openSNP | rs1799971

Links to SNPedia

Title	Summary
rs1799971 A/G	Stronger cravings for alcohol. if alcoholic, naltrexone treatment 2x more successful
rs1799971 A/A	Normal
rs1799971 G/G	More pain

Note: For some SNPs, testing providers detect the genotype from the opposite strand of DNA, so that the genotypes listed on openSNP don't appear here. In those cases, please replace "A" by "T" or "G" by "C" (and vice-versa).

Publications on this SNP on the Public Library of Science:

First Author	Title	Year of Publication	# of readers
Helen Vossen	The Genetic Influence on the Cortical Processing of Experimental Pain and the Moderating Effect of Pain Status	2010	4802
Alexandra Doehring	Effect Sizes in Experimental Pain Produced by Gender, Genetic Variants and Sensitization Procedures	2011	5847
Theresa M. Marteau	Effect on Adherence to Nicotine Replacement Therapy of Informing Smokers Their Dose Is Determined by Their Genotype: A Randomised Controlled Trial	2012	2835
Beate Beer	Association of Polymorphisms in Pharmacogenetic Candidate Genes (OPRD1, GAL, ABCB1, OPRM1) with Opioid Dependence in European Population: A Case-Control Study	2013	3561
Mary R. Lee	Functional Polymorphism of the Mu-Opioid Receptor Gene (OPRM1) Influences Reinforcement Learning in Humans	2011	4496
Marina Chiara Garassino	Randomised Phase II Trial (NCT00637975) Evaluating Activity and Toxicity of Two Different Escalating Strategies for Pregabalin and Oxycodone Combination Therapy for Neuropathic Pain in Cancer Patients	2013	4910
Yongshuai Jiang	MCPerm: A Monte Carlo Permutation Method for Accurately Correcting the Multiple Testing in a Meta-Analysis of Genetic Association Studies	2014	1871
Lauren E. Kelly	A Clinical Tool for Reducing Central Nervous System Depression among Neonates Exposed to Codeine through Breast Milk	2013	3965
Zoraida Verde	‘Smoking Genes’: A Genetic Association Study	2011	7416
Grace Su Yin Pang	A Non-Synonymous Single Nucleotide Polymorphism in an OPRM1 Splice Variant Is Associated with Fentanyl-Induced Emesis in Women Undergoing Minor Gynaecological Surgery	2012	2821
Roshan Mascarenhas	Allele-Selective Transcriptome Recruitment to Polysomes Primed for Translation: Protein-Coding and Noncoding RNAs, and RNA Isoforms	2015	2707
Daniel T. Barratt	Innate Immune Signalling Genetics of Pain, Cognitive Dysfunction and Sickness Symptoms in Cancer Pain Patients Treated with Transdermal Fentanyl	2015	2411

