openSNP | rs1799884

Links to SNPedia

Title	Summary
rs1799884 A/G	1.3x increased risk for type 2 diabetes. mothers have babies 27g heavier.
rs1799884 G/G	Mothers have typical birth-weight babies. slightly lower risk of type 2 diabetes.
rs1799884 C/C	No summary provided.
rs1799884 A/A	2.7x increased risk for type 2 diabetes. mothers have babies 54g heavier.

Note: For some SNPs, testing providers detect the genotype from the opposite strand of DNA, so that the genotypes listed on openSNP don't appear here. In those cases, please replace "A" by "T" or "G" by "C" (and vice-versa).

Publications on this SNP on the Public Library of Science:

First Author	Title	Year of Publication	# of readers
Pablo Perez-Martinez	Glucokinase Regulatory Protein Genetic Variant Interacts with Omega-3 PUFA to Influence Insulin Resistance and Inflammation in Metabolic Syndrome	2011	4862
Claudia Ha Ting Tam	Common Polymorphisms in MTNR1B, G6PC2 and GCK Are Associated with Increased Fasting Plasma Glucose and Impaired Beta-Cell Function in Chinese Subjects	2010	4641
Guillaume Paré	Novel Association of HK1 with Glycated Hemoglobin in a Non-Diabetic Population: A Genome-Wide Evaluation of 14,618 Participants in the Women's Genome Health Study	2008	6594
Ying Wang	Association of Six Single Nucleotide Polymorphisms with Gestational Diabetes Mellitus in a Chinese Population	2011	5772
Cheng Hu	Effects of GCK, GCKR, G6PC2 and MTNR1B Variants on Glucose Metabolism and Insulin Secretion	2010	4144
Jennifer K. Lowe	Genome-Wide Association Studies in an Isolated Founder Population from the Pacific Island of Kosrae	2009	12839
Simon D. Rees	Effects of 16 Genetic Variants on Fasting Glucose and Type 2 Diabetes in South Asians: ADCY5 and GLIS3 Variants May Predispose to Type 2 Diabetes	2011	5111
Da Fu	Genetic Polymorphism of Glucokinase on the Risk of Type 2 Diabetes and Impaired Glucose Regulation: Evidence Based on 298, 468 Subjects	2013	2916
Xiaomu Kong	Association of Genetic Variants with Isolated Fasting Hyperglycaemia and Isolated Postprandial Hyperglycaemia in a Han Chinese Population	2013	3152
Peng Chen	A Study Assessing the Association of Glycated Hemoglobin A_1C (HbA_1C) Associated Variants with HbA_1C, Chronic Kidney Disease and Diabetic Retinopathy in Populations of Asian Ancestry	2013	3418
Mark Bi	Association of rs780094 in GCKR with Metabolic Traits and Incident Diabetes and Cardiovascular Disease: The ARIC Study	2010	3657
Andrea D. Coviello	A Genome-Wide Association Meta-Analysis of Circulating Sex Hormone–Binding Globulin Reveals Multiple Loci Implicated in Sex Steroid Hormone Regulation	2012	12436
Haoran Wang	Large Scale Meta-Analyses of Fasting Plasma Glucose Raising Variants in GCK, GCKR, MTNR1B and G6PC2 and Their Impacts on Type 2 Diabetes Mellitus Risk	2013	3846
Steven Haney	RNAi Screening in Primary Human Hepatocytes of Genes Implicated in Genome-Wide Association Studies for Roles in Type 2 Diabetes Identifies Roles for CAMK1D and CDKAL1, among Others, in Hepatic Glucose Regulation	2013	4518
Yue Shen	GCKR Variants Increase Triglycerides While Protecting from Insulin Resistance in Chinese Children	2013	1947
Tamuno Alfred	Associations between a Polymorphism in the Pleiotropic GCKR and Age-Related Phenotypes: The HALCyon Programme	2013	1978
Hongyan Mao	Meta-Analysis of the Relationship between Common Type 2 Diabetes Risk Gene Variants with Gestational Diabetes Mellitus	2012	7343
Pei-Chao Lin	Transcription Factor 7-Like 2 (TCF7L2) rs7903146 Polymorphism as a Risk Factor for Gestational Diabetes Mellitus: A Meta-Analysis	2016	3855

Publications on this SNP on Mendeley

First Author	Title	Pub. Year	# of Readers	DOI
P Bahillo Curieses	Fasting hyperglycaemia and polymorphism in glucokinase promoter (rs1799884). [Spanish] Hiperglucemia en ayunas y polimorfismo en el promotor de la glucoquinasa (rs1799884)	2011	0	10.1016/j.anpedi.2011.05.009
Michael N Weedon	A common haplotype of the glucokinase gene alters fasting glucose and birth weight: association in six studies and population-genetics analyses.	2006	20	10.1086/509517
Johan Holmkvist	Common variants in maturity-onset diabetes of the young genes and future risk of type 2 diabetes.	2008	4	10.2337/db06-1464
M N Weedon	A common haplotype of the glucokinase gene alters fasting glucose and birth weight: association in six studies and population-genetics analyses	2006	10	10.1086/509517
Rachel M Freathy	Type 2 diabetes TCF7L2 risk genotypes alter birth weight: a study of 24,053 individuals.	2007	1	-
P. Bahíllo Curieses	Hiperglucemia en ayunas y polimorfismo en el promotor de la glucoquinasa (rs1799884)	2011	0	10.1016/j.anpedi.2011.05.009
Michael N Weedon	A common haplotype of the glucokinase gene alters fasting glucose and birth weight: association in six studies and population-genetics analyses.	2006	9	-
R M Freathy	Hyperglycemia and Adverse Pregnancy Outcome (HAPO) study: common genetic variants in GCK and TCF7L2 are associated with fasting and postchallenge glucose levels in pregnancy and with the new consensus definition of gestational diabetes mellitus from the I	2010	1	-
Rachel M Freathy	Type 2 diabetes TCF7L2 risk genotypes alter birth weight: a study of 24,053 individuals.	2007	19	-
Ali S Murad	A polymorphism in the glucokinase gene that raises plasma fasting glucose, rs1799884, is associated with diabetes mellitus and prostate cancer: findings from a population-based, case-control study (the ProtecT study)	2010	1
Jose Ignacio Gonzalez	Relevant associations of the glucokinase regulatory protein/glucokinase gene variation with TAG concentrations in a high-cardiovascular risk population: modulation by the Mediterranean diet	2012	1	10.1017/S0007114512000918

Evidence compiled by the Personal Genome Project

There are no results from the Personal Genome Project yet. Please come back later.

Publications listed by Genome.gov

First Author	Title	Journal	Publication Date	Trait	p-value	Confidence Interval
Kim YJ	Large-scale genome-wide association studies in East Asians identify new genetic loci influencing metabolic traits.	Nat Genet	09/11/2011	Metabolite levels	2.0e-19 (FPG)	[0.049-0.075] mg/dL increase
Soranzo N	Common variants at 10 genomic loci influence hemoglobin A₁(C) levels via glycemic and nonglycemic pathways.	Diabetes	09/21/2010	Glycated hemoglobin levels	1.0e-20	[0.03-0.05] % increase

Name	rs1799884
Chromosome	7
Position	44189469
Weight of evidence	71

SNP rs1799884

Basic Information

Genotype Frequency

Allele Frequency

Additional Information

Links to SNPedia

Publications on this SNP on the Public Library of Science:

Publications on this SNP on Mendeley

Evidence compiled by the Personal Genome Project

Publications listed by Genome.gov

Users who share this SNP:

Genome Browser

Contacts