openSNP | rs1544410

SNP rs1544410

Basic Information

Name	rs1544410
Chromosome	12
Position	47846052
Weight of evidence	160

Links to SNPedia

Title	Summary
rs1544410 A/G	Intermediate risk of low bone mineral density disorders
rs1544410 G/G	Decreased risk of low bone mineral density disorders
rs1544410 A/A	Increased risk of low bone mineral density disorders

Note: For some SNPs, testing providers detect the genotype from the opposite strand of DNA, so that the genotypes listed on openSNP don't appear here. In those cases, please replace "A" by "T" or "G" by "C" (and vice-versa).

Publications on this SNP on the Public Library of Science:

First Author	Title	Year of Publication	# of readers
Nasser M. Al-Daghri	Vitamin D Receptor Gene Polymorphisms Are Associated with Obesity and Inflammosome Activity	2014	6843
Cheng Chen	Vitamin D Receptor Gene Polymorphisms on the Risk of Tuberculosis, a Meta-Analysis of 29 Case-Control Studies	2013	4986
Guofeng Wang	Associations between Two Polymorphisms (FokI and BsmI) of Vitamin D Receptor Gene and Type 1 Diabetes Mellitus in Asian Population: A Meta-Analysis	2014	3698
Irene Stefanaki	Replication and Predictive Value of SNPs Associated with Melanoma and Pigmentation Traits in a Southern European Case-Control Study	2013	5283
Jacques Fellay	Common Genetic Variation and the Control of HIV-1 in Humans	2009	20820
Linda Larcombe	Vitamin D in a Northern Canadian First Nation Population: Dietary Intake, Serum Concentrations and Functional Gene Polymorphisms	2012	3559
Yanling Liu	Polymorphisms in the Vitamin D Receptor (VDR) and the Risk of Ovarian Cancer: A Meta-Analysis	2013	2745
Lingyun Lai	Is the Serum Vitamin D Level at the Time of Hospital-Acquired Acute Kidney Injury Diagnosis Associated with Prognosis?	2013	1868
Kai Zhang	Association between Vitamin D Receptor Gene Polymorphisms and Breast Cancer Risk: A Meta-Analysis of 39 Studies	2014	4191
Hassan Ashktorab	Case-Control Study of Vitamin D, dickkopf homolog 1 (DKK1) Gene Methylation, VDR Gene Polymorphism and the Risk of Colon Adenoma in African Americans	2011	4080
Sara Karami	Analysis of SNPs and Haplotypes in Vitamin D Pathway Genes and Renal Cancer Risk	2009	6886
Elena García-Martín	Influence of Vitamin D-Related Gene Polymorphisms (CYP27B and VDR) on the Response to Interferon/Ribavirin Therapy in Chronic Hepatitis C	2013	4155
Sonia S. Kupfer	Genetic Associations in the Vitamin D Receptor and Colorectal Cancer in African Americans and Caucasians	2011	3869
Monika H. E. Christensen	1,25-Dihydroxyvitamin D and the Vitamin D Receptor Gene Polymorphism Apa1 Influence Bone Mineral Density in Primary Hyperparathyroidism	2013	3341
Yu-jiao Wu	Association of Vitamin D Receptor BsmI Gene Polymorphism with Risk of Tuberculosis: A Meta-Analysis of 15 Studies	2013	2968
Dhruva K. Mishra	Vitamin D Receptor Gene Polymorphisms and Prognosis of Breast Cancer among African-American and Hispanic Women	2013	5689
Takanori Hama	Prognostic Significance of Vitamin D Receptor Polymorphisms in Head and Neck Squamous Cell Carcinoma	2011	4537
Laura N. Anderson	Genetic Variants in Vitamin D Pathway Genes and Risk of Pancreas Cancer; Results from a Population-Based Case-Control Study in Ontario, Canada	2013	3079
Maria Pedrera-Canal	Lack of Influence of Vitamin D Receptor BsmI (rs1544410) Polymorphism on the Rate of Bone Loss in a Cohort of Postmenopausal Spanish Women Affected by Osteoporosis and Followed for Five Years	2015	687
Hui-Qin Tian	Association of VDR and CYP2R1 Polymorphisms with Mite-Sensitized Persistent Allergic Rhinitis in a Chinese Population	2015	1482
Mohamed N. Saad	Genetic Case-Control Study for Eight Polymorphisms Associated with Rheumatoid Arthritis	2015	2622
Muhammad Usman Rashid	Association between the BsmI Polymorphism in the Vitamin D Receptor Gene and Breast Cancer Risk: Results from a Pakistani Case-Control Study	2015	1587
Rabeah Abbas Al-Temaimi	The Association of Vitamin D Receptor Polymorphisms with Multiple Sclerosis in a Case-Control Study from Kuwait	2015	3480
Ieva Zostautiene	Genetic Variations in the Vitamin D Receptor Predict Type 2 Diabetes and Myocardial Infarction in a Community-Based Population: The Tromsø Study	2015	2678
Amita Gupta	Low Vitamin-D Levels Combined with PKP3-SIGIRR-TMEM16J Host Variants Is Associated with Tuberculosis and Death in HIV-Infected and -Exposed Infants	2016	2126
Peter Johansen	Pigmentary Markers in Danes – Associations with Quantitative Skin Colour, Nevi Count, Familial Atypical Multiple-Mole, and Melanoma Syndrome	2016	1723
Alessandra Colombini	BsmI, ApaI and TaqI Polymorphisms in the Vitamin D Receptor Gene (VDR) and Association with Lumbar Spine Pathologies: An Italian Case-Control Study	2016	4184

