SNP rs12979860

Basic Information
Name rs12979860
Chromosome 19
Position 44430627
Weight of evidence 847
Additional Information

Publications on this SNP on the Public Library of Science:

First Author Title Year of Publication # of readers
Verónica Saludes Baseline Prediction of Combination Therapy Outcome in Hepatitis C Virus 1b Infected Patients by Discriminant Analysis Using Viral and Host Factors 2010 27
Linda Dunford A Multicentre Molecular Analysis of Hepatitis B and Blood-Borne Virus Coinfections in Viet Nam 2012
Chun-Yen Lin IL28B SNP rs12979860 Is a Critical Predictor for On-Treatment and Sustained Virologic Response in Patients with Hepatitis C Virus Genotype-1 Infection 2011 134
Derek D. Cyr Characterization of Serum Proteins Associated with IL28B Genotype among Patients with Chronic Hepatitis C 2011 342
Camila da Silva Ferreira A Fast and Cost-Effective Method for Identifying a Polymorphism of Interleukin 28B Related to Hepatitis C 2013
Ciara Keane Variation in Both IL28B and KIR2DS3 Genes Influence Pegylated Interferon and Ribavirin Hepatitis C Treatment Outcome in HIV-1 Co-Infection 2013
Philippe Halfon Detection of IL28B SNP DNA from Buccal Epithelial Cells, Small Amounts of Serum, and Dried Blood Spots 2012
Sridhar R. Allam The Association of IL28B Polymorphism and Graft Survival in Patients with Hepatitis C Undergoing Liver Transplantation 2013
Iva Subhanova Expression of Biliverdin Reductase A in Peripheral Blood Leukocytes Is Associated with Treatment Response in HCV-Infected Patients 2013
Ahmed S. Abdel-Moneim HCV Infection among Saudi Population: High Prevalence of Genotype 4 and Increased Viral Clearance Rate 2012
Tetsuro Takayama Prediction of Effect of Pegylated Interferon Alpha-2b plus Ribavirin Combination Therapy in Patients with Chronic Hepatitis C Infection 2011 795
Ángeles Ruiz-Extremera Variation of Transaminases, HCV-RNA Levels and Th1/Th2 Cytokine Production during the Post-Partum Period in Pregnant Women with Chronic Hepatitis C 2013
Benjamin Maasoumy Eligibility and Safety of Triple Therapy for Hepatitis C: Lessons Learned from the First Experience in a Real World Setting 2013
Samantha J. Griffiths A Systematic Analysis of Host Factors Reveals a Med23-Interferon-λ Regulatory Axis against Herpes Simplex Virus Type 1 Replication 2013
Aihua Zhang Urinary Metabolic Biomarker and Pathway Study of Hepatitis B Virus Infected Patients Based on UPLC-MS System 2013
Åsa Alsiö Impact of Obesity on the Bioavailability of Peginterferon-α2a and Ribavirin and Treatment Outcome for Chronic Hepatitis C Genotype 2 or 3 2012
Luis F. López-Cortés Influence of IL28B Polymorphisms on Response to a Lower-Than-Standard Dose peg-IFN-α 2a for Genotype 3 Chronic Hepatitis C in HIV-Coinfected Patients 2012
David Gardiner A Randomized, Double-Blind, Placebo-Controlled Assessment of BMS-936558, a Fully Human Monoclonal Antibody to Programmed Death-1 (PD-1), in Patients with Chronic Hepatitis C Virus Infection 2013
Verónica Saludes Relevance of Baseline Viral Genetic Heterogeneity and Host Factors for Treatment Outcome Prediction in Hepatitis C Virus 1b-Infected Patients 2013
Nafisa-Katrin Seich al Basatena KIR2DL2 Enhances Protective and Detrimental HLA Class I-Mediated Immunity in Chronic Viral Infection 2011 440
Amy E. L. Stone Hepatitis C Virus Pathogen Associated Molecular Pattern (PAMP) Triggers Production of Lambda-Interferons by Human Plasmacytoid Dendritic Cells 2013
Ahmad Amanzada Interferon-λ4 (IFNL4) Transcript Expression in Human Liver Tissue Samples 2013
Silvana Gaudieri Genetic Variations in IL28B and Allergic Disease in Children 2012 202
Sayeh Ezzikouri Genetic Variation in the Interleukin-28B Gene Is Associated with Spontaneous Clearance and Progression of Hepatitis C Virus in Moroccan Patients 2013
Magdalena Ydreborg Impact of IL28B-Related Single Nucleotide Polymorphisms on Liver Transient Elastography in Chronic Hepatitis C Infection 2013
