openSNP | rs12979860

Links to SNPedia

Title	Summary
rs12979860 T/T	~20-25% of such hepatitis c patients respond to treatment
rs12979860 C/C	~80% of such hepatitis c patients respond to treatment
rs12979860 C/T	~20-40% of such hepatitis c patients respond to treatment

Note: For some SNPs, testing providers detect the genotype from the opposite strand of DNA, so that the genotypes listed on openSNP don't appear here. In those cases, please replace "A" by "T" or "G" by "C" (and vice-versa).

Publications on this SNP on the Public Library of Science:

First Author	Title	Year of Publication	# of readers
Karolina Rembeck	Impact of IL28B-Related Single Nucleotide Polymorphisms on Liver Histopathology in Chronic Hepatitis C Genotype 2 and 3	2012	4997
Simone Susser	Predictive Value of Interferon-Lambda Gene Polymorphisms for Treatment Response in Chronic Hepatitis C	2014	2387
Giuseppe Indolfi	Comparative Analysis of rs12979860 SNP of the IFNL3 Gene in Children with Hepatitis C and Ethnic Matched Controls Using 1000 Genomes Project Data	2014	1574
Nobuhiro Harada	Impact of Donor and Recipient Single Nucleotide Polymorphisms of IL28B rs8099917 in Living Donor Liver Transplantation for Hepatitis C	2014	1568
Seung Up Kim	Association between IL28B Polymorphisms and Spontaneous Clearance of Hepatitis B Virus Infection	2013	3544
Tetsuro Takayama	Prediction of Effect of Pegylated Interferon Alpha-2b plus Ribavirin Combination Therapy in Patients with Chronic Hepatitis C Infection	2011	3124
Vijayaprakash Suppiah	IL28B, HLA-C, and KIR Variants Additively Predict Response to Therapy in Chronic Hepatitis C Virus Infection in a European Cohort: A Cross-Sectional Study	2011	13348
Felix M. Key	Selection on a Variant Associated with Improved Viral Clearance Drives Local, Adaptive Pseudogenization of Interferon Lambda 4 (IFNL4)	2014	5675
Jordan J. Feld	Plasma Interferon-Gamma-Inducible Protein-10 Levels Are Associated with Early, but Not Sustained Virological Response during Treatment of Acute or Early Chronic HCV Infection	2013	2380
Dawn N. Birdsell	Melt Analysis of Mismatch Amplification Mutation Assays (Melt-MAMA): A Functional Study of a Cost-Effective SNP Genotyping Assay in Bacterial Models	2012	8969
Christian M. Lange	A Genetic Validation Study Reveals a Role of Vitamin D Metabolism in the Response to Interferon-Alfa-Based Therapy of Chronic Hepatitis C	2012	4085
Ciara Keane	Variation in Both IL28B and KIR2DS3 Genes Influence Pegylated Interferon and Ribavirin Hepatitis C Treatment Outcome in HIV-1 Co-Infection	2013	1534
Yasuteru Kondo	1(OH) Vitamin D3 Supplementation Improves the Sensitivity of the Immune-Response during Peg-IFN/RBV Therapy in Chronic Hepatitis C Patients-Case Controlled Trial	2013	2868
I-Cheng Lee	IL28B Polymorphism Correlates with Active Hepatitis in Patients with HBeAg-Negative Chronic Hepatitis B	2013	3108
Man-Qing Liu	IFN-λ3 Inhibits HIV Infection of Macrophages through the JAK-STAT Pathway	2012	5032
Elżbieta Jabłonowska	Hepatic HMOX1 Expression Positively Correlates with Bach-1 and miR-122 in Patients with HCV Mono and HIV/HCV Coinfection	2014	1204
Sayeh Ezzikouri	Genetic Variation in the Interleukin-28B Gene Is Associated with Spontaneous Clearance and Progression of Hepatitis C Virus in Moroccan Patients	2013	3141
Lene Fogt Lundbo	Influence of Hepatitis C Virus and IL28B Genotypes on Liver Stiffness	2014	1134
Chun-Yen Lin	IL28B SNP rs12979860 Is a Critical Predictor for On-Treatment and Sustained Virologic Response in Patients with Hepatitis C Virus Genotype-1 Infection	2011	10815
Martin Probst	IL28B Polymorphism Cannot Predict Response to Interferon Alpha Treatment in Patients with Melanoma	2014	803
Shan-shan Su	Regulatory Phenotype, PD-1 and TLR3 Expression in T Cells and Monocytes from HCV Patients Undergoing Antiviral Therapy: A Randomized Clinical Trial	2014	2032
Charlotte H. B. S. van den Berg	Female Sex and IL28B, a Synergism for Spontaneous Viral Clearance in Hepatitis C Virus (HCV) Seroconverters from a Community-Based Cohort	2011	4834