Publications on this SNP on Mendeley

First Author	Title	Pub. Year	# of Readers	DOI
Jara Valtueña	Factors Associated with Vitamin D Deficiency in European Adolescents: The HELENA Study.	2013	0
J D McKay	Vitamin D receptor polymorphisms and breast cancer risk: results from the National Cancer Institute Breast and Prostate Cancer Cohort Consortium	2009	0	10.1158/1055-9965.EPI-08-0539
Irene Orlow	Vitamin D receptor polymorphisms in patients with cutaneous melanoma.	2011	0	10.1002/ijc.26023
Darius L Mason	Nervous system autoantibodies and vitamin D receptor gene polymorphisms in hemodialysis patients.	2012	0	10.1111/j.1542-4758.2012.00727.x
Adrianna Mostowska	Vitamin D Receptor Gene BsmI and FokI Polymorphisms in Relation to Ovarian Cancer Risk in the Polish Population.	2013	0	10.1089/gtmb.2012.0332
X M Pan	No association between vitamin D receptor polymorphisms and coronary artery disease in a Chinese population	2009	0	10.1089/dna.2009.0908
Mazda Jenab	Vitamin D Receptor and Calcium Sensing Receptor Polymorphisms and the Risk of Colorectal Cancer in European Populations.	2009	0	10.1158/1055-9965.EPI-09-0319
Xin-Min Pan	No association between vitamin D receptor polymorphisms and coronary artery disease in a Chinese population.	2009	0	10.1089/dna.2009.0908
Don Vu	Association of vitamin D binding protein polymorphism with long-term kidney allograft survival in Hispanic kidney transplant recipients.	2013	1	10.1007/s11033-012-2134-6
M S De La Torre	Vitamin D receptor gene haplotypes and susceptibility to HIV-1 infection in injection drug users	2008	2	-
Charalambos Panierakis	Vitamin D receptor gene polymorphisms and susceptibility to type 1 diabetes in Crete, Greece	2009	2	10.1016/j.clim.2009.08.004
Daniela A F Ferrarezi	Allelic variations in the vitamin D receptor gene, insulin secretion and parents' heights are independently associated with height in obese children and adolescents.	2012	1	10.1016/j.metabol.2012.03.018
Yavuz Selim Yıldırım	Otosclerosis and vitamin D receptor gene polymorphism.	2013	1	10.1016/j.amjoto.2013.03.016
James D McKay	Vitamin D receptor polymorphisms and breast cancer risk: results from the National Cancer Institute Breast and Prostate Cancer Cohort Consortium.	2009	0	10.1158/1055-9965.EPI-08-0539
J García-Lestón	Genotoxic effects of occupational exposure to lead and influence of polymorphisms in genes involved in lead toxicokinetics and in DNA repair	2012	1	10.1016/j.envint.2012.03.001
Ranjit K. Thirumaran	Intestinal CYP3A4 and midazolam disposition in vivo associate with VDR polymorphisms and show seasonal variation	2012	7	10.1016/j.bcp.2012.03.017
Juliette A. Randerson-Moor	Vitamin D receptor gene polymorphisms, serum 25-hydroxyvitamin D levels, and melanoma: UK case-control comparisons and a meta-analysis of published VDR data	2009	25	10.1016/j.ejca.2009.06.011
J D McKay	Vitamin D receptor polymorphisms and breast cancer risk: results from the National Cancer Institute Breast and Prostate Cancer Cohort Consortium	2009	0
Ranjit K Thirumaran	Intestinal CYP3A4 and midazolam disposition in vivo associate with VDR polymorphisms and show seasonal variation.	2012	0	10.1016/j.bcp.2012.03.017
Jara Valtueña	Factors associated with vitamin D deficiency in European adolescents: the HELENA study.	2013	11	10.3177/jnsv.5...
M A Beydoun	Vitamin D receptor and megalin gene polymorphisms and their associations with longitudinal cognitive change in US adults	2012	1	-
Carmen Torres	Immunophenotype of vitamin D receptor polymorphism associated to risk of HIV-1 infection and rate of disease progression.	2010	0
James D McKay	Vitamin D receptor polymorphisms and breast cancer risk: results from the National Cancer Institute Breast and Prostate Cancer Cohort Consortium.	2009	0	10.1158/1055-9965.EPI-08-0539