Martin Lagging Response Prediction in Chronic Hepatitis C by Assessment of IP-10 and IL28B-Related Single Nucleotide Polymorphisms 2011 176
Chun-Yen Lin IL28B SNP rs12979860 Is a Critical Predictor for On-Treatment and Sustained Virologic Response in Patients with Hepatitis C Virus Genotype-1 Infection 2011 134
Jennifer M. Reynolds Sequence Analysis of the IL28A/IL28B Inverted Gene Duplication That Contains Polymorphisms Associated with Treatment Response in Hepatitis C Patients 2012 2193
Xiaodong Shi IL28B Genetic Variation Is Associated with Spontaneous Clearance of Hepatitis C Virus, Treatment Response, Serum IL-28B Levels in Chinese Population 2012
Zhifang Jia Test of IL28B Polymorphisms in Chronic Hepatitis C Patients Treated with PegIFN and Ribavirin Depends on HCV Genotypes: Results from a Meta-Analysis 2012
Montserrat de Castellarnau Deciphering the Interleukin 28B Variants That Better Predict Response to Pegylated Interferon-α and Ribavirin Therapy in HCV/HIV-1 Coinfected Patients 2012 475
Karolina Rembeck Impact of IL28B-Related Single Nucleotide Polymorphisms on Liver Histopathology in Chronic Hepatitis C Genotype 2 and 3 2012 791
Giuseppe Indolfi Comparative Analysis of rs12979860 SNP of the IFNL3 Gene in Children with Hepatitis C and Ethnic Matched Controls Using 1000 Genomes Project Data 2014
Seung Up Kim Association between IL28B Polymorphisms and Spontaneous Clearance of Hepatitis B Virus Infection 2013
Vincent Pedergnana Analysis of IL28B Variants in an Egyptian Population Defines the 20 Kilobases Minimal Region Involved in Spontaneous Clearance of Hepatitis C Virus 2012
Thomas R. O'Brien An IL28B Genotype-Based Clinical Prediction Model for Treatment of Chronic Hepatitis C 2011 711
Janett Fischer Association of IFNL3 rs12979860 and rs8099917 with Biochemical Predictors of Interferon Responsiveness in Chronic Hepatitis C Virus Infection 2013
Barham K. Abu Dayyeh IL28B Alleles Exert an Additive Dose Effect When Applied to HCV-HIV Coinfected Persons Undergoing Peginterferon and Ribavirin Therapy 2011 397
Charlotte H. B. S. van den Berg Female Sex and IL28B, a Synergism for Spontaneous Viral Clearance in Hepatitis C Virus (HCV) Seroconverters from a Community-Based Cohort 2011 369
Jie Chen Association Analysis between SNPs in IL-28B Gene and the Progress of Hepatitis B Infection in Han Chinese 2012
Derek D. Cyr Characterization of Serum Proteins Associated with IL28B Genotype among Patients with Chronic Hepatitis C 2011 342
Camila da Silva Ferreira A Fast and Cost-Effective Method for Identifying a Polymorphism of Interleukin 28B Related to Hepatitis C 2013
Wen-Juei Jeng None of the Six SNPs of IL28B Could Predict Treatment Responses in Genotype 2 Chronic HCV Infected Patients by Propensity Score Matching Analysis 2012
I-Cheng Lee IL28B Polymorphism Correlates with Active Hepatitis in Patients with HBeAg-Negative Chronic Hepatitis B 2013
José A. Agúndez Relation of IL28B Gene Polymorphism with Biochemical and Histological Features in Hepatitis C Virus-Induced Liver Disease 2012
Babs E. Verstrepen Evaluation of IL-28B Polymorphisms and Serum IP-10 in Hepatitis C Infected Chimpanzees 2012
Christian M. Lange A Genetic Validation Study Reveals a Role of Vitamin D Metabolism in the Response to Interferon-Alfa-Based Therapy of Chronic Hepatitis C 2012
Gloria Taliani IL28B Gene Polymorphisms and US Liver Fatty Changes in Patients Who Spontaneously Cleared Hepatitis C Virus Infection 2013
Ciara Keane Variation in Both IL28B and KIR2DS3 Genes Influence Pegylated Interferon and Ribavirin Hepatitis C Treatment Outcome in HIV-1 Co-Infection 2013
Ahmad Amanzada Interferon-λ4 (IFNL4) Transcript Expression in Human Liver Tissue Samples 2013
G. L. Abby Harrison Infection Frequency of Hepatitis C Virus and IL28B Haplotypes in Papua New Guinea, Fiji, and Kiribati 2013
