SNP rs12979860

Basic Information
Name rs12979860
Chromosome 19
Position 39248147
Weight of evidence 2394
Additional Information

Publications on this SNP on the Public Library of Science:

First Author Title Year of Publication # of readers
Dawn N. Birdsell Melt Analysis of Mismatch Amplification Mutation Assays (Melt-MAMA): A Functional Study of a Cost-Effective SNP Genotyping Assay in Bacterial Models 2012 4770
Thomas H. King A Whole Recombinant Yeast-Based Therapeutic Vaccine Elicits HBV X, S and Core Specific T Cells in Mice and Activates Human T Cells Recognizing Epitopes Linked to Viral Clearance 2014 885
Verónica Saludes Relevance of Baseline Viral Genetic Heterogeneity and Host Factors for Treatment Outcome Prediction in Hepatitis C Virus 1b-Infected Patients 2013 1297
David Gardiner A Randomized, Double-Blind, Placebo-Controlled Assessment of BMS-936558, a Fully Human Monoclonal Antibody to Programmed Death-1 (PD-1), in Patients with Chronic Hepatitis C Virus Infection 2013 3134
Dong-Won Kim Naturally Occurring Mutations in the Nonstructural Region 5B of Hepatitis C Virus (HCV) from Treatment-Naïve Korean Patients Chronically Infected with HCV Genotype 1b 2014 782
Nafisa-Katrin Seich al Basatena KIR2DL2 Enhances Protective and Detrimental HLA Class I-Mediated Immunity in Chronic Viral Infection 2011 3719
Yasuteru Kondo 1(OH) Vitamin D3 Supplementation Improves the Sensitivity of the Immune-Response during Peg-IFN/RBV Therapy in Chronic Hepatitis C Patients-Case Controlled Trial 2013 1421
Mark A. A. Claassen Negative Regulation of Hepatitis C Virus Specific Immunity Is Highly Heterogeneous and Modulated by Pegylated Interferon-Alpha/Ribavirin Therapy 2012 1267
Verónica Saludes Baseline Prediction of Combination Therapy Outcome in Hepatitis C Virus 1b Infected Patients by Discriminant Analysis Using Viral and Host Factors 2010 3336
Luis F. López-Cortés Influence of IL28B Polymorphisms on Response to a Lower-Than-Standard Dose peg-IFN-α 2a for Genotype 3 Chronic Hepatitis C in HIV-Coinfected Patients 2012 2288
Nicola Coppola Cannabinoid Receptor 2-63 QQ Variant Is Associated with Persistently Normal Aminotransferase Serum Levels in Chronic Hepatitis C 2014 364
Alex Thompson Prediction of Treatment Week Eight Response & Sustained Virologic Response in Patients Treated with Boceprevir Plus Peginterferon Alfa and Ribavirin 2014 266
Shan-shan Su Regulatory Phenotype, PD-1 and TLR3 Expression in T Cells and Monocytes from HCV Patients Undergoing Antiviral Therapy: A Randomized Clinical Trial 2014 791
Yuichi Nozawa KIR, HLA, and IL28B Variant Predict Response to Antiviral Therapy in Genotype 1 Chronic Hepatitis C Patients in Japan 2013 821
Aihua Zhang Urinary Metabolic Biomarker and Pathway Study of Hepatitis B Virus Infected Patients Based on UPLC-MS System 2013 1844
Man-Qing Liu IFN-λ3 Inhibits HIV Infection of Macrophages through the JAK-STAT Pathway 2012 3313
Antonio Rivero-Juárez Differences in HCV Viral Decline between Low and Standard-Dose Pegylated-Interferon-Alpha-2a with Ribavirin in HIV/HCV Genotype 3 Patients 2012 959
Åsa Alsiö Impact of Obesity on the Bioavailability of Peginterferon-α2a and Ribavirin and Treatment Outcome for Chronic Hepatitis C Genotype 2 or 3 2012 1768
Francesc Vidal Pharmacogenetics of Efficacy and Safety of HCV Treatment in HCV-HIV Coinfected Patients: Significant Associations with IL28B and SOCS3 Gene Variants 2012 2556
Amy E. L. Stone Hepatitis C Virus Pathogen Associated Molecular Pattern (PAMP) Triggers Production of Lambda-Interferons by Human Plasmacytoid Dendritic Cells 2013 4535
Samantha J. Griffiths A Systematic Analysis of Host Factors Reveals a Med23-Interferon-λ Regulatory Axis against Herpes Simplex Virus Type 1 Replication 2013 8516
Ángeles Ruiz-Extremera Variation of Transaminases, HCV-RNA Levels and Th1/Th2 Cytokine Production during the Post-Partum Period in Pregnant Women with Chronic Hepatitis C 2013 1154
Nobuhiro Harada Impact of Donor and Recipient Single Nucleotide Polymorphisms of IL28B rs8099917 in Living Donor Liver Transplantation for Hepatitis C 2014 598