Francesc Vidal	Pharmacogenetics of Efficacy and Safety of HCV Treatment in HCV-HIV Coinfected Patients: Significant Associations with IL28B and SOCS3 Gene Variants	2012	4283
Alex Thompson	Prediction of Treatment Week Eight Response & Sustained Virologic Response in Patients Treated with Boceprevir Plus Peginterferon Alfa and Ribavirin	2014	860
Ming-Ling Chang	Distinct Patterns of the Lipid Alterations between Genotype 1 and 2 Chronic Hepatitis C Patients after Viral Clearance	2014	1009
Chun-Yen Lin	IL28B SNP rs12979860 Is a Critical Predictor for On-Treatment and Sustained Virologic Response in Patients with Hepatitis C Virus Genotype-1 Infection	2011	9747
Dinara Khudayberganova	IL28B Polymorphisms and Clinical Implications for Hepatitis C Virus Infection in Uzbekistan	2014	2236
Dong-Won Kim	Naturally Occurring Mutations in the Nonstructural Region 5B of Hepatitis C Virus (HCV) from Treatment-Naïve Korean Patients Chronically Infected with HCV Genotype 1b	2014	1999
David Gardiner	A Randomized, Double-Blind, Placebo-Controlled Assessment of BMS-936558, a Fully Human Monoclonal Antibody to Programmed Death-1 (PD-1), in Patients with Chronic Hepatitis C Virus Infection	2013	6391
Sridhar R. Allam	The Association of IL28B Polymorphism and Graft Survival in Patients with Hepatitis C Undergoing Liver Transplantation	2013	2044
Janett Fischer	Association of IFNL3 rs12979860 and rs8099917 with Biochemical Predictors of Interferon Responsiveness in Chronic Hepatitis C Virus Infection	2013	2807
Babs E. Verstrepen	Evaluation of IL-28B Polymorphisms and Serum IP-10 in Hepatitis C Infected Chimpanzees	2012	2536
Sara Corchado	Liver Fibrosis, Host Genetic and Hepatitis C Virus Related Parameters as Predictive Factors of Response to Therapy against Hepatitis C Virus in HIV/HCV Coinfected Patients	2014	1723
Ángeles Ruiz-Extremera	Variation of Transaminases, HCV-RNA Levels and Th1/Th2 Cytokine Production during the Post-Partum Period in Pregnant Women with Chronic Hepatitis C	2013	1916
Jose Ramón Vidal-Castiñeira	Diversity of Killer Cell Immunoglobulin-Like Receptor (KIR) Genotypes and KIR2DL2/3 Variants in HCV Treatment Outcome	2014	1453
Georgios Grammatikos	Vitamin D Levels Vary during Antiviral Treatment but Are Unable to Predict Treatment Outcome in HCV Genotype 1 Infected Patients	2014	2875
Jennifer M. Reynolds	Sequence Analysis of the IL28A/IL28B Inverted Gene Duplication That Contains Polymorphisms Associated with Treatment Response in Hepatitis C Patients	2012	5290
Tonggang Liu	IL-28B Polymorphisms Correlated with Treatment Response in HCV-4 Mono-Infected Patients: A Meta-Analysis	2014	2432
Alessandra Mangia	Individualized Treatment of Genotype 1 Naïve Patients: An Italian Multicenter Field Practice Experience	2014	1067
Ming-Lung Yu	Revisiting the Stopping Rule for Hepatitis C Genotype 1 Patients Treated with Peginterferon Plus Ribavirin	2012	2247
Edmondo Falleti	Genetic Polymorphisms of Vitamin D Pathway Predict Antiviral Treatment Outcome in Slow Responder Naïve Patients with Chronic Hepatitis C	2013	2612
Lawrence M. Pfeffer	An Interferon Response Gene Signature Is Associated with the Therapeutic Response of Hepatitis C Patients	2014	1694
Salvatore Petta	PNPLA3 GG Genotype and Carotid Atherosclerosis in Patients with Non-Alcoholic Fatty Liver Disease	2013	3303
Yuichi Nozawa	KIR, HLA, and IL28B Variant Predict Response to Antiviral Therapy in Genotype 1 Chronic Hepatitis C Patients in Japan	2013	2081
Luis M. Real	IFNL4 ss469415590 Variant Shows Similar Performance to rs12979860 as Predictor of Response to Treatment against Hepatitis C Virus Genotype 1 or 4 in Caucasians	2014	1410
Philippe Halfon	Detection of IL28B SNP DNA from Buccal Epithelial Cells, Small Amounts of Serum, and Dried Blood Spots	2012	2898
José A. Agúndez	Relation of IL28B Gene Polymorphism with Biochemical and Histological Features in Hepatitis C Virus-Induced Liver Disease	2012	3784
