openSNP | rs1558902

Links to SNPedia

Title	Summary
rs1558902 T/T	Normal
rs1558902 A/T	higher bmi than normal
rs1558902 A/A	higher bmi than normal

Note: For some SNPs, testing providers detect the genotype from the opposite strand of DNA, so that the genotypes listed on openSNP don't appear here. In those cases, please replace "A" by "T" or "G" by "C" (and vice-versa).

Publications on this SNP on the Public Library of Science:

First Author	Title	Year of Publication	# of readers
André Scherag	Two New Loci for Body-Weight Regulation Identified in a Joint Analysis of Genome-Wide Association Studies for Early-Onset Extreme Obesity in French and German Study Groups	2010	14060
Peter Würtz	Metabolic Signatures of Adiposity in Young Adults: Mendelian Randomization Analysis and Effects of Weight Change	2014	18512
Nancy L. Heard-Costa	NRXN3 Is a Novel Locus for Waist Circumference: A Genome-Wide Association Study from the CHARGE Consortium	2009	12820
Lavinia Paternoster	Genome-Wide Population-Based Association Study of Extremely Overweight Young Adults – The GOYA Study	2011	5672
Li-Jun Tan	Replication of 6 Obesity Genes in a Meta-Analysis of Genome-Wide Association Studies from Diverse Ancestries	2014	4826
Raquel Granell	Effects of BMI, Fat Mass, and Lean Mass on Asthma in Childhood: A Mendelian Randomization Study	2014	12583
Caroline S. Fox	Genome-Wide Association for Abdominal Subcutaneous and Visceral Adipose Reveals a Novel Locus for Visceral Fat in Women	2012	15244
Chibo Liu	FTO Gene Variant and Risk of Overweight and Obesity among Children and Adolescents: a Systematic Review and Meta-Analysis	2013	6121
Reedik Mägi	Contribution of 32 GWAS-Identified Common Variants to Severe Obesity in European Adults Referred for Bariatric Surgery	2013	4094
Junqing Wu	Association of FTO Polymorphisms with Obesity and Metabolic Parameters in Han Chinese Adolescents	2014	2595
Ulrike Peters	A Systematic Mapping Approach of 16q12.2/FTO and BMI in More Than 20,000 African Americans Narrows in on the Underlying Functional Variation: Results from the Population Architecture using Genomics and Epidemiology (PAGE) Study	2013	6943
Symen Ligthart	Pleiotropy among Common Genetic Loci Identified for Cardiometabolic Disorders and C-Reactive Protein	2015	2172
Bo Xi	Study of 11 BMI-Associated Loci Identified in GWAS for Associations with Central Obesity in the Chinese Children	2013	4675
Koichi Akiyama	Systematic Fine-Mapping of Association with BMI and Type 2 Diabetes at the FTO Locus by Integrating Results from Multiple Ethnic Groups	2014	2526
Paul T. Williams	Quantile-Specific Penetrance of Genes Affecting Lipoproteins, Adiposity and Height	2012	2409
Rebecca C. Richmond	Assessing Causality in the Association between Child Adiposity and Physical Activity Levels: A Mendelian Randomization Analysis	2014	17333
Benjamin W. Domingue	Polygenic Risk Predicts Obesity in Both White and Black Young Adults	2014	3261
Yutaka Kamura	FTO Gene Polymorphism Is Associated with Type 2 Diabetes through Its Effect on Increasing the Maximum BMI in Japanese Men	2016	1759
Mathias Rask-Andersen	Gene-environment interaction study for BMI reveals interactions between genetic factors and physical activity, alcohol consumption and socioeconomic status	2017	7045
Theresia M. Schnurr	Genetic Correlation between Body Fat Percentage and Cardiorespiratory Fitness Suggests Common Genetic Etiology	2016	3673
Marta Sobalska-Kwapis	Genetic association of FTO/IRX region with obesity and overweight in the Polish population	2017	1790
Alastair J. Noyce	Estimating the causal influence of body mass index on risk of Parkinson disease: A Mendelian randomisation study	2017	8567
Joel Eriksson	Causal relationship between obesity and serum testosterone status in men: A bi-directional mendelian randomization analysis	2017	2230
Kathrin Landgraf	FTO Obesity Risk Variants Are Linked to Adipocyte IRX3 Expression and BMI of Children - Relevance of FTO Variants to Defend Body Weight in Lean Children?	2016	2098
Sara Lindström	A comprehensive survey of genetic variation in 20,691 subjects from four large cohorts	2017	1720
Lauren E. Mokry	Obesity and Multiple Sclerosis: A Mendelian Randomization Study	2016	8779
Thomas J. Baranski	A high throughput, functional screen of human Body Mass Index GWAS loci using tissue-specific RNAi Drosophila melanogaster crosses	2018	1324
Yan Guo	Genetically Predicted Body Mass Index and Breast Cancer Risk: Mendelian Randomization Analyses of Data from 145,000 Women of European Descent	2016	7381
Maggie C. Y. Ng	Discovery and fine-mapping of adiposity loci using high density imputation of genome-wide association studies in individuals of African ancestry: African Ancestry Anthropometry Genetics Consortium	2017	4707
Eleanor Wheeler	Impact of common genetic determinants of Hemoglobin A1c on type 2 diabetes risk and diagnosis in ancestrally diverse populations: A transethnic genome-wide meta-analysis	2017	15689