Tetsuro Takayama Prediction of Effect of Pegylated Interferon Alpha-2b plus Ribavirin Combination Therapy in Patients with Chronic Hepatitis C Infection 2011 2282
Antonio Rivero-Juarez Natural Killer KIR3DS1 Is Closely Associated with HCV Viral Clearance and Sustained Virological Response in HIV/HCV Patients 2013 1236
Masato Nakamura No Correlation between PNPLA3 rs738409 Genotype and Fatty Liver and Hepatic Cirrhosis in Japanese Patients with HCV 2013 1422
Benjamin Maasoumy Eligibility and Safety of Triple Therapy for Hepatitis C: Lessons Learned from the First Experience in a Real World Setting 2013 5010
Akihito Tsubota Involvement of MAP3K8 and miR-17-5p in Poor Virologic Response to Interferon-Based Combination Therapy for Chronic Hepatitis C 2014 608
Ming-Lung Yu Revisiting the Stopping Rule for Hepatitis C Genotype 1 Patients Treated with Peginterferon Plus Ribavirin 2012 1157
Felix M. Key Selection on a Variant Associated with Improved Viral Clearance Drives Local, Adaptive Pseudogenization of Interferon Lambda 4 (IFNL4) 2014 1651
Silvana Gaudieri Genetic Variations in IL28B and Allergic Disease in Children 2012 2343
Rushna Firdaus Impact of Host IL28B rs12979860, rs8099917 in Interferon Responsiveness and Advanced Liver Disease in Chronic Genotype 3 Hepatitis C Patients 2014 477
Luis M. Real IFNL4 ss469415590 Variant Shows Similar Performance to rs12979860 as Predictor of Response to Treatment against Hepatitis C Virus Genotype 1 or 4 in Caucasians 2014 725
Masaya Sato Impact of IL28B Genetic Variation on HCV-Induced Liver Fibrosis, Inflammation, and Steatosis: A Meta-Analysis 2014 924
Thomas H. King A Whole Recombinant Yeast-Based Therapeutic Vaccine Elicits HBV X, S and Core Specific T Cells in Mice and Activates Human T Cells Recognizing Epitopes Linked to Viral Clearance 2014 885
Dawn N. Birdsell Melt Analysis of Mismatch Amplification Mutation Assays (Melt-MAMA): A Functional Study of a Cost-Effective SNP Genotyping Assay in Bacterial Models 2012 4770
Verónica Saludes Baseline Prediction of Combination Therapy Outcome in Hepatitis C Virus 1b Infected Patients by Discriminant Analysis Using Viral and Host Factors 2010 3336
Verónica Saludes Relevance of Baseline Viral Genetic Heterogeneity and Host Factors for Treatment Outcome Prediction in Hepatitis C Virus 1b-Infected Patients 2013 1297
Nafisa-Katrin Seich al Basatena KIR2DL2 Enhances Protective and Detrimental HLA Class I-Mediated Immunity in Chronic Viral Infection 2011 3719
Dong-Won Kim Naturally Occurring Mutations in the Nonstructural Region 5B of Hepatitis C Virus (HCV) from Treatment-Naïve Korean Patients Chronically Infected with HCV Genotype 1b 2014 782
Mark A. A. Claassen Negative Regulation of Hepatitis C Virus Specific Immunity Is Highly Heterogeneous and Modulated by Pegylated Interferon-Alpha/Ribavirin Therapy 2012 1267
David Gardiner A Randomized, Double-Blind, Placebo-Controlled Assessment of BMS-936558, a Fully Human Monoclonal Antibody to Programmed Death-1 (PD-1), in Patients with Chronic Hepatitis C Virus Infection 2013 3134
Yasuteru Kondo 1(OH) Vitamin D3 Supplementation Improves the Sensitivity of the Immune-Response during Peg-IFN/RBV Therapy in Chronic Hepatitis C Patients-Case Controlled Trial 2013 1421
Yuichi Nozawa KIR, HLA, and IL28B Variant Predict Response to Antiviral Therapy in Genotype 1 Chronic Hepatitis C Patients in Japan 2013 821
Nicola Coppola Cannabinoid Receptor 2-63 QQ Variant Is Associated with Persistently Normal Aminotransferase Serum Levels in Chronic Hepatitis C 2014 364
Luis F. López-Cortés Influence of IL28B Polymorphisms on Response to a Lower-Than-Standard Dose peg-IFN-α 2a for Genotype 3 Chronic Hepatitis C in HIV-Coinfected Patients 2012 2288
Shan-shan Su Regulatory Phenotype, PD-1 and TLR3 Expression in T Cells and Monocytes from HCV Patients Undergoing Antiviral Therapy: A Randomized Clinical Trial 2014 791
Alex Thompson Prediction of Treatment Week Eight Response & Sustained Virologic Response in Patients Treated with Boceprevir Plus Peginterferon Alfa and Ribavirin 2014 266
