonia.	2011	7	-
a H Omar	The rs150311303 polymorphism in FcγRIIa enhances IgG binding capacity.	2012	3	10.1111/j.1365-3083.2012.02715.x
C Barnett	Fcgamma receptor polymorphisms do not predict response to intravenous immunoglobulin in myasthenia gravis	2012	1	10.1097/CND.0b013e31825c566b\n00131402-201209000-00001 [pii]
A H Tremoulet	Calcineurin inhibitor treatment of intravenous immunoglobulin-resistant Kawasaki disease	2012	3	10.1016/j.jpeds.2012.02.048
T Qidwai	DNA sequence variation and regulation of genes involved in pathogenesis of pulmonary tuberculosis.	2012	5	10.1111/j.1365-3083.2012.02696.x
S Adamovic	Association study of IL2/IL21 and FcgRIIa: significant association with the IL2/IL21 region in Scandinavian coeliac disease families.	2008	7	10.1038/gene.2008.27
Mari Hirvinen	Fc-gamma receptor polymorphisms as predictive and prognostic factors in patients receiving oncolytic adenovirus treatment.	2013	1	10.1186/1479-5876-11-193
K Haldorsen	No association of primary Sjögren's syndrome with Fcγ receptor gene variants.	2013	1	10.1038/gene.2013.12
Jianming Wu	Functional Fcgamma Receptor Polymorphisms Are Associated with Human Allergy	2014	4	10.1371/journal.pone.0089196
J Zúñiga	Genetic variants associated with severe pneumonia in A/H1N1 influenza infection	2012	1	-
K Asano	A genome-wide association study identifies three new susceptibility loci for ulcerative colitis in the Japanese population	2009	5	ng.482 [pii]\r10.1038/ng.482
Kadija Yesmin	Association of FcGRIIa with Graves' disease: a potential role for dysregulated autoantibody clearance in disease onset/progression.	2010	6	10.1111/j.1365-2265.2010.03780.x
José A Lopez-Escamez	Polymorphisms of CD16A and CD32 Fcγ receptors and circulating immune complexes in Ménière's disease: a case-control study	2011	4	10.1186/1471-2350-12-2
Lorenzo Beretta	Survival dimensionality reduction (SDR): development and clinical application of an innovative approach to detect epistasis in presence of right-censored data.	2010	7	10.1186/1471-2105-11-416
I Sareneva	Linkage and association study of FcgammaR polymorphisms in celiac disease.	2009	3	-
A H Omar	The rs150311303 polymorphism in FcγRIIa enhances IgG binding capacity.	2012	1	10.1111/j.1365-3083.2012.02715.x
Yuanlong Yan	Combined analysis of genome-wide-linked susceptibility loci to Kawasaki disease in Han Chinese.	2013	1	10.1007/s00439-013-1279-2
J A Lopez-Escamez	Polymorphisms of CD16A and CD32 Fc gamma receptors and circulating immune complexes in Meniere's disease: a case-control study	2011	2
Gwan Gyu Song	Associations between FCGR2A rs1801274, FCGR3A rs396991, FCGR3B NA1/NA2 polymorphisms and periodontitis: a meta-analysis.	2013	2	10.1007/s11033-013-2599-y
J Zúñiga	Genetic variants associated with severe pneumonia in A/H1N1 influenza infection.	2011	3	10.1183/09031936.00020611
Elizabeth E Brown	Common variants in genes that mediate immunity and risk of multiple myeloma.	2007	5	10.1002/ijc.22618
Khalid Sadki	Analysis of MIF, FCGR2A and FCGR3A gene polymorphisms with susceptibility to pulmonary tuberculosis in Moroccan population.	2010	5	-
Xu-Jie Zhou	FCGR2B gene polymorphism rather than FCGR2A, FCGR3A and FCGR3B is associated with anti-GBM disease in Chinese.	2010	1	-
K Asano	A genome-wide association study identifies three new susceptibility loci for ulcerative colitis in the Japanese population	2009	3	ng.482 [pii]\n10.1038/ng.482 [doi]
B Maiga	Fc gamma Receptor IIa- H131 R Polymorphism and Malaria Susceptibility in Sympatric Ethnic Groups, Fulani and Dogon of Mali.	2014	1	-
Kadija Yesmin	Association of FcGRIIa with Graves' disease: a potential role for dysregulated autoantibody clearance in disease onset/progression.	2010	0
Hyeri Kim	Association of FCGR2A, JAK2 or HNF4A variants with ulcerative colitis in Koreans	2011	5	10.1016/j.dld.2011.07.006
Yoshihiro Onouchi	A genome-wide association study identifies three new risk loci for Kawasaki disease	2012	27	10.1038/ng.2220
Niki L Dimou	Fc γ receptor polymorphisms and their association with periodontal disease: a meta-analysis.	2010	1	-
K Asano	A genome-wide association study identifies three new susceptibility loci for ulcerative colitis in the Japanese population	2009	4	10.1038/ng.482
B K Flesch	The FCGR2A--Arg131 variant is no major mortality factor in the elderly--evidence from a German centenarian study.	2006	5	-
Jose A. Lopez-Escamez	Polymorphisms of CD16A and CD32 Fc gamma receptors and circulating immune complexes in Meniere's disease: a case-control study	2011	3	10.1186/1471-2350-12-2
Carolina Barnett	Fcγ Receptor Polymorphisms Do Not Predict Response to Intravenous Immunoglobulin in Myasthenia Gravis	2012	1	10.1097/CND.0b013e31825c566b
Cátia P Caetano	Nepalese populations show no association between the distribution of malaria and protective alleles	2006	2	-
H.-Z. Xia	E-selectin rs5361 and FCGR2A rs1801274 variants were associated with increased risk of gastric cancer in a Chinese population	2012	1

Evidence compiled by the Personal Genome Project

There are no results from the Personal Genome Project yet. Please come back later.

Publications listed by Genome.gov

First Author	Title	Journal	Publication Date	Trait	p-value	Confidence Interval
Asano K	A genome-wide association study identifies three new susceptibility loci for ulcerative colitis in the Japanese population.	Nat Genet	11/15/2009	Ulcerative colitis	2.0e-12	[1.39-1.82]
Anderson CA	Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47.	Nat Genet	02/06/2011	Ulcerative colitis	2.0e-20	[1.16-1.26]
Khor CC	Genome-wide association study identifies FCGR2A as a susceptibility locus for Kawasaki disease.	Nat Genet	11/13/2011	Kawasaki disease	7.0e-11	[1.22-1.44]

Name	rs1801274
Chromosome	1
Position	161509955
Weight of evidence	142

SNP rs1801274

Basic Information

Genotype Frequency

Allele Frequency

Additional Information

Links to SNPedia

Publications on this SNP on the Public Library of Science:

Publications on this SNP on Mendeley

Evidence compiled by the Personal Genome Project

Publications listed by Genome.gov

Users who share this SNP:

Genome Browser

Contacts