Xiaoyan Guo	Genetic Variation in Interleukin 28B and Response to Antiviral Therapy in Patients with Dual Chronic Infection with Hepatitis B and C Viruses	2013	1993
Åsa Alsiö	Impact of Obesity on the Bioavailability of Peginterferon-α2a and Ribavirin and Treatment Outcome for Chronic Hepatitis C Genotype 2 or 3	2012	2448
Verónica Saludes	Relevance of Baseline Viral Genetic Heterogeneity and Host Factors for Treatment Outcome Prediction in Hepatitis C Virus 1b-Infected Patients	2013	1792
Isabelle Morard	Clinical Significance of the CCR5delta32 Allele in Hepatitis C	2014	1302
Antonio Rivero-Juárez	Differences in HCV Viral Decline between Low and Standard-Dose Pegylated-Interferon-Alpha-2a with Ribavirin in HIV/HCV Genotype 3 Patients	2012	1665
Xiaodong Shi	IL28B Genetic Variation Is Associated with Spontaneous Clearance of Hepatitis C Virus, Treatment Response, Serum IL-28B Levels in Chinese Population	2012	6079
Rushna Firdaus	Impact of Host IL28B rs12979860, rs8099917 in Interferon Responsiveness and Advanced Liver Disease in Chronic Genotype 3 Hepatitis C Patients	2014	2330
Jie Chen	Association Analysis between SNPs in IL-28B Gene and the Progress of Hepatitis B Infection in Han Chinese	2012	3080
Thomas R. O'Brien	An IL28B Genotype-Based Clinical Prediction Model for Treatment of Chronic Hepatitis C	2011	8089
Masahiro Ishikane	Acute Hepatitis C in HIV-1 Infected Japanese Cohort: Single Center Retrospective Cohort Study	2014	2045
Aihua Zhang	Urinary Metabolic Biomarker and Pathway Study of Hepatitis B Virus Infected Patients Based on UPLC-MS System	2013	3322
I-Cheng Lee	CXCL9 Associated with Sustained Virological Response in Chronic Hepatitis B Patients Receiving Peginterferon Alfa-2a Therapy: A Pilot Study	2013	2606
Montserrat de Castellarnau	Deciphering the Interleukin 28B Variants That Better Predict Response to Pegylated Interferon-α and Ribavirin Therapy in HCV/HIV-1 Coinfected Patients	2012	3809
Samantha J. Griffiths	A Systematic Analysis of Host Factors Reveals a Med23-Interferon-λ Regulatory Axis against Herpes Simplex Virus Type 1 Replication	2013	11741
Iva Subhanova	Expression of Biliverdin Reductase A in Peripheral Blood Leukocytes Is Associated with Treatment Response in HCV-Infected Patients	2013	1657
Wen-Juei Jeng	None of the Six SNPs of IL28B Could Predict Treatment Responses in Genotype 2 Chronic HCV Infected Patients by Propensity Score Matching Analysis	2012	2271
Nafisa-Katrin Seich al Basatena	KIR2DL2 Enhances Protective and Detrimental HLA Class I-Mediated Immunity in Chronic Viral Infection	2011	4536
G. L. Abby Harrison	Infection Frequency of Hepatitis C Virus and IL28B Haplotypes in Papua New Guinea, Fiji, and Kiribati	2013	2856
Antonio Rivero-Juarez	Natural Killer KIR3DS1 Is Closely Associated with HCV Viral Clearance and Sustained Virological Response in HIV/HCV Patients	2013	2405
Akihito Tsubota	Involvement of MAP3K8 and miR-17-5p in Poor Virologic Response to Interferon-Based Combination Therapy for Chronic Hepatitis C	2014	2010
Daiki Miki	HLA-DQB1*03 Confers Susceptibility to Chronic Hepatitis C in Japanese: A Genome-Wide Association Study	2013	3060
Zhifang Jia	Test of IL28B Polymorphisms in Chronic Hepatitis C Patients Treated with PegIFN and Ribavirin Depends on HCV Genotypes: Results from a Meta-Analysis	2012	6690
Masaya Sugiyama	Genetic Variation of the IL-28B Promoter Affecting Gene Expression	2011	5862
Adrian Egli	IL-28B is a Key Regulator of B- and T-Cell Vaccine Responses against Influenza	2014	9074
Barham K. Abu Dayyeh	IL28B Alleles Exert an Additive Dose Effect When Applied to HCV-HIV Coinfected Persons Undergoing Peginterferon and Ribavirin Therapy	2011	3436
Ahmed S. Abdel-Moneim	HCV Infection among Saudi Population: High Prevalence of Genotype 4 and Increased Viral Clearance Rate	2012	6749
Vincent Pedergnana	Analysis of IL28B Variants in an Egyptian Population Defines the 20 Kilobases Minimal Region Involved in Spontaneous Clearance of Hepatitis C Virus	2012	2692
