SNP rs1260326

Basic Information
Name rs1260326
Chromosome 2
Position 27508073
Weight of evidence 156
Additional Information

Links to SNPedia

Title Summary
rs1260326 T/T Slightly higher risk for gout
rs1260326 C/T Slightly higher risk for gout
rs1260326 C/C No summary provided.
Note: For some SNPs, testing providers detect the genotype from the opposite strand of DNA, so that the genotypes listed on openSNP don't appear here. In those cases, please replace "A" by "T" or "G" by "C" (and vice-versa).

Publications on this SNP on the Public Library of Science:

First Author Title Year of Publication # of readers
Michael Inouye An Immune Response Network Associated with Blood Lipid Levels 2010 9649
Rajkumar Dorajoo Are C-Reactive Protein Associated Genetic Variants Associated with Serum Levels and Retinal Markers of Microvascular Pathology in Asian Populations from Singapore? 2013 2516
Carsten A. Böger Association of eGFR-Related Loci Identified by GWAS with Incident CKD and ESRD 2011 8224
Yue Shen GCKR Variants Increase Triglycerides While Protecting from Insulin Resistance in Chinese Children 2013 1346
Ching-Ti Liu Genetic Association for Renal Traits among Participants of African Ancestry Reveals New Loci for Renal Function 2011 9550
Tamuno Alfred Associations between a Polymorphism in the Pleiotropic GCKR and Age-Related Phenotypes: The HALCyon Programme 2013 1562
Ying Wu Trans-Ethnic Fine-Mapping of Lipid Loci Identifies Population-Specific Signals and Allelic Heterogeneity That Increases the Trait Variance Explained 2013 8144
Elizabeth K. Speliotes Genome-Wide Association Analysis Identifies Variants Associated with Nonalcoholic Fatty Liver Disease That Have Distinct Effects on Metabolic Traits 2011 24990
Andreas Leiherer Genome-Wide Association Study Reveals a Polymorphism in the Podocyte Receptor RANK for the Decline of Renal Function in Coronary Patients 2014 657
Molly A. Hall Detection of Pleiotropy through a Phenome-Wide Association Study (PheWAS) of Epidemiologic Data as Part of the Environmental Architecture for Genes Linked to Environment (EAGLE) Study 2014 3524
Clara C. Elbers Gene-Centric Meta-Analysis of Lipid Traits in African, East Asian and Hispanic Populations 2012 3514
Salvatore Petta Glucokinase Regulatory Protein Gene Polymorphism Affects Liver Fibrosis in Non-Alcoholic Fatty Liver Disease 2014 2365
Conall M. O'Seaghdha Meta-Analysis of Genome-Wide Association Studies Identifies Six New Loci for Serum Calcium Concentrations 2013 8948
Logan Dumitrescu Genetic Determinants of Lipid Traits in Diverse Populations from the Population Architecture using Genomics and Epidemiology (PAGE) Study 2011 7184
Claudia Ha Ting Tam Common Polymorphisms in MTNR1B, G6PC2 and GCK Are Associated with Increased Fasting Plasma Glucose and Impaired Beta-Cell Function in Chinese Subjects 2010 3731
Mathew J. Barber Genome-Wide Association of Lipid-Lowering Response to Statins in Combined Study Populations 2010 10492
Jan Windholz Effects of Genetic Variants in ADCY5, GIPR, GCKR and VPS13C on Early Impairment of Glucose and Insulin Metabolism in Children 2011 2124
Susan K. Service Re-sequencing Expands Our Understanding of the Phenotypic Impact of Variants at GWAS Loci 2014 9174
Wael Osman Association of Common Variants in TNFRSF13B, TNFSF13, and ANXA3 with Serum Levels of Non-Albumin Protein and Immunoglobulin Isotypes in Japanese 2012 2145
Gleb Kichaev Integrating Functional Data to Prioritize Causal Variants in Statistical Fine-Mapping Studies 2014 10652
Claudia Giambartolomei Bayesian Test for Colocalisation between Pairs of Genetic Association Studies Using Summary Statistics 2014 9447
Kiran Musunuru Multi-Ethnic Analysis of Lipid-Associated Loci: The NHLBI CARe Project 2012 2484
Rahul C. Deo Genetic Differences between the Determinants of Lipid Profile Phenotypes in African and European Americans: The Jackson Heart Study 2009 7807
Simon D. Rees Effects of 16 Genetic Variants on Fasting Glucose and Type 2 Diabetes in South Asians: ADCY5 and GLIS3 Variants May Predispose to Type 2 Diabetes 2011 4115
Christy L. Avery A Phenomics-Based Strategy Identifies Loci on APOC1, BRAP, and PLCG1 Associated with Metabolic Syndrome Phenotype Domains 2011 6759
Mark Bi Association of rs780094 in GCKR with Metabolic Traits and Incident Diabetes and Cardiovascular Disease: The ARIC Study 2010 2984
Xiaomu Kong Association of Genetic Variants with Isolated Fasting Hyperglycaemia and Isolated Postprandial Hyperglycaemia in a Han Chinese Population 2013 2420
Daniel Shriner Multiple Loci Associated with Renal Function in African Americans 2012 1515
Paul F. O’Reilly MultiPhen: Joint Model of Multiple Phenotypes Can Increase Discovery in GWAS 2012 9586
Gareth J. McKay Association Analysis of Dyslipidemia-Related Genes in Diabetic Nephropathy 2013 2695
Tibor V. Varga Genetic Determinants of Long-Term Changes in Blood Lipid Concentrations: 10-Year Follow-Up of the GLACIER Study 2014 3887
Andrew Mente Causal Relationship between Adiponectin and Metabolic Traits: A Mendelian Randomization Study in a Multiethnic Population 2013 2136
Michael Inouye Novel Loci for Metabolic Networks and Multi-Tissue Expression Studies Reveal Genes for Atherosclerosis 2012 8750
Pablo Perez-Martinez Glucokinase Regulatory Protein Genetic Variant Interacts with Omega-3 PUFA to Influence Insulin Resistance and Inflammation in Metabolic Syndrome 2011 4233
Dov Shiffman A Gene Variant in CERS2 Is Associated with Rate of Increase in Albuminuria in Patients with Diabetes from ONTARGET and TRANSCEND 2014 1330
Yann C. Klimentidis Triglyceride-Increasing Alleles Associated with Protection against Type-2 Diabetes 2015 2332
Symen Ligthart Pleiotropy among Common Genetic Loci Identified for Cardiometabolic Disorders and C-Reactive Protein 2015 1086
Momoko Horikoshi Discovery and Fine-Mapping of Glycaemic and Obesity-Related Trait Loci Using High-Density Imputation 2015 3622
Marte C. Liefaard Vitamin D and C-Reactive Protein: A Mendelian Randomization Study 2015 1422

