openSNP | rs1800896

Links to SNPedia

Title	Summary
rs1800896 A/A	1.8x increased prostate cancer risk
rs1800896 A/G	1.6x increased prostate cancer risk
rs1800896 G/G	Normal prostate cancer risk

Note: For some SNPs, testing providers detect the genotype from the opposite strand of DNA, so that the genotypes listed on openSNP don't appear here. In those cases, please replace "A" by "T" or "G" by "C" (and vice-versa).

Publications on this SNP on the Public Library of Science:

First Author	Title	Year of Publication	# of readers
Yohei Yatagai	Genome-Wide Association Study for Levels of Total Serum IgE Identifies HLA-C in a Japanese Population	2013	2918
Jun Jin	Relationship between Interleukin-10 −1082A/G Polymorphism and Risk of Ischemic Stroke: A Meta-Analysis	2014	1420
Sebastian Okser	Genetic Variants and Their Interactions in the Prediction of Increased Pre-Clinical Carotid Atherosclerosis: The Cardiovascular Risk in Young Finns Study	2010	8490
Beata Jurecka-Lubieniecka	Association between Age at Diagnosis of Graves' Disease and Variants in Genes Involved in Immune Response	2013	3716
Chuan-Jiang Li	Impact of the CYP3A5, CYP3A4, COMT, IL-10 and POR Genetic Polymorphisms on Tacrolimus Metabolism in Chinese Renal Transplant Recipients	2014	3792
Chizu Tanikawa	Impact of PSCA Variation on Gastric Ulcer Susceptibility	2013	2455
Ambreen Ansari	Differential Combination of Cytokine and Interferon- γ +874 T/A Polymorphisms Determines Disease Severity in Pulmonary Tuberculosis	2011	3591
Marcela Caleffi da Costa Lima Caniatti	Association of Cytokines in Individuals Sensitive and Insensitive to Dust Mites in a Brazilian Population	2014	1961
Francesc Vidal	Pharmacogenetics of Efficacy and Safety of HCV Treatment in HCV-HIV Coinfected Patients: Significant Associations with IL28B and SOCS3 Gene Variants	2012	4283
Patricia López	Influence of Atg5 Mutation in SLE Depends on Functional IL-10 Genotype	2013	2600
Michelle A. T. Hildebrandt	Genetic Variants in Inflammation-Related Genes Are Associated with Radiation-Induced Toxicity Following Treatment for Non-Small Cell Lung Cancer	2010	6708
Mark G. J. de Boer	Influence of Polymorphisms in Innate Immunity Genes on Susceptibility to Invasive Aspergillosis after Stem Cell Transplantation	2011	4083
Xiaoyan Liu	Association Study of Candidate Gene Polymorphisms with Amnestic Mild Cognitive Impairment in a Chinese Population	2012	2464
Daisuke Sakurai	Preferential Binding to Elk-1 by SLE-Associated IL10 Risk Allele Upregulates IL10 Expression	2013	5074
Thorsten Thye	IL10 Haplotype Associated with Tuberculin Skin Test Response but Not with Pulmonary TB	2009	3394
María Asunción García-González	Prognostic Role of Host Cyclooxygenase and Cytokine Genotypes in a Caucasian Cohort of Patients with Gastric Adenocarcinoma	2012	3381
Esther Erdei	Cytokines and Tumor Metastasis Gene Variants in Oral Cancer and Precancer in Puerto Rico	2013	2522
Tobias O. Apinjoh	Association of Cytokine and Toll-Like Receptor Gene Polymorphisms with Severe Malaria in Three Regions of Cameroon	2013	3296
Simone da Silva Santos	Investigation of Host Candidate Malaria-Associated Risk/Protective SNPs in a Brazilian Amazonian Population	2012	3870
Marleen M. Welsh	Genetic Determinants of UV-Susceptibility in Non-Melanoma Skin Cancer	2011	4640