Xiaoyan Guo Genetic Variation in Interleukin 28B and Response to Antiviral Therapy in Patients with Dual Chronic Infection with Hepatitis B and C Viruses 2013
Philippe Halfon Detection of IL28B SNP DNA from Buccal Epithelial Cells, Small Amounts of Serum, and Dried Blood Spots 2012
Sreedhar Chinnaswamy A Single Nucleotide Polymorphism Associated with Hepatitis C Virus Infections Located in the Distal Region of the IL28B Promoter Influences NF-κB-Mediated Gene Transcription 2013
Edmondo Falleti Genetic Polymorphisms of Vitamin D Pathway Predict Antiviral Treatment Outcome in Slow Responder Naïve Patients with Chronic Hepatitis C 2013
Vijayaprakash Suppiah IL28B, HLA-C, and KIR Variants Additively Predict Response to Therapy in Chronic Hepatitis C Virus Infection in a European Cohort: A Cross-Sectional Study 2011 2187
Sridhar R. Allam The Association of IL28B Polymorphism and Graft Survival in Patients with Hepatitis C Undergoing Liver Transplantation 2013
Jonas Söderholm Impact of Soluble CD26 on Treatment Outcome and Hepatitis C Virus-Specific T Cells in Chronic Hepatitis C Virus Genotype 1 Infection 2013
Elena García-Martín Influence of Vitamin D-Related Gene Polymorphisms (CYP27B and VDR) on the Response to Interferon/Ribavirin Therapy in Chronic Hepatitis C 2013
I-Cheng Lee CXCL9 Associated with Sustained Virological Response in Chronic Hepatitis B Patients Receiving Peginterferon Alfa-2a Therapy: A Pilot Study 2013
Daiki Miki HLA-DQB1*03 Confers Susceptibility to Chronic Hepatitis C in Japanese: A Genome-Wide Association Study 2013
Linda Dunford A Multicentre Molecular Analysis of Hepatitis B and Blood-Borne Virus Coinfections in Viet Nam 2012
Salvatore Petta PNPLA3 GG Genotype and Carotid Atherosclerosis in Patients with Non-Alcoholic Fatty Liver Disease 2013
Iva Subhanova Expression of Biliverdin Reductase A in Peripheral Blood Leukocytes Is Associated with Treatment Response in HCV-Infected Patients 2013
Ester Aparicio IL28B SNP rs8099917 Is Strongly Associated with Pegylated Interferon-α and Ribavirin Therapy Treatment Failure in HCV/HIV-1 Coinfected Patients 2010 38
Masaya Sugiyama Genetic Variation of the IL-28B Promoter Affecting Gene Expression 2011 300
Jordan J. Feld Plasma Interferon-Gamma-Inducible Protein-10 Levels Are Associated with Early, but Not Sustained Virological Response during Treatment of Acute or Early Chronic HCV Infection 2013
Georgios Grammatikos Vitamin D Levels Vary during Antiviral Treatment but Are Unable to Predict Treatment Outcome in HCV Genotype 1 Infected Patients 2014
Ahmed S. Abdel-Moneim HCV Infection among Saudi Population: High Prevalence of Genotype 4 and Increased Viral Clearance Rate 2012
Benjamin Maasoumy Eligibility and Safety of Triple Therapy for Hepatitis C: Lessons Learned from the First Experience in a Real World Setting 2013
Masato Nakamura No Correlation between PNPLA3 rs738409 Genotype and Fatty Liver and Hepatic Cirrhosis in Japanese Patients with HCV 2013
Antonio Rivero-Juarez Natural Killer KIR3DS1 Is Closely Associated with HCV Viral Clearance and Sustained Virological Response in HIV/HCV Patients 2013
Tetsuro Takayama Prediction of Effect of Pegylated Interferon Alpha-2b plus Ribavirin Combination Therapy in Patients with Chronic Hepatitis C Infection 2011 795
Ming-Lung Yu Revisiting the Stopping Rule for Hepatitis C Genotype 1 Patients Treated with Peginterferon Plus Ribavirin 2012
Ángeles Ruiz-Extremera Variation of Transaminases, HCV-RNA Levels and Th1/Th2 Cytokine Production during the Post-Partum Period in Pregnant Women with Chronic Hepatitis C 2013
Samantha J. Griffiths A Systematic Analysis of Host Factors Reveals a Med23-Interferon-λ Regulatory Axis against Herpes Simplex Virus Type 1 Replication 2013
Amy E. L. Stone Hepatitis C Virus Pathogen Associated Molecular Pattern (PAMP) Triggers Production of Lambda-Interferons by Human Plasmacytoid Dendritic Cells 2013
