openSNP | rs1447295

Links to SNPedia

Title	Summary
rs1447295 A/C	1.4x increased risk of prostate cancer
rs1447295 C/C	Normal
rs1447295 A/A	1.7x increased risk of prostate cancer

Note: For some SNPs, testing providers detect the genotype from the opposite strand of DNA, so that the genotypes listed on openSNP don't appear here. In those cases, please replace "A" by "T" or "G" by "C" (and vice-versa).

Publications on this SNP on the Public Library of Science:

First Author	Title	Year of Publication	# of readers
Elizabeth A. Manrao	Nucleotide Discrimination with DNA Immobilized in the MspA Nanopore	2011	7400
Dennis J. Hazelett	Comprehensive Functional Annotation of 77 Prostate Cancer Risk Loci	2014	17668
Janelle M. Hoskins	Association of Eleven Common, Low-Penetrance Colorectal Cancer Susceptibility Genetic Variants at Six Risk Loci with Clinical Outcome	2012	2433
Mian Li	Genetic Variants on Chromosome 8q24 and Colorectal Neoplasia Risk: A Case-Control Study in China and a Meta-Analysis of the Published Literature	2011	3407
Ilir Agalliu	Characterization of SNPs Associated with Prostate Cancer in Men of Ashkenazic Descent from the Set of GWAS Identified SNPs: Impact of Cancer Family History and Cumulative SNP Risk Prediction	2013	3014
Amy M. Dworkin	Germline Variation Controls the Architecture of Somatic Alterations in Tumors	2010	4651
Lenora W. M. Loo	In Silico Functional Pathway Annotation of 86 Established Prostate Cancer Risk Variants	2015	2456
Ethan M. Lange	Genome-Wide Association Scan for Variants Associated with Early-Onset Prostate Cancer	2014	2533
Tohru Nakagawa	A Tissue Biomarker Panel Predicting Systemic Progression after PSA Recurrence Post-Definitive Prostate Cancer Therapy	2008	10273
Xuelin Zhang	Polymorphisms on 8q24 Are Associated with Lung Cancer Risk and Survival in Han Chinese	2012	1927
Sara Lindstrom	Characterizing Associations and SNP-Environment Interactions for GWAS-Identified Prostate Cancer Risk Markers—Results from BPC3	2011	7343
Pawel Gaj	Pooled Sample-Based GWAS: A Cost-Effective Alternative for Identifying Colorectal and Prostate Cancer Risk Variants in the Polish Population	2012	4915
Eva J. A. Morris	A Retrospective Observational Study of the Relationship between Single Nucleotide Polymorphisms Associated with the Risk of Developing Colorectal Cancer and Survival	2015	1498