Margrit Urbanek	The Role of Inflammatory Pathway Genetic Variation on Maternal Metabolic Phenotypes during Pregnancy	2012	4645
Qi Ding	The Interleukin-10 Promoter Polymorphism rs1800872 (-592C>A), Contributes to Cancer Susceptibility: Meta-Analysis of 16 785 Cases and 19 713 Controls	2013	2574
Lei Gao	Association of Interleukin-10 Polymorphisms with Schizophrenia: A Meta-Analysis	2014	1913
Cristina Cunha	Human Genetic Susceptibility to Invasive Aspergillosis	2013	4832
Mark A. A. Claassen	Negative Regulation of Hepatitis C Virus Specific Immunity Is Highly Heterogeneous and Modulated by Pegylated Interferon-Alpha/Ribavirin Therapy	2012	1878
Myung-Han Hyun	Interleukin-10 Promoter Gene Polymorphisms and Susceptibility to Asthma: A Meta-Analysis	2013	3827
Ousmane Toure	Candidate Polymorphisms and Severe Malaria in a Malian Population	2012	3484
D. Shane O'Mahony	Inflammation and Immune-Related Candidate Gene Associations with Acute Lung Injury Susceptibility and Severity: A Validation Study	2012	2927
Song Yao	Common Genetic Variants Are Associated with Accelerated Bone Mineral Density Loss after Hematopoietic Cell Transplantation	2011	2647
Susanna Esposito	Genetic Polymorphisms and Sepsis in Premature Neonates	2014	5500
Yongshuai Jiang	Meta-Analysis of 125 Rheumatoid Arthritis-Related Single Nucleotide Polymorphisms Studied in the Past Two Decades	2012	3263
Jason D. Christie	Genome Wide Association Identifies PPFIA1 as a Candidate Gene for Acute Lung Injury Risk Following Major Trauma	2012	4338
Ebun Omoyinmi	Association of the IL-10 Gene Family Locus on Chromosome 1 with Juvenile Idiopathic Arthritis (JIA)	2012	3318
Eero Lauhkonen	IL-10 Gene Polymorphisms Are Associated with Post-Bronchiolitis Lung Function Abnormalities at Six Years of Age	2015	911
Lucia Elena Alvarado-Arnez	Association of IL10 Polymorphisms and Leprosy: A Meta-Analysis	2015	1459
Yong An	IL-10 Genetic Polymorphisms Were Associated with Valvular Calcification in Han, Uygur and Kazak Populations in Xinjiang, China	2015	555
Kaspar René Nielsen	Inherited Inflammatory Response Genes Are Associated with B-Cell Non-Hodgkin’s Lymphoma Risk and Survival	2015	1434
Jiachuan Xiong	Lack of Association between Interleukin-10 Gene Polymorphisms and Graft Rejection Risk in Kidney Transplantation Recipients: A Meta-Analysis	2015	873
Heiko Schotte	Putative IL-10 Low Producer Genotypes Are Associated with a Favourable Etanercept Response in Patients with Rheumatoid Arthritis	2015	590
Daniel T. Barratt	Innate Immune Signalling Genetics of Pain, Cognitive Dysfunction and Sickness Symptoms in Cancer Pain Patients Treated with Transdermal Fentanyl	2015	2411
Jung-Pil Jang	Multiplex Genotyping of Cytokine Gene SNPs Using Fluorescence Bead Array	2015	2246
Shirley B. Russell	Pleiotropic Effects of Immune Responses Explain Variation in the Prevalence of Fibroproliferative Diseases	2015	4266
Rosa M. Barsova	Variants of the Coagulation and Inflammation Genes Are Replicably Associated with Myocardial Infarction and Epistatically Interact in Russians	2015	1457
Tonia C. Rothuizen	Candidate Gene Analysis of Mortality in Dialysis Patients	2015	1645
Mariana Milano	Single Nucleotide Polymorphisms in IL17A and IL6 Are Associated with Decreased Risk for Pulmonary Tuberculosis in Southern Brazilian Population	2016	506

