openSNP | rs1799983

Links to SNPedia

Title	Summary
rs1799983 G/G	Normal risk
rs1799983 G/T	Increased risk of preeclampsia
rs1799983 T/T	Increased risk of preeclampsia, also heart disease

Note: For some SNPs, testing providers detect the genotype from the opposite strand of DNA, so that the genotypes listed on openSNP don't appear here. In those cases, please replace "A" by "T" or "G" by "C" (and vice-versa).

Publications on this SNP on the Public Library of Science:

First Author	Title	Year of Publication	# of readers
Lova Satyanarayana Matsa	Haplotypes of NOS3 Gene Polymorphisms in Dilated Cardiomyopathy	2013	1744
Ilana Blech	Predicting Diabetic Nephropathy Using a Multifactorial Genetic Model	2011	4643
Wenquan Niu	An Updated Meta-Analysis of Endothelial Nitric Oxide Synthase Gene: Three Well-Characterized Polymorphisms with Hypertension	2011	4412
Rubina Tabassum	Genetic Variant of AMD1 Is Associated with Obesity in Urban Indian Children	2012	3984
Sebastian Okser	Genetic Variants and Their Interactions in the Prediction of Increased Pre-Clinical Carotid Atherosclerosis: The Cardiovascular Risk in Young Finns Study	2010	8490
Jan Bressler	Interaction between the NOS3 Gene and Obesity as a Determinant of Risk of Type 2 Diabetes: The Atherosclerosis Risk in Communities Study	2013	2310
Jaesung Choi	The Associations between Immunity-Related Genes and Breast Cancer Prognosis in Korean Women	2014	2957
Lifeng Yan	Genetic Variants in Nitric Oxide Synthase Genes and the Risk of Male Infertility in a Chinese Population: A Case-Control Study	2014	1000
Sourabh Chand	Endothelial Nitric Oxide Synthase Single Nucleotide Polymorphism and Left Ventricular Function in Early Chronic Kidney Disease	2015	1573
Ruth Clapauch	Endothelial Function and Insulin Resistance in Early Postmenopausal Women with Cardiovascular Risk Factors: Importance of ESR1 and NOS3 Polymorphisms	2014	1154
Michelle A. T. Hildebrandt	Genetic Variants in Inflammation-Related Genes Are Associated with Radiation-Induced Toxicity Following Treatment for Non-Small Cell Lung Cancer	2010	6708
Ruixuan Geng	Oxidative Stress-Related Genetic Polymorphisms Are Associated with the Prognosis of Metastatic Gastric Cancer Patients Treated with Epirubicin, Oxaliplatin and 5-Fluorouracil Combination Chemotherapy	2014	2443
Jian-Bo Zhou	Contributions of Renin-Angiotensin System-Related Gene Interactions to Obesity in a Chinese Population	2012	3213
Jizheng Qin	Genetic Polymorphism of NOS3 with Susceptibility to Deep Vein Thrombosis after Orthopedic Surgery: A Case-Control Study in Chinese Han Population	2013	1190
Wenjing Ou	Association of CVD Candidate Gene Polymorphisms with Ischemic Stroke and Cerebral Hemorrhage in Chinese Individuals	2014	2033
Robert Carreras-Torres	Genetic Risk Score of NOS Gene Variants Associated with Myocardial Infarction Correlates with Coronary Incidence across Europe	2014	2567
Himanshu Rai	Association of Endothelial Nitric Oxide Synthase Gene Polymorphisms with Coronary Artery Disease: An Updated Meta-Analysis and Systematic Review	2014	1970
Xue Zhang	Pharmacogenetic Association of NOS3 Variants with Cardiovascular Disease in Patients with Hypertension: The GenHAT Study	2012	3939
Jeffrey J. W. Verschuren	Systematic Testing of Literature Reported Genetic Variation Associated with Coronary Restenosis: Results of the GENDER Study	2012	2110
Chiara Poggi	Genetic Contributions to the Development of Complications in Preterm Newborns	2015	2356
Sirpa Koskela	Endothelial Nitric Oxide Synthase G894T Polymorphism Associates with Disease Severity in Puumala Hantavirus Infection	2015	889
Katherine E. Beaney	Clinical Utility of a Coronary Heart Disease Risk Prediction Gene Score in UK Healthy Middle Aged Men and in the Pakistani Population	2015	2273
Zsolt Szelid	Right Ventricular Adaptation Is Associated with the Glu298Asp Variant of the NOS3 Gene in Elite Athletes	2015	1161
Min Chen	Tumor Necrosis Factor (TNF) –308G>A, Nitric Oxide Synthase 3 (NOS3) +894G>T Polymorphisms and Migraine Risk: A Meta-Analysis	2015	737

