openSNP | rs1800734

Links to SNPedia

Title	Summary
rs1800734 G/G	Common in clinvar

Note: For some SNPs, testing providers detect the genotype from the opposite strand of DNA, so that the genotypes listed on openSNP don't appear here. In those cases, please replace "A" by "T" or "G" by "C" (and vice-versa).

Publications on this SNP on the Public Library of Science:

First Author	Title	Year of Publication	# of readers
Leonid O. Bryzgalov	Detection of Regulatory SNPs in Human Genome Using ChIP-seq ENCODE Data	2013	6438
Miralem Mrkonjic	Specific Variants in the MLH1 Gene Region May Drive DNA Methylation, Loss of Protein Expression, and MSI-H Colorectal Cancer	2010	5281
Irene Rodríguez-Hernández	Integrated Analysis of Mismatch Repair System in Malignant Astrocytomas	2013	2159
Andrea J. Savio	MLH1 Region Polymorphisms Show a Significant Association with CpG Island Shore Methylation in a Large Cohort of Healthy Individuals	2012	3212
Marion Dawn Teare	Comparing Methods for Mapping cis Acting Polymorphisms Using Allelic Expression Ratios	2011	1431
Eva S. Schernhammer	B Vitamins, Methionine and Alcohol Intake and Risk of Colon Cancer in Relation to BRAF Mutation and CpG Island Methylator Phenotype (CIMP)	2011	3831
Matjaz Vogelsang	The Cumulative Effects of Polymorphisms in the DNA Mismatch Repair Genes and Tobacco Smoking in Oesophageal Cancer Risk	2012	3950
Ting Wang	Association between MLH1 -93G>A Polymorphism and Risk of Colorectal Cancer	2012	1622
Leilei Niu	The hMLH1 −93G>A Polymorphism and Risk of Ovarian Cancer in the Chinese Population	2015	576
Sanmitra Basu	A Study of Molecular Signals Deregulating Mismatch Repair Genes in Prostate Cancer Compared to Benign Prostatic Hyperplasia	2015	3890

Publications on this SNP on Mendeley

First Author	Title	Pub. Year	# of Readers	DOI
Yen-Li Lo	Polymorphisms of MLH1 and MSH2 genes and the risk of lung cancer among never smokers.	2011	0	10.1016/j.lungcan.2010.10.009
Ting Wang	Association between MLH1 -93G>A Polymorphism and Risk of Colorectal Cancer	2012	1	10.1371/journal.pone.0050449
Huiping Chen	Evidence for heritable predisposition to epigenetic silencing of MLH1.	2007	7	10.1002/ijc.22406
MN Zahary	Predominance of MLH1 -93G>A promoter polymorphism among Malaysian Lynch syndrome patients	2011	0
Huiping Chen	Evidence for heritable predisposition to epigenetic silencing of MLH1.	2007	5	-
L J Worrillow	Polymorphic MLH1 and risk of cancer after methylating chemotherapy for Hodgkin lymphoma.	2008	7	10.1136/jmg.2007.053850
Mohd Nizam Zahary	Predominance of MLH1-93G > A Promoter Polymorphism among Malaysian Lynch Syndrome Patients	2011	0
Mauro Santibanez Koref	MLH1 Differential allelic expression in mutation carriers and controls.	2010	3	10.1111/j.1469-1809.2010.00603.x
Nicola Whiffin	MLH1-93G > A is a risk factor for MSI colorectal cancer.	2011	0	10.1093/carcin/bgr089
Ian P M Tomlinson	Investigation of the effects of DNA repair gene polymorphisms on the risk of colorectal cancer.	2012	2	10.1093/mutage/ger070
Miralem Mrkonjic	Specific Variants in the MLH1 Gene Region May Drive DNA Methylation, Loss of Protein Expression, and MSI-H Colorectal Cancer	2010	4	10.1371/journal.pone.0013314
Miralem Mrkonjic	Specific variants in the MLH1 gene region may drive DNA methylation, loss of protein expression, and MSI-H colorectal cancer.	2010	0	10.1371/journal.pone.0013314
T Wang	Association between MLH1 -93G>A Polymorphism and Risk of Colorectal Cancer	2012	1	10.1371/journal.pone.0050449
Savio A.J.	MLH1 Region Polymorphisms Show a Significant Association with CpG Island Shore Methylation in a Large Cohort of Healthy Individuals	2012	0	10.1371/journal.pone.0051531
T Wang	Association between MLH1 -93G>A Polymorphism and Risk of Colorectal Cancer	2012	1	10.1371/journal.pone.0050449
L J Worrillow	Polymorphic MLH1 and risk of cancer after methylating chemotherapy for Hodgkin lymphoma.	2008	8	10.1136/jmg.2007.053850
Miralem Mrkonjic	Specific variants in the MLH1 gene region may drive DNA methylation, loss of protein expression, and MSI-H colorectal cancer	2010	11	10.1371/journal.pone.0013314
Ian P M Tomlinson	Investigation of the effects of DNA repair gene polymorphisms on the risk of colorectal cancer.	2012	2	10.1093/mutage/ger070
Yen Li Lo	Polymorphisms of MLH1 and MSH2 genes and the risk of lung cancer among never smokers	2011	8	10.1016/j.lungcan.2010.10.009
Andrea J. Savio	MLH1 Region Polymorphisms Show a Significant Association with CpG Island Shore Methylation in a Large Cohort of Healthy Individuals	2012	7	10.1371/journal.pone.0051531
Mohd Nizam Zahary	Germline mutation analysis of MLH1 and MSH2 in Malaysian Lynch syndrome patients.	2012	9	10.3748/wjg.v18.i8.814
Mohd Nizam Zahary	Germline mutation analysis of MLH1 and MSH2 in Malaysian Lynch syndrome patients.	2012	5	10.3748/wjg.v18.i8.814
Andrea J Savio	MLH1 region polymorphisms show a significant association with CpG island shore methylation in a large cohort of healthy individuals.	2012	2	10.1371/journal.pone.0051531
Yen-Li Lo	Polymorphisms of MLH1 and MSH2 genes and the risk of lung cancer among never smokers.	2011	6	-
Miralem Mrkonjic	Specific variants in the MLH1 gene region may drive DNA methylation, loss of protein expression, and MSI-H colorectal cancer.	2010	1	-
MN Zahary	Predominance of MLH1 -93G>A promoter polymorphism among Malaysian Lynch syndrome patients	2011	1	-
Nicola Whiffin	MLH1-93G > A is a risk factor for MSI colorectal cancer.	2011	3	-

Evidence compiled by the Personal Genome Project

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Publications listed by Genome.gov

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Name	rs1800734
Chromosome	3
Position	36993455
Weight of evidence	52

SNP rs1800734

Basic Information

Genotype Frequency

Allele Frequency

Additional Information

Links to SNPedia

Publications on this SNP on the Public Library of Science:

Publications on this SNP on Mendeley

Evidence compiled by the Personal Genome Project

Publications listed by Genome.gov

Users who share this SNP:

Genome Browser

Contacts