Verónica Saludes	Baseline Prediction of Combination Therapy Outcome in Hepatitis C Virus 1b Infected Patients by Discriminant Analysis Using Viral and Host Factors	2010	3847
Thomas H. King	A Whole Recombinant Yeast-Based Therapeutic Vaccine Elicits HBV X, S and Core Specific T Cells in Mice and Activates Human T Cells Recognizing Epitopes Linked to Viral Clearance	2014	3841
Amy E. L. Stone	Hepatitis C Virus Pathogen Associated Molecular Pattern (PAMP) Triggers Production of Lambda-Interferons by Human Plasmacytoid Dendritic Cells	2013	5986
Derek D. Cyr	Characterization of Serum Proteins Associated with IL28B Genotype among Patients with Chronic Hepatitis C	2011	3722
Luis F. López-Cortés	Influence of IL28B Polymorphisms on Response to a Lower-Than-Standard Dose peg-IFN-α 2a for Genotype 3 Chronic Hepatitis C in HIV-Coinfected Patients	2012	2710
Gloria Taliani	IL28B Gene Polymorphisms and US Liver Fatty Changes in Patients Who Spontaneously Cleared Hepatitis C Virus Infection	2013	1702
Linda Dunford	A Multicentre Molecular Analysis of Hepatitis B and Blood-Borne Virus Coinfections in Viet Nam	2012	4351
Martin Lagging	Response Prediction in Chronic Hepatitis C by Assessment of IP-10 and IL28B-Related Single Nucleotide Polymorphisms	2011	8379
Masato Nakamura	No Correlation between PNPLA3 rs738409 Genotype and Fatty Liver and Hepatic Cirrhosis in Japanese Patients with HCV	2013	3438
Mark A. A. Claassen	Negative Regulation of Hepatitis C Virus Specific Immunity Is Highly Heterogeneous and Modulated by Pegylated Interferon-Alpha/Ribavirin Therapy	2012	1878
Sreedhar Chinnaswamy	A Single Nucleotide Polymorphism Associated with Hepatitis C Virus Infections Located in the Distal Region of the IL28B Promoter Influences NF-κB-Mediated Gene Transcription	2013	4298
Benjamin Maasoumy	Eligibility and Safety of Triple Therapy for Hepatitis C: Lessons Learned from the First Experience in a Real World Setting	2013	6315
Masaya Sato	Impact of IL28B Genetic Variation on HCV-Induced Liver Fibrosis, Inflammation, and Steatosis: A Meta-Analysis	2014	2372
Camila da Silva Ferreira	A Fast and Cost-Effective Method for Identifying a Polymorphism of Interleukin 28B Related to Hepatitis C	2013	1593
Ahmad Amanzada	Interferon-λ₄ (IFNL4) Transcript Expression in Human Liver Tissue Samples	2013	2589
Jonas Söderholm	Impact of Soluble CD26 on Treatment Outcome and Hepatitis C Virus-Specific T Cells in Chronic Hepatitis C Virus Genotype 1 Infection	2013	2577
Ester Aparicio	IL28B SNP rs8099917 Is Strongly Associated with Pegylated Interferon-α and Ribavirin Therapy Treatment Failure in HCV/HIV-1 Coinfected Patients	2010	7691
Tatiane Assone	IL28B Gene Polymorphism SNP rs8099917 Genotype GG Is Associated with HTLV-1-Associated Myelopathy/Tropical Spastic Paraparesis (HAM/TSP) in HTLV-1 Carriers	2014	4908
Silvana Gaudieri	Genetic Variations in IL28B and Allergic Disease in Children	2012	3624
Lindsay Y. King	Host Genetics Predict Clinical Deterioration in HCV-Related Cirrhosis	2014	1856
Elena García-Martín	Influence of Vitamin D-Related Gene Polymorphisms (CYP27B and VDR) on the Response to Interferon/Ribavirin Therapy in Chronic Hepatitis C	2013	4155
Magdalena Ydreborg	Impact of IL28B-Related Single Nucleotide Polymorphisms on Liver Transient Elastography in Chronic Hepatitis C Infection	2013	2318
Eleonora Lalle	IFN-Alpha Receptor-1 Upregulation in PBMC from HCV Naïve Patients Carrying CC Genotype. Possible Role of IFN-Lambda	2014	1261
Nicola Coppola	Cannabinoid Receptor 2-63 QQ Variant Is Associated with Persistently Normal Aminotransferase Serum Levels in Chronic Hepatitis C	2014	1050
Vo Duy Thong	Prevalence of Thymine—Adenine Dinucleotide Repeat, IL28B and IFNL4 in Thai Population and Correlation with Spontaneous Clearance and Treatment Outcome of Hepatitis C Infection	2015	919
Krzysztof Domagalski	The Impact of IL28B Genotype and Liver Fibrosis on the Hepatic Expression of IP10, IFI27, ISG15, and MX1 and Their Association with Treatment Outcomes in Patients with Chronic Hepatitis C	2015	1345