Publications on this SNP on Mendeley

First Author	Title	Pub. Year	# of Readers	DOI
Christopher M Morris	NOS3 gene rs1799983 polymorphism and incident dementia in elderly stroke survivors.	2011	9	10.1016/j.neurobiolaging.2010.06.012
Ana C.T. Palei	Tag SNP Haplotypes in Hypertensive Disorders of Pregnancy	2012	5	10.1089/dna.2012.1768
Kui Zhang	The G894T polymorphism on endothelial nitric oxide synthase gene is associated with increased coronary heart disease among Asia population: evidence from a Meta analysis.	2012	5	10.1016/j.thromres.2012.02.015
Wenquan Niu	An Updated Meta-Analysis of Endothelial Nitric Oxide Synthase Gene: Three Well-Characterized Polymorphisms with Hypertension	2011	5	10.1371/journal.pone.0024266
T a Abdel-Aziz	Association of endothelial nitric oxide synthase gene polymorphisms with classical risk factors in development of premature coronary artery disease.	2013	3	10.1007/s11033-012-2380-7
Norma C Serrano	Frequency of eNOS polymorphisms in the Colombian general population.	2010	3	10.1186/1471-2156-11-54
G F Mitchell	Vascular stiffness and genetic variation at the endothelial nitric oxide synthase locus: the Framingham Heart study	2007	1	-
Nell E	An association between components of the apoptosis pathway and the genetic predisposition to achilles tendinopathy.	2013	2	10.1136/bjsports-2013-092459.16
Kui Zhang	The G894T polymorphism on endothelial nitric oxide synthase gene is associated with increased coronary heart disease among Asia population: evidence from a Meta analysis.	2012	5	10.1016/j.thromres.2012.02.015
Ludmila Muniz	eNOS tag SNP haplotypes in hypertensive disorders of pregnancy.	2012	2	10.1089/dna.2012.1768
Lyle G Best	Genetic Variants, Endothelial Function, and Risk of Preeclampsia Among American Indians.	2010	1	10.3109/10641955.2010.525276
Kui Zhang	The G894T polymorphism on endothelial nitric oxide synthase gene is associated with increased coronary heart disease among Asia population: Evidence from a Meta analysis	2012	5	10.1016/j.thromres.2012.02.015
Erica-Mari M Nell	The apoptosis pathway and the genetic predisposition to Achilles tendinopathy	2012	12	10.1002/jor.22144
S Alexander	Endothelial nitric oxide synthase tagging single nucleotide polymorphisms and recovery from aneurysmal subarachnoid hemorrhage	2009	2	10.1177/1099800409334751
Elena Galluccio	Hyperinsulinemia and impaired leptin-adiponectin ratio associate with endothelial nitric oxide synthase polymorphisms in subjects with in-stent restenosis.	2008	3	10.1152/ajpendo.00003.2008
Eddi Buldreghini	Single nucleotide polymorphism (SNP) of the endothelial nitric oxide synthase (eNOS) gene (Glu298Asp variant) in infertile men with asthenozoospermia.	2010	0	-
Gary F Mitchell	Vascular stiffness and genetic variation at the endothelial nitric oxide synthase locus: the Framingham Heart study.	2007	4	-
Lei Yao	The association between two polymorphisms of eNOS and breast cancer risk: a meta-analysis.	2010	0	10.1007/s10549-010-0800-8
Anna Möllsten	Glu298Asp and NOS4ab polymorphisms in diabetic nephropathy.	2006	1	10.1080/07853890600969213
T Okochi	Genetic Association Analysis of NOS3 and Methamphetamine-Induced Psychosis Among Japanese.	2011	2	10.2174/157015911795017119
Lei Yao	The association between two polymorphisms of eNOS and breast cancer risk: a meta-analysis.	2010	0	-
A Ikenouchi-Sugita	Three polymorphisms of the eNOS gene and plasma levels of metabolites of nitric oxide in depressed Japanese patients: a preliminary report 19	2011	1
B Yang	Polymorphisms of rs1799983 (G>T) and rs1800780 (A>G) of the eNOS gene associated with susceptibility to essential hypertension in the Chinese Hui ethnic population	2013	1	10.4238/2013.March.26.2
Anna Möllsten	Glu298Asp and NOS4ab polymorphisms in diabetic nephropathy.	2006	1	-
Negar Azarpira	Influence of endothelial nitric oxide synthase gene polymorphisms (-786T/C, 4a4b, 894G/T) on Iranian kidney transplant recipients.	2013	1	-
