openSNP | rs1695

Links to SNPedia

Title	Summary
rs1695 A/A	Normal asthma risk in certain populations
rs1695 G/G	3.5x asthma risk in certain populations
rs1695 A/G	?

Note: For some SNPs, testing providers detect the genotype from the opposite strand of DNA, so that the genotypes listed on openSNP don't appear here. In those cases, please replace "A" by "T" or "G" by "C" (and vice-versa).

Publications on this SNP on the Public Library of Science:

First Author	Title	Year of Publication	# of readers
Jessica L. Barrington-Trimis	Parental Smoking and Risk of Childhood Brain Tumors by Functional Polymorphisms in Polycyclic Aromatic Hydrocarbon Metabolism Genes	2013	2464
Ruixuan Geng	Oxidative Stress-Related Genetic Polymorphisms Are Associated with the Prognosis of Metastatic Gastric Cancer Patients Treated with Epirubicin, Oxaliplatin and 5-Fluorouracil Combination Chemotherapy	2014	2443
Jie Ge	The GSTP1 105Val Allele Increases Breast Cancer Risk and Aggressiveness but Enhances Response to Cyclophosphamide Chemotherapy in North China	2013	1790
Laura W. Goff	Thymidylate Synthase Genotype-Directed Chemotherapy for Patients with Gastric and Gastroesophageal Junction Cancers	2014	1884
Tatjana I. Djukic	Glutathione S-Transferase T1, O1 and O2 Polymorphisms Are Associated with Survival in Muscle Invasive Bladder Cancer Patients	2013	2291
Amit A. Negandhi	MTHFR Glu429Ala and ERCC5 His46His Polymorphisms Are Associated with Prognosis in Colorectal Cancer Patients: Analysis of Two Independent Cohorts from Newfoundland	2013	3424
Orsolya Lautner-Csorba	Roles of Genetic Polymorphisms in the Folate Pathway in Childhood Acute Lymphoblastic Leukemia Evaluated by Bayesian Relevance and Effect Size Analysis	2013	3555
Goutham Hassan Venkatesh	Polymorphisms in Radio-Responsive Genes and Its Association with Acute Toxicity among Head and Neck Cancer Patients	2014	3638
Sheng-xin Huang	The Glutathione S-Transferase P1 341C>T Polymorphism and Cancer Risk: A Meta-Analysis of 28 Case-Control Studies	2013	2877
Mancheng Gong	Genetic Polymorphisms of GSTM1, GSTT1, and GSTP1 with Prostate Cancer Risk: A Meta-Analysis of 57 Studies	2012	3796
Cholendra Arja	Genetic Determinants of Chronic Obstructive Pulmonary Disease in South Indian Male Smokers	2014	2721
Ching-Yu Lai	Tumor Site- and Stage-Specific Associations between Allelic Variants of Glutathione S-Transferase and DNA-Repair Genes and Overall Survival in Colorectal Cancer Patients Receiving 5-Fluorouracil-Based Chemotherapy	2013	1907
Ming-Wei Su	Gene-Gene and Gene-Environmental Interactions of Childhood Asthma: A Multifactor Dimension Reduction Approach	2012	7101
Akiko Shiotani	Novel Single Nucleotide Polymorphism Markers for Low Dose Aspirin-Associated Small Bowel Bleeding	2013	2363
Xingliang Yang	Glutathione S-Transferase Polymorphisms (GSTM1, GSTT1 and GSTP1) and Their Susceptibility to Renal Cell Carcinoma: An Evidence-Based Meta-Analysis	2013	1728
Marco Matejcic	Association of a Deletion of GSTT2B with an Altered Risk of Oesophageal Squamous Cell Carcinoma in a South African Population: A Case-Control Study	2011	2832
Ji-Ye Yin	Meta-Analysis on Pharmacogenetics of Platinum-Based Chemotherapy in Non Small Cell Lung Cancer (NSCLC) Patients	2012	5268
Junhua Wu	Modifying Role of GSTP1 Polymorphism on the Association between Tea Fluoride Exposure and the Brick-Tea Type Fluorosis	2015	1069
Mohammad Abbas	Glutathione S-Transferase Gene Polymorphisms and Treatment Outcome in Cervical Cancer Patients under Concomitant Chemoradiation	2015	2027