K Baur	Therapy response in chronic hepatitis C patients is affected by common vitamin D receptor (NR 1i1) polymorphisms	2010	2	-
An Qi	Intestinal CYP3A4 and midazolam disposition in vivo associate with VDR polymorphisms and show seasonal variation	2012	0	10.1016/j.bcp.2012.03.017
Marissa Penna-Martinez	Vitamin D receptor polymorphisms in differentiated thyroid carcinoma.	2009	1	-
Gabriella M Anic	An exploratory analysis of common genetic variants in the vitamin D pathway including genome-wide associated variants in relation to glioma risk and outcome.	2012	2	10.1007/s10552-012-0018-7
Ming Feng	Polymorphisms in the vitamin D receptor gene and risk of autoimmune thyroid diseases: a meta-analysis.	2013	2	10.1007/s12020-012-9812-y
Mazda Jenab	Vitamin D Receptor and Calcium Sensing Receptor Polymorphisms and the Risk of Colorectal Cancer in European Populations	2009	0	10.1158/1055-9965.epi-09-0319
L Li	Association of vitamin D receptor gene polymorphisms with pancreatic cancer: A pilot study in a North China Population	2013	0	10.3892/ol.2013.1215
Kuen Tak Suh	Polymorphism in vitamin D receptor is associated with bone mineral density in patients with adolescent idiopathic scoliosis.	2010	0	10.1007/s00586-010-1385-y
X.-Y. Luo	Vitamin D receptor gene BsmI polymorphism B allele, but not BB genotype, is associated with systemic lupus erythematosus in a Han Chinese population	2012	1	10.1177/0961203311422709
P. Gapska	Vitamin D receptor variants and the malignant melanoma risk: A population-based study	2009	6	10.1016/j.canep.2009.06.006
Darius L Mason	Nervous system autoantibodies and vitamin D receptor gene polymorphisms in hemodialysis patients.	2012	0	10.1111/j.1542-4758.2012.00727.x
J C Mertens	Common vitamin D receptor (NR 1I1) gene polymorphisms promote fibrosis progression in chronic hepatitis C patients	2010	2	-
Stuart Macgregor	Vitamin D receptor gene polymorphisms have negligible effect on human height.	2008	3	-
Daniela A F Ferrarezi	Allelic variations in the vitamin D receptor gene, insulin secretion and parents' heights are independently associated with height in obese children and adolescents	2012	4	10.1016/j.metabol.2012.03.018
M. Stefanic	Association of vitamin D receptor gene 3'-variants with Hashimoto's thyroiditis in the Croatian population	2008	1	-
James D McKay	Vitamin D receptor polymorphisms and breast cancer risk: results from the National Cancer Institute Breast and Prostate Cancer Cohort Consortium.	2009	0	10.1158/1055-9965.EPI-08-0539
a González-Mercado	Association analysis of vitamin D receptor gene polymorphisms and bone mineral density in postmenopausal Mexican-Mestizo women.	2013	1	10.4238/2013.July.30.13
Mazda Jenab	Vitamin D receptor and calcium sensing receptor polymorphisms and the risk of colorectal cancer in European populations.	2009	9	-
X Y Luo	Vitamin D receptor gene BsmI polymorphism B allele, but not BB genotype, is associated with systemic lupus erythematosus in a Han Chinese population	2012	0	10.1177/0961203311422709; 10.1177/0961203311422709
Stuart Macgregor	Vitamin D receptor gene polymorphisms have negligible effect on human height.	2008	0	10.1375/twin.11.5.488
Ewelina Po??piech	The common occurrence of epistasis in the determination of human pigmentation and its impact on DNA-based pigmentation phenotype prediction	2014	3	10.1016/j.fsigen.2014.01.012
J B Pao	Vitamin D receptor gene variants and clinical outcomes after androgen-deprivation therapy for prostate cancer	2011	0	10.1007/s00345-011-0813-x
Fu Jia	Vitamin D receptor BsmI polymorphism and osteoporosis risk: a meta-analysis from 26 studies.	2013	2	10.1089/gtmb.2012.0267
S Macgregor	Vitamin D receptor gene polymorphisms have negligible effect on human height	2008	0	10.1375/twin.11.5.488\r10.1375/twin.11.5.488 [pii]
