openSNP | rs1800566

Links to SNPedia

Title	Summary
rs1800566 T/T	Benzene toxicity; cancer risks
rs1800566 C/C	Common in clinvar
rs1800566 C/T	Higher cancer risk

Note: For some SNPs, testing providers detect the genotype from the opposite strand of DNA, so that the genotypes listed on openSNP don't appear here. In those cases, please replace "A" by "T" or "G" by "C" (and vice-versa).

Publications on this SNP on the Public Library of Science:

First Author	Title	Year of Publication	# of readers
Hongping Yu	A Functional NQO1 609C>T Polymorphism and Risk of Gastrointestinal Cancers: A Meta-Analysis	2012	4235
Fernando Pires Hartwig	Evidence for an Epistatic Effect between TP53 R72P and MDM2 T309G SNPs in HIV Infection: A Cross-Sectional Study in Women from South Brazil	2014	1562
Marie-Abele Bind	A Novel Genetic Score Approach Using Instruments to Investigate Interactions between Pathways and Environment: Application to Air Pollution	2014	2386
Georgios Athanasiadis	A Genome-Wide Association Study of the Protein C Anticoagulant Pathway	2011	3536
Juan L. Rodriguez-Flores	Exome Sequencing of Only Seven Qataris Identifies Potentially Deleterious Variants in the Qatari Population	2012	3672
Shujie Guo	Lack of Association between NADPH Quinone Oxidoreductase 1 (NQO1) Gene C609T Polymorphism and Lung Cancer: A Case-Control Study and a Meta-Analysis	2012	2475
P. Roberto Bakker	Antipsychotic-Induced Movement Disorders in Long-Stay Psychiatric Patients and 45 Tag SNPs in 7 Candidate Genes: A Prospective Study	2012	4400
Jessica L. Barrington-Trimis	Parental Smoking and Risk of Childhood Brain Tumors by Functional Polymorphisms in Polycyclic Aromatic Hydrocarbon Metabolism Genes	2013	2464
Ruixuan Geng	Oxidative Stress-Related Genetic Polymorphisms Are Associated with the Prognosis of Metastatic Gastric Cancer Patients Treated with Epirubicin, Oxaliplatin and 5-Fluorouracil Combination Chemotherapy	2014	2443
Sen Yang	The Association between NQO1 Pro187Ser Polymorphism and Bladder Cancer Susceptibility: A Meta-Analysis of 15 Studies	2015	1270
Jorge Duconge	A Novel Admixture-Based Pharmacogenetic Approach to Refine Warfarin Dosing in Caribbean Hispanics	2016	655

