openSNP | rs17817449

Links to SNPedia

Title	Summary
rs17817449 G/T	~1.3x increased obesity risk
rs17817449 G/G	~1.7x increased obesity risk
rs17817449 T/T	Normal

Note: For some SNPs, testing providers detect the genotype from the opposite strand of DNA, so that the genotypes listed on openSNP don't appear here. In those cases, please replace "A" by "T" or "G" by "C" (and vice-versa).

Publications on this SNP on the Public Library of Science:

First Author	Title	Year of Publication	# of readers
Timo D. Müller	Emerging Function of Fat Mass and Obesity-Associated Protein (Fto)	2013	9586
Ge Zhang	Common SNPs in FTO Gene Are Associated with Obesity Related Anthropometric Traits in an Island Population from the Eastern Adriatic Coast of Croatia	2010	4926
Chibo Liu	The FTO Gene rs9939609 Polymorphism Predicts Risk of Cardiovascular Disease: A Systematic Review and Meta-Analysis	2013	4760
Jirong Long	Evaluating Genome-Wide Association Study-Identified Breast Cancer Risk Variants in African-American Women	2013	4523
Jan Bressler	Risk of Type 2 Diabetes and Obesity Is Differentially Associated with Variation in FTO in Whites and African-Americans in the ARIC Study	2010	6264
Kathryn G. Ewens	FTO and MC4R Gene Variants Are Associated with Obesity in Polycystic Ovary Syndrome	2011	7106
Kai Wang	A Genome-Wide Association Study on Obesity and Obesity-Related Traits	2011	13518
Christopher G. Bell	Integrated Genetic and Epigenetic Analysis Identifies Haplotype-Specific Methylation in the FTO Type 2 Diabetes and Obesity Susceptibility Locus	2010	20501
Jianjin Guo	Fat Mass and Obesity Associated Gene (FTO) Expression Is Regulated Negatively by the Transcription Factor Foxa2	2012	4340
Ulrike Peters	A Systematic Mapping Approach of 16q12.2/FTO and BMI in More Than 20,000 African Americans Narrows in on the Underlying Functional Variation: Results from the Population Architecture using Genomics and Epidemiology (PAGE) Study	2013	6943
Josefin A. Jacobsson	Detailed Analysis of Variants in FTO in Association with Body Composition in a Cohort of 70-Year-Olds Suggests a Weakened Effect among Elderly	2011	2282
Li-Jun Tan	Replication of 6 Obesity Genes in a Meta-Analysis of Genome-Wide Association Studies from Diverse Ancestries	2014	4826
Cindy Thron	FTO Is Associated with Aortic Valve Stenosis in a Gender Specific Manner of Heterozygote Advantage: A Population-Based Case-Control Study	2015	1448
Yolanda Saldaña-Alvarez	Gender-Dependent Association of FTO Polymorphisms with Body Mass Index in Mexicans	2016	2882