Francesc Vidal Pharmacogenetics of Efficacy and Safety of HCV Treatment in HCV-HIV Coinfected Patients: Significant Associations with IL28B and SOCS3 Gene Variants 2012
Åsa Alsiö Impact of Obesity on the Bioavailability of Peginterferon-α2a and Ribavirin and Treatment Outcome for Chronic Hepatitis C Genotype 2 or 3 2012
Antonio Rivero-Juárez Differences in HCV Viral Decline between Low and Standard-Dose Pegylated-Interferon-Alpha-2a with Ribavirin in HIV/HCV Genotype 3 Patients 2012
Aihua Zhang Urinary Metabolic Biomarker and Pathway Study of Hepatitis B Virus Infected Patients Based on UPLC-MS System 2013
Man-Qing Liu IFN-λ3 Inhibits HIV Infection of Macrophages through the JAK-STAT Pathway 2012
Luis F. López-Cortés Influence of IL28B Polymorphisms on Response to a Lower-Than-Standard Dose peg-IFN-α 2a for Genotype 3 Chronic Hepatitis C in HIV-Coinfected Patients 2012
Yuichi Nozawa KIR, HLA, and IL28B Variant Predict Response to Antiviral Therapy in Genotype 1 Chronic Hepatitis C Patients in Japan 2013
Verónica Saludes Relevance of Baseline Viral Genetic Heterogeneity and Host Factors for Treatment Outcome Prediction in Hepatitis C Virus 1b-Infected Patients 2013
Yasuteru Kondo 1(OH) Vitamin D3 Supplementation Improves the Sensitivity of the Immune-Response during Peg-IFN/RBV Therapy in Chronic Hepatitis C Patients-Case Controlled Trial 2013
David Gardiner A Randomized, Double-Blind, Placebo-Controlled Assessment of BMS-936558, a Fully Human Monoclonal Antibody to Programmed Death-1 (PD-1), in Patients with Chronic Hepatitis C Virus Infection 2013
Mark A. A. Claassen Negative Regulation of Hepatitis C Virus Specific Immunity Is Highly Heterogeneous and Modulated by Pegylated Interferon-Alpha/Ribavirin Therapy 2012
Verónica Saludes Baseline Prediction of Combination Therapy Outcome in Hepatitis C Virus 1b Infected Patients by Discriminant Analysis Using Viral and Host Factors 2010 27
Dong-Won Kim Naturally Occurring Mutations in the Nonstructural Region 5B of Hepatitis C Virus (HCV) from Treatment-Naïve Korean Patients Chronically Infected with HCV Genotype 1b 2014
Nafisa-Katrin Seich al Basatena KIR2DL2 Enhances Protective and Detrimental HLA Class I-Mediated Immunity in Chronic Viral Infection 2011 440
Dawn N. Birdsell Melt Analysis of Mismatch Amplification Mutation Assays (Melt-MAMA): A Functional Study of a Cost-Effective SNP Genotyping Assay in Bacterial Models 2012
Masaya Sato Impact of IL28B Genetic Variation on HCV-Induced Liver Fibrosis, Inflammation, and Steatosis: A Meta-Analysis 2014
Silvana Gaudieri Genetic Variations in IL28B and Allergic Disease in Children 2012 202
Sayeh Ezzikouri Genetic Variation in the Interleukin-28B Gene Is Associated with Spontaneous Clearance and Progression of Hepatitis C Virus in Moroccan Patients 2013
Tonggang Liu IL-28B Polymorphisms Correlated with Treatment Response in HCV-4 Mono-Infected Patients: A Meta-Analysis 2014
Magdalena Ydreborg Impact of IL28B-Related Single Nucleotide Polymorphisms on Liver Transient Elastography in Chronic Hepatitis C Infection 2013
Martin Lagging Response Prediction in Chronic Hepatitis C by Assessment of IP-10 and IL28B-Related Single Nucleotide Polymorphisms 2011 176
Chun-Yen Lin IL28B SNP rs12979860 Is a Critical Predictor for On-Treatment and Sustained Virologic Response in Patients with Hepatitis C Virus Genotype-1 Infection 2011 134
Jennifer M. Reynolds Sequence Analysis of the IL28A/IL28B Inverted Gene Duplication That Contains Polymorphisms Associated with Treatment Response in Hepatitis C Patients 2012 2193

Publications listed by Genome.gov

First Author Title Journal Publication Date Trait p-value Confidence Interval
Ge D Genetic variation in IL28B predicts hepatitis C treatment-induced viral clearance. Nature 08/16/2009 Response to hepatitis C treatment 1.0e-28 (combined) [1.8-2.3] (European-Americans)

Evidence compiled by the Personal Genome Project

There are no results from the Personal Genome Project yet. Please come back later.

