SNP rs12979860

Basic Information
Name rs12979860
Chromosome 19
Position 39248147
Weight of evidence 914
Additional Information

Publications on this SNP on the Public Library of Science:

First Author Title Year of Publication # of readers
Karolina Rembeck Impact of IL28B-Related Single Nucleotide Polymorphisms on Liver Histopathology in Chronic Hepatitis C Genotype 2 and 3 2012 4330
Simone Susser Predictive Value of Interferon-Lambda Gene Polymorphisms for Treatment Response in Chronic Hepatitis C 2014 1349
Giuseppe Indolfi Comparative Analysis of rs12979860 SNP of the IFNL3 Gene in Children with Hepatitis C and Ethnic Matched Controls Using 1000 Genomes Project Data 2014 1485
Nobuhiro Harada Impact of Donor and Recipient Single Nucleotide Polymorphisms of IL28B rs8099917 in Living Donor Liver Transplantation for Hepatitis C 2014 1024
Seung Up Kim Association between IL28B Polymorphisms and Spontaneous Clearance of Hepatitis B Virus Infection 2013 2780
Tetsuro Takayama Prediction of Effect of Pegylated Interferon Alpha-2b plus Ribavirin Combination Therapy in Patients with Chronic Hepatitis C Infection 2011 2968
Vijayaprakash Suppiah IL28B, HLA-C, and KIR Variants Additively Predict Response to Therapy in Chronic Hepatitis C Virus Infection in a European Cohort: A Cross-Sectional Study 2011 12336
Felix M. Key Selection on a Variant Associated with Improved Viral Clearance Drives Local, Adaptive Pseudogenization of Interferon Lambda 4 (IFNL4) 2014 4223
Jordan J. Feld Plasma Interferon-Gamma-Inducible Protein-10 Levels Are Associated with Early, but Not Sustained Virological Response during Treatment of Acute or Early Chronic HCV Infection 2013 1720
Dawn N. Birdsell Melt Analysis of Mismatch Amplification Mutation Assays (Melt-MAMA): A Functional Study of a Cost-Effective SNP Genotyping Assay in Bacterial Models 2012 6733
Christian M. Lange A Genetic Validation Study Reveals a Role of Vitamin D Metabolism in the Response to Interferon-Alfa-Based Therapy of Chronic Hepatitis C 2012 3275
Ciara Keane Variation in Both IL28B and KIR2DS3 Genes Influence Pegylated Interferon and Ribavirin Hepatitis C Treatment Outcome in HIV-1 Co-Infection 2013 1416
Yasuteru Kondo 1(OH) Vitamin D3 Supplementation Improves the Sensitivity of the Immune-Response during Peg-IFN/RBV Therapy in Chronic Hepatitis C Patients-Case Controlled Trial 2013 1994
I-Cheng Lee IL28B Polymorphism Correlates with Active Hepatitis in Patients with HBeAg-Negative Chronic Hepatitis B 2013 2434
Man-Qing Liu IFN-λ3 Inhibits HIV Infection of Macrophages through the JAK-STAT Pathway 2012 4089
Elżbieta Jabłonowska Hepatic HMOX1 Expression Positively Correlates with Bach-1 and miR-122 in Patients with HCV Mono and HIV/HCV Coinfection 2014 1060
Sayeh Ezzikouri Genetic Variation in the Interleukin-28B Gene Is Associated with Spontaneous Clearance and Progression of Hepatitis C Virus in Moroccan Patients 2013 2442
Lene Fogt Lundbo Influence of Hepatitis C Virus and IL28B Genotypes on Liver Stiffness 2014 996
Chun-Yen Lin IL28B SNP rs12979860 Is a Critical Predictor for On-Treatment and Sustained Virologic Response in Patients with Hepatitis C Virus Genotype-1 Infection 2011 9776
Martin Probst IL28B Polymorphism Cannot Predict Response to Interferon Alpha Treatment in Patients with Melanoma 2014 664
Shan-shan Su Regulatory Phenotype, PD-1 and TLR3 Expression in T Cells and Monocytes from HCV Patients Undergoing Antiviral Therapy: A Randomized Clinical Trial 2014 1765
Charlotte H. B. S. van den Berg Female Sex and IL28B, a Synergism for Spontaneous Viral Clearance in Hepatitis C Virus (HCV) Seroconverters from a Community-Based Cohort 2011 3982
Francesc Vidal Pharmacogenetics of Efficacy and Safety of HCV Treatment in HCV-HIV Coinfected Patients: Significant Associations with IL28B and SOCS3 Gene Variants 2012 3515
Alex Thompson Prediction of Treatment Week Eight Response & Sustained Virologic Response in Patients Treated with Boceprevir Plus Peginterferon Alfa and Ribavirin 2014 732
Ming-Ling Chang Distinct Patterns of the Lipid Alterations between Genotype 1 and 2 Chronic Hepatitis C Patients after Viral Clearance 2014 883
Chun-Yen Lin IL28B SNP rs12979860 Is a Critical Predictor for On-Treatment and Sustained Virologic Response in Patients with Hepatitis C Virus Genotype-1 Infection 2011 9747
Dinara Khudayberganova IL28B Polymorphisms and Clinical Implications for Hepatitis C Virus Infection in Uzbekistan 2014 1500
Dong-Won Kim Naturally Occurring Mutations in the Nonstructural Region 5B of Hepatitis C Virus (HCV) from Treatment-Naïve Korean Patients Chronically Infected with HCV Genotype 1b 2014 1332