Publications on this SNP on Mendeley

First Author	Title	Pub. Year	# of Readers	DOI
J Cotignola	Glutathione-S-transferase (GST) polymorphisms are associated with relapse after radical prostatectomy	2012	2	10.1038/pcan.2012.45
Huanxi Shen	Genetic variation in GSTM1 is associated with susceptibility to noise-induced hearing loss in a Chinese population.	2012	2	10.1097/JOM.0b013e31825902ce
M Ibarrola-Villava	Role of glutathione S-transferases in melanoma susceptibility: association with GSTP1 rs1695 polymorphism.	2012	3	10.1111/j.1365-2133.2012.10831.x
Hee Nam Kim	Polymorphisms of drug-metabolizing genes and risk of non-Hodgkin lymphoma.	2009	0
Sonam Tulsyan	Pharmacogenetic influence of GST polymorphisms on anthracycline-based chemotherapy responses and toxicity in breast cancer patients: a multi-analytical approach.	2013	1	10.1007/s40291-013-0045-4
C. Kiyohara	GST polymorphisms, interaction with smoking and pesticide use, and risk for Parkinson's disease in a Japanese population	2010	5	10.1016/j.parkreldis.2010.04.009
Kerryn W Reding	Investigation of genetic polymorphisms in the progesterone and estrogen pathways as modifiers of the effect of hormone therapy on breast cancer	2008	1	-
Robert K Sylvester	Temozolomide-induced severe myelosuppression: analysis of clinically associated polymorphisms in two patients.	2011	4	10.1097/CAD.0b013e3283407e9f
B R Joubert	Evaluation of genetic susceptibility to childhood allergy and asthma in an African American urban population	2011	2	10.1186/1471-2350-12-25
Edyta Reszka	GSTP1 mRNA expression in human circulating blood leukocytes is associated with GSTP1 genetic polymorphism.	2011	0	-
A Romero	Glutathione S-transferase P1 c.313A > G polymorphism could be useful in the prediction of doxorubicin response in breast cancer patients.	2011	8	10.1093/annonc/mdr483
Amanda B Spurdle	Need for clarification of results in the recent meta-analysis about SULT1A1 codon 213 polymorphism and breast cancer risk.	2010	2	-
Christopher G. Mathew	Association of a Deletion of GSTT2B with an Altered Risk of Oesophageal Squamous Cell Carcinoma in a South African Population: A Case-Control Study	2011	4	10.1371/journal.pone.0029366
Norberto Krivoy	Pharmacokinetic and pharmacogenetic analysis of oral busulfan in stem cell transplantation: prediction of poor drug metabolism to prevent drug toxicity.	2012	1	-
Meira Epplein	Urinary isothiocyanates; glutathione S-transferase M1, T1, and P1 polymorphisms; and risk of colorectal cancer: the Multiethnic Cohort Study.	2009	10	-
Mª Asunción García-González	Relevance of GSTM1, GSTT1, and GSTP1 gene polymorphisms to gastric cancer susceptibility and phenotype	2012	1	-
a Romero	Glutathione S-transferase P1 c.313A > G polymorphism could be useful in the prediction of doxorubicin response in breast cancer patients.	2012	12	10.1093/annonc/mdr483
Luiz Alexandre V Magno	Glutathione s-transferase variants in a brazilian population.	2009	7	10.1159/000205823
Pin Sun	Polymorphisms in phase I and phase II metabolism genes and risk of chronic benzene poisoning in a Chinese occupational population.	2008	2	-
Amanda B Spurdle	Pooled analysis indicates that the GSTT1 deletion, GSTM1 deletion, and GSTP1 Ile105Val polymorphisms do not modify breast cancer risk in BRCA1 and BRCA2 mutation carriers.	2010	2	10.1007/s10549-009-0601-0
Hee Nam Kim	Polymorphisms of drug-metabolizing genes and risk of non-Hodgkin lymphoma.	2009	3	-
S Rednam	Glutathione s-transferase P1 single nucleotide polymorphism predicts permanent ototoxicity in children with medulloblastoma	2012	5	10.1002/pbc.24366