Michelle A T Hildebrandt	Genetic variants in inflammation-related genes are associated with radiation-induced toxicity following treatment for non-small cell lung cancer	2010	7	10.1371/journal.pone.0012402
J H Kim	eNOS gene polymorphisms modify the association of PM(10) with oxidative stress	2012	1	10.1016/j.toxlet.2012.09.006
Fabiola Dach	Interaction among nitric oxide (NO)-related genes in migraine susceptibility	2012	1	10.1007/s11010-012-1409-5
A. K. Sharma	Lack of association between Glu298Asp polymorphism and coronary artery disease in North Indians	2012	4	10.1007/s11033-011-1412-z
Pei Wang	A variant of the endothelial nitric oxide synthase gene (NOS3) associated with AMS susceptibility is less common in the Quechua, a high altitude Native population.	2010	3	10.1089/ham.2009.1054
Best L.G.	Genetic variants, endothelial function, and risk of preeclampsia among American Indians	2012	1	-
Marcelo R Luizon	Epistasis among eNOS, MMP-9 and VEGF maternal genotypes in hypertensive disorders of pregnancy	2012	2	10.1038/hr.2012.60
Pascal L Kingah	Association of NOS3 Glu298Asp SNP with hypertension and possible effect modification of dietary fat intake in the ARIC study.	2010	1	10.1038/hr.2009.198
Yu A Shuvalova	Association between polymorphisms of eNOS and GPx-1 genes, activity of free-radical processes and in-stent restenosis.	2012	1	10.1007/s11010-012-1419-3
Ewelina Synowiec	Association between polymorphism of the NQO1, NOS3 and NFE2L2 genes and AMD.	2013	1	-
L G Best	Genetic variants, endothelial function, and risk of preeclampsia among American Indians	2012	1	10.3109/10641955.2010.525276
A Ikenouchi-Sugita	Three polymorphisms of the eNOS gene and plasma levels of metabolites of nitric oxide in depressed Japanese patients: a preliminary report 19	2011	1	-
Ebru Alp	Lack of association between matrix metalloproteinase-9 and endothelial nitric oxide synthase gene polymorphisms and coronary artery disease in Turkish population.	2009	1
Gary F Mitchell	Vascular stiffness and genetic variation at the endothelial nitric oxide synthase locus: the Framingham Heart study.	2007	5	10.1161/HYPERTENSIONAHA.106.085266
Valeria C Sandrim	Effects of eNOS polymorphisms on nitric oxide formation in healthy pregnancy and in pre-eclampsia.	2010	8	10.1093/molehr/gaq030
A C P Martins	Endothelial nitric oxide synthase genotypes and haplotypes modify the responses to sildenafil in patients with erectile dysfunction	2011	2	10.1038/tpj.2011.49
Christopher M. Morris	NOS3 gene rs1799983 polymorphism and incident dementia in elderly stroke survivors	2011	9	10.1016/j.neurobiolaging.2010.06.012
Barry R. Davis	Pharmacogenetic Association of NOS3 Variants with Cardiovascular Disease in Patients with Hypertension: The GenHAT Study	2012	9	10.1371/journal.pone.0034217
Sheila Alexander	Endothelial nitric oxide synthase tagging single nucleotide polymorphisms and recovery from aneurysmal subarachnoid hemorrhage.	2009	4	-
Ying Xin	A common variant of the eNOS gene (E298D) is an independent risk factor for left ventricular hypertrophy in human essential hypertension.	2009	3	10.1042/CS20080476
Yoon-Hyeong Choi	eNOS gene polymorphisms modify the association of PM10 with oxidative stress	2012	1	10.1016/j.toxlet.2012.09.006
Sudhansu Sekhar Nishank	Endothelial Nitric Oxide Synthase (eNOS) Gene Polymorphism is Associated with Age Onset of Menarche in Sickle Cell Disease Females of India.	2013	1	10.4084/MJHID.2013.036
Erica-Mari Nell	The apoptosis pathway and the genetic predisposition to Achilles tendinopathy.	2012	17	10.1002/jor.22144
Jane F Ferguson	NOS3 gene polymorphisms are associated with risk markers of cardiovascular disease, and interact with omega-3 polyunsaturated fatty acids	2010	7	-
Lyle G Best	Genetic Variants, Endothelial Function, and Risk of Preeclampsia Among American Indians	2012	1	10.3109/10641955.2010.525276