David Gardiner A Randomized, Double-Blind, Placebo-Controlled Assessment of BMS-936558, a Fully Human Monoclonal Antibody to Programmed Death-1 (PD-1), in Patients with Chronic Hepatitis C Virus Infection 2013 5410
Sridhar R. Allam The Association of IL28B Polymorphism and Graft Survival in Patients with Hepatitis C Undergoing Liver Transplantation 2013 1915
Janett Fischer Association of IFNL3 rs12979860 and rs8099917 with Biochemical Predictors of Interferon Responsiveness in Chronic Hepatitis C Virus Infection 2013 2102
Babs E. Verstrepen Evaluation of IL-28B Polymorphisms and Serum IP-10 in Hepatitis C Infected Chimpanzees 2012 2103
Sara Corchado Liver Fibrosis, Host Genetic and Hepatitis C Virus Related Parameters as Predictive Factors of Response to Therapy against Hepatitis C Virus in HIV/HCV Coinfected Patients 2014 1455
Ángeles Ruiz-Extremera Variation of Transaminases, HCV-RNA Levels and Th1/Th2 Cytokine Production during the Post-Partum Period in Pregnant Women with Chronic Hepatitis C 2013 1742
Jose Ramón Vidal-Castiñeira Diversity of Killer Cell Immunoglobulin-Like Receptor (KIR) Genotypes and KIR2DL2/3 Variants in HCV Treatment Outcome 2014 1205
Georgios Grammatikos Vitamin D Levels Vary during Antiviral Treatment but Are Unable to Predict Treatment Outcome in HCV Genotype 1 Infected Patients 2014 1926
Jennifer M. Reynolds Sequence Analysis of the IL28A/IL28B Inverted Gene Duplication That Contains Polymorphisms Associated with Treatment Response in Hepatitis C Patients 2012 4718
Tonggang Liu IL-28B Polymorphisms Correlated with Treatment Response in HCV-4 Mono-Infected Patients: A Meta-Analysis 2014 1849
Alessandra Mangia Individualized Treatment of Genotype 1 Naïve Patients: An Italian Multicenter Field Practice Experience 2014 976
Ming-Lung Yu Revisiting the Stopping Rule for Hepatitis C Genotype 1 Patients Treated with Peginterferon Plus Ribavirin 2012 1698
Edmondo Falleti Genetic Polymorphisms of Vitamin D Pathway Predict Antiviral Treatment Outcome in Slow Responder Naïve Patients with Chronic Hepatitis C 2013 1946
Lawrence M. Pfeffer An Interferon Response Gene Signature Is Associated with the Therapeutic Response of Hepatitis C Patients 2014 1445
Salvatore Petta PNPLA3 GG Genotype and Carotid Atherosclerosis in Patients with Non-Alcoholic Fatty Liver Disease 2013 2276
Yuichi Nozawa KIR, HLA, and IL28B Variant Predict Response to Antiviral Therapy in Genotype 1 Chronic Hepatitis C Patients in Japan 2013 1471
Luis M. Real IFNL4 ss469415590 Variant Shows Similar Performance to rs12979860 as Predictor of Response to Treatment against Hepatitis C Virus Genotype 1 or 4 in Caucasians 2014 1556
Philippe Halfon Detection of IL28B SNP DNA from Buccal Epithelial Cells, Small Amounts of Serum, and Dried Blood Spots 2012 2781
José A. Agúndez Relation of IL28B Gene Polymorphism with Biochemical and Histological Features in Hepatitis C Virus-Induced Liver Disease 2012 2936
Xiaoyan Guo Genetic Variation in Interleukin 28B and Response to Antiviral Therapy in Patients with Dual Chronic Infection with Hepatitis B and C Viruses 2013 1473
Åsa Alsiö Impact of Obesity on the Bioavailability of Peginterferon-α2a and Ribavirin and Treatment Outcome for Chronic Hepatitis C Genotype 2 or 3 2012 2305
Verónica Saludes Relevance of Baseline Viral Genetic Heterogeneity and Host Factors for Treatment Outcome Prediction in Hepatitis C Virus 1b-Infected Patients 2013 1712
Isabelle Morard Clinical Significance of the CCR5delta32 Allele in Hepatitis C 2014 1141
Antonio Rivero-Juárez Differences in HCV Viral Decline between Low and Standard-Dose Pegylated-Interferon-Alpha-2a with Ribavirin in HIV/HCV Genotype 3 Patients 2012 1243
Xiaodong Shi IL28B Genetic Variation Is Associated with Spontaneous Clearance of Hepatitis C Virus, Treatment Response, Serum IL-28B Levels in Chinese Population 2012 5108
Rushna Firdaus Impact of Host IL28B rs12979860, rs8099917 in Interferon Responsiveness and Advanced Liver Disease in Chronic Genotype 3 Hepatitis C Patients 2014 1389
Jie Chen Association Analysis between SNPs in IL-28B Gene and the Progress of Hepatitis B Infection in Han Chinese 2012 2423
Thomas R. O'Brien An IL28B Genotype-Based Clinical Prediction Model for Treatment of Chronic Hepatitis C 2011 7307
Masahiro Ishikane Acute Hepatitis C in HIV-1 Infected Japanese Cohort: Single Center Retrospective Cohort Study 2014 1165
Aihua Zhang Urinary Metabolic Biomarker and Pathway Study of Hepatitis B Virus Infected Patients Based on UPLC-MS System 2013 3027
I-Cheng Lee CXCL9 Associated with Sustained Virological Response in Chronic Hepatitis B Patients Receiving Peginterferon Alfa-2a Therapy: A Pilot Study 2013 1720