Publications on this SNP on Mendeley

First Author	Title	Pub. Year	# of Readers	DOI
Kikuko Hotta	Variations in the FTO gene are associated with severe obesity in the Japanese	2008	18	10.1007/s10038-008-0283-1
T E Thorgeirsson	A common biological basis of obesity and nicotine addiction.	2013	9	10.1038/tp.2013.81
Peter Rzehak	Associations between BMI and the FTO gene are age dependent: Results from the GINI and LISA birth cohort studies up to age 6 years	2010	6	10.1159/000314612
Kazuhiko Kotani	FTO gene polymorphisms and platelet counts in a general Japanese population.	2012	2	10.231/JIM.0b013e318240527c
K Kotani	FTO gene polymorphisms and platelet counts in a general Japanese population	2012	1	10.231/JIM.0b013e318240527c
Paul T. Williams	Quantile-specific penetrance of genes affecting lipoproteins, adiposity and height	2012	6	10.1371/journal.pone.0028764
Wu Bin	FTO, Abdominal Adiposity, Fasting Hyperglycemia Associated with Elevated HbA1c in Japanese Middle-Aged Women	2012	2	10.5551/jat.11940
T E Thorgeirsson	A common biological basis of obesity and nicotine addiction.	2013	2	10.1038/tp.2013.81
X Zhang	FTO Genotype and 2-Year Change in Body Composition and Fat Distribution in Response to Weight-Loss Diets: The POUNDS LOST Trial	2012	2	-
Elizabeth K Speliotes	Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index.	2010	285	10.1038/ng.686
Peter Rzehak	Associations between BMI and the FTO gene are age dependent: results from the GINI and LISA birth cohort studies up to age 6 years.	2010	6	10.1159/000314612
X Sim	Replication of 13 obesity loci among Singaporean Chinese, Malay and Asian-Indian populations	2012	17	10.1038/ijo.2011.86
K Kotani	FTO gene polymorphisms and platelet counts in a general Japanese population	2012	1	10.231/JIM.0b013e318240527c
Jaroslav A Hubacek	FTO first intron rs1558902 variant and platelets count in white middle-aged women: prague pre- and post-menopausal females (3PMFs) study.	2013	4	10.231/JIM.0b013e31827b9994
M Tanaka	FTO, abdominal adiposity, fasting hyperglycemia associated with elevated HbA1c in Japanese middle-aged women	2012	1	-
Keiko Shinozaki	Fat-mass and obesity-associated gene variant and changes of body mass index from ages 3 to 13 years	2013	1	10.1016/j.orcp.2013.07.005
Q. Qi	FTO Genotype and 2-Year Change in Body Composition and Fat Distribution in Response to Weight-Loss Diets: The POUNDS LOST Trial	2012	8	10.2337/db11-1799
T.E.a Thorgeirsson	A common biological basis of obesity and nicotine addiction	2013	1
Peter Rzehak	Associations between BMI and the FTO gene are age dependent: results from the GINI and LISA birth cohort studies up to age 6 years.	2010	5	-

Evidence compiled by the Personal Genome Project

There are no results from the Personal Genome Project yet. Please come back later.

Publications listed by Genome.gov

First Author	Title	Journal	Publication Date	Trait	p-value	Confidence Interval
Scherag A	Two new Loci for body-weight regulation identified in a joint analysis of genome-wide association studies for early-onset extreme obesity in French and german study groups.	PLoS Genet	04/22/2010	Obesity (extreme)	7.0e-13	[1.26-1.50]
Speliotes EK	Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index.	Nat Genet	10/10/2010	Body mass index	1.0e-100	[0.35-0.43] kg/m2 increase
Heard-Costa NL	NRXN3 is a novel locus for waist circumference: a genome-wide association study from the CHARGE Consortium.	PLoS Genet	06/26/2009	Waist circumference	5.0e-19	NR

Name	rs1558902
Chromosome	16
Position	53769662
Weight of evidence	100

SNP rs1558902

Basic Information

Genotype Frequency

Allele Frequency

Additional Information

Links to SNPedia

Publications on this SNP on the Public Library of Science:

Publications on this SNP on Mendeley

Evidence compiled by the Personal Genome Project

Publications listed by Genome.gov

Users who share this SNP:

Genome Browser

Contacts