Mazda Jenab	Vitamin D receptor and calcium sensing receptor polymorphisms and the risk of colorectal cancer in European populations.	2009	0	10.1158/1055-9965.EPI-09-0319
Yuan-Jun Li	Polymorphisms in the Vitamin D Receptor Gene and Risk of Primary Biliary Cirrhosis: a meta-analysis.	2013	1	10.1111/jgh.12443
James D McKay	Vitamin D receptor polymorphisms and breast cancer risk: results from the National Cancer Institute Breast and Prostate Cancer Cohort Consortium.	2009	0
K Alagarasu	Association of vitamin D receptor gene polymorphisms with clinical outcomes of dengue virus infection.	2012	7	10.1016/j.humimm.2012.08.007
Irene Orlow	Vitamin D receptor polymorphisms in patients with cutaneous melanoma.	2012	5	10.1002/ijc.26023
Jose C E Serrano	Vitamin D receptor BsmI polymorphism modulates soy intake and 25-hydroxyvitamin D supplementation benefits in cardiovascular disease risk factors profile.	2013	3	10.1007/s12263-013-0356-4
D. A F Ferrarezi	Allelic variations of the vitamin D receptor (VDR) gene are associated with increased risk of coronary artery disease in type 2 diabetics: The DIABHYCAR prospective study	2013	1	10.1016/j.diabet.2012.11.004
C Panierakis	Vitamin D receptor gene polymorphisms and susceptibility to type 1 diabetes in Crete, Greece	2009	1	10.1016/j.clim.2009.08.004
James D McKay	Vitamin D receptor polymorphisms and breast cancer risk: results from the National Cancer Institute Breast and Prostate Cancer Cohort Consortium.	2009	0	10.1158/1055-9965.EPI-08-0539
Yufei Li	Association between vitamin D receptor gene polymorphisms and bone mineral density in Chinese women	2012	2	10.1007/s11033-011-1380-3
Stuart Macgregor	Vitamin D receptor gene polymorphisms have negligible effect on human height.	2008	0	10.1375/twin.11.5.488
Fu Jia	Vitamin D receptor BsmI polymorphism and osteoporosis risk: a meta-analysis from 26 studies.	2013	0	10.1089/gtmb.2012.0267
S Macgregor	Vitamin D receptor gene polymorphisms have negligible effect on human height	2008	1	10.1375/twin.11.5.488
Masahiko Suzuki	25-hydroxyvitamin D, vitamin D receptor gene polymorphisms, and severity of Parkinson's disease.	2012	7	10.1002/mds.24016
B Frederiksen	Interaction between VDR and PTPN2 predicts progression to type 1 diabetes in children with islet autoimmunity. The diabetes autoimmunity study in the young (DAISY)	2011	0	-
Julia Garc??a-Lest??n	Genotoxic effects of occupational exposure to lead and influence of polymorphisms in genes involved in lead toxicokinetics and in DNA repair	2012	5	10.1016/j.envint.2012.03.001
C Torres	Immunophenotype of vitamin D receptor polymorphism associated to risk of HIV-1 infection and rate of disease progression	2010	2	-
J B Pao	Vitamin D receptor gene variants and clinical outcomes after androgen-deprivation therapy for prostate cancer	2011	2	10.1007/s00345-011-0813-x
Carmen Torres	Immunophenotype of vitamin D receptor polymorphism associated to risk of HIV-1 infection and rate of disease progression	2010	2	-
J D McKay	Vitamin D receptor polymorphisms and breast cancer risk: results from the National Cancer Institute Breast and Prostate Cancer Cohort Consortium	2009	0
Yuan-Jun Li	Polymorphisms in the vitamin D receptor gene and risk of primary biliary cirrhosis: A meta-analysis.	2014	1	10.1111/jgh.12443
M Jenab	Vitamin D receptor and calcium sensing receptor polymorphisms and the risk of colorectal cancer in European populations	2009	0	10.1158/1055-9965.EPI-09-0319
X-Y Luo	Vitamin D receptor gene BsmI polymorphism B allele, but not BB genotype, is associated with systemic lupus erythematosus in a Han Chinese population.	2012	2	10.1177/0961203311422709