Publications on this SNP on Mendeley

First Author	Title	Pub. Year	# of Readers	DOI
S Lilly Zheng	Association between two unlinked loci at 8q24 and prostate cancer risk among European Americans.	2007	8	-
J M Murabito	A genome-wide association study of breast and prostate cancer in the NHLBI's Framingham Heart Study	2007	2
Meredith Yeager	Comprehensive resequence analysis of a 136 kb region of human chromosome 8q24 associated with prostate and colon cancers	2008	35	10.1007/s00439-008-0535-3
Tatsuya Hamano	Association of SNP rs1447295 and microsatellite marker DG8S737 with familial prostate cancer and high grade disease	2010	2	10.1016/j.juro.2010.03.102
Trevor J Pemberton	Prevalence of common disease-associated variants in Asian Indians	2008	18	10.1186/1471-2156-9-13
Ethan M Lange	Early onset prostate cancer has a significant genetic component.	2011	2	10.1002/pros.21414
M T Ng	Assessment of novel genetic polymorphisms and risk of upper gastrointestinal carcinoma	2010	1	-
Miia Suuriniemi	Confirmation of a positive association between prostate cancer risk and a locus at chromosome 8q24.	2007	6	-
Liang Wang	Two common chromosome 8q24 variants are associated with increased risk for prostate cancer.	2007	2	10.1158/0008-5472.CAN-06-3186
L. Wang	Two Common Chromosome 8q24 Variants Are Associated with Increased Risk for Prostate Cancer	2007	1	10.1158/0008-5472.CAN-06-3186
Liang Wang	Two common chromosome 8q24 variants are associated with increased risk for prostate cancer.	2007	6	-
Samantha E T Larkin	Association of common variations of 8q24 with the risk of prostate cancer in Koreans and a review of the Asian population	2012	1	-
M Liu	Risk loci on chromosome 8q24 are associated with prostate cancer in northern Chinese men	2012	3	10.1016/j.juro.2011.09.011
Dominika Wokołorczyk	The rs1447295 and DG8S737 markers on chromosome 8q24 and cancer risk in the Polish population.	2010	1	10.1097/CEJ.0b013e32832945c3
Maurice P Zeegers	Genetic marker polymorphisms on chromosome 8q24 and prostate cancer in the Dutch population: DG8S737 may not be the causative variant.	2011	1	-
S P Huang	Prognostic significance of prostate cancer susceptibility variants on prostate-specific antigen recurrence after radical prostatectomy	2009	2	18/11/3068 [pii]\r10.1158/1055-9965.EPI-09-0665
Maurice P Zeegers	Genetic marker polymorphisms on chromosome 8q24 and prostate cancer in the Dutch population: DG8S737 may not be the causative variant.	2011	1	10.1038/ejhg.2010.133
Shu-Pin Huang	Prognostic significance of prostate cancer susceptibility variants on prostate-specific antigen recurrence after radical prostatectomy.	2009	3	10.1158/1055-9965.EPI-09-0665
Marcelo Chen	The rs1447295 at 8q24 is a risk variant for prostate cancer in Taiwanese men.	2009	1	10.1016/j.urology.2009.02.035
Trevor J Pemberton	Prevalence of common disease-associated variants in Asian Indians.	2008	24	10.1186/1471-2156-9-13
Miia Suuriniemi	Confirmation of a positive association between prostate cancer risk and a locus at chromosome 8q24.	2007	7	10.1158/1055-9965.EPI-06-1049
Tatsuya Hamano	Association of SNP rs1447295 and microsatellite marker DG8S737 with familial prostate cancer and high grade disease.	2010	2	-
L Wang	Two common chromosome 8q24 variants are associated with increased risk for prostate cancer	2007	2	10.1158/0008-5472.CAN-06-3186
L Wang	Two common chromosome 8q24 variants are associated with increased risk for prostate cancer	2007	1
Joanne M Murabito	A genome-wide association study of breast and prostate cancer in the NHLBI's Framingham Heart Study.	2007	19	10.1186/1471-2350-8-S1-S6
Marcelo Chen	The rs1447295 at 8q24 is a risk variant for prostate cancer in Taiwanese men.	2009	1	-
Paul Lochhead	Possible association between a genetic polymorphism at 8q24 and risk of upper gastrointestinal cancer.	2011	2	10.1097/CEJ.0b013e328341e320
Natalia A. Oskina	A replication study examining association of rs6983267, rs10090154, and rs1447295 common single nucleotide polymorphisms in 8q24 region with prostate cancer in Siberians{star, open}	2013	1	10.1016/j.urolonc.2013.02.017
Marcelo Chen	The rs1447295 at 8q24 Is a Risk Variant for Prostate Cancer in Taiwanese Men	2009	1	10.1016/j.urology.2009.02.035
J Murabito	A genome-wide association study of breast and prostate cancer in the NHLBI's Framingham Heart Study	2007	1
Joanne M Murabito	A genome-wide association study of breast and prostate cancer in the NHLBI's Framingham Heart Study.	2007	2	10.1186/1471-2350-8-S1-S6
Gianluca Severi	The common variant rs1447295 on chromosome 8q24 and prostate cancer risk: results from an Australian population-based case-control study.	2007	3	-
Fredrick R Schumacher	A common 8q24 variant in prostate and breast cancer from a large nested case-control study.	2007	10	10.1158/0008-5472.CAN-06-3591
Tatsuya Hamano	Association of SNP rs1447295 and microsatellite marker DG8S737 with familial prostate cancer and high grade disease.	2010	2	10.1016/j.juro.2010.03.102
J Murabito	A genome-wide association study of breast and prostate cancer in the NHLBIs Framingham Heart Study	2007	1	-
M T Ng	Assessment of novel genetic polymorphisms and risk of upper gastrointestinal carcinoma	2010	0	-
A S Kibel	Genome-wide association study of prostate cancer identifies a second risk locus at 8q24Yeager M, Orr N, Hayes RB, Jacobs KB, Kraft P, Wacholder S, Minichiello MJ, Fearnhead P, Yu K, Chatterjee N, Wang Z, Welch R, Staats BJ, Calle EE, Feigelson HS, Thun MJ	2007	2	10.1016/j.urolonc.2007.07.002
Gianluca Severi	The common variant rs1447295 on chromosome 8q24 and prostate cancer risk: results from an Australian population-based case-control study.	2007	3	10.1158/1055-9965.EPI-06-0872
Prodipto Pal	Common variants in 8q24 are associated with risk for prostate cancer and tumor aggressiveness in men of European ancestry.	2005	4	-
Fredrick R Schumacher	A common 8q24 variant in prostate and breast cancer from a large nested case-control study.	2007	9	-
J M Murabito	A genome-wide association study of breast and prostate cancer in the NHLBI's Framingham Heart Study	2007	7	1471-2350-8-S1-S6 [pii]\r10.1186/1471-2350-8-S1-S6
J Murabito	A genome-wide association study of breast and prostate cancer in the NHLBIs Framingham Heart Study	2007	1	-
Naoki Terada	Association of genetic polymorphisms at 8q24 with the risk of prostate cancer in a Japanese population.	2008	8	-

Evidence compiled by the Personal Genome Project

There are no results from the Personal Genome Project yet. Please come back later.

Publications listed by Genome.gov

First Author	Title	Journal	Publication Date	Trait	p-value	Confidence Interval
Yeager M	Genome-wide association study of prostate cancer identifies a second risk locus at 8q24.	Nat Genet	04/01/2007	Prostate cancer	2.0e-14	[1.29-1.59]
Gudmundsson J	Genome-wide association and replication studies identify four variants associated with prostate cancer susceptibility.	Nat Genet	09/20/2009	Prostate cancer	2.0e-19	[1.43-1.74]
Gudmundsson J	Genome-wide association study identifies a second prostate cancer susceptibility variant at 8q24.	Nat Genet	04/01/2007	Prostate cancer	6.0e-18	[1.43-1.77]

Name	rs1447295
Chromosome	8
Position	127472793
Weight of evidence	90

SNP rs1447295

Basic Information

Genotype Frequency

Allele Frequency

Additional Information

Links to SNPedia

Publications on this SNP on the Public Library of Science:

Publications on this SNP on Mendeley

Evidence compiled by the Personal Genome Project

Publications listed by Genome.gov

Users who share this SNP:

Genome Browser

Contacts