Antonio Rivero-Juárez Differences in HCV Viral Decline between Low and Standard-Dose Pegylated-Interferon-Alpha-2a with Ribavirin in HIV/HCV Genotype 3 Patients 2012 959
Aihua Zhang Urinary Metabolic Biomarker and Pathway Study of Hepatitis B Virus Infected Patients Based on UPLC-MS System 2013 1844
Åsa Alsiö Impact of Obesity on the Bioavailability of Peginterferon-α2a and Ribavirin and Treatment Outcome for Chronic Hepatitis C Genotype 2 or 3 2012 1768
Man-Qing Liu IFN-λ3 Inhibits HIV Infection of Macrophages through the JAK-STAT Pathway 2012 3313
Francesc Vidal Pharmacogenetics of Efficacy and Safety of HCV Treatment in HCV-HIV Coinfected Patients: Significant Associations with IL28B and SOCS3 Gene Variants 2012 2556
Amy E. L. Stone Hepatitis C Virus Pathogen Associated Molecular Pattern (PAMP) Triggers Production of Lambda-Interferons by Human Plasmacytoid Dendritic Cells 2013 4535
Samantha J. Griffiths A Systematic Analysis of Host Factors Reveals a Med23-Interferon-λ Regulatory Axis against Herpes Simplex Virus Type 1 Replication 2013 8516
Akihito Tsubota Involvement of MAP3K8 and miR-17-5p in Poor Virologic Response to Interferon-Based Combination Therapy for Chronic Hepatitis C 2014 608
Nobuhiro Harada Impact of Donor and Recipient Single Nucleotide Polymorphisms of IL28B rs8099917 in Living Donor Liver Transplantation for Hepatitis C 2014 598
Masato Nakamura No Correlation between PNPLA3 rs738409 Genotype and Fatty Liver and Hepatic Cirrhosis in Japanese Patients with HCV 2013 1422
Ángeles Ruiz-Extremera Variation of Transaminases, HCV-RNA Levels and Th1/Th2 Cytokine Production during the Post-Partum Period in Pregnant Women with Chronic Hepatitis C 2013 1154
Ming-Lung Yu Revisiting the Stopping Rule for Hepatitis C Genotype 1 Patients Treated with Peginterferon Plus Ribavirin 2012 1157
Benjamin Maasoumy Eligibility and Safety of Triple Therapy for Hepatitis C: Lessons Learned from the First Experience in a Real World Setting 2013 5010
Tetsuro Takayama Prediction of Effect of Pegylated Interferon Alpha-2b plus Ribavirin Combination Therapy in Patients with Chronic Hepatitis C Infection 2011 2282
Antonio Rivero-Juarez Natural Killer KIR3DS1 Is Closely Associated with HCV Viral Clearance and Sustained Virological Response in HIV/HCV Patients 2013 1236
Felix M. Key Selection on a Variant Associated with Improved Viral Clearance Drives Local, Adaptive Pseudogenization of Interferon Lambda 4 (IFNL4) 2014 1651
Ahmed S. Abdel-Moneim HCV Infection among Saudi Population: High Prevalence of Genotype 4 and Increased Viral Clearance Rate 2012 4077
Sara Corchado Liver Fibrosis, Host Genetic and Hepatitis C Virus Related Parameters as Predictive Factors of Response to Therapy against Hepatitis C Virus in HIV/HCV Coinfected Patients 2014 457
Georgios Grammatikos Vitamin D Levels Vary during Antiviral Treatment but Are Unable to Predict Treatment Outcome in HCV Genotype 1 Infected Patients 2014 1168
Jordan J. Feld Plasma Interferon-Gamma-Inducible Protein-10 Levels Are Associated with Early, but Not Sustained Virological Response during Treatment of Acute or Early Chronic HCV Infection 2013 1072
Masaya Sugiyama Genetic Variation of the IL-28B Promoter Affecting Gene Expression 2011 4273
Ester Aparicio IL28B SNP rs8099917 Is Strongly Associated with Pegylated Interferon-α and Ribavirin Therapy Treatment Failure in HCV/HIV-1 Coinfected Patients 2010 6417
Elżbieta Jabłonowska Hepatic HMOX1 Expression Positively Correlates with Bach-1 and miR-122 in Patients with HCV Mono and HIV/HCV Coinfection 2014 471
Iva Subhanova Expression of Biliverdin Reductase A in Peripheral Blood Leukocytes Is Associated with Treatment Response in HCV-Infected Patients 2013 1123
Daiki Miki HLA-DQB1*03 Confers Susceptibility to Chronic Hepatitis C in Japanese: A Genome-Wide Association Study 2013 1115
Salvatore Petta PNPLA3 GG Genotype and Carotid Atherosclerosis in Patients with Non-Alcoholic Fatty Liver Disease 2013 1342
Linda Dunford A Multicentre Molecular Analysis of Hepatitis B and Blood-Borne Virus Coinfections in Viet Nam 2012 3023