Publications on this SNP on Mendeley

First Author	Title	Pub. Year	# of Readers	DOI
Chee Seng Hee	Comparison of single nucleotide polymorphisms in the human interleukin-10 gene promoter between rheumatoid arthritis patients and normal subjects in Malaysia.	2007	2	10.1007/s10165-007-0612-9
Jie Liu	Polymorphisms of interleukin-10 promoter are not associated with prognosis of advanced gastric cancer.	2011	3	10.3748/wjg.v17.i10.1362
Gary M. Hunninghake	Dust mite exposure modifies the effect of functional IL10 polymorphisms on allergy and asthma exacerbations	2008	12	10.1016/j.jaci.2008.03.015
Petri Koponen	Polymorphism of the rs1800896 IL10 promoter gene protects children from post-bronchiolitis asthma.	2013	1	10.1002/ppul.22909
Oussama Kebir	Association of inflammation genes with alcohol dependence/abuse: a systematic review and a meta-analysis.	2011	1	10.1159/000324849
Giusi Irma Forte	Relevance of gamma interferon, tumor necrosis factor alpha, and interleukin-10 gene polymorphisms to susceptibility to Mediterranean spotted fever.	2009	3	10.1128/CVI.00121-09
Ramkumar Menon	Association of genetic variants, ethnicity and preterm birth with amniotic fluid cytokine concentrations.	2010	0	-
Vibeke Andersen	The polymorphism rs3024505 proximal to IL-10 is associated with risk of ulcerative colitis and Crohns disease in a Danish case-control study.	2010	12	10.1186/1471-2350-11-82
Chen Yang	The associations between two polymorphisms in the interleukin-10 gene promoter and breast cancer risk	2012	5	10.1007/s10549-010-1133-3
Asmaa Abu-Maziad	Role of polymorphic variants as genetic modulators of infection in neonatal sepsis.	2010	6	-
Daniele S Pereira	Interaction between cytokine gene polymorphisms and the effect of physical exercise on clinical and inflammatory parameters in older women: study protocol for a randomized controlled trial.	2012	3	10.1186/1745-6215-13-134
M D Johnson	Functional IL-10 and IL-12B polymorphisms are associated with persistent Candida spp. bloodstream infection	2010	2
Anjana Munshi	Interleukin-10-1082 promoter polymorphism and ischemic stroke risk in a South Indian population.	2010	2	10.1016/j.cyto.2010.09.013
Clayton F. Moraes	Cytokine gene polymorphisms and alzheimer's disease in Brazil	2013	1	10.1159000350368
Yan-Feng Zou	Lack of association of IL-10 gene polymorphisms with prostate cancer: evidence from 11,581 subjects.	2011	17	10.1016/j.ejca.2010.11.034
Silvia Bagnoli	Association of IL10 promoter polymorphism in Italian Alzheimer's disease	2007	5	10.1016/j.neulet.2007.03.030
Johnson M D	Functional IL-10 and IL-12B polymorphisms are associated with persistent Candida spp. bloodstream infection	2010	2	-
Melissa D Johnson	Cytokine gene polymorphisms and the outcome of invasive candidiasis: a prospective cohort study.	2012	13	10.1093/cid/cir827
D Kube	Effect of Lnterleukin-10 gene polymorphisms on clinical outcome of patients with aggressive non-hodgkin's lymphoma: An exploratory study	2008	1
Daniele S Pereira	Interaction between cytokine gene polymorphisms and the effect of physical exercise on clinical and inflammatory parameters in older women: study protocol for a randomized controlled trial	2012	1	http://dx.doi.org/10.1186/1745-6215-13-134
Nan Liu	An association of interleukin-10 gene polymorphisms with Graves' disease in two Chinese populations.	2011	1	10.1007/s12020-011-9444-7
Elias Zintzaras	Synopsis and synthesis of candidate-gene association studies in chronic lymphocytic leukemia: the CUMAGAS-CLL information system.	2009	0	-