Publications on this SNP on Mendeley

First Author	Title	Pub. Year	# of Readers	DOI
Vahid Salimi	Opioid Receptors Control Viral Replication in the Airways	2013	3	10.1097/CCM.0b013e31826767a8
A M Dlugos	OPRM1 gene variants modulate amphetamine-induced euphoria in humans.	2011	0	10.1111/j.1601-183X.2010.00655.x
Arpana Agrawal	Testing multiple levels of influence in the intergenerational transmission of alcohol disorders from a developmental perspective: The example of alcohol use promoting peers and μ-opioid receptor M1 variation	2012	0	10.1017/S0954579412000478
Dingyan Chen	Ethnic-specific meta-analyses of association between the OPRM1 A118G polymorphism and alcohol dependence among Asians and Caucasians.	2012	1	10.1016/j.drugalcdep.2011.10.012
Omar Serý	A118G polymorphism of OPRM1 gene is associated with schizophrenia.	2010	0	10.1007/s12031-010-9327-z
Orna Levran	Haplotype block structure of the genomic region of the mu opioid receptor gene.	2011	0	10.1038/jhg.2010.150
Noora Rouvinen-Lagerström	μ-Opioid Receptor Gene (OPRM1) Polymorphism A118G: Lack of Association in Finnish Populations with Alcohol Dependence or Alcohol Consumption.	2013	0	10.1093/alcalc/agt050
T K Clarke	Low frequency genetic variants in the mu-opioid receptor (OPRM1) affect risk for addiction to heroin and cocaine	2013	0	10.1016/j.neulet.2013.02.018
Bruno G Oertel	Genetic-epigenetic interaction modulates μ-opioid receptor regulation.	2012	8	10.1093/hmg/dds314
Robert Miranda	Initial evidence of an association between OPRM1 and adolescent alcohol misuse.	2010	7	-
R. Andrew Sewell	Pharmacogenetically Driven Treatments for Alcoholism	2012	0	10.2165/11633180-000000000-00000
Noora Rouvinen-Lagerström	Opioid Receptor Gene (OPRM1) Polymorphism A118G: Lack of Association in Finnish Populations with Alcohol Dependence or Alcohol Consumption.	2013	1	10.1093/alcalc/agt050
Batoul Sadat Haerian	OPRM1 rs1799971 polymorphism and opioid dependence: evidence from a meta-analysis.	2013	0	10.2217/pgs.13.57
A J Arias	Variation in OPRM1 and risk of suicidal behavior in drug-dependent individuals	2012	0	10.1111/j.1521-0391.2011.00195.x [doi]
A M Dlugos	OPRM1 gene variants modulate amphetamine-induced euphoria in humans.	2011	4	10.1111/j.1601-183X.2010.00655.x
Albert J Arias	Pharmacogenetically driven treatments for alcoholism: are we there yet?	2012	6	10.2165/11633180-000000000-00000
Hollis C Karoly	Genetic Influences on Physiological and Subjective Responses to an Aerobic Exercise Session among Sedentary Adults.	2012	5	10.1155/2012/540563
Ling Xu	OPRM1 gene is associated with BMI in Uyghur population.	2009	0
Dingyan Chen	Ethnic-specific meta-analyses of association between the OPRM1 A118G polymorphism and alcohol dependence among Asians and Caucasians	2012	0	10.1016/j.drugalcdep.2011.10.012
Gabriele Koller	Possible association between OPRM1 genetic variance at the 118 locus and alcohol dependence in a large treatment sample: relationship to alcohol dependence symptoms.	2012	0	10.1111/j.1530-0277.2011.01714.x
Momchil A Nikolov	No evidence of association between 118A>G OPRM1 polymorphism and heroin dependence in a large Bulgarian case-control sample.	2011	1	-
Vahid Salimi	Opioid receptors control viral replication in the airways.	2013	5	10.1097/CCM.0b013e31826767a8
Stephanie-May Ruchat	Association between mu-opioid receptor-1 102T>C polymorphism and intermediate type 2 diabetes phenotypes: results from the Quebec Family Study (QFS).	2008	2	-
BS Haerian	OPRM1 rs1799971 polymorphism and opioid dependence: evidence from a meta-analysis	2013	2	10.2217/pgs.13.57
Orna Levran	Haplotype block structure of the genomic region of the mu opioid receptor gene.	2011	2	-
Bruno G Oertel	Genetic-epigenetic interaction modulates μ-opioid receptor regulation.	2012	9	10.1093/hmg/dds314
Dingyan Chen	Ethnic-specific meta-analyses of association between the OPRM1 A118G polymorphism and alcohol dependence among Asians and Caucasians	2012	5	10.1016/j.drugalcdep.2011.10.012
C A Hardman	Lack of association between DRD2 and OPRM1 genotypes and adiposity.	2013	2	10.1038/ijo.2013.144
Ling Xu	OPRM1 gene is associated with BMI in Uyghur population.	2009	0	10.1038/oby.2008.504
A J Arias	Variation in OPRM1 and Risk of Suicidal Behavior in Drug-Dependent Individuals	2012	2	10.1111/j.1521-0391.2011.00195.x
Momchil A Nikolov	No evidence of association between 118A>G OPRM1 polymorphism and heroin dependence in a large Bulgarian case-control sample.	2011	0	10.1016/j.drugalcdep.2010.12.026
Carmen Walter	µ-opioid receptor gene variant OPRM1 118 A>G: a summary of its molecular and clinical consequences for pain.	2013	3	10.2217/pgs.13.187
Robert Miranda	Initial evidence of an association between OPRM1 and adolescent alcohol misuse.	2010	0	10.1111/j.1530-0277.2009.01073.x
Batoul Sadat Haerian	OPRM1 rs1799971 polymorphism and opioid dependence: evidence from a meta-analysis.	2013	3	10.2217/pgs.13.57
AJ Arias	Variation in OPRM1 and Risk of Suicidal Behavior in Drug- Dependent Individuals	2012	5	10.1111/j.1521-0391.2011.00195.x.Variation
Dmitri Proudnikov	Association of polymorphisms of the mu opioid receptor gene with the severity of HIV infection and response to HIV treatment.	2012	4	10.1093/infdis/jis264
Noora Rouvinen-Lagerström	Opioid Receptor Gene (OPRM1) Polymorphism A118G: Lack of Association in Finnish Populations with Alcohol Dependence or Alcohol Consumption.	2013	1	-
Laurie Chassin	Testing multiple levels of influence in the intergenerational transmission of alcohol disorders from a developmental perspective: the example of alcohol use promoting peers and μ-opioid receptor M1 variation.	2012	1	10.1017/S0954579412000478
Momchil A. Nikolov	No evidence of association between 118A>G OPRM1 polymorphism and heroin dependence in a large Bulgarian case-control sample	2011	2	10.1016/j.drugalcdep.2010.12.026
Stephanie-May Ruchat	Association between mu-opioid receptor-1 102T>C polymorphism and intermediate type 2 diabetes phenotypes: results from the Quebec Family Study (QFS).	2008	0	10.1111/j.1440-1681.2008.04972.x
T K Clarke	Low frequency genetic variants in the mu-opioid receptor (OPRM1) affect risk for addiction to heroin and cocaine	2013	0	10.1016/j.neulet.2013.02.018
Gabriele Koller	Possible Association Between OPRM1 Genetic Variance at the 118 Locus and Alcohol Dependence in a Large Treatment Sample: Relationship to Alcohol Dependence Symptoms.	2012	2	10.1111/j.1530-0277.2011.01714.x
Hollis C. Karoly	Genetic influences on physiological and subjective responses to an aerobic exercise session among sedentary adults	2012	11	10.1155/2012/540563
Bruno G Oertel	Genetic-epigenetic interaction modulates μ-opioid receptor regulation.	2012	0	10.1093/hmg/dds314
Omar Serý	A118G polymorphism of OPRM1 gene is associated with schizophrenia.	2010	2	-

Evidence compiled by the Personal Genome Project

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Publications listed by Genome.gov

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Name	rs1799971
Chromosome	6
Position	154039662
Weight of evidence	84

SNP rs1799971

Basic Information

Genotype Frequency

Allele Frequency

Additional Information

Links to SNPedia

Publications on this SNP on the Public Library of Science:

Publications on this SNP on Mendeley

Evidence compiled by the Personal Genome Project

Publications listed by Genome.gov

Users who share this SNP:

Genome Browser

Contacts