Montserrat de Castellarnau Deciphering the Interleukin 28B Variants That Better Predict Response to Pegylated Interferon-α and Ribavirin Therapy in HCV/HIV-1 Coinfected Patients 2012 3221
Samantha J. Griffiths A Systematic Analysis of Host Factors Reveals a Med23-Interferon-λ Regulatory Axis against Herpes Simplex Virus Type 1 Replication 2013 11266
Iva Subhanova Expression of Biliverdin Reductase A in Peripheral Blood Leukocytes Is Associated with Treatment Response in HCV-Infected Patients 2013 1528
Wen-Juei Jeng None of the Six SNPs of IL28B Could Predict Treatment Responses in Genotype 2 Chronic HCV Infected Patients by Propensity Score Matching Analysis 2012 1872
Nafisa-Katrin Seich al Basatena KIR2DL2 Enhances Protective and Detrimental HLA Class I-Mediated Immunity in Chronic Viral Infection 2011 4336
G. L. Abby Harrison Infection Frequency of Hepatitis C Virus and IL28B Haplotypes in Papua New Guinea, Fiji, and Kiribati 2013 2054
Antonio Rivero-Juarez Natural Killer KIR3DS1 Is Closely Associated with HCV Viral Clearance and Sustained Virological Response in HIV/HCV Patients 2013 1799
Akihito Tsubota Involvement of MAP3K8 and miR-17-5p in Poor Virologic Response to Interferon-Based Combination Therapy for Chronic Hepatitis C 2014 1238
Daiki Miki HLA-DQB1*03 Confers Susceptibility to Chronic Hepatitis C in Japanese: A Genome-Wide Association Study 2013 2332
Zhifang Jia Test of IL28B Polymorphisms in Chronic Hepatitis C Patients Treated with PegIFN and Ribavirin Depends on HCV Genotypes: Results from a Meta-Analysis 2012 5654
Masaya Sugiyama Genetic Variation of the IL-28B Promoter Affecting Gene Expression 2011 5186
Adrian Egli IL-28B is a Key Regulator of B- and T-Cell Vaccine Responses against Influenza 2014 6821
Barham K. Abu Dayyeh IL28B Alleles Exert an Additive Dose Effect When Applied to HCV-HIV Coinfected Persons Undergoing Peginterferon and Ribavirin Therapy 2011 2936
Ahmed S. Abdel-Moneim HCV Infection among Saudi Population: High Prevalence of Genotype 4 and Increased Viral Clearance Rate 2012 6487
Vincent Pedergnana Analysis of IL28B Variants in an Egyptian Population Defines the 20 Kilobases Minimal Region Involved in Spontaneous Clearance of Hepatitis C Virus 2012 2136
Verónica Saludes Baseline Prediction of Combination Therapy Outcome in Hepatitis C Virus 1b Infected Patients by Discriminant Analysis Using Viral and Host Factors 2010 3747
Thomas H. King A Whole Recombinant Yeast-Based Therapeutic Vaccine Elicits HBV X, S and Core Specific T Cells in Mice and Activates Human T Cells Recognizing Epitopes Linked to Viral Clearance 2014 3127
Amy E. L. Stone Hepatitis C Virus Pathogen Associated Molecular Pattern (PAMP) Triggers Production of Lambda-Interferons by Human Plasmacytoid Dendritic Cells 2013 5726
Derek D. Cyr Characterization of Serum Proteins Associated with IL28B Genotype among Patients with Chronic Hepatitis C 2011 3613
Luis F. López-Cortés Influence of IL28B Polymorphisms on Response to a Lower-Than-Standard Dose peg-IFN-α 2a for Genotype 3 Chronic Hepatitis C in HIV-Coinfected Patients 2012 2620
Gloria Taliani IL28B Gene Polymorphisms and US Liver Fatty Changes in Patients Who Spontaneously Cleared Hepatitis C Virus Infection 2013 1300
Linda Dunford A Multicentre Molecular Analysis of Hepatitis B and Blood-Borne Virus Coinfections in Viet Nam 2012 4054
Martin Lagging Response Prediction in Chronic Hepatitis C by Assessment of IP-10 and IL28B-Related Single Nucleotide Polymorphisms 2011 7658
Masato Nakamura No Correlation between PNPLA3 rs738409 Genotype and Fatty Liver and Hepatic Cirrhosis in Japanese Patients with HCV 2013 2603
Mark A. A. Claassen Negative Regulation of Hepatitis C Virus Specific Immunity Is Highly Heterogeneous and Modulated by Pegylated Interferon-Alpha/Ribavirin Therapy 2012 1756
Sreedhar Chinnaswamy A Single Nucleotide Polymorphism Associated with Hepatitis C Virus Infections Located in the Distal Region of the IL28B Promoter Influences NF-κB-Mediated Gene Transcription 2013 3381
Benjamin Maasoumy Eligibility and Safety of Triple Therapy for Hepatitis C: Lessons Learned from the First Experience in a Real World Setting 2013 6109
Masaya Sato Impact of IL28B Genetic Variation on HCV-Induced Liver Fibrosis, Inflammation, and Steatosis: A Meta-Analysis 2014 1599
Camila da Silva Ferreira A Fast and Cost-Effective Method for Identifying a Polymorphism of Interleukin 28B Related to Hepatitis C 2013 1488
Ahmad Amanzada Interferon-λ4 (IFNL4) Transcript Expression in Human Liver Tissue Samples 2013 2383
Jonas Söderholm Impact of Soluble CD26 on Treatment Outcome and Hepatitis C Virus-Specific T Cells in Chronic Hepatitis C Virus Genotype 1 Infection 2013 2014