Publications on this SNP on Mendeley

First Author	Title	Pub. Year	# of Readers	DOI
Sohan Punia	Leads from xenobiotic metabolism genes for Parkinson's disease among north Indians	2011	0	10.1097/FPC.0b013e32834bcd74
Rainer Fagerholm	NAD(P)H:quinone oxidoreductase 1 NQO1*2 genotype (P187S) is a strong prognostic and predictive factor in breast cancer.	2008	26	-
Cizao Ren	Air pollution and homocysteine: more evidence that oxidative stress-related genes modify effects of particulate air pollution.	2010	10	-
R Ding	Association of NQO1 rs1800566 polymorphism and the risk of colorectal cancer: A meta-analysis	2012	1
Miluse Hubackova	NAD(P)H:quinone oxidoreductase 1 Pro187Ser polymorphism and expression do not cosegregate with clinico-pathological characteristics of human mammary tumors.	2009	6	10.1097/FPC.0b013e32832cf9cf
Maral Jamshidi	NQO1 expression correlates inversely with NFκB activation in human breast cancer	2012	8	10.1007/s10549-011-1629-5
Jing Chen	Contribution of NAD(P)H Quinone Oxidoreductase 1 (NQO1) Pro187Ser Polymorphism and Risk of Colorectal Adenoma and Colorectal Cancer in Caucasians: A Meta-analysis	2012	1	10.1016/j.arcmed.2012.01.005
Hongping Yu	A functional NQO1 609C>T polymorphism and risk of gastrointestinal cancers: a meta-analysis.	2012	3	10.1371/journal.pone.0030566
Juan Zhang	Detection of quinone oxidoreductase 1 (NQO1) single-nucleotide polymorphisms (SNP) related to benzene metabolism in immortalized B lymphocytes from a Chinese Han population.	2010	1	10.1080/15287390903523436
Zhi-jie Huang	Contribution of NAD(P)H Quinone Oxidoreductase 1 (NQO1) Pro187Ser Polymorphism and Risk of Colorectal Adenoma and Colorectal Cancer in Caucasians: A Meta-analysis	2012	1	10.1016/j.arcmed.2012.01.005
J Chen	Contribution of NAD(P)H quinone oxidoreductase 1 (NQO1) Pro187Ser polymorphism and risk of colorectal adenoma and colorectal cancer in Caucasians: a meta-analysis	2012	0	10.1016/j.arcmed.2012.01.005
Christopher M Cabello	DCPIP (2,6-dichlorophenolindophenol) as a genotype-directed redox chemotherapeutic targeting NQO1*2 breast carcinoma.	2011	1	-
Maria Timofeeva	Genetic polymorphisms of MPO, GSTT1, GSTM1, GSTP1, EPHX1 and NQO1 as risk factors of early-onset lung cancer.	2010	0
Hongping Yu	A functional NQO1 609C>T polymorphism and risk of gastrointestinal cancers: A meta-analysis	2012	6	10.1371/journal.pone.0030566
Maral Jamshidi	NQO1 expression correlates inversely with NFκB activation in human breast cancer.	2011	6	10.1007/s10549-011-1629-5
Sungkyoon Kim	Genetic polymorphisms and benzene metabolism in humans exposed to a wide range of air concentrations.	2007	8	-
Francianne Gomes Andrade	RAS mutations in early age leukaemia modulated by NQO1 rs1800566 (C609T) are associated with second-hand smoking exposures.	2014	1	10.1186/1471-2407-14-133
Bruno Alves Aguiar Gonçalves	NQO1 rs1800566 (C609T), PON1 rs662 (Q192R), and PON1 rs854560 (L55M) polymorphisms segregate the risk of childhood acute leukemias according to age range distribution	2012	1	10.1007/s10552-012-0060-5
Hikmet Akkiz	No association of NAD(P)H: quinone oxidoreductase 1 (NQO1) C609T polymorphism and risk of hepatocellular carcinoma development in Turkish subjects.	2010	1	-
Hikmet Akkiz	No association of NAD(P)H: quinone oxidoreductase 1 (NQO1) C609T polymorphism and risk of hepatocellular carcinoma development in Turkish subjects.	2010	3
Maral Jamshidi	NQO1 expression correlates inversely with NFκB activation in human breast cancer.	2012	6	10.1007/s10549-011-1629-5
Shujie Guo	Lack of Association between NADPH Quinone Oxidoreductase 1 (NQO1) Gene C609T Polymorphism and Lung Cancer: A Case-Control Study and a Meta-Analysis	2012	3	10.1371/journal.pone.0047939
B Lajin	The NQO1 polymorphism C609T (Pro187Ser) and cancer susceptibility: a comprehensive meta-analysis.	2013	3	10.1038/bjc.2013.357
Christopher M Cabello	DCPIP (2,6-dichlorophenolindophenol) as a genotype-directed redox chemotherapeutic targeting NQO1*2 breast carcinoma.	2011	2	10.3109/10715762.2010.526766
B Lajin	The NQO1 polymorphism C609T (Pro187Ser) and cancer susceptibility: a comprehensive meta-analysis.	2013	2	10.1038/bjc.2013.357
Zhon Min Huang	Association of polymorphisms in iNOS and NQO1 with bladder cancer risk in cigarette smokers	2014	1	10.1016/j.jcma.2013.10.005
Julieann Sludden	Two minor NQO1 and NQO2 alleles predict poor response of breast cancer patients to adjuvant doxorubicin and cyclophosphamide therapy	2011	12	10.1097/FPC.0b013e32834b6918
Juan Zhang	Detection of quinone oxidoreductase 1 (NQO1) single-nucleotide polymorphisms (SNP) related to benzene metabolism in immortalized B lymphocytes from a Chinese Han population.	2010	0	-
Rainer Fagerholm	2008 Nature Publishing Group http://www.nature.com/naturegenetics ( P187S ) is a strong prognostic and predictive factor in breast cancer	2008	3	10.1038/ng.155
B Lajin	The NQO1 polymorphism C609T (Pro187Ser) and cancer susceptibility: a comprehensive meta-analysis.	2013	5	10.1038/bjc.2013.357
Rui Ding	Association of NQO1 rs1800566 polymorphism and the risk of colorectal cancer: a meta-analysis.	2012	1	10.1007/s00384-011-1396-0
Thomas S Price	Fetal genotype for the xenobiotic metabolizing enzyme NQO1 influences intrauterine growth among infants whose mothers smoked during pregnancy.	2010	7	-
Rainer Fagerholm	NAD(P)H:quinone oxidoreductase 1 NQO1*2 genotype (P187S) is a strong prognostic and predictive factor in breast cancer.	2008	29	10.1038/ng.155
Yuqiong Li	Lack of Association between NADPH Quinone Oxidoreductase 1 (NQO1) Gene C609T Polymorphism and Lung Cancer: A Case-Control Study and a Meta-Analysis	2012	3	10.1371/journal.pone.0047939
Maria Timofeeva	Genetic polymorphisms of MPO, GSTT1, GSTM1, GSTP1, EPHX1 and NQO1 as risk factors of early-onset lung cancer	2010	2	10.1002/ijc.25175
Rui Ding	Association of NQO1 rs1800566 polymorphism and the risk of colorectal cancer: a meta-analysis	2012	1	10.1007/s00384-011-1396-0
Miluse Hubackova	NAD(P)H:quinone oxidoreductase 1 Pro187Ser polymorphism and expression do not cosegregate with clinico-pathological characteristics of human mammary tumors.	2009	3	-
Marco Peluso	Aromatic DNA adducts and number of lung cancer risk alleles in Map-Ta-Phut Industrial Estate workers and nearby residents.	2013	1	10.1093/mutage/ges053
Jira Chansaenroj	Polymorphisms in TP53 (rs1042522), p16 (rs11515 and rs3088440) and NQO1 (rs1800566) genes in Thai cervical cancer patients with HPV 16 infection.	2013	3	-
Maral Jamshidi	NQO1 expression correlates inversely with NFκB activation in human breast cancer.	2011	1	10.1007/s10549-011-1629-5
Li-E Wang	A Functional NQO1 609C>T Polymorphism and Risk of Gastrointestinal Cancers: A Meta-Analysis	2012	5	10.1371/journal.pone.0030566

Evidence compiled by the Personal Genome Project

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Publications listed by Genome.gov

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Name	rs1800566
Chromosome	16
Position	69711242
Weight of evidence	78

SNP rs1800566

Basic Information

Genotype Frequency

Allele Frequency

Additional Information

Links to SNPedia

Publications on this SNP on the Public Library of Science:

Publications on this SNP on Mendeley

Evidence compiled by the Personal Genome Project

Publications listed by Genome.gov

Users who share this SNP:

Genome Browser

Contacts