Publications on this SNP on Mendeley

First Author	Title	Pub. Year	# of Readers	DOI
Thomas J Urban	IL28B genotype is associated with differential expression of intrahepatic interferon-stimulated genes in patients with chronic hepatitis C.	2010	52	10.1002/hep.23912
Benjamin Krämer	Variation in IFNL4 genotype and response to interferon-based therapy of hepatitis C in HIV-positive patients with acute and chronic hepatitis C.	2013	5	10.1097/01.aids.0000433234.78807.54
Anu Osinusi	IL28B polymorphism is not associated with HCV protease diversity in patients co-infected with HIV and HCV treated with pegylated interferon and ribavirin.	2012	1	10.1002/jmv.23376
Evaldo Stanislau Affonso de Araujo	Pharmacodynamics of PEG-IFN-[alpha]-2a and HCV response as a function of IL28B polymorphism in HIV/HCV-coinfected patients.	2011	19	10.1097/QAI.0b013e3182020596
Davide Bitetto	Complementary role of vitamin D deficiency and the interleukin-28B rs12979860 C/T polymorphism in predicting antiviral response in chronic hepatitis C.	2011	15	10.1002/hep.24201
J A Pineda	Prediction of Response to Pegylated Interferon plus Ribavirin by IL28B Gene Variation in Patients Coinfected with HIV and Hepatitis C Virus	2010	0	10.1086/656235
Tomokazu Kawaoka	Predictive value of the IL28B polymorphism on the effect of interferon therapy in chronic hepatitis C patients with genotypes 2a and 2b.	2011	13	10.1016/j.jhep.2010.07.032
E G Giannini	IL28B rs12979860 C/T polymorphism in elderly chronic hepatitis C patients treated with pegylated-interferon and ribavirin.	2011	0	10.1111/j.1365-2036.2011.04734.x
Stéphanie Bibert	IL28B expression depends on a novel TT/-G polymorphism which improves HCV clearance prediction.	2013	13	10.1084/jem.20130012
Sandra Beinhardt	Serum level of IP-10 increases predictive value of IL28B polymorphisms for spontaneous clearance of acute HCV infection.	2012	1	-
M Venegas	IL28B polymorphisms associated with therapy response in Chilean chronic hepatitis C patients	2011	1	10.3748/wjg.v17.i31.3636
Jama M Darling	THE PREDICTIVE VALUE OF IL28B GENE POLYMORPHISM FOR RESPONSE TO PEGINTERFERON AND RIBAVIRIN IS ENHANCED BY QUANTITATION OF IP-10 IN PRETREATMENT SERUM	2010	1	-
Alexandra Doehring	Screening for IL28B gene variants identifies predictors of hepatitis C therapy success.	2010	1	-
J a Del Campo	Insulin resistance predicts sustained virological response to treatment of chronic hepatitis C independently of the IL28b rs12979860 polymorphism.	2013	5	10.1111/apt.12113
a Piluso	Value of IL28B genotyping in patients with HCV-related mixed cryoglobulinemia: results of a large, prospective study.	2013	2	10.1111/jvh.12017
Norma I Rallón	Association of a single nucleotide polymorphism near the interleukin-28B gene with response to hepatitis C therapy in HIV/hepatitis C virus-coinfected patients.	2010	32	10.1097/QAD.0b013e3283391d6d
T Reiberger	Portal Pressure Predicts Outcome and Safety of Antiviral Therapy in Cirrhotic Patients with HCV infection	2011	3	10.1016/j.cgh.2011.03.002
James Everhart	Association of [gamma]-glutamyl transferase (GGT) activity with treatment and clinical outcomes in chronic hepatitis C (HCV).	2013	3	10.1002/hep.26203
K Neukam	Efficacy of chronic hepatitis C therapy with pegylated interferon and ribavirin in patients on methadone maintenance treatment	2012	2	DOI 10.1007/s10096-011-1433-5
Y Maor	Genetic polymorphism of IL28B in hepatitis C-infected haemophilia patients in Israel.	2013	1	10.1111/j.1365-2516.2012.02932.x
K Neukam	Prediction of response to pegylated interferon/ribavirin by interleukin 28B genotype is modified by SNPS at multiple genes in HIV/hepatitis C virus genotype 1/4-coinfected patients	2013	2	10.1016/S0168-8278(13)60885-5
Seok Hoo Jeong	Efficacy of peginterferon and ribavirin is associated with the IL28B gene in Korean patients with chronic hepatitis C.	2012	3	10.3350/cmh.2012.18.4.360
Derek D. Cyr	Characterization of serum proteins associated with IL28B genotype among patients with chronic hepatitis C	2011	7	10.1371/journal.pone.0021854
Ahmad Amanzada	Early anemia and rapid virological response improve the predictive efficiency of IL28B-genotype for treatment outcome to antiviral combination therapy in patients infected with chronic HCV genotype 1.	2012	3	10.1002/jmv.23323
Salvatore Petta	IL28B and PNPLA3 polymorphisms affect histological liver damage in patients with non-alcoholic fatty liver disease.	2012	3	10.1016/j.jhep.2012.01.007