Ester Aparicio IL28B SNP rs8099917 Is Strongly Associated with Pegylated Interferon-α and Ribavirin Therapy Treatment Failure in HCV/HIV-1 Coinfected Patients 2010 7007
Tatiane Assone IL28B Gene Polymorphism SNP rs8099917 Genotype GG Is Associated with HTLV-1-Associated Myelopathy/Tropical Spastic Paraparesis (HAM/TSP) in HTLV-1 Carriers 2014 4094
Silvana Gaudieri Genetic Variations in IL28B and Allergic Disease in Children 2012 2995
Lindsay Y. King Host Genetics Predict Clinical Deterioration in HCV-Related Cirrhosis 2014 1039
Elena García-Martín Influence of Vitamin D-Related Gene Polymorphisms (CYP27B and VDR) on the Response to Interferon/Ribavirin Therapy in Chronic Hepatitis C 2013 3224
Magdalena Ydreborg Impact of IL28B-Related Single Nucleotide Polymorphisms on Liver Transient Elastography in Chronic Hepatitis C Infection 2013 1753
Eleonora Lalle IFN-Alpha Receptor-1 Upregulation in PBMC from HCV Naïve Patients Carrying CC Genotype. Possible Role of IFN-Lambda 2014 1104
Nicola Coppola Cannabinoid Receptor 2-63 QQ Variant Is Associated with Persistently Normal Aminotransferase Serum Levels in Chronic Hepatitis C 2014 875
Vo Duy Thong Prevalence of Thymine—Adenine Dinucleotide Repeat, IL28B and IFNL4 in Thai Population and Correlation with Spontaneous Clearance and Treatment Outcome of Hepatitis C Infection 2015 711
Krzysztof Domagalski The Impact of IL28B Genotype and Liver Fibrosis on the Hepatic Expression of IP10, IFI27, ISG15, and MX1 and Their Association with Treatment Outcomes in Patients with Chronic Hepatitis C 2015 501

Publications listed by Genome.gov

First Author Title Journal Publication Date Trait p-value Confidence Interval
Ge D Genetic variation in IL28B predicts hepatitis C treatment-induced viral clearance. Nature 08/16/2009 Response to hepatitis C treatment 1.0e-28 (combined) [1.8-2.3] (European-Americans)

Evidence compiled by the Personal Genome Project

There are no results from the Personal Genome Project yet. Please come back later.

Publications on this SNP on Mendeley

First Author Title Pub. Year # of Readers DOI
Thomas J Urban IL28B genotype is associated with differential expression of intrahepatic interferon-stimulated genes in patients with chronic hepatitis C. 2010 52 10.1002/hep.23912Oa logo 3fe7f006c5ef1789206c801af1f0d0538300f10d15d3a6c1285e1dfe3e8d62b5
Benjamin Krämer Variation in IFNL4 genotype and response to interferon-based therapy of hepatitis C in HIV-positive patients with acute and chronic hepatitis C. 2013 5 10.1097/01.aids.0000433234.78807.54
Anu Osinusi IL28B polymorphism is not associated with HCV protease diversity in patients co-infected with HIV and HCV treated with pegylated interferon and ribavirin. 2012 1 10.1002/jmv.23376
Evaldo Stanislau Affonso de Araujo Pharmacodynamics of PEG-IFN-[alpha]-2a and HCV response as a function of IL28B polymorphism in HIV/HCV-coinfected patients. 2011 19 10.1097/QAI.0b013e3182020596Oa logo 3fe7f006c5ef1789206c801af1f0d0538300f10d15d3a6c1285e1dfe3e8d62b5
Davide Bitetto Complementary role of vitamin D deficiency and the interleukin-28B rs12979860 C/T polymorphism in predicting antiviral response in chronic hepatitis C. 2011 15 10.1002/hep.24201Oa logo 3fe7f006c5ef1789206c801af1f0d0538300f10d15d3a6c1285e1dfe3e8d62b5
J A Pineda Prediction of Response to Pegylated Interferon plus Ribavirin by IL28B Gene Variation in Patients Coinfected with HIV and Hepatitis C Virus 2010 0 10.1086/656235Oa logo 3fe7f006c5ef1789206c801af1f0d0538300f10d15d3a6c1285e1dfe3e8d62b5
Tomokazu Kawaoka Predictive value of the IL28B polymorphism on the effect of interferon therapy in chronic hepatitis C patients with genotypes 2a and 2b. 2011 13 10.1016/j.jhep.2010.07.032Oa logo 3fe7f006c5ef1789206c801af1f0d0538300f10d15d3a6c1285e1dfe3e8d62b5
E G Giannini IL28B rs12979860 C/T polymorphism in elderly chronic hepatitis C patients treated with pegylated-interferon and ribavirin. 2011 0 10.1111/j.1365-2036.2011.04734.xOa logo 3fe7f006c5ef1789206c801af1f0d0538300f10d15d3a6c1285e1dfe3e8d62b5
Stéphanie Bibert IL28B expression depends on a novel TT/-G polymorphism which improves HCV clearance prediction. 2013 13 10.1084/jem.20130012
Sandra Beinhardt Serum level of IP-10 increases predictive value of IL28B polymorphisms for spontaneous clearance of acute HCV infection. 2012 1 -
M Venegas IL28B polymorphisms associated with therapy response in Chilean chronic hepatitis C patients 2011 1 10.3748/wjg.v17.i31.3636Oa logo 3fe7f006c5ef1789206c801af1f0d0538300f10d15d3a6c1285e1dfe3e8d62b5
Jama M Darling THE PREDICTIVE VALUE OF IL28B GENE POLYMORPHISM FOR RESPONSE TO PEGINTERFERON AND RIBAVIRIN IS ENHANCED BY QUANTITATION OF IP-10 IN PRETREATMENT SERUM 2010 1 -