C S Hee	The relationship between single nucleotide polymorphisms of the interleukin-10 gene promoter in systemic lupus erythematosus patients in Malaysia: A pilot study	2008	2
Bin Wang	Association of the -1082G/A polymorphism in the interleukin-10 gene with systemic lupus erythematosus: A meta-analysis	2013	2	10.1016/j.gene.2013.01.026
N Schoof	Distal and proximal interleukin (IL)-10 promoter polymorphisms associated with risk of cutaneous melanoma development: a case--control study.	2009	1	10.1038/gene.2009.40
Anjana Munshi	Interleukin-10-1082 promoter polymorphism and ischemic stroke risk in a South Indian population.	2010	2	-
Bin Wang	Association of the -1082G/A polymorphism in the interleukin-10 gene with systemic lupus erythematosus: a meta-analysis.	2013	2	10.1016/j.gene.2013.01.026
D S Pereira	Interaction between cytokine gene polymorphisms and the effect of physical exercise on clinical and inflammatory parameters in older women: study protocol for a randomized controlled trial	2012	1	10.1186/1745-6215-13-134
C S Hee	The relationship between single nucleotide polymorphisms of the interleukin-10 gene promoter in systemic lupus erythematosus patients in Malaysia: A pilot study	2008	1	-
Min Li	The −1082A/G polymorphism in the Interleukin-10 gene and the risk of rheumatoid arthritis: A meta-analysis	2011	3	10.1016/j.cyto.2011.05.022
Wen-jia Peng	Association of the interleukin-10 1082G/A, 819C/T and 3575T/A gene polymorphisms with systemic sclerosis: a meta-analysis	2012	2	10.1007/s11033-012-1510-6
Philippe Nguyen	Interleukin-10 promoter microsatellite polymorphisms influence the immune response to heparin and the risk of heparin-induced thrombocytopenia	2012	1	10.1016/j.thromres.2011.09.033
Munshi A.	Interleukin-10-1082 promoter polymorphism and ischemic stroke risk in a South Indian population	2010	1	-
Alice H Wang	The effect of IL-10 genetic variation and IL-10 serum levels on Crohn's Disease susceptibility in a New Zealand population.	2011	1	10.1016/j.humimm.2011.02.014
Nahid A Eid	Candidate malaria susceptibility/protective SNPs in hospital and population-based studies: the effect of sub-structuring	2010	8	10.1186/1475-2875-9-119
Y M Zhang	Meta-analysis of epidemiological studies of association of two polymorphisms in the interleukin-10 gene promoter and colorectal cancer risk	2012	1	10.4238/2012.September.25.7
Daniele S Pereira	Interaction between cytokine gene polymorphisms and the effect of physical exercise on clinical and inflammatory parameters in older women: study protocol for a randomized controlled trial	2012	2	http://dx.doi.org/10.1186/1745-6215-13-134
M Ianni	Genetic factors regulating inflammation and DNA methylation associated with prostate cancer.	2012	5	10.1038/pcan.2012.30
J. Xu	Variation in IL10 and Other Genes Involved in the Immune Response and in Oxidation and Prostate Cancer Recurrence	2012	2	10.1158/1055-9965.EPI-12-0458
Dieter Kube	Effect of interleukin-10 gene polymorphisms on clinical outcome of patients with aggressive non-Hodgkin's lymphoma: an exploratory study.	2008	1
Miikael Heiskanen	Polymorphism in the IL10 promoter region and early markers of atherosclerosis: the Cardiovascular Risk in Young Finns Study.	2010	0	10.1016/j.atherosclerosis.2009.06.032
Christopher Medway	The sex-specific associations of the aromatase gene with Alzheimer's disease and its interaction with IL10 in the Epistasis Project.	2013	1	10.1038/ejhg.2013.116
E Amirian	Genetic variants in inflammation pathway genes and asthma in glioma susceptibility.	2010	7	10.1093/neuonc/nop057