Tarciana Grandi	Response to treatment in Brazilian patients with chronic hepatitis C is associated with a single-nucleotide polymorphism near the interleukin-28B gene.	2013	6
Ludmila Prokunina-Olsson	A variant upstream of IFNL3 (IL28B) creating a new interferon gene IFNL4 is associated with impaired clearance of hepatitis C virus.	2013	40	10.1038/ng.2521
Lucy Golden-Mason	Natural killer inhibitory receptor expression associated with treatment failure and interleukin-28B genotype in patients with chronic hepatitis C.	2011	1	10.1002/hep.24556
Thomas J Urban	IL28B genotype is associated with differential expression of intrahepatic interferon-stimulated genes in patients with chronic hepatitis C.	2010	48	10.1002/hep.23912
Z Gerlei	Measurement and clinical significance of interleukin 28B in hepatitis C virus-infected liver transplant patients.	2012	1	10.1016/j.transproceed.2012.07.101
Mostafa M Ragheb	Strong prediction of virological response to combination therapy by IL28B gene variants rs12979860 and rs8099917 in chronic hepatitis C genotype 4.	2013	4	10.1111/liv.12321
Fumitaka Suzuki	Association of two polymorphisms of the IL28B gene with viral factors and treatment response in 1,518 patients infected with hepatitis C virus	2012	4	10.1007/s00535-012-0531-1
Martin Lagging	Response Prediction in Chronic Hepatitis C by Assessment of IP-10 and <italic>IL28B</italic>-Related Single Nucleotide Polymorphisms	2011	1
T R O'Brien	An IL28B genotype-based model for personalized prediction of response to pegylatedinterferon-alfa and ribavirin in the treatment of chronic hepatitis C	2010	1
Jeff Connell	A Multicentre Molecular Analysis of Hepatitis B and Blood-Borne Virus Coinfections in Viet Nam	2012	4	10.1371/journal.pone.0039027
Norma I Rallon	IL28B gene polymorphisms and viral kinetics in HIV/hepatitis C virus-coinfected patients treated with pegylated interferon and ribavirin	2011	0	10.1097/QAD.0b013e3283471cae
Y. Kamiyama	Effect of pH and salt on the adsorption and interactions of an amphoteric polyelectrolyte	1992	7	10.1002/hep.24623
Alajos Pár	[IL28B CC genotype: a protective factor and predictor of the response to interferon treatment in chronic hepatitis C virus infection].	2013	1	10.1556/OH.2013.29680
Vito Di Marco	IL28B polymorphisms influence stage of fibrosis and spontaneous or interferon-induced viral clearance in thalassemia patients with hepatitis C virus infection.	2012	2	-
Özlem Kandemir	Chronic hepatitis B and IL28B rs12979860 polymorphism: preliminary study.	2013	1	10.1007/s11033-013-2730-0
Zoe Raglow	IL28B genotype and the expression of ISGs in normal liver.	2013	2	10.1111/liv.12148
Esther J. Pav??n-Castillero	Importance of IL-10 and IL-6 during chronic hepatitis c genotype-1 treatment and their relation with IL28B	2013	6	10.1016/j.cyto.2012.10.009
Jun Liong Chin	Spontaneous clearance of hepatitis C infection after liver transplantation from IL28B rs12979860 CC donors.	2012	1	-
Lin Liu	Spontaneous Clearance of Primary Acute Hepatitis C Virus Infection Correlated With High Initial Viral RNA Level and Rapid HVR1 Evolution	2012	7	10.1002/hep.25575
Jama M Darling	Quantitation of Pretreatment Serum IP-10 Improves the Predictive Value of an IL28B Gene Polymorphism for Hepatitis C Treatment Response	2010	1
Ana Treviño	Development of tropical spastic paraparesis in human T-lymphotropic virus type 1 carriers is influenced by interleukin 28B gene polymorphisms.	2012	3	10.1093/cid/cis343
Jie Chen	Association Analysis between SNPs in IL-28B Gene and the Progress of Hepatitis B Infection in Han Chinese	2012	3	10.1371/journal.pone.0050787
Flisiak R.	Alisporivir (ALV) plus PegIFN/RBV (PR) has 100% SVR in IL28B rs12979860 CC allele and superior efficacy in chronic hepatitis C genotype (G) 1 treatment na	2012	2
Stella De Nicola	An IL28B polymorphism predicts pegylated interferon plus ribavirin treatment outcome in chronic hepatitis c genotype 4.	2011	4	10.1002/hep.24683
L Golden Mason	Natural killer inhibitory receptor expression associated with treatment failure and interleukin‐28B genotype in patients with chronic hepatitis C	2011	6	10.1002/hep.24556
K Neukam	Different distributions of hepatitis C virus genotypes among HIV-infected patients with acute and chronic hepatitis C according to interleukin-28B genotype.	2011	5	10.1111/j.1468-1293.2011.00912.x
L J Peng	IL28B rs12979860 polymorphism does not influence outcomes of hepatitis B virus infection.	2012	2	10.1111/j.1399-0039.2011.01835.x
S Gaudieri	Genetic variations in IL28B and allergic disease in children	2012	2	10.1371/journal.pone.0030607