Viviana Ystaas	Sample-to-SNP kit: A reliable, easy and fast tool for the detection of HFE p.H63D and p.C282Y variations associated to hereditary hemochromatosis	2012	1	10.1016/j.gene.2012.06.020
Catherine Duggan	Associations between null mutations in GSTT1 and GSTM1, the GSTP1 Ile(105)Val polymorphism, and mortality in breast cancer survivors.	2013	6	10.1186/2193-1801-2-450
Robert K Sylvester	Temozolomide-induced severe myelosuppression: analysis of clinically associated polymorphisms in two patients.	2011	1	-
Bo Chen	The influence of metabolic gene polymorphisms on urinary 1-hydroxypyrene concentrations in Chinese coke oven workers.	2007	4	10.1016/j.scitotenv.2007.02.021
Hortensia Moreno-Macías	Ozone exposure, vitamin C intake, and genetic susceptibility of asthmatic children in Mexico City: a cohort study.	2013	1	10.1186/1465-9921-14-14
J R Cerhan	Genetic polymorphisms in genes involved in R-CHOP metabolism and event-free and overall survival in diffuse large B-cell lymphoma	2010	1
Meira Epplein	Urinary isothiocyanates; glutathione S-transferase M1, T1, and P1 polymorphisms; and risk of colorectal cancer: the Multiethnic Cohort Study.	2009	9	10.1158/1055-9965.EPI-08-0627
Hortensia Moreno-Macías	Ozone exposure, vitamin C intake, and genetic susceptibility of asthmatic children in Mexico City: a cohort study.	2013	3	10.1186/1465-9921-14-14
Luiz Alexandre V Magno	Glutathione S-transferase variants in a Brazilian population	2009	7	10.1159/000205823
N.V. Litviakov	Influence of gene polymorphism on the expression of the multidrug resistance genes in breast tumor during neoadjuvant chemotherapy	2011	1
Catherine Duggan	Associations between null mutations in GSTT1 and GSTM1, the GSTP1 Ile(105)Val polymorphism, and mortality in breast cancer survivors.	2013	1	10.1186/2193-1801-2-450
Huanxi Shen	Genetic variation in GSTM1 is associated with susceptibility to noise-induced hearing loss in a Chinese population.	2012	1	10.1097/JOM.0b013e31825902ce
Edyta Reszka	GSTP1 mRNA expression in human circulating blood leukocytes is associated with GSTP1 genetic polymorphism.	2011	0	10.1016/j.clinbiochem.2011.05.024
K Ross-Hansen	The role of glutathione S-transferase and claudin-1 gene polymorphisms in contact sensitization: a cross-sectional study.	2013	1	10.1111/bjd.12126
Marco Matejcic	Association of a deletion of GSTT2B with an altered risk of oesophageal squamous cell carcinoma in a South African population: A Case-Control study	2011	6	10.1371/journal.pone.0029366
A B Spurdle	Pooled analysis indicates that the GSTT1 deletion, GSTM1 deletion, and GSTP1 Ile105Val polymorphisms do not modify breast cancer risk in BRCA1 and BRCA2 mutation carriers	2010	1	10.1007/s10549-009-0601-0
A. F. S. Amaral	Interaction between gas cooking and GSTM1 null genotype in bronchial responsiveness: results from the European Community Respiratory Health Survey	2014	1	10.1136/thoraxjnl-2013-204574
Pin Sun	Polymorphisms in phase I and phase II metabolism genes and risk of chronic benzene poisoning in a Chinese occupational population.	2008	5	10.1093/carcin/bgn208
a Romero	Glutathione S-transferase P1 c.313A > G polymorphism could be useful in the prediction of doxorubicin response in breast cancer patients.	2011	9	10.1093/annonc/mdr483
B R Joubert	Evaluation of genetic susceptibility to childhood allergy and asthma in an African American urban population	2011	1	10.1186/1471-2350-12-25