Daniela A F Ferrarezi	Allelic variations in the vitamin D receptor gene, insulin secretion and parents' heights are independently associated with height in obese children and adolescents.	2012	1	10.1016/j.metabol.2012.03.018
Betânia R Santos	Vitamin D deficiency in girls from South Brazil: a cross-sectional study on prevalence and association with vitamin D receptor gene variants	2012	4	10.1186/1471-2431-12-62
Farkhondeh Pouresmaeili	Association between Vitamin D Receptor Gene BsmI Polymorphism and Bone Mineral Density in A Population of 146 Iranian Women.	2013	2
W. Zheng	Common Genetic Variants in the Vitamin D Pathway Including Genome-Wide Associated Variants Are Not Associated with Breast Cancer Risk among Chinese Women	2011	0	10.1158/1055-9965.EPI-11-0704
Natalie Many	Genetic variations in bile acid homeostasis are not overrepresented in alcoholic cirrhosis compared to patients with heavy alcohol abuse and absent liver disease.	2012	2	10.1093/mutage/ges020
Chrissa Sioka	Vitamin D receptor gene polymorphisms in multiple sclerosis patients in northwest Greece	2011	10	10.1186/1477-5751-10-3
M Stefanic	Association of vitamin D receptor gene 3'-variants with Hashimoto's thyroiditis in the Croatian population	2008	1	-
I Rucevic	Lack of association of vitamin D receptor gene 3'-haplotypes with psoriasis in Croatian patients	2012	1	10.1111/j.1346-8138.2011.01296.x
Darius L Mason	Nervous system autoantibodies and vitamin D receptor gene polymorphisms in hemodialysis patients.	2013	0	10.1111/j.1542-4758.2012.00727.x
Adrianna Mostowska	Vitamin D receptor gene BsmI, FokI, ApaI and TaqI polymorphisms and the risk of systemic lupus erythematosus.	2013	3	10.1007/s11033-012-2118-6
Fu Jia	Vitamin D receptor BsmI polymorphism and osteoporosis risk: a meta-analysis from 26 studies.	2013	0	10.1089/gtmb.2012.0267
X-Y Luo	Vitamin D receptor gene BsmI polymorphism B allele, but not BB genotype, is associated with systemic lupus erythematosus in a Han Chinese population.	2012	0	10.1177/0961203311422709
K Li	Association of vitamin D receptor gene polymorphisms and serum 25-hydroxyvitamin D levels with vitiligo	2012	0	-
M Feng	Polymorphisms in the vitamin D receptor gene and risk of autoimmune thyroid diseases: a meta-analysis	2013	1	10.1007/s12020-012-9812-y
Jose C E Serrano	Vitamin D receptor BsmI polymorphism modulates soy intake and 25-hydroxyvitamin D supplementation benefits in cardiovascular disease risk factors profile.	2013	1	10.1007/s12263-013-0356-4
Manuel C. Lemos	Lack of association of vitamin D receptor gene polymorphisms with susceptibility to type 1 diabetes mellitus in the Portuguese population	2008	4	10.1016/j.humimm.2008.01.008
J B Pao	Vitamin D receptor gene variants and clinical outcomes after androgen-deprivation therapy for prostate cancer	2011	0	10.1007/s00345-011-0813-x
Galina Lurie	Vitamin D receptor gene polymorphisms and epithelial ovarian cancer risk.	2007	1	10.1158/1055-9965.EPI-07-0753
Carmen Torres	Immunophenotype of vitamin D receptor polymorphism associated to risk of HIV-1 infection and rate of disease progression.	2010	4	-
Sezgin Gunes	Analysis of vitamin D receptor gene polymorphisms in patients with chronic periodontitis.	2008	1	-
Jara Valtueña	Factors associated with vitamin D deficiency in european adolescents: the HELENA study.	2013	2

Evidence compiled by the Personal Genome Project

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Publications listed by Genome.gov

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SNP rs1544410

Basic Information

Genotype Frequency

Allele Frequency

Additional Information

Links to SNPedia

Publications on this SNP on the Public Library of Science:

Publications on this SNP on Mendeley

Evidence compiled by the Personal Genome Project

Publications listed by Genome.gov

Users who share this SNP:

Genome Browser

Contacts