Ming-Ling Chang Distinct Patterns of the Lipid Alterations between Genotype 1 and 2 Chronic Hepatitis C Patients after Viral Clearance 2014 356
Jose Ramón Vidal-Castiñeira Diversity of Killer Cell Immunoglobulin-Like Receptor (KIR) Genotypes and KIR2DL2/3 Variants in HCV Treatment Outcome 2014 463
I-Cheng Lee CXCL9 Associated with Sustained Virological Response in Chronic Hepatitis B Patients Receiving Peginterferon Alfa-2a Therapy: A Pilot Study 2013 1102
Elena García-Martín Influence of Vitamin D-Related Gene Polymorphisms (CYP27B and VDR) on the Response to Interferon/Ribavirin Therapy in Chronic Hepatitis C 2013 2365
Jonas Söderholm Impact of Soluble CD26 on Treatment Outcome and Hepatitis C Virus-Specific T Cells in Chronic Hepatitis C Virus Genotype 1 Infection 2013 1631
Lawrence M. Pfeffer An Interferon Response Gene Signature Is Associated with the Therapeutic Response of Hepatitis C Patients 2014 505
Alessandra Mangia Individualized Treatment of Genotype 1 Naïve Patients: An Italian Multicenter Field Practice Experience 2014
Masahiro Ishikane Acute Hepatitis C in HIV-1 Infected Japanese Cohort: Single Center Retrospective Cohort Study 2014 483
Sridhar R. Allam The Association of IL28B Polymorphism and Graft Survival in Patients with Hepatitis C Undergoing Liver Transplantation 2013 1342
Isabelle Morard Clinical Significance of the CCR5delta32 Allele in Hepatitis C 2014 318
Vijayaprakash Suppiah IL28B, HLA-C, and KIR Variants Additively Predict Response to Therapy in Chronic Hepatitis C Virus Infection in a European Cohort: A Cross-Sectional Study 2011 11208
Edmondo Falleti Genetic Polymorphisms of Vitamin D Pathway Predict Antiviral Treatment Outcome in Slow Responder Naïve Patients with Chronic Hepatitis C 2013 1342
Martin Probst IL28B Polymorphism Cannot Predict Response to Interferon Alpha Treatment in Patients with Melanoma 2014
Sreedhar Chinnaswamy A Single Nucleotide Polymorphism Associated with Hepatitis C Virus Infections Located in the Distal Region of the IL28B Promoter Influences NF-κB-Mediated Gene Transcription 2013 2596
Philippe Halfon Detection of IL28B SNP DNA from Buccal Epithelial Cells, Small Amounts of Serum, and Dried Blood Spots 2012 2281
Xiaoyan Guo Genetic Variation in Interleukin 28B and Response to Antiviral Therapy in Patients with Dual Chronic Infection with Hepatitis B and C Viruses 2013 1085
G. L. Abby Harrison Infection Frequency of Hepatitis C Virus and IL28B Haplotypes in Papua New Guinea, Fiji, and Kiribati 2013 1398
Ahmad Amanzada Interferon-λ4 (IFNL4) Transcript Expression in Human Liver Tissue Samples 2013 1259
Ciara Keane Variation in Both IL28B and KIR2DS3 Genes Influence Pegylated Interferon and Ribavirin Hepatitis C Treatment Outcome in HIV-1 Co-Infection 2013 1001
Christian M. Lange A Genetic Validation Study Reveals a Role of Vitamin D Metabolism in the Response to Interferon-Alfa-Based Therapy of Chronic Hepatitis C 2012 2728
Gloria Taliani IL28B Gene Polymorphisms and US Liver Fatty Changes in Patients Who Spontaneously Cleared Hepatitis C Virus Infection 2013 948
Babs E. Verstrepen Evaluation of IL-28B Polymorphisms and Serum IP-10 in Hepatitis C Infected Chimpanzees 2012 1405
José A. Agúndez Relation of IL28B Gene Polymorphism with Biochemical and Histological Features in Hepatitis C Virus-Induced Liver Disease 2012 2440
I-Cheng Lee IL28B Polymorphism Correlates with Active Hepatitis in Patients with HBeAg-Negative Chronic Hepatitis B 2013 1932
Wen-Juei Jeng None of the Six SNPs of IL28B Could Predict Treatment Responses in Genotype 2 Chronic HCV Infected Patients by Propensity Score Matching Analysis 2012 1404

Publications listed by Genome.gov

First Author Title Journal Publication Date Trait p-value Confidence Interval
Ge D Genetic variation in IL28B predicts hepatitis C treatment-induced viral clearance. Nature 08/16/2009 Response to hepatitis C treatment 1.0e-28 (combined) [1.8-2.3] (European-Americans)

Evidence compiled by the Personal Genome Project

There are no results from the Personal Genome Project yet. Please come back later.