Alessandra Mangia	An IL28B polymorphism determines treatment response of hepatitis C virus genotype 2 or 3 patients who do not achieve a rapid virologic response	2010	28	10.1053/j.gastro.2010.05.079
Scott W Biggins	Differential effects of donor and recipient IL28B and DDX58 SNPs on severity of HCV after liver transplantation.	2013	4	10.1016/j.jhep.2012.12.027
Golden-Mason L.	NK inhibitory receptor expression associated with treatment failure and IL-28B genotype in patients with chronic hepatitis C	2011	1
Jun-Qiang Xie	Relationship between the genetic variation in interleukin 28B and response to antiviral therapy in patients with chronic hepatitis C.	2012	1	10.3760/cma.j.issn.0366-6999.2012.13.017
Li-Sheng Wu	Two IL28B polymorphisms are associated with the treatment response of different genotypes of hepatitis C in different racial populations: A meta-analysis.	2012	3	10.3892/etm.2011.385
J A Pineda	Prediction of response to pegylated interferon plus ribavirin by IL28B gene variation in patients coinfected with HIV and hepatitis C virus	2010	1
Hans L. Tillmann	Beneficial IL28B genotype associated with lower frequency of hepatic steatosis in patients with chronic hepatitis C	2011	11	10.1016/j.jhep.2011.03.015
Sandra Beinhardt	Serum level of IP-10 increases predictive value of IL28B polymorphisms for spontaneous clearance of acute HCV infection.	2012	1	-
E Jablonowska	Sustained virologic response and IL28B single-nucleotide polymorphisms in patients with chronic hepatitis C treated with pegylated interferon alfa and ribavirin	2012	1	-
D.R Paul	Control of the morphology of polyamide/styrene-acrylonitrile copolymer blends via reactive compatibilizers	1994	4	10.1016/0032-3861(94)90082-5
Runyan Jin	Optimum ribavirin exposure overcomes racial disparity in efficacy of peginterferon and ribavirin treatment for hepatitis C genotype 1.	2012	1	10.1038/ajg.2012.306
B J Veldt	Recipient IL28B polymorphism is an important independent predictor of posttransplant diabetes mellitus in liver transplant patients with chronic hepatitis C.	2012	11	10.1111/j.1600-6143.2011.03843.x
Susanne Knapp	A polymorphism in IL28B distinguishes exposed, uninfected individuals from spontaneous resolvers of HCV infection.	2011	11	10.1053/j.gastro.2011.04.005
E G Giannini	IL28B rs12979860 C/T polymorphism in elderly chronic hepatitis C patients treated with pegylated-interferon and ribavirin.	2011	2	10.1111/j.1365-2036.2011.04734.x
Jeanette J McCarthy	Replicated Association Between an Interleukin-28B Gene Variant and a Sustained Response to Pegylated Interferon and Ribavirin.	2010	6	10.1053/j.gastro.2010.02.009
Josephine H Li	Interferon-lambda genotype and low serum low-density lipoprotein cholesterol levels in patients with chronic hepatitis C infection.	2010	0
Chun-Yen Lin	IL28B SNP rs12979860 Is a Critical Predictor for On-Treatment and Sustained Virologic Response in Patients with Hepatitis C Virus Genotype-1 Infection	2011	0	10.1371/journal.pone.0018322
F. Negro	IL28B polymorphisms predict reduction of HCV RNA from the first day of therapy in chronic hepatitis C	2011	14	10.1016/j.jhep.2011.01.050
Jeanette J McCarthy	Replicated association between an IL28B gene variant and a sustained response to pegylated interferon and ribavirin.	2010	1	10.1053/j.gastro.2010.02.009
Z Raglow	IL28B genotype and the expression of ISGs in normal liver.	2013	7	10.1111/liv.12148
Evaldo Stanislau Affonso De Araujo	Pharmacodynamics of PEG-IFN-[alpha]-2a and HCV response as a function of IL28B polymorphism in HIV/HCV-coinfected patients.	2011	11	10.1097/QAI.0b013e3182020596
Fred Poordad	Factors that predict response of patients with hepatitis C virus infection to boceprevir.	2012	1	-
Pietro Lampertico	IL28B polymorphisms predict interferon-related HBsAg seroclearance in genotype D HBeAg-negative patients with chronic hepatitis B.	2012	7	10.1002/hep.25749
Amir Moghaddam	IL28B genetic variation and treatment response in patients with hepatitis C virus genotype 3 infection	2011	3	10.1002/hep.24154
Tarik Asselah	IL28B polymorphism is associated with treatment response in patients with genotype 4 chronic hepatitis C	2012	9	10.1016/j.jhep.2011.09.008
Mostafa M Ragheb	Strong prediction of virological response to combination therapy by IL28B gene variants rs12979860 and rs8099917 in chronic hepatitis C genotype 4.	2013	1	10.1111/liv.12321
M Lindh	Interleukin 28B Gene Variation at rs12979860 Determines Early Viral Kinetics During Treatment in Patients Carrying Genotypes 2 or 3 of Hepatitis C Virus	2011	0	10.1093/infdis/jir193