Alexandra Doehring Screening for IL28B gene variants identifies predictors of hepatitis C therapy success. 2010 1 -
J a Del Campo Insulin resistance predicts sustained virological response to treatment of chronic hepatitis C independently of the IL28b rs12979860 polymorphism. 2013 5 10.1111/apt.12113Oa logo 3fe7f006c5ef1789206c801af1f0d0538300f10d15d3a6c1285e1dfe3e8d62b5
a Piluso Value of IL28B genotyping in patients with HCV-related mixed cryoglobulinemia: results of a large, prospective study. 2013 2 10.1111/jvh.12017Oa logo 3fe7f006c5ef1789206c801af1f0d0538300f10d15d3a6c1285e1dfe3e8d62b5
Norma I Rallón Association of a single nucleotide polymorphism near the interleukin-28B gene with response to hepatitis C therapy in HIV/hepatitis C virus-coinfected patients. 2010 32 10.1097/QAD.0b013e3283391d6d
T Reiberger Portal Pressure Predicts Outcome and Safety of Antiviral Therapy in Cirrhotic Patients with HCV infection 2011 3 10.1016/j.cgh.2011.03.002Oa logo 3fe7f006c5ef1789206c801af1f0d0538300f10d15d3a6c1285e1dfe3e8d62b5
James Everhart Association of [gamma]-glutamyl transferase (GGT) activity with treatment and clinical outcomes in chronic hepatitis C (HCV). 2013 3 10.1002/hep.26203Oa logo 3fe7f006c5ef1789206c801af1f0d0538300f10d15d3a6c1285e1dfe3e8d62b5
K Neukam Efficacy of chronic hepatitis C therapy with pegylated interferon and ribavirin in patients on methadone maintenance treatment 2012 2 DOI 10.1007/s10096-011-1433-5Oa logo 3fe7f006c5ef1789206c801af1f0d0538300f10d15d3a6c1285e1dfe3e8d62b5
Y Maor Genetic polymorphism of IL28B in hepatitis C-infected haemophilia patients in Israel. 2013 1 10.1111/j.1365-2516.2012.02932.x
K Neukam Prediction of response to pegylated interferon/ribavirin by interleukin 28B genotype is modified by SNPS at multiple genes in HIV/hepatitis C virus genotype 1/4-coinfected patients 2013 2 10.1016/S0168-8278(13)60885-5
Seok Hoo Jeong Efficacy of peginterferon and ribavirin is associated with the IL28B gene in Korean patients with chronic hepatitis C. 2012 3 10.3350/cmh.2012.18.4.360Oa logo 3fe7f006c5ef1789206c801af1f0d0538300f10d15d3a6c1285e1dfe3e8d62b5
Derek D. Cyr Characterization of serum proteins associated with IL28B genotype among patients with chronic hepatitis C 2011 7 10.1371/journal.pone.0021854Oa logo 3fe7f006c5ef1789206c801af1f0d0538300f10d15d3a6c1285e1dfe3e8d62b5
Ahmad Amanzada Early anemia and rapid virological response improve the predictive efficiency of IL28B-genotype for treatment outcome to antiviral combination therapy in patients infected with chronic HCV genotype 1. 2012 3 10.1002/jmv.23323
Salvatore Petta IL28B and PNPLA3 polymorphisms affect histological liver damage in patients with non-alcoholic fatty liver disease. 2012 3 10.1016/j.jhep.2012.01.007Oa logo 3fe7f006c5ef1789206c801af1f0d0538300f10d15d3a6c1285e1dfe3e8d62b5
Tarciana Grandi Response to treatment in Brazilian patients with chronic hepatitis C is associated with a single-nucleotide polymorphism near the interleukin-28B gene. 2013 6 Oa logo 3fe7f006c5ef1789206c801af1f0d0538300f10d15d3a6c1285e1dfe3e8d62b5
Ludmila Prokunina-Olsson A variant upstream of IFNL3 (IL28B) creating a new interferon gene IFNL4 is associated with impaired clearance of hepatitis C virus. 2013 40 10.1038/ng.2521Oa logo 3fe7f006c5ef1789206c801af1f0d0538300f10d15d3a6c1285e1dfe3e8d62b5
Lucy Golden-Mason Natural killer inhibitory receptor expression associated with treatment failure and interleukin-28B genotype in patients with chronic hepatitis C. 2011 1 10.1002/hep.24556Oa logo 3fe7f006c5ef1789206c801af1f0d0538300f10d15d3a6c1285e1dfe3e8d62b5
Thomas J Urban IL28B genotype is associated with differential expression of intrahepatic interferon-stimulated genes in patients with chronic hepatitis C. 2010 48 10.1002/hep.23912
Z Gerlei Measurement and clinical significance of interleukin 28B in hepatitis C virus-infected liver transplant patients. 2012 1 10.1016/j.transproceed.2012.07.101
Mostafa M Ragheb Strong prediction of virological response to combination therapy by IL28B gene variants rs12979860 and rs8099917 in chronic hepatitis C genotype 4. 2013 4 10.1111/liv.12321
Fumitaka Suzuki Association of two polymorphisms of the IL28B gene with viral factors and treatment response in 1,518 patients infected with hepatitis C virus 2012 4 10.1007/s00535-012-0531-1
Martin Lagging Response Prediction in Chronic Hepatitis C by Assessment of IP-10 and <italic>IL28B</italic>-Related Single Nucleotide Polymorphisms 2011 1 Oa logo 3fe7f006c5ef1789206c801af1f0d0538300f10d15d3a6c1285e1dfe3e8d62b5