Jie Zhang	The -1082A/G polymorphism in the Interleukin-10 gene and the risk of rheumatoid arthritis: a meta-analysis.	2011	1	10.1016/j.cyto.2011.05.022
Chunyu Liu	Genome-Wide Association Scan Identifies Candidate Polymorphisms Associated with Differential Response to Anti-TNF Treatment in Rheumatoid Arthritis	2008	13	10.2119/2008-00056.Liu
Melissa D Johnson	Cytokine gene polymorphisms and the outcome of invasive candidiasis: a prospective cohort study.	2012	8	10.1093/cid/cir827
Blanca Rueda	Influence of interleukin 10 promoter polymorphisms in susceptibility to giant cell arteritis in Northwestern Spain.	2007	0
Chia-Wen Tsai	Association of interleukin-10 (IL10) promoter genotypes with nasopharyngeal carcinoma risk in Taiwan.	2013	1
G I Forte	Risk profiles in type 2 diabetes (metabolic syndrome): integration of IL-10 polymorphisms and laboratory parameters to identify vascular damages related complications.	2010	3	10.2174/138161210790883642
Yu-Tsan Lin	Association between human IL-10 gene polymorphisms and serum IL-10 level in patients with food allergy	2012	2	10.1016/j.jfma.2011.11.027
Octavio Fernandes	Investigation of Host Candidate Malaria-Associated Risk/Protective SNPs in a Brazilian Amazonian Population	2012	11	10.1371/journal.pone.0036692
Jacquita S Affandi	Searching for an immunogenetic factor that will illuminate susceptibility to non-tuberculous mycobacterial disease.	2013	1	10.1016/j.humimm.2013.06.019
Silvia Bagnoli	Association of IL10 promoter polymorphism in Italian Alzheimer's disease.	2007	5	10.1016/j.neulet.2007.03.030
Florin Burada	Interleukin-4 receptor -3223T→C polymorphism is associated with increased gastric adenocarcinoma risk.	2012	2
James R Cerhan	Design and validity of a clinic-based case-control study on the molecular epidemiology of lymphoma.	2011	1
Christopher Medway	The sex-specific associations of the aromatase gene with Alzheimer's disease and its interaction with IL10 in the Epistasis Project.	2013	0	10.1038/ejhg.2013.116
Chunyu Liu	Genome-Wide Association Scan Identifies Candidate Polymorphisms Associated with Differential Response to Anti-TNF Treatment in Rheumatoid Arthritis	2008	20	10.2119/2008-00056.Liu
Lakshma V. Nayak	Polymorphic variations in IL-1β, IL-6 and IL-10 genes, their circulating serum levels and breast cancer risk in Indian women	2012	5	10.1016/j.cyto.2012.06.241
B Y Gueuvoghlanian-Silva	Profile of Inflammatory Mediators in Gestational Diabetes Mellitus: Phenotype and Genotype	2012	1
L A Davis	Association of medicaons and rheumatoid arthritis susceptibility polymorphism with lipid profiles in patients with rheumatoid arthritis	2011	2
G I Forte	Relevance of Interferon-gamma, Tumor Necrosis Factor-alpha and Interleukin 10 gene polymorphisms for Mediterranean Spotted Fever susceptibility	2009	1
A V Grant	Polymorphisms in IL10 are associated with total Immunoglobulin E levels and Schistosoma mansoni infection intensity in a Brazilian population.	2011	10	10.1038/gene.2010.50
Lavanya Joshi	Association of Interleukin-10 Gene Promoter Polymorphism in Allergic Patients	2012	2	10.1089/gtmb.2011.0255
Alajos Pár	IL28B and IL10R -1087 polymorphisms are protective for chronic genotype 1 HCV infection and predictors of response to interferon-based therapy in an East-Central European cohort.	2014	1	10.1186/1756-0500-7-12
D Kube	The interleukin-10 gene promoter polymorphism -1087AG does not correlate with clinical outcome in non-Hodgkin's lymphoma.	2007	1	10.1038/sj.gene.6364364
E Amirian	Genetic variants in inflammation pathway genes and asthma in glioma susceptibility.	2010	5	-