Publications on this SNP on Mendeley

First Author Title Pub. Year # of Readers DOI
Marina Berenguer Hepatitis C virus viral kinetics during ??-2a or ??-2b pegylated interferon plus ribavirin therapy in liver transplant recipients with different immunosuppression regimes 2012 3 10.1016/j.jcv.2011.12.005
Z. Gerlei Measurement and clinical significance of interleukin 28B in hepatitis C virus-infected liver transplant patients 2012 3 10.1016/j.transproceed.2012.07.101
K Neukam Efficacy of chronic hepatitis C therapy with pegylated interferon and ribavirin in patients on methadone maintenance treatment 2012 2 10.1007/s10096-011-1433-5
Eric G Meissner IFNL4-ΔG Genotype Is Associated With Slower Viral Clearance in Hepatitis C, Genotype-1 Patients Treated With Sofosbuvir and Ribavirin. 2014 2 10.1093/infdis/jit827
Yan Cui Update on epidemiology of hepatitis B and C in China. 2013 2 10.1111/jgh.12220
Jacinta a Holmes IL28B genotype is not useful for predicting treatment outcome in Asian chronic hepatitis B patients treated with pegylated interferon-α. 2013 6 10.1111/jgh.12110
Marija Zeremski IL28B polymorphism, pretreatment CXCL10, and HCV RNA levels predict treatment response in racially diverse HIV/HCV coinfected and HCV monoinfected patients. 2013 6 10.1097/QAI.0b013e31828323c1
Chuang W.-L. Albinterferon-alfa-2b every four weeks plus ribavirin: Treatment of chronic hepatitis C genotype 2/3: Safety, efficacy and genetic variation of IL28B 2011 1 -
Huiying Rao Distribution and clinical correlates of viral and host genotypes in Chinese patients with chronic hepatitis C virus infection. 2014 1 10.1111/jgh.12398
T W Lapinski [Predictive factors of virological response in chronically HCV infected] 2012 1 -
Norma I Rallon Interferon-stimulated genes are associated with peginterferon/ribavirin treatment response regardless of IL28B alleles in hepatitis C virus/HIV-coinfected patients. 2013 7 10.1097/QAD.0b013e32835ce2c1
S Saito IFI6 response predicts outcome of treatment for infection with hepatitis c virus with novel method for the quantification of interferon-induced mRNA in whole blood. 2013 2 -
L M Real An allelic variant in the IRF3 gene is associated with liver cirrhosis in hepatitis C virus carriers 2013 2 10.1016/S0168-8278(13)60491-2
James E Everhart Association of γ-glutamyl transferase (GGT) activity with treatment and clinical outcomes in chronic hepatitis C (HCV). 2013 4 10.1002/hep.26203
A F Stättermayer Association of the IL28B genotype with insulin resistance in patients with chronic hepatitis C 2012 1 -
Elisabetta Cariani Interleukin 28B genotype determination using DNA from different sources: A simple and reliable tool for the epidemiological and clinical characterization of hepatitis C 2011 3 10.1016/j.jviromet.2011.08.021
Vincent Pedergnana Analysis of IL28B variants in an Egyptian population defines the 20 Kilobases minimal region involved in spontaneous clearance of hepatitis C virus 2012 3 10.1371/journal.pone.0038578Oa logo 3fe7f006c5ef1789206c801af1f0d0538300f10d15d3a6c1285e1dfe3e8d62b5
Akihito Tsubota Contribution of ribavirin transporter gene polymorphism to treatment response in peginterferon plus ribavirin therapy for HCV genotype 1b patients. 2012 9 10.1111/j.1478-3231.2011.02727.x
Andres Duarte-Rojo The course of posttransplant hepatitis C infection: comparative impact of donor and recipient source of the favorable IL28B genotype and other variables. 2012 5 10.1097/TP.0b013e3182547551
Qinglai Meng During chronic HCV infection NCR dependent NK cytolytic activity directed at HCV is associated with liver inflammation, African American Race, IL28B genotype and response to PegIFN/RBV therapy. 2013 3 10.1093/infdis/jit677
Maria Cubero Identification of host and viral factors involved in a dissimilar resolution of a hepatitis C virus infection. 2013 3 10.1111/liv.12362
Peter V Aka Association of the IFNL4-ΔG Allele With Impaired Spontaneous Clearance of Hepatitis C Virus. 2014 3 10.1093/infdis/jit433
Sreedhar Chinnaswamy A Single Nucleotide Polymorphism Associated with Hepatitis C Virus Infections Located in the Distal Region of the IL28B Promoter Influences NF-??B-Mediated Gene Transcription 2013 3 10.1371/journal.pone.0075495Oa logo 3fe7f006c5ef1789206c801af1f0d0538300f10d15d3a6c1285e1dfe3e8d62b5
H Noguchi How do material constraints affect design creativity? 1999 5 10.1002/hep.24074
Priya Duggal Genome-wide association study of spontaneous resolution of hepatitis C virus infection: data from multiple cohorts. 2013 10 10.7326/0003-4819-158-4-201302190-00003
Enea Spada Role of IL28B gene polymorphism and cell-mediated immunity in spontaneous resolution of acute hepatitis C. 2013 6 10.1093/cid/cit402