Publications on this SNP on Mendeley

First Author Title Pub. Year # of Readers DOI
Magnus Lindh Interleukin 28B gene variation at rs12979860 determines early viral kinetics during treatment in patients carrying genotypes 2 or 3 of hepatitis C virus. 2011 0 Oa_logo
Edmondo Falleti Role of Interleukin 28B rs12979860 C/T Polymorphism on the Histological Outcome of Chronic Hepatitis C: Relationship with Gender and Viral Genotype. 2011 0 10.1007/s10875-011-9547-1Oa_logo
Chun-Yen Lin IL28B SNP rs12979860 Is a Critical Predictor for On-Treatment and Sustained Virologic Response in Patients with Hepatitis C Virus Genotype-1 Infection 2011 0 10.1371/journal.pone.0018322Oa_logo
C Scagnolari Evaluation of interleukin 28B single nucleotide polymorphisms in infants suffering from bronchiolitis 2012 3 -
Stella De Nicola An IL28B polymorphism predicts pegylated interferon plus ribavirin treatment outcome in chronic hepatitis c genotype 4. 2011 6 10.1002/hep.24683
Yasuhiro Asahina Association of gene expression involving innate immunity and genetic variation in interleukin 28B with antiviral response. 2012 12 10.1002/hep.24623
Yoichiro Kamiyama Association between 45T/G Polymorphism of Adiponectin Gene and Coronary Artery Disease in an Iranian Population. 1992 4 -
Stella De Nicola Interleukin 28B polymorphism predicts pegylated interferon plus ribavirin treatment outcome in chronic hepatitis C genotype 4. 2012 0 10.1002/hep.24683Oa_logo
Derek D Cyr Characterization of Serum Proteins Associated with IL28B Genotype among Patients with Chronic Hepatitis C 2011 4 10.1371/journal.pone.0021854Oa_logo
Erik Alestig Core mutations, IL28B polymorphisms and response to peginterferon/ribavirin treatment in Swedish patients with hepatitis C virus genotype 1 infection 2011 0 10.1186/1471-2334-11-124Oa_logo
Silvana Gaudieri Genetic variations in IL28B and allergic disease in children 2012 14 10.1371/journal.pone.0030607Oa_logo
José A Agúndez Relation of IL28B Gene Polymorphism with Biochemical and Histological Features in Hepatitis C Virus-Induced Liver Disease. 2012 10 10.1371/journal.pone.0037998Oa_logo
Magnus Lindh Multiwavelength erbium-doped fibre laser using intracavity etalon and cooled by liquid nitrogen 1996 0 10.1093/infdis/jir193Oa_logo
P Lutz Progression of liver fibrosis in HIV/HCV genotype 1 co-infected patients is related to the T allele of the rs12979860 polymorphism of the IL28B gene. 2011 0 Oa_logo
José M Ladero Predicting response to therapy in chronic hepatitis C: an approach combining interleukin-28B gene polymorphisms and clinical data 2011 4 10.1111/j.1440-1746.2011.06834.x
Philippe Halfon A single IL28B genotype SNP rs12979860 determination predicts treatment response in patients with chronic hepatitis C Genotype 1 virus. 2011 4 10.1097/MEG.0b013e328349d0ef
Sandra Beinhardt Serum Level of IP-10 Increases Predictive Value of IL28B Polymorphisms for Spontaneous Clearance of Acute HCV Infection. 2012 14 10.1053/j.gastro.2011.09.039
Anja Kovanda Real-time polymerase chain reaction assay based on high-resolution melting analysis for the determination of the rs12979860 polymorphism involved in hepatitis C treatment response. 2011 3 -
Tomokazu Kawaoka Predictive value of the IL28B polymorphism on the effect of interferon therapy in chronic hepatitis C patients with genotypes 2a and 2b. 2011 12 -
Nobuhiko Hiraga Impact of viral amino acid substitutions and host interleukin-28b polymorphism on replication and susceptibility to interferon of hepatitis C virus. 2011 10 10.1002/hep.24453
K Neukam Different distributions of hepatitis C virus genotypes among HIV-infected patients with acute and chronic hepatitis C according to interleukin-28B genotype. 2011 5 10.1111/j.1468-1293.2011.00912.x
Jacob Nattermann The predictive value of IL28B gene polymorphism for spontaneous clearance in a single source outbreak cohort is limited in patients carrying the CCR5Δ32 mutation. 2011 6 10.1016/j.jhep.2011.03.011
S Satta VARIAZIONI AL LOCUS IL28B IN PAZIENTI SARDI CON TALASSEMIA MAJOR HCV POSITIVI 2011 3 -
M Mandorfer The impact of IL28B rs12979860 SNP and advanced liver fibrosis on response-guided therapy in HIV/HCV coinfected patients of particular clinical interest 2012 2 -
B J Veldt Recipient IL28B Polymorphism Is an Important Independent Predictor of Posttransplant Diabetes Mellitus in Liver Transplant Patients with Chronic Hepatitis C. 2012 6 10.1111/j.1600-6143.2011.03843.x