T R O'Brien An IL28B genotype-based model for personalized prediction of response to pegylatedinterferon-alfa and ribavirin in the treatment of chronic hepatitis C 2010 1 Oa logo 3fe7f006c5ef1789206c801af1f0d0538300f10d15d3a6c1285e1dfe3e8d62b5
Jeff Connell A Multicentre Molecular Analysis of Hepatitis B and Blood-Borne Virus Coinfections in Viet Nam 2012 4 10.1371/journal.pone.0039027
Norma I Rallon IL28B gene polymorphisms and viral kinetics in HIV/hepatitis C virus-coinfected patients treated with pegylated interferon and ribavirin 2011 0 10.1097/QAD.0b013e3283471cae
Y. Kamiyama Effect of pH and salt on the adsorption and interactions of an amphoteric polyelectrolyte 1992 7 10.1002/hep.24623Oa logo 3fe7f006c5ef1789206c801af1f0d0538300f10d15d3a6c1285e1dfe3e8d62b5
Alajos Pár [IL28B CC genotype: a protective factor and predictor of the response to interferon treatment in chronic hepatitis C virus infection]. 2013 1 10.1556/OH.2013.29680
Vito Di Marco IL28B polymorphisms influence stage of fibrosis and spontaneous or interferon-induced viral clearance in thalassemia patients with hepatitis C virus infection. 2012 2 -
Özlem Kandemir Chronic hepatitis B and IL28B rs12979860 polymorphism: preliminary study. 2013 1 10.1007/s11033-013-2730-0
Zoe Raglow IL28B genotype and the expression of ISGs in normal liver. 2013 2 10.1111/liv.12148Oa logo 3fe7f006c5ef1789206c801af1f0d0538300f10d15d3a6c1285e1dfe3e8d62b5
Esther J. Pav??n-Castillero Importance of IL-10 and IL-6 during chronic hepatitis c genotype-1 treatment and their relation with IL28B 2013 6 10.1016/j.cyto.2012.10.009
Jun Liong Chin Spontaneous clearance of hepatitis C infection after liver transplantation from IL28B rs12979860 CC donors. 2012 1 -
Lin Liu Spontaneous Clearance of Primary Acute Hepatitis C Virus Infection Correlated With High Initial Viral RNA Level and Rapid HVR1 Evolution 2012 7 10.1002/hep.25575
Jama M Darling Quantitation of Pretreatment Serum IP-10 Improves the Predictive Value of an IL28B Gene Polymorphism for Hepatitis C Treatment Response 2010 1 Oa logo 3fe7f006c5ef1789206c801af1f0d0538300f10d15d3a6c1285e1dfe3e8d62b5
Ana Treviño Development of tropical spastic paraparesis in human T-lymphotropic virus type 1 carriers is influenced by interleukin 28B gene polymorphisms. 2012 3 10.1093/cid/cis343Oa logo 3fe7f006c5ef1789206c801af1f0d0538300f10d15d3a6c1285e1dfe3e8d62b5
Jie Chen Association Analysis between SNPs in IL-28B Gene and the Progress of Hepatitis B Infection in Han Chinese 2012 3 10.1371/journal.pone.0050787Oa logo 3fe7f006c5ef1789206c801af1f0d0538300f10d15d3a6c1285e1dfe3e8d62b5
Flisiak R. Alisporivir (ALV) plus PegIFN/RBV (PR) has 100% SVR in IL28B rs12979860 CC allele and superior efficacy in chronic hepatitis C genotype (G) 1 treatment na 2012 2 Oa logo 3fe7f006c5ef1789206c801af1f0d0538300f10d15d3a6c1285e1dfe3e8d62b5
Stella De Nicola An IL28B polymorphism predicts pegylated interferon plus ribavirin treatment outcome in chronic hepatitis c genotype 4. 2011 4 10.1002/hep.24683Oa logo 3fe7f006c5ef1789206c801af1f0d0538300f10d15d3a6c1285e1dfe3e8d62b5
L Golden Mason Natural killer inhibitory receptor expression associated with treatment failure and interleukin‐28B genotype in patients with chronic hepatitis C 2011 6 10.1002/hep.24556Oa logo 3fe7f006c5ef1789206c801af1f0d0538300f10d15d3a6c1285e1dfe3e8d62b5
K Neukam Different distributions of hepatitis C virus genotypes among HIV-infected patients with acute and chronic hepatitis C according to interleukin-28B genotype. 2011 5 10.1111/j.1468-1293.2011.00912.x
L J Peng IL28B rs12979860 polymorphism does not influence outcomes of hepatitis B virus infection. 2012 2 10.1111/j.1399-0039.2011.01835.x
S Gaudieri Genetic variations in IL28B and allergic disease in children 2012 2 10.1371/journal.pone.0030607Oa logo 3fe7f006c5ef1789206c801af1f0d0538300f10d15d3a6c1285e1dfe3e8d62b5
Alessandra Mangia An IL28B polymorphism determines treatment response of hepatitis C virus genotype 2 or 3 patients who do not achieve a rapid virologic response 2010 28 10.1053/j.gastro.2010.05.079
Scott W Biggins Differential effects of donor and recipient IL28B and DDX58 SNPs on severity of HCV after liver transplantation. 2013 4 10.1016/j.jhep.2012.12.027Oa logo 3fe7f006c5ef1789206c801af1f0d0538300f10d15d3a6c1285e1dfe3e8d62b5
Golden-Mason L. NK inhibitory receptor expression associated with treatment failure and IL-28B genotype in patients with chronic hepatitis C 2011 1 Oa logo 3fe7f006c5ef1789206c801af1f0d0538300f10d15d3a6c1285e1dfe3e8d62b5
Jun-Qiang Xie Relationship between the genetic variation in interleukin 28B and response to antiviral therapy in patients with chronic hepatitis C. 2012 1 10.3760/cma.j.issn.0366-6999.2012.13.017Oa logo 3fe7f006c5ef1789206c801af1f0d0538300f10d15d3a6c1285e1dfe3e8d62b5