Antonio Rivero-Juarez The IL28B effect on hepatitis C virus kinetics among HIV patients after the first weeks of pegylated-interferon/ribavirin treatment varies according to hepatitis C virus-1 subtype. 2013 6 10.1097/QAD.0b013e328360ea1e
Renzo Scaggiante Acute hepatitis C virus infection in a nurse trainee following a needlestick injury. 2013 6 10.3748/wjg.v19.i4.581
Eric Lawitz A phase 2a trial of 12-week interferon-free therapy with two direct-acting antivirals (ABT-450/r, ABT-072) and ribavirin in IL28B C/C patients with chronic hepatitis C genotype 1 2013 6 10.1016/j.jhep.2013.02.009
H L Tillmann Beneficial IL28B genotype associated with lower frequency of hepatic steatosis in patients with chronic hepatitis C 2011 1 -
Jose Medrano Modeling the Probability of Sustained Virological Response to Therapy with Pegylated Interferon plus Ribavirin in Patients Coinfected with Hepatitis C Virus and HIV 2010 1 10.1086/656811
Andrzej Cieśla IL28B polymorphism as a predictor of antiviral response in chronic hepatitis C. 2012 3 10.3748/wjg.v18.i35.4892
Pietro Lampertico IL28B polymorphisms predict interferon-related hepatitis B surface antigen seroclearance in genotype D hepatitis B e antigen-negative patients with chronic hepatitis B. 2013 12 10.1002/hep.25749
Ana Treviño Development of tropical spastic paraparesis in human T-lymphotropic virus type 1 carriers is influenced by interleukin 28B gene polymorphisms. 2012 4 10.1093/cid/cis343
K D Watt Investigation of PNPLA3 and IL28B genotypes on diabetes and obesity after liver transplantation: insight into mechanisms of disease. 2013 4 10.1111/ajt.12355
Gonzalo Crespo Combinations of simple baseline variables accurately predict sustained virological response in patients with recurrent hepatitis C after liver transplantation. 2013 4 10.1007/s00535-012-0680-2
Alessandra Mangia Treatment optimization and prediction of HCV clearance in patients with acute HCV infection 2013 4 10.1016/j.jhep.2013.04.007
Lucy Golden-Mason Natural killer inhibitory receptor expression associated with treatment failure and interleukin-28B genotype in patients with chronic hepatitis C. 2011 13 10.1002/hep.24556
Linda Dunford A multicentre molecular analysis of hepatitis B and blood-borne virus coinfections in Viet Nam 2012 7 10.1371/journal.pone.0039027Oa logo 3fe7f006c5ef1789206c801af1f0d0538300f10d15d3a6c1285e1dfe3e8d62b5
Gloria Taliani IL28B Gene Polymorphisms and US Liver Fatty Changes in Patients Who Spontaneously Cleared Hepatitis C Virus Infection 2013 2 10.1371/journal.pone.0067301Oa logo 3fe7f006c5ef1789206c801af1f0d0538300f10d15d3a6c1285e1dfe3e8d62b5
V Di Marco Who is more likely to respond to dual treatment with pegylated-interferon and ribavirin for chronic hepatitis C? A gender-oriented analysis. 2013 2 10.1111/jvh.12106
Jun-Qiang Xie Relationship between the genetic variation in interleukin 28B and response to antiviral therapy in patients with chronic hepatitis C. 2012 1 10.3760/cma.j.issn.0366-6999.2012.13.017Oa logo 3fe7f006c5ef1789206c801af1f0d0538300f10d15d3a6c1285e1dfe3e8d62b5
Eugenia Vispo Different impact of IL28B polymorphisms on response to peginterferon-?? plus ribavirin in HIV-positive patients infected with HCV subtypes 1a or 1b 2012 8 10.1016/j.jcv.2012.05.012
Heba F. Pasha Cytokines genes polymorphisms in chronic hepatitis C: Impact on susceptibility to infection and response to therapy 2013 5 10.1016/j.cyto.2012.11.003
Philippe Halfon Detection of IL28B SNP DNA from buccal epithelial cells, small amounts of serum, and dried blood spots 2012 9 10.1371/journal.pone.0033000Oa logo 3fe7f006c5ef1789206c801af1f0d0538300f10d15d3a6c1285e1dfe3e8d62b5
Karin Neukam Prediction of response to pegylated interferon plus ribavirin in HIV/hepatitis C virus (HCV)-coinfected patients using HCV genotype, IL28B variations, and HCV-RNA load 2012 19 10.1016/j.jhep.2011.11.008
Susanna Naggie Dysregulation of innate immunity in hepatitis C virus genotype 1 IL28B-unfavorable genotype patients: impaired viral kinetics and therapeutic response. 2012 21 10.1002/hep.25647
Zobair M Younossi The impact of IL28B genotype on the gene expression profile of patients with chronic hepatitis C treated with pegylated interferon alpha and ribavirin 2012 11 10.1186/1479-5876-10-25Oa logo 3fe7f006c5ef1789206c801af1f0d0538300f10d15d3a6c1285e1dfe3e8d62b5
Seok Hoo Jeong Efficacy of peginterferon and ribavirin is associated with the IL28B gene in Korean patients with chronic hepatitis C. 2012 3 10.3350/cmh.2012.18.4.360Oa logo 3fe7f006c5ef1789206c801af1f0d0538300f10d15d3a6c1285e1dfe3e8d62b5
Norma I Rallón Impact of IL28B gene polymorphisms on interferon-λ3 plasma levels during pegylated interferon-α/ribavirin therapy for chronic hepatitis C in patients coinfected with HIV. 2012 3 10.1093/jac/dkr598
Jason Grebely The effects of female sex, viral genotype, and IL28B genotype on spontaneous clearance of acute hepatitis C virus infection. 2014 12 10.1002/hep.26639