Publications on this SNP on Mendeley

First Author	Title	Pub. Year	# of Readers	DOI
Marisela Villalobos-Comparán	The FTO gene is associated with adulthood obesity in the Mexican population.	2008	0
Jaroslav A Hubacek	A common variant in the FTO gene is associated with body mass index in males and postmenopausal females but not in premenopausal females. Czech post-MONICA and 3PMFs studies.	2009	3	10.1515/CCLM.2009.109
Jaroslav a Hubacek	Under-Mining the Environment	2011	4	10.1093/ndt/gfr418
Marta González-Carpio	FTO Risk Haplotype Among Early Onset and Severe Obesity Cases in a Population of Western Spain	2012	2	10.1038/oby.2011.325
Jan Bressler	Fat mass and obesity gene and cognitive decline: the Atherosclerosis Risk in Communities Study.	2013	3	10.1212/WNL.0b013e3182768910
Jaroslav A Hubacek	The FTO gene and obesity in a large Eastern European population sample: the HAPIEE study.	2008	11	10.1038/oby.2008.421
Nora L Nock	FTO polymorphisms are associated with adult body mass index (BMI) and colorectal adenomas in African-Americans.	2011	9	-
Jaroslav A Hubacek	A FTO variant and risk of acute coronary syndrome	2010	1	10.1016/j.cca.2010.03.037
JA Hubacek	The FTO gene and obesity in a large Eastern European population sample: the HAPIEE study.	2008	9	-
J A Hubáček	FTO variant, energy intake, physical activity and basal metabolic rate in Caucasians. The HAPIEE study.	2011	13
Nora L Nock	FTO polymorphisms are associated with adult body mass index (BMI) and colorectal adenomas in African-Americans.	2011	9	10.1093/carcin/bgr026
Kai Wang	A genome-wide association study on obesity and obesity-related traits.	2011	35	10.1371/journal.pone.0018939
R Arlen Price	FTO gene SNPs associated with extreme obesity in cases, controls and extremely discordant sister pairs.	2008	16	10.1186/1471-2350-9-4
Hubacek J.A.	Fto polymorphism is associated with diabetes mellitus complications	2011	2
Jaroslav A Hubacek	A common variant in the FTO gene is associated with body mass index in males and postmenopausal females but not in premenopausal females. Czech post-MONICA and 3PMFs studies.	2009	3	-
Seong W Cha	Replication of genetic effects of FTO polymorphisms on BMI in a Korean population.	2008	12	10.1038/oby.2008.314
J Schum	Variants of the FTO gene in obese children and their impact on body composition and metabolism before and after lifestyle intervention	2012	1	10.1055/s-0031-1295403
Kai Wang	A genome-wide association study on obesity and obesity-related traits	2011	41	10.1371/journal.pone.0018939
Jaroslav A Hubacek	A FTO variant and risk of acute coronary syndrome.	2010	1	10.1016/j.cca.2010.03.037
D. Dlouha	Association between FTO 1st intron tagging variant and telomere length in middle aged females. 3PMFs study	2012	1	10.1016/j.cca.2012.03.025
J.A. Hubacek	Association between FTO 1st intron tagging variant and telomere length in middle aged females. 3PMFs study	2012	1	10.1016/j.cca.2012.03.025
Robert A Scott	FTO genotype and adiposity in children: physical activity levels influence the effect of the risk genotype in adolescent males	2010	15	10.1038/ejhg.2010.131
D Dlouhá	Body mass index change in females after short-time life style intervention is not dependent on the FTO polymorphisms.	2011	4	-
M R Wing	Analysis of FTO gene variants with obesity and glucose homeostasis measures in the multiethnic Insulin Resistance Atherosclerosis Study cohort.	2011	6	10.1038/ijo.2010.244
Simon Dyer	Under-Mining the Environment	2008	8	10.1093/ndt/gfr418
Jaroslav A Hubacek	A FTO variant and risk of acute coronary syndrome.	2010	3	-
Ron Do	Genetic variants of FTO influence adiposity, insulin sensitivity, leptin levels, and resting metabolic rate in the Quebec Family Study.	2008	31	10.2337/db07-1267
D Dlouha	Association between FTO 1st intron tagging variant and telomere length in middle aged females. 3PMFs study	2012	1	-
Hubacek J.A.	A FTO variant and risk of acute coronary syndrome	2010	1	-
Jai Prakash	Association of FTO rs17817449 SNP with obesity and associated physiological parameters in a north Indian population	2011	6	10.3109/03014460.2011.614278
Jaroslav A. Hubacek	A FTO variant and risk of acute coronary syndrome	2010	1
Hubacek J A	Fto polymorphism is associated with diabetes mellitus complications	2011	2	-
Maria R Wing	Analysis of FTO gene variants with measures of obesity and glucose homeostasis in the IRAS Family Study.	2009	16	10.1007/s00439-009-0656-3
JA Hubacek	The FTO gene polymorphism is associated with end-stage renal disease: two large independent case-control studies in a general population.	2011	1	-
Jaroslav A. Hubacek	A FTO variant and risk of acute coronary syndrome	2010	1	10.1016/j.cca.2010.03.037
Jun Ohashi	FTO polymorphisms in oceanic populations.	2007	18	10.1007/s10038-007-0198-2
Balraj Mittal	Association of FTO rs17817449 SNP with obesity and associated physiological parameters in a north Indian population	2011	6	10.3109/03014460.2011.614278
Robert A Scott	FTO genotype and adiposity in children: physical activity levels influence the effect of the risk genotype in adolescent males.	2010	17	10.1038/ejhg.2010.131
JA Hubacek	FTO Variant, Energy Intake, Physical Activity and Basal Metabolic Rate in Caucasians. The HAPIEE Study	2011	11	-
Ron Do	Genetic variants of FTO influence adiposity, insulin sensitivity, leptin levels, and resting metabolic rate in the Quebec Family Study.	2008	22	-
Marisela Villalobos-Comparán	The FTO gene is associated with adulthood obesity in the Mexican population.	2008	24	10.1038/oby.2008.367

Evidence compiled by the Personal Genome Project

There are no results from the Personal Genome Project yet. Please come back later.

Publications listed by Genome.gov

First Author	Title	Journal	Publication Date	Trait	p-value	Confidence Interval
Wang K	A genome-wide association study on obesity and obesity-related traits.	PLoS One	04/28/2011	Obesity	2.0e-12 (obesity)	NR

Name	rs17817449
Chromosome	16
Position	53779455
Weight of evidence	86

SNP rs17817449

Basic Information

Genotype Frequency

Allele Frequency

Additional Information

Links to SNPedia

Publications on this SNP on the Public Library of Science:

Publications on this SNP on Mendeley

Evidence compiled by the Personal Genome Project

Publications listed by Genome.gov

Users who share this SNP:

Genome Browser

Contacts