Daniele Sirineu Pereira	TNF-α, IL6, and IL10 polymorphisms and the effect of physical exercise on inflammatory parameters and physical performance in elderly women.	2013	2	10.1007/s11357-013-9515-1
Bin Wang	Association of the -1082G/A polymorphism in the interleukin-10 gene with systemic lupus erythematosus: a meta-analysis.	2013	1	10.1016/j.gene.2013.01.026
Asmaa Abu-Maziad	Role of polymorphic variants as genetic modulators of infection in neonatal sepsis.	2010	10	10.1203/PDR.0b013e3181e6a068
Elias Zintzaras	Synopsis and synthesis of candidate-gene association studies in chronic lymphocytic leukemia: the CUMAGAS-CLL information system.	2009	1
Hee	Comparison of single nucleotide polymorphisms in the human interleukin-10 gene promoter between rheumatoid arthritis patients and normal subjects in Malaysia	2007	1	10.1007/s10165-007-0612-9
Adjimon Gatien Lokossou	Association of IL-4 and IL-10 maternal haplotypes with immune responses to P. falciparum in mothers and newborns.	2013	2	10.1186/1471-2334-13-215
Silvia Bagnoli	Lack of association of two chromosome 10q24 SNPs with Alzheimer's disease.	2006	1	-
Kirvis Torres-Poveda	The SNP at -592 of human IL-10 gene is associated with serum IL-10 levels and increased risk for human papillomavirus cervical lesion development.	2012	8	10.1186/1750-9378-7-32
Jie Zhang	The -1082A/G polymorphism in the Interleukin-10 gene and the risk of rheumatoid arthritis: A meta-analysis	2011	3	10.1016/j.cyto.2011.05.022
Ramkumar Menon	Association of genetic variants, ethnicity and preterm birth with amniotic fluid cytokine concentrations.	2010	0
Christine F Skibola	Tumor necrosis factor (TNF) and lymphotoxin-alpha (LTA) polymorphisms and risk of non-Hodgkin lymphoma in the InterLymph Consortium.	2010	28	10.1093/aje/kwp383
Anjana Munshi	Interleukin-10-1082 promoter polymorphism and ischemic stroke risk in a South Indian population	2010	3	10.1016/j.cyto.2010.09.013
Hildson Dornelas Angelo da Silva	Interferon gamma and Interleukin 10 polymorphisms in Brazilian patients with systemic lupus erythematosus.	2014	2	10.1007/s11033-014-3106-9
Dieter Kube	Effect of interleukin-10 gene polymorphisms on clinical outcome of patients with aggressive non-Hodgkin's lymphoma: an exploratory study.	2008	2	10.1158/1078-0432.CCR-07-5182
Alice H Wang	The effect of IL-10 genetic variation and interleukin 10 serum levels on Crohn's disease susceptibility in a New Zealand population.	2011	4	10.1016/j.humimm.2011.02.014
Silvia Bagnoli	Association of IL10 promoter polymorphism in Italian Alzheimer's disease	2007	9	10.1016/j.neulet.2007.03.030
Bárbara Yasmin Gueuvoghlanian-Silva	Profile of inflammatory mediators in gestational diabetes mellitus: phenotype and genotype.	2012	6	10.1111/j.1600-0897.2011.01090.x
Baddela M V Srikanth Babu	Cytokine gene polymorphisms in the susceptibility to acute coronary syndrome.	2012	1	10.1089/gtmb.2011.0182

Evidence compiled by the Personal Genome Project

There are no results from the Personal Genome Project yet. Please come back later.

Publications listed by Genome.gov

There are no results from genome.gov yet. Please come back later.

Name	rs1800896
Chromosome	1
Position	206773552
Weight of evidence	189

SNP rs1800896

Basic Information

Genotype Frequency

Allele Frequency

Additional Information

Links to SNPedia

Publications on this SNP on the Public Library of Science:

Publications on this SNP on Mendeley

Evidence compiled by the Personal Genome Project

Publications listed by Genome.gov

Users who share this SNP:

Genome Browser

Contacts