Lin Liu Spontaneous clearance of primary acute hepatitis C virus infection correlated with high initial viral RNA level and rapid HVR1 evolution. 2012 12 10.1002/hep.25575
J Medrano Modeling the Probability of Sustained Virological Response to Therapy with Pegylated Interferon plus Ribavirin in Patients Coinfected with Hepatitis C Virus and HIV 2010 2 10.1086/656811
Alessandra Mangia Limited use of interleukin 28B in the setting of response-guided treatment with detailed on-treatment virological monitoring. 2011 13 10.1002/hep.24458
T Asselah IL28B polymorphism is associated with treatment response in patients with genotype 4 chronic hepatitis C. 2012 1 -
Marvin D. Siperstein Role of cholesterogenesis and isoprenoid synthesis in DNA replication and cell growth 1984 1 10.1089/aid.2011.0096
Michela E Burlone IL28B polymorphism, blood interferon-alpha concentration, and disease stage of HCV mono-infected and HCV-HIV co-infected patients. 2013 4 -
B J Veldt Recipient IL28B polymorphism is an important independent predictor of posttransplant diabetes mellitus in liver transplant patients with chronic hepatitis C. 2012 16 10.1111/j.1600-6143.2011.03843.x
Barbara Oliviero Natural killer cell dynamic profile is associated with treatment outcome in patients with chronic HCV infection 2013 9 10.1016/j.jhep.2013.03.003
Ian McGilvray Hepatic cell-type specific gene expression better predicts HCV treatment outcome than IL28B genotype 2012 17 10.1053/j.gastro.2012.01.028
Joop E. Arends Association between IL28B polymorphisms and first-phase viral load decrease in chronic hepatitis C virus-infected patients treated with peginterferon alfa-2b/ribavirin 2011 4 10.1016/j.ijantimicag.2011.08.010
Tom W. Chu Effect of IL28B genotype on early viral kinetics during interferon-free treatment of patients with chronic hepatitis C 2012 18 10.1053/j.gastro.2011.12.057
J A Pineda Prediction of response to pegylated interferon plus ribavirin by IL28B gene variation in patients coinfected with HIV and hepatitis C virus 2010 1 10.1086/656235
Neal D. Freedman Coffee consumption is associated with response to peginterferon and ribavirin therapy in patients with chronic hepatitis C 2011 19 10.1053/j.gastro.2011.02.061
Fuat Kurbanov Genetic polymorphism in IL28B is associated with spontaneous clearance of hepatitis C virus genotype 4 infection in an Egyptian cohort. 2011 5 10.1093/infdis/jir536
Esther J. Pav??n-Castillero Importance of IL-10 and IL-6 during chronic hepatitis c genotype-1 treatment and their relation with IL28B 2013 6 10.1016/j.cyto.2012.10.009
C-M Liang Role of hepatitis C virus substitutions and interleukin-28B polymorphism on response to peginterferon plus ribavirin in a prospective study of response-guided therapy. 2013 1 10.1111/jvh.12097
G J Suo Association of the interleukin-28B gene polymorphism with development of hepatitis virus-related hepatocellular carcinoma and liver cirrhosis: a meta-analysis. 2013 1 10.4238/2013.September.19.1
Alessandra Mangia An IL28B polymorphism determines treatment response of hepatitis C virus genotype 2 or 3 patients who do not achieve a rapid virologic response 2010 28 10.1053/j.gastro.2010.05.079
Alexander J. Thompson Interleukin-28B Polymorphism Improves Viral Kinetics and Is the Strongest Pretreatment Predictor of Sustained Virologic Response in Genotype 1 Hepatitis C Virus 2010 67 10.1053/j.gastro.2010.04.013
Wen Juei Jeng None of the Six SNPs of IL28B Could Predict Treatment Responses in Genotype 2 Chronic HCV Infected Patients by Propensity Score Matching Analysis 2012 4 10.1371/journal.pone.0048217Oa logo 3fe7f006c5ef1789206c801af1f0d0538300f10d15d3a6c1285e1dfe3e8d62b5
Jose Medrano Modeling the Probability of Sustained Virological Response to Therapy with Pegylated Interferon plus Ribavirin in Patients Coinfected with Hepatitis C Virus and HIV 2010 4 10.1086/656811
Daniel M Forton Hepatitis C treatment--clearing the mind. 2012 7 10.1016/j.jhep.2011.11.004
a Rojas Hepatitis C virus infection alters lipid metabolism depending on IL28B polymorphism and viral genotype and modulates gene expression in vivo and in vitro. 2014 2 10.1111/jvh.12209
Jacob Nattermann The predictive value of IL28B gene polymorphism for spontaneous clearance in a single source outbreak cohort is limited in patients carrying the CCR5??32 mutation 2011 8 10.1016/j.jhep.2011.03.011
Albert Friedrich Stättermayer Association of the IL28B genotype with insulin resistance in patients with chronic hepatitis C 2012 4 10.1016/j.jhep.2012.04.036
F a Di Lello Effects of the genetic pattern defined by low-density lipoprotein receptor and IL28B genotypes on the outcome of hepatitis C virus infection. 2013 5 10.1007/s10096-013-1894-9