Pascal L Kingah	Association of NOS3 Glu298Asp SNP with hypertension and possible effect modification of dietary fat intake in the ARIC study.	2010	7	10.1038/hr.2009.198
Wenquan Niu	An updated meta-analysis of endothelial nitric oxide synthase gene: three well-characterized polymorphisms with hypertension.	2011	5	10.1371/journal.pone.0024266
Pablo Coto-Segura	Influence of endothelial nitric oxide synthase polymorphisms in psoriasis risk.	2011	3	10.1007/s00403-011-1129-9
Steve Rich	SNPS IN NOS3 ARE ASSOCIATED WITH A CARDIOVASCULAR DISEASE SCORE IN ASYMPTOMATIC INDIVIDUALS	2011	2	10.1016/S0735-1097(11)61603-3
Ewelina Synowiec	Association between polymorphism of the NQO1, NOS3 and NFE2L2 genes and AMD.	2013	1
Himanshu Rai	Lack of association between Glu298Asp polymorphism and coronary artery disease in North Indians.	2012	3	10.1007/s11033-011-1412-z
Pablo Coto-Segura	Influence of endothelial nitric oxide synthase polymorphisms in psoriasis risk.	2011	1	-
Kui Zhang	The G894T polymorphism on endothelial nitric oxide synthase gene is associated with increased coronary heart disease among Asia population: evidence from a Meta analysis.	2012	2	10.1016/j.thromres.2012.02.015
X Zhang	Pharmacogenetic association of nos3 variants with cardiovascular disease in patients with hypertension: The genhat study1368	2012	1	-
Pei Wang	A variant of the endothelial nitric oxide synthase gene (NOS3) associated with AMS susceptibility is less common in the Quechua, a high altitude Native population.	2010	1	-
C.J. Xiao	Association of eNOS gene polymorphisms with essential hypertension in the Han population in southwestern China	2011	1	10.4238/vol10-3gmr1160
訳・監修独産業技術総合研究所計量標準総合センター	SI）国際文書第8版 (2006)	2010	0	-
Gilberto Vargas-Alarcon	The -974 C>A (rs3087459) gene polymorphism in the endothelin gene (EDN1) is associated with risk of developing acute coronary syndrome in Mexican patients.	2013	1	10.1016/j.gene.2013.09.003
Sheila Alexander	Endothelial nitric oxide synthase tagging single nucleotide polymorphisms and recovery from aneurysmal subarachnoid hemorrhage.	2009	4	10.1177/1099800409334751
Gary F Mitchell	Vascular stiffness and genetic variation at the endothelial nitric oxide synthase locus: the Framingham Heart study.	2007	1	10.1161/HYPERTENSIONAHA.106.085266
T A Abdel-Aziz	Association of endothelial nitric oxide synthase gene polymorphisms with classical risk factors in development of premature coronary artery disease.	2013	2	10.1007/s11033-012-2380-7
L G Best	Genetic Variants, Endothelial Function, and Risk of Preeclampsia Among American Indians	2012	1	Doi 10.3109/10641955.2010.525276
Christopher M Morris	NOS3 gene rs1799983 polymorphism and incident dementia in elderly stroke survivors.	2011	8	-
María Toriello	Lack of association of endothelial nitric oxide synthase polymorphisms and migraine.	2008	5	10.1111/j.1526-4610.2008.01181.x
Flavia M Gonçalves	Endothelial nitric oxide synthase haplotypes associated with aura in patients with migraine.	2011	1	10.1089/dna.2010.1152
L Kimura	Multilocus family-based association analysis of seven candidate polymorphisms with essential hypertension in an african-derived semi-isolated brazilian population.	2012	1	10.1155/2012/859219

Evidence compiled by the Personal Genome Project

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Publications listed by Genome.gov

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Name	rs1799983
Chromosome	7
Position	150999023
Weight of evidence	134

SNP rs1799983

Basic Information

Genotype Frequency

Allele Frequency

Additional Information

Links to SNPedia

Publications on this SNP on the Public Library of Science:

Publications on this SNP on Mendeley

Evidence compiled by the Personal Genome Project

Publications listed by Genome.gov

Users who share this SNP:

Genome Browser

Contacts