M Romero-Gomez IL28B genetic variants and hepatitis virus infection by different viral genotypes 2010 4 -
Daniel M Forton Hepatitis C treatment--clearing the mind. 2012 8 10.1016/j.jhep.2011.11.004
Norma I Rallón IL28B gene polymorphisms and viral kinetics in HIV/hepatitis C virus-coinfected patients treated with pegylated interferon and ribavirin. 2011 14 -
Carlo Fabris IL-28B rs12979860 C/T allele distribution in patients with liver cirrhosis: role in the course of chronic viral hepatitis and the development of HCC. 2011 16 -
G Wishart Surveys of parasites of Hylemya spp. (Diptera: Anthomyiidae) that attack cruciferous crops in Canada 1957 3 10.4039/Ent89510-11
Francesco Marabita Genetic variation in the interleukin-28B gene is not associated with fibrosis progression in patients with chronic hepatitis C and known date of infection. 2011 7 10.1002/hep.24503
Mohammad M Sajadi IL28B Genotype Does Not Correlate with HIV Control in African Americans. 2011 1 -
Alessandra Mangia Limited utility of IL28B in the setting of response-guided treatment with detailed on- treatment virological monitoring 2011 1 -
Alessandra Mangia Limited use of interleukin 28B in the setting of response-guided treatment with detailed on-treatment virological monitoring. 2011 12 10.1002/hep.24458
Edward J Gane Once Daily PSI-977 Plus Ribavirin: Pegylated Interferon-Alfa Not Required For Complete Rapid Viral Response in Treatment-Naive Patients with HCV GT2 or GT3 2011 2 -
Hisataka Noguchi How do material constraints affect design creativity? 1999 3 10.1002/hep.24074
C Nelson Hayes Genetics of IL28B and HCV-response to infection and treatment. 2012 16 10.1038/nrgastro.2012.101
Marina Nu Pegylated IFN-Æ2b plus ribavirin as therapy for chronic hepatitis C in HIV-infected patients 2003 5 10.1097/01.aids.0000060353.78202.30
Jama M Darling Quantitation of pretreatment serum interferon-γ-inducible protein-10 improves the predictive value of an IL28B gene polymorphism for hepatitis C treatment response. 2011 14 10.1002/hep.24056
Thomas R O'Brien An IL28B Genotype-Based Clinical Prediction Model for Treatment of Chronic Hepatitis C 2011 14 10.1371/journal.pone.0020904Oa_logo
Susanna Naggie Dysregulation Of Innate Immunity In HCV Genotype 1IL28B Unfavorable Genotype Patients: Impaired Viral Kinetics And Therapeutic Response 2012 1 -
Alexander J Thompson Interleukin-28B polymorphism improves viral kinetics and is the strongest pretreatment predictor of sustained virologic response in genotype 1 hepatitis C virus. 2010 36 -
J A Pineda Prediction of Response to Pegylated Interferon plus Ribavirin by IL28B Gene Variation in Patients Coinfected with HIV and Hepatitis C Virus 2010 0 10.1086/656235Oa_logo
Elisa Cisneros Increased Risk of Severe Hepatitis C Virus Recurrence After Liver Transplantation in Patients With a T Allele of IL28B rs12979860. 2012 0 10.1097/TP.0b013e31825668f6Oa_logo
Yueqiu Luo Association study of IL28B: rs12979860 and rs8099917 polymorphisms with SVR in patients infected with chronic HCV genotype 1 to PEG-INF/RBV therapy using systematic meta-analysis. 2013 3 10.1016/j.gene.2012.10.030
Mairene Coto-Llerena Determination of IL28B polymorphisms in liver biopsies obtained after liver transplantation 2012 0 10.1016/j.jhep.2011.07.027
Simone Moreira A straightforward genotyping of the relevant IL28B SNPs for the prediction of hepatitis C treatment outcome. 2012 2 10.1016/j.jviromet.2012.05.024
Kok Siong Poon Targeting both rs12979860 and rs8099917 polymorphisms with a single-tube high-resolution melting assay for IL28b genotyping. 2012 2 10.1128/JCM.01718-12
Concha De La Fuente Interleukin 28B rs12979860 (CT/TT) Genotype Is Associated with Milder Hepatic Damage in the Natural Evolution of HCV/HIV Coinfection. 2012 0 Oa_logo
Jean-François Gélinas IL28B SNP screening and distribution in the French Canadian population using a rapid PCR-based test. 2013 1 10.1007/s00251-013-0688-7
Kawthar Machmach IL28B single-nucleotide polymorphism rs12979860 is associated with spontaneous HIV control in white subjects. 2013 0 10.1093/infdis/jis717Oa_logo
G M Prati The extended follow up of the mist cohort prospectively validates the protective role of a sustained virological response on liverrelated complications 2011 1 -