Olav E. Yri	Polymorphisms in genes encoding interleukin-10 and drug metabolizing enzymes GSTP1, GSTT1, GSTA1 and UGT1A1 influence risk and outcome in Hodgkin lymphoma	2012	2	10.3109/10428194.2012.682307
Maria Timofeeva	Genetic polymorphisms of <I>MPO, GSTT1, GSTM1, GSTP1, EPHX1</I> and <I>NQO1</I> as risk factors of early-onset lung cancer	2010	1	10.1002/ijc.25175
Maria Timofeeva	Genetic polymorphisms of MPO, GSTT1, GSTM1, GSTP1, EPHX1 and NQO1 as risk factors of early-onset lung cancer.	2010	10	10.1002/ijc.25175
S Rednam	Glutathione S-transferase P1 single nucleotide polymorphism predicts permanent ototoxicity in children with medulloblastoma	2013	8	10.1002/pbc.24366 [doi]
Madé Wenten	In utero smoke exposure, glutathione S-transferase P1 haplotypes, and respiratory illness-related absence among schoolchildren.	2009	3	-
Edyta Reszka	GSTP1 mRNA expression in human circulating blood leukocytes is associated with GSTP1 genetic polymorphism	2011	1	10.1016/j.clinbiochem.2011.05.024
J Cotignola	Glutathione-S-transferase (GST) polymorphisms are associated with relapse after radical prostatectomy.	2013	7	10.1038/pcan.2012.45
M Asunción García-González	Relevance of GSTM1, GSTT1, and GSTP1 gene polymorphisms to gastric cancer susceptibility and phenotype.	2012	3	10.1093/mutage/ges049
Tsila Zuckerman	Pharmacokinetic and Pharmacogenetic Analysis of Oral Busulfan in Stem Cell Transplantation: Prediction of Poor Drug Metabolism to Prevent Drug Toxicity	2012	3	10.2174/157488612803251324
Ben Zhang	Evaluation of functional genetic variants for breast cancer risk: results from the Shanghai breast cancer study.	2011	3	10.1093/aje/kwr004
Cristina Canova	PM10-induced Hospital Admissions for Asthma and Chronic Obstructive Pulmonary Disease: The Modifying Effect of Individual Characteristics.	2012	9	10.1097/EDE.0b013e3182572563
Bo Chen	The influence of metabolic gene polymorphisms on urinary 1-hydroxypyrene concentrations in Chinese coke oven workers	2007	4	10.1016/j.scitotenv.2007.02.021
Peter B. Nielsen	Sample-to-SNP kit: A reliable, easy and fast tool for the detection of HFE p.H63D and p.C282Y variations associated to hereditary hemochromatosis	2012	6	10.1016/j.gene.2012.06.020
Huanxi Shen	Genetic variation in GSTM1 is associated with susceptibility to noise-induced hearing loss in a Chinese population.	2012	1	10.1097/JOM.0b013e31825902ce
M Matejcic	Association of a deletion of GSTT2B with an altered risk of oesophageal squamous cell carcinoma in a South African population: A Case-Control study	2011	3	10.1371/journal.pone.0029366
Luiz Alexandre V Magno	Glutathione s-transferase variants in a brazilian population.	2009	5	-
B T Keenan	Effect of glutathione S-transferase T1, M1, P1 and heme oxygenase-1 gene promoter polymorphisms interactions with heavy smoking on the risk of rheumatoid arthritis	2009	3
Hortensia Moreno-Macías	Ozone exposure, vitamin C intake, and genetic susceptibility of asthmatic children in Mexico City: a cohort study.	2013	8	10.1186/1465-9921-14-14
M Ibarrola-Villava	Role of glutathione S-transferases in melanoma susceptibility: association with GSTP1 rs1695 polymorphism.	2012	1	10.1111/j.1365-2133.2012.10831.x

Evidence compiled by the Personal Genome Project

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Publications listed by Genome.gov

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Users who share this SNP:

E. Campbell

Genotype AG

17.09.2012 13:55

Probably increased asthma risk.

Name	rs1695
Chromosome	11
Position	67585218
Weight of evidence	114

SNP rs1695

Basic Information

Genotype Frequency

Allele Frequency

Additional Information