Publications on this SNP on Mendeley

First Author Title Pub. Year # of Readers DOI
Jan Windholz Effects of genetic variants in ADCY5, GIPR, GCKR and VPS13C on early impairment of glucose and insulin metabolism in children 2011 10 10.1371/journal.pone.0022101Oa logo
B Køster Novel polymorphisms in the GCKR gene and their influence on glucose and insulin levels in a Danish twin population. 2005 4 10.1111/j.1464-5491.2005.01700.xOa logo
Anette Varbo TRIB1 and GCKR Polymorphisms, Lipid Levels, and Risk of Ischemic Heart Disease in the General Population. 2010 9 10.1161/ATVBAHA.110.216333Oa logo
E Reiling Combined effects of single-nucleotide polymorphisms in GCK, GCKR, G6PC2 and MTNR1B on fasting plasma glucose and type 2 diabetes risk. 2009 8 10.1007/s00125-009-1413-9Oa logo
Ching Ti Liu Genetic association for renal traits among participants of African Ancestry reveals new loci for renal function 2011 12 10.1371/journal.pgen.1002264Oa logo
A Varbo TRIB1 and GCKR polymorphisms, lipid levels, and risk of ischemic heart disease in the general population 2011 1 -
Anna Kottgen New loci associated with kidney function and chronic kidney disease. 2010 1 Oa logo
Abbas Dehghan Meta-analysis of genome-wide association studies in >80 000 subjects identifies multiple loci for C-reactive protein levels. 2011 41 10.1161/CIRCULATIONAHA.110.948570Oa logo
A Varbo TRIB1 and GCKR polymorphisms, lipid levels, and risk of ischemic heart disease in the general population 2011 1 ATVBAHA.110.216333 [pii]\r10.1161/ATVBAHA.110.216333Oa logo
Varbo A. TRIB1 and GCKR polymorphisms, lipid levels, and