M Mandorfer	Revisiting predictors of virologic response to PEGIFN + RBV therapy in HIV-/HCV-coinfected patients: the role of metabolic factors and elevated GGT levels	2014	1	10.1111/jvh.12118
Alessandra Mangia	Treatment optimization and prediction of HCV clearance in patients with acute HCV infection	2013	4	10.1016/j.jhep.2013.04.007
Erik Alestig	Core mutations, IL28B polymorphisms and response to peginterferon/ribavirin treatment in Swedish patients with hepatitis C virus genotype 1 infection	2011	0	10.1186/1471-2334-11-124
Christoph Sarrazin	Importance of IL28B gene polymorphisms in hepatitis C virus genotype 2 and 3 infected patients.	2010	2	10.1016/j.jhep.2010.07.041
Hiromi Abe	Inverse association of IL28B genotype and liver mRNA expression of genes promoting or suppressing antiviral state.	2011	9	10.1002/jmv.22158
Karin Neukam	Prediction of response to pegylated interferon plus ribavirin in HIV/hepatitis C virus (HCV)-coinfected patients using HCV genotype, IL28B variations, and HCV-RNA load.	2012	1	-
Zobair M Younossi	The impact of IL28B genotype on the gene expression profile of patients with chronic hepatitis C treated with pegylated interferon alpha and ribavirin.	2012	4	10.1186/1479-5876-10-25
Jacob Nattermann	The predictive value of IL28B gene polymorphism for spontaneous clearance in a single source outbreak cohort is limited in patients carrying the CCR5Δ32 mutation.	2011	6	10.1016/j.jhep.2011.03.011
J.C. Palomares	1173 VARIATION IN INTERLEUKIN 28B GEN PREDICTS RESPONSE TO PEGYLATED INTERFERON PLUS RIBAVIRIN IN HIV/HEPATITIS C VIRUS-COINFECTED PATIENTS	2010	3	10.1016/S0168-8278(10)61174-9
Brian L Pearlman	The IL-28 genotype: how it will affect the care of patients with hepatitis C virus infection.	2011	7	10.1007/s11894-010-0161-9
Moutaz Derbala	Interleukin-28 and hepatitis C virus genotype-4: treatment-induced clearance and liver fibrosis.	2012	3	10.3748/wjg.v18.i47.7003
Simone Moreira	A straightforward genotyping of the relevant IL28B SNPs for the prediction of hepatitis C treatment outcome.	2012	2	10.1016/j.jviromet.2012.05.024
Elisabetta Cariani	Interleukin 28B genotype determination using DNA from different sources: A simple and reliable tool for the epidemiological and clinical characterization of hepatitis C	2011	3	10.1016/j.jviromet.2011.08.021
Miquel Navasa	Determination of IL28B polymorphisms in liver biopsies obtained after liver transplantation	2012	2	10.1016/j.jhep.2011.07.027
Ochi H.	Il-28b predicts response to chronic hepatitis C therapy -fine-mapping and replication study in Asian populations	2011	1
K Neukam	Different distributions of hepatitis C virus genotypes among HIV-infected patients with acute and chronic hepatitis C according to interleukin-28B genotype	2011	2	10.1111/j.1468-1293.2011.00912.x
Butt M. Derbala M, Rizk NM, Al-Kaabi S, John A, Sharma M, El-Dweik N, Yakoob R, Pasic F, Almohanadi M, Alejji K, Abdelmola A	The predictive value of IL28B rs12979860, rs11881222 and rs8099917 polymorphisms and IP-10 in the therapeutic response of Egyptian genotype 4 patients.	2013	1	Virology. 2013 Sep;444(1-2):292-300. doi: 10.1016/j.virol.2013.06.025. Epub 2013 Jul 16.
Gonzalo Crespo	Combinations of simple baseline variables accurately predict sustained virological response in patients with recurrent hepatitis C after liver transplantation.	2012	2	10.1007/s00535-012-0680-2
Kawthar Machmach	IL28B single-nucleotide polymorphism rs12979860 is associated with spontaneous HIV control in white subjects.	2013	8	10.1093/infdis/jis717
Kathleen A. Ryan	Single nucleotide polymorphism upstream of interleukin 28B associated with phase 1 and phase 2 of early viral kinetics in patients infected with HCV genotype 1	2012	10	10.1016/j.jhep.2011.10.004

Evidence compiled by the Personal Genome Project

There are no results from the Personal Genome Project yet. Please come back later.

Publications listed by Genome.gov

First Author	Title	Journal	Publication Date	Trait	p-value	Confidence Interval
Ge D	Genetic variation in IL28B predicts hepatitis C treatment-induced viral clearance.	Nature	08/16/2009	Response to hepatitis C treatment	1.0e-28 (combined)	[1.8-2.3] (European-Americans)

Users who share this SNP:

SatoriFound

Treatment response

14.02.2018 01:13

I am TT and I responded to treatment. I've been hep c clear since 2004.

Name	rs12979860
Chromosome	19
Position	39248147
Weight of evidence	926

SNP rs12979860

Basic Information

Genotype Frequency

Allele Frequency

Additional Information