Li-Sheng Wu Two IL28B polymorphisms are associated with the treatment response of different genotypes of hepatitis C in different racial populations: A meta-analysis. 2012 3 10.3892/etm.2011.385
J A Pineda Prediction of response to pegylated interferon plus ribavirin by IL28B gene variation in patients coinfected with HIV and hepatitis C virus 2010 1 Oa logo 3fe7f006c5ef1789206c801af1f0d0538300f10d15d3a6c1285e1dfe3e8d62b5
Hans L. Tillmann Beneficial IL28B genotype associated with lower frequency of hepatic steatosis in patients with chronic hepatitis C 2011 11 10.1016/j.jhep.2011.03.015
Sandra Beinhardt Serum level of IP-10 increases predictive value of IL28B polymorphisms for spontaneous clearance of acute HCV infection. 2012 1 -
E Jablonowska Sustained virologic response and IL28B single-nucleotide polymorphisms in patients with chronic hepatitis C treated with pegylated interferon alfa and ribavirin 2012 1 -
D.R Paul Control of the morphology of polyamide/styrene-acrylonitrile copolymer blends via reactive compatibilizers 1994 4 10.1016/0032-3861(94)90082-5
Runyan Jin Optimum ribavirin exposure overcomes racial disparity in efficacy of peginterferon and ribavirin treatment for hepatitis C genotype 1. 2012 1 10.1038/ajg.2012.306
B J Veldt Recipient IL28B polymorphism is an important independent predictor of posttransplant diabetes mellitus in liver transplant patients with chronic hepatitis C. 2012 11 10.1111/j.1600-6143.2011.03843.xOa logo 3fe7f006c5ef1789206c801af1f0d0538300f10d15d3a6c1285e1dfe3e8d62b5
Susanne Knapp A polymorphism in IL28B distinguishes exposed, uninfected individuals from spontaneous resolvers of HCV infection. 2011 11 10.1053/j.gastro.2011.04.005Oa logo 3fe7f006c5ef1789206c801af1f0d0538300f10d15d3a6c1285e1dfe3e8d62b5
E G Giannini IL28B rs12979860 C/T polymorphism in elderly chronic hepatitis C patients treated with pegylated-interferon and ribavirin. 2011 2 10.1111/j.1365-2036.2011.04734.xOa logo 3fe7f006c5ef1789206c801af1f0d0538300f10d15d3a6c1285e1dfe3e8d62b5
Jeanette J McCarthy Replicated Association Between an Interleukin-28B Gene Variant and a Sustained Response to Pegylated Interferon and Ribavirin. 2010 6 10.1053/j.gastro.2010.02.009Oa logo 3fe7f006c5ef1789206c801af1f0d0538300f10d15d3a6c1285e1dfe3e8d62b5
Josephine H Li Interferon-lambda genotype and low serum low-density lipoprotein cholesterol levels in patients with chronic hepatitis C infection. 2010 0 Oa logo 3fe7f006c5ef1789206c801af1f0d0538300f10d15d3a6c1285e1dfe3e8d62b5
Chun-Yen Lin IL28B SNP rs12979860 Is a Critical Predictor for On-Treatment and Sustained Virologic Response in Patients with Hepatitis C Virus Genotype-1 Infection 2011 0 10.1371/journal.pone.0018322Oa logo 3fe7f006c5ef1789206c801af1f0d0538300f10d15d3a6c1285e1dfe3e8d62b5
F. Negro IL28B polymorphisms predict reduction of HCV RNA from the first day of therapy in chronic hepatitis C 2011 14 10.1016/j.jhep.2011.01.050
Jeanette J McCarthy Replicated association between an IL28B gene variant and a sustained response to pegylated interferon and ribavirin. 2010 1 10.1053/j.gastro.2010.02.009
Z Raglow IL28B genotype and the expression of ISGs in normal liver. 2013 7 10.1111/liv.12148
Evaldo Stanislau Affonso De Araujo Pharmacodynamics of PEG-IFN-[alpha]-2a and HCV response as a function of IL28B polymorphism in HIV/HCV-coinfected patients. 2011 11 10.1097/QAI.0b013e3182020596
Fred Poordad Factors that predict response of patients with hepatitis C virus infection to boceprevir. 2012 1 -
Pietro Lampertico IL28B polymorphisms predict interferon-related HBsAg seroclearance in genotype D HBeAg-negative patients with chronic hepatitis B. 2012 7 10.1002/hep.25749
Amir Moghaddam IL28B genetic variation and treatment response in patients with hepatitis C virus genotype 3 infection 2011 3 10.1002/hep.24154Oa logo 3fe7f006c5ef1789206c801af1f0d0538300f10d15d3a6c1285e1dfe3e8d62b5
Tarik Asselah IL28B polymorphism is associated with treatment response in patients with genotype 4 chronic hepatitis C 2012 9 10.1016/j.jhep.2011.09.008
Mostafa M Ragheb Strong prediction of virological response to combination therapy by IL28B gene variants rs12979860 and rs8099917 in chronic hepatitis C genotype 4. 2013 1 10.1111/liv.12321Oa logo 3fe7f006c5ef1789206c801af1f0d0538300f10d15d3a6c1285e1dfe3e8d62b5
M Lindh Interleukin 28B Gene Variation at rs12979860 Determines Early Viral Kinetics During Treatment in Patients Carrying Genotypes 2 or 3 of Hepatitis C Virus 2011 0 10.1093/infdis/jir193Oa logo 3fe7f006c5ef1789206c801af1f0d0538300f10d15d3a6c1285e1dfe3e8d62b5