Jie Chen Association Analysis between SNPs in IL-28B Gene and the Progress of Hepatitis B Infection in Han Chinese 2012 3 10.1371/journal.pone.0050787Oa logo 3fe7f006c5ef1789206c801af1f0d0538300f10d15d3a6c1285e1dfe3e8d62b5
David A. Sheridan Apolipoprotein-E and hepatitis C lipoviral particles in genotype 1 infection: Evidence for an association with interferon sensitivity 2012 11 10.1016/j.jhep.2012.02.017
Z Raglow IL28B genotype and the expression of ISGs in normal liver. 2013 7 10.1111/liv.12148
Jennifer M. Reynolds Sequence analysis of the IL28A/IL28B inverted gene duplication that contains polymorphisms associated with treatment response in hepatitis C patients 2012 7 10.1371/journal.pone.0029983Oa logo 3fe7f006c5ef1789206c801af1f0d0538300f10d15d3a6c1285e1dfe3e8d62b5
Joachim Lupberger Interferon-lambda polymorphisms and hepatitis C virus clearance revisited. 2013 8 10.1002/hep.26443
M Bes IL28B genetic variation and hepatitis C virus-specific CD4(+) T-cell responses in anti-HCV-positive blood donors. 2012 7 10.1111/j.1365-2893.2012.01631.x
Susanne Knapp A polymorphism in IL28B distinguishes exposed, uninfected individuals from spontaneous resolvers of HCV infection 2011 17 10.1053/j.gastro.2011.04.005
Stella De Nicola Interleukin 28B polymorphism predicts pegylated interferon plus ribavirin treatment outcome in chronic hepatitis C genotype 4. 2012 8 10.1002/hep.24683
Hans L. Tillmann Beneficial IL28B genotype associated with lower frequency of hepatic steatosis in patients with chronic hepatitis C 2011 11 10.1016/j.jhep.2011.03.015
Paul J. Clark The Association of Genetic Variants with Hepatic Steatosis in Patients with Genotype 1 Chronic Hepatitis C Infection 2012 5 10.1007/s10620-012-2171-y
Benjamin Krämer Variation in IFNL4 genotype and response to interferon-based therapy of hepatitis C in HIV-positive patients with acute and chronic hepatitis C. 2013 5 10.1097/01.aids.0000433234.78807.54
Moutaz Derbala Interleukin-28 and hepatitis C virus genotype-4: treatment-induced clearance and liver fibrosis. 2012 3 10.3748/wjg.v18.i47.7003
Jos?? A. Ag??ndez Relation of IL28b gene polymorphism with biochemical and histological features in hepatitis C virus-induced liver disease 2012 11 10.1371/journal.pone.0037998Oa logo 3fe7f006c5ef1789206c801af1f0d0538300f10d15d3a6c1285e1dfe3e8d62b5
Charles D. Howell Single nucleotide polymorphism upstream of interleukin 28B associated with phase 1 and phase 2 of early viral kinetics in patients infected with HCV genotype 1 2012 12 10.1016/j.jhep.2011.10.004
Norma I Rallón Association of a single nucleotide polymorphism near the interleukin-28B gene with response to hepatitis C therapy in HIV/hepatitis C virus-coinfected patients. 2010 32 10.1097/QAD.0b013e3283391d6d
Magdalena Ydreborg Impact of IL28B-related single nucleotide polymorphisms on liver transient elastography in chronic hepatitis C infection 2013 3 10.1371/journal.pone.0080172Oa logo 3fe7f006c5ef1789206c801af1f0d0538300f10d15d3a6c1285e1dfe3e8d62b5
Tarik Asselah IL28B polymorphism is associated with treatment response in patients with genotype 4 chronic hepatitis C 2012 9 10.1016/j.jhep.2011.09.008
Milan J. Sonneveld Polymorphisms near IL28B and serologic response to peginterferon in HBeAg-positive patients with chronic hepatitis B 2012 18 10.1053/j.gastro.2011.11.025
Nasser M. Rizk Genetic polymorphisms of ICAM 1 and IL28 as predictors of liver fibrosis severity and viral 2013 3 10.1016/j.clinre.2012.09.012
Silvana Gaudieri Genetic variations in il28b and allergic disease in children 2012 12 10.1371/journal.pone.0030607Oa logo 3fe7f006c5ef1789206c801af1f0d0538300f10d15d3a6c1285e1dfe3e8d62b5
Ludmila Prokunina-Olsson A variant upstream of IFNL3 (IL28B) creating a new interferon gene IFNL4 is associated with impaired clearance of hepatitis C virus. 2013 62 10.1038/ng.2521
Mark A. Cervinski Validation of interleukin 28B genotyping assay for clinical use 2014 2 10.1016/j.clinbiochem.2014.01.009
Samar Samir Youssef Association of IL28B polymorphism with fibrosis, liver inflammation, gender respective natural history of hepatitis C virus in egyptian patients with genotype 4. 2014 2 10.1089/jir.2013.0036

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Title Summary
rs12979860 T/T ~20-25% of such hepatitis c patients respond to treatment
rs12979860 C/T ~20-40% of such hepatitis c patients respond to treatment
rs12979860 T/T ~20-25% of such hepatitis c patients respond to treatment
rs12979860 C/T ~20-40% of such hepatitis c patients respond to treatment
rs12979860 C/C ~80% of such hepatitis c patients respond to treatment
Note: For some SNPs, testing providers detect the genotype from the opposite strand of DNA, so that the genotypes listed at openSNP don't appear here. In those cases, please replace "A" by "T" or "G" by "C" (and vice-versa).

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