E Galmozzi A tetra-primer amplification refractory mutation system polymerase chain reaction for the evaluation of rs12979860 IL28B genotype. 2011 12 10.1111/j.1365-2893.2010.01349.x
Ke-Qing Shi Interleukin-28B polymorphisms on the SVR in the treatment of naïve chronic hepatitis C with pegylated interferon-α plus ribavirin: A meta-analysis. 2012 2 10.1016/j.gene.2012.07.026
M Lindh Interleukin 28B Gene Variation at rs12979860 Determines Early Viral Kinetics During Treatment in Patients Carrying Genotypes 2 or 3 of Hepatitis C Virus 2011 0 10.1093/infdis/jir193Oa_logo
Juan A Pineda Prediction of response to pegylated interferon plus ribavirin by IL28B gene variation in patients coinfected with HIV and hepatitis C virus. 2010 20 -
Kees Doets Basic Model Theory 1996 0 10.1097/QAD.0b013e32834488e7Oa_logo
Anja Kovanda Real-time polymerase chain reaction assay based on high-resolution melting analysis for the determination of the rs12979860 polymorphism involved in hepatitis C treatment response. 2011 1 10.1016/j.jviromet.2011.04.018
Salvatore Petta IL28B and PNPLA3 polymorphisms affect histological liver damage in patients with non-alcoholic fatty liver disease. 2012 2 10.1016/j.jhep.2012.01.007
C Chua Genotyping of IL28B polymorphism rs12979860 by high resolution melting of unlabeled probe 2011 1 -
Heba F Pasha Cytokines genes polymorphisms in chronic hepatitis C: impact on susceptibility to infection and response to therapy. 2013 3 10.1016/j.cyto.2012.11.003
Charles D Howell Single nucleotide polymorphism upstream of interleukin 28B associated with phase 1 and phase 2 of early viral kinetics in patients infected with HCV genotype 1. 2011 3 10.1016/j.jhep.2011.10.004
Lorenzo Uccellini HCV RNA levels in a multiethnic cohort of injection drug users: human genetic, viral and demographic associations. 2012 1 10.1002/hep.25652
Xiang-Wei Liao Association of genetic variation in IL28B with hepatitis C treatment-induced viral clearance in the Chinese Han population. 2011 9 -
M E Burlone IL28B Polymorphism, Blood Interferon-Alpha Concentration, and Disease Stage of HCV Mono-Infected and HCV-HIV Co-Infected Patients 2013 1 -
M IL28B Polymorphism, Blood Interferon-Alpha Concentration, and Disease Stage of HCV Mono-Infected and HCV-HIV Co-Infected Patients. 2013 1 -
Vagner Ricardo Lunge IL28B Polymorphism Associated with Spontaneous Clearance of Hepatitis C Infection in a Southern Brazilian HIV Type 1 Population. 2011 21 10.1089/aid.2011.0096
Hans L Tillmann Beneficial IL28B genotype associated with lower frequency of hepatic steatosis in patients with chronic hepatitis C. 2011 3 10.1016/j.jhep.2011.03.015
Esther-J Pavón-Castillero Importance of IL-10 and IL-6 during chronic hepatitis c genotype-1 treatment and their relation with IL28B. 2013 1 10.1016/j.cyto.2012.10.009
J A Del Campo Insulin resistance predicts sustained virological response to treatment of chronic hepatitis C independently of the IL28b rs12979860 polymorphism. 2012 2 10.1111/apt.12113
T R O'Brien IL28B genetic attributable risk in hepatitis c-associated hepatocellular carcinoma and decompensated liver disease 2011 1 -
Flisiak R Alisporivir (ALV) plus PegIFN/RBV (PR) has 100% SVR in IL28B rs12979860 CC allele and superior efficacy in chronic hepatitis C genotype (G) 1 treatment na 2012 1 -
Alessandra Mangia Treatment optimization of and prediction of HCV clearance in patients with acute HCV infection. 2013 3 10.1016/j.jhep.2013.04.007
E Jablonowska Sustained virologic response and IL28B single-nucleotide polymorphisms in patients with chronic hepatitis C treated with pegylated interferon alfa and ribavirin 2012 1 -
Zobair M Younossi The impact of IL28B genotype on the gene expression profile of patients with chronic hepatitis C treated with pegylated interferon alpha and ribavirin. 2012 7 10.1186/1479-5876-10-25Oa_logo
Li-Sheng Wu Two IL28B polymorphisms are associated with the treatment response of different genotypes of hepatitis C in different racial populations: A meta-analysis. 2012 3 10.3892/etm.2011.385
Wai-Kay Seto HLA-DP and IL28B Polymorphisms: Influence of Host Genome on Hepatitis B Surface Antigen Seroclearance in Chronic Hepatitis B. 2013 2 10.1093/cid/cit121
Loretta Fiorina Comparison of three different methods for the evaluation of IL28 and ITPA polymorphisms in patients infected with HCV. 2012 2 10.1016/j.jviromet.2012.05.006