M Mandorfer Revisiting predictors of virologic response to PEGIFN + RBV therapy in HIV-/HCV-coinfected patients: the role of metabolic factors and elevated GGT levels 2014 1 10.1111/jvh.12118
Alessandra Mangia Treatment optimization and prediction of HCV clearance in patients with acute HCV infection 2013 4 10.1016/j.jhep.2013.04.007
Erik Alestig Core mutations, IL28B polymorphisms and response to peginterferon/ribavirin treatment in Swedish patients with hepatitis C virus genotype 1 infection 2011 0 10.1186/1471-2334-11-124Oa logo 3fe7f006c5ef1789206c801af1f0d0538300f10d15d3a6c1285e1dfe3e8d62b5
Christoph Sarrazin Importance of IL28B gene polymorphisms in hepatitis C virus genotype 2 and 3 infected patients. 2010 2 10.1016/j.jhep.2010.07.041Oa logo 3fe7f006c5ef1789206c801af1f0d0538300f10d15d3a6c1285e1dfe3e8d62b5
Hiromi Abe Inverse association of IL28B genotype and liver mRNA expression of genes promoting or suppressing antiviral state. 2011 9 10.1002/jmv.22158
Karin Neukam Prediction of response to pegylated interferon plus ribavirin in HIV/hepatitis C virus (HCV)-coinfected patients using HCV genotype, IL28B variations, and HCV-RNA load. 2012 1 -
Zobair M Younossi The impact of IL28B genotype on the gene expression profile of patients with chronic hepatitis C treated with pegylated interferon alpha and ribavirin. 2012 4 10.1186/1479-5876-10-25Oa logo 3fe7f006c5ef1789206c801af1f0d0538300f10d15d3a6c1285e1dfe3e8d62b5
Jacob Nattermann The predictive value of IL28B gene polymorphism for spontaneous clearance in a single source outbreak cohort is limited in patients carrying the CCR5Δ32 mutation. 2011 6 10.1016/j.jhep.2011.03.011
J.C. Palomares 1173 VARIATION IN INTERLEUKIN 28B GEN PREDICTS RESPONSE TO PEGYLATED INTERFERON PLUS RIBAVIRIN IN HIV/HEPATITIS C VIRUS-COINFECTED PATIENTS 2010 3 10.1016/S0168-8278(10)61174-9
Brian L Pearlman The IL-28 genotype: how it will affect the care of patients with hepatitis C virus infection. 2011 7 10.1007/s11894-010-0161-9Oa logo 3fe7f006c5ef1789206c801af1f0d0538300f10d15d3a6c1285e1dfe3e8d62b5
Moutaz Derbala Interleukin-28 and hepatitis C virus genotype-4: treatment-induced clearance and liver fibrosis. 2012 3 10.3748/wjg.v18.i47.7003
Simone Moreira A straightforward genotyping of the relevant IL28B SNPs for the prediction of hepatitis C treatment outcome. 2012 2 10.1016/j.jviromet.2012.05.024
Elisabetta Cariani Interleukin 28B genotype determination using DNA from different sources: A simple and reliable tool for the epidemiological and clinical characterization of hepatitis C 2011 3 10.1016/j.jviromet.2011.08.021
Miquel Navasa Determination of IL28B polymorphisms in liver biopsies obtained after liver transplantation 2012 2 10.1016/j.jhep.2011.07.027
Ochi H. Il-28b predicts response to chronic hepatitis C therapy -fine-mapping and replication study in Asian populations 2011 1 Oa logo 3fe7f006c5ef1789206c801af1f0d0538300f10d15d3a6c1285e1dfe3e8d62b5
K Neukam Different distributions of hepatitis C virus genotypes among HIV-infected patients with acute and chronic hepatitis C according to interleukin-28B genotype 2011 2 10.1111/j.1468-1293.2011.00912.xOa logo 3fe7f006c5ef1789206c801af1f0d0538300f10d15d3a6c1285e1dfe3e8d62b5
Butt M. Derbala M, Rizk NM, Al-Kaabi S, John A, Sharma M, El-Dweik N, Yakoob R, Pasic F, Almohanadi M, Alejji K, Abdelmola A The predictive value of IL28B rs12979860, rs11881222 and rs8099917 polymorphisms and IP-10 in the therapeutic response of Egyptian genotype 4 patients. 2013 1 Virology. 2013 Sep;444(1-2):292-300. doi: 10.1016/j.virol.2013.06.025. Epub 2013 Jul 16.Oa logo 3fe7f006c5ef1789206c801af1f0d0538300f10d15d3a6c1285e1dfe3e8d62b5
Gonzalo Crespo Combinations of simple baseline variables accurately predict sustained virological response in patients with recurrent hepatitis C after liver transplantation. 2012 2 10.1007/s00535-012-0680-2
Kawthar Machmach IL28B single-nucleotide polymorphism rs12979860 is associated with spontaneous HIV control in white subjects. 2013 8 10.1093/infdis/jis717
Kathleen A. Ryan Single nucleotide polymorphism upstream of interleukin 28B associated with phase 1 and phase 2 of early viral kinetics in patients infected with HCV genotype 1 2012 10 10.1016/j.jhep.2011.10.004

Links to SNPedia

Title Summary
rs12979860 T/T ~20-25% of such hepatitis c patients respond to treatment
rs12979860 C/C ~80% of such hepatitis c patients respond to treatment
rs12979860 C/T ~20-40% of such hepatitis c patients respond to treatment
Note: For some SNPs, testing providers detect the genotype from the opposite strand of DNA, so that the genotypes listed at openSNP don't appear here. In those cases, please replace "A" by "T" or "G" by "C" (and vice-versa).

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