Gonzalo Crespo Combinations of simple baseline variables accurately predict sustained virological response in patients with recurrent hepatitis C after liver transplantation. 2012 2 10.1007/s00535-012-0680-2
A Piluso Value of IL28B genotyping in patients with HCV-related mixed cryoglobulinemia: results of a large, prospective study. 2013 2 10.1111/jvh.12017
K Neukam Efficacy of chronic hepatitis C therapy with pegylated interferon and ribavirin in patients on methadone maintenance treatment 2012 1 10.1007/s10096-011-1433-5
Evaldo Stanislau Affonso De Araujo Pharmacodynamics of PEG-IFN-[alpha]-2a and HCV response as a function of IL28B polymorphism in HIV/HCV-coinfected patients. 2011 11 10.1097/QAI.0b013e3182020596
E Jablonowska Sustained virologic response and IL28B single-nucleotide polymorphisms in patients with chronic hepatitis C treated with pegylated interferon alfa and ribavirin 2012 1 -
Ana Treviño Development of tropical spastic paraparesis in human T-lymphotropic virus type 1 carriers is influenced by interleukin 28B gene polymorphisms. 2012 3 10.1093/cid/cis343
Elisabetta Cariani Interleukin 28B genotype determination using DNA from different sources: A simple and reliable tool for the epidemiological and clinical characterization of hepatitis C. 2011 1 10.1016/j.jviromet.2011.08.021
Pietro Lampertico IL28B polymorphisms predict interferon-related hepatitis B surface antigen seroclearance in genotype D hepatitis B e antigen–negative patients with chronic hepatitis B 2013 3 10.1002/hep.25749
Linda Dunford A multicentre molecular analysis of hepatitis B and blood-borne virus coinfections in Viet Nam. 2012 3 10.1371/journal.pone.0039027
Z Gerlei Measurement and clinical significance of interleukin 28B in hepatitis C virus-infected liver transplant patients. 2012 1 10.1016/j.transproceed.2012.07.101
James E Everhart Association of γ-glutamyltransferase (GGT) activity with treatment and clinical outcomes in chronic hepatitis C (HCV). 2012 7 10.1002/hep.26203
A Amanzada Ultra-Rapid Virological Response, Young Age, Low gamma-GT/ALT-Ratio, and Absence of Steatosis Identify a Subgroup of HCV Genotype 3 Patients Who Achieve SVR with IFN-alpha(2a) Monotherapy 2011 0 10.1007/s10620-011-1933-2
V Calvaruso Risk of disease decompensation and HCC in patients with HCV cirrhosis non responders to peg ifn plus RBV 2012 1 -
S Yapali IL28B genotype has no impact on spontaneous Hepatitis B surface antigen (HBSAG) clearance in inactive carriers: A long term, case-matched retrospective cohort study 2012 1 -
T R O'Brien An IL28B genotype-based model for personalized prediction of response to pegylatedinterferon-alfa and ribavirin in the treatment of chronic hepatitis C 2010 1 -
Alessandra Mangia An IL28B polymorphism determines treatment response of hepatitis C virus genotype 2 or 3 patients who do not achieve a rapid virologic response. 2010 22 -
Alessandra Mangia Interleukin-28B Polymorphism Determines Treatment Response of Patients With Hepatitis C Genotypes 2 or 3 Who Do Not Achieve a Rapid Virologic Response 2010 2 10.1053/j.gastro.2010.05.079
Christian M Lange Impact of donor and recipient IL28B rs12979860 genotypes on hepatitis C virus liver graft reinfection. 2011 9 -
Matthew L Albert Interferon induced protein 10 remains a useful biomarker of treatment failure in patients stratified for the interleukin-28B rs12979860 haplotype. 2011 1 10.1002/hep.24055
J A Del Campo 1340 Hepatitis C Virus Infection Alters Lipid Metabolism Depending on the Rs12979860 Polymorphism in the Il28B Gene 2011 1 10.1016/S0168-8278(11)61342-1
D Bitetto 1322 Recipient Il-28B Rs12979860 Ot Polymorphism Predicts Acute Cellular Rejection in Liver Transplanted Patients 2011 1 10.1016/S0168-8278(11)61324-X
Jeanette J McCarthy Replicated Association Between an IL28B Gene Variant and a Sustained Response to Pegylated Interferon and Ribavirin 2010 4 10.1053/j.gastro.2010.02.009

Links to SNPedia

Title Summary
rs12979860 C/C ~80% of such hepatitis c patients respond to treatment
rs12979860 C/T ~20-40% of such hepatitis c patients respond to treatment
rs12979860 T/T ~20-25% of such hepatitis c patients respond to treatment
Note: For some SNPs, testing providers detect the genotype from the opposite strand of DNA, so that the genotypes listed at openSNP don't appear here. In those cases, please replace "A" by "T" or "G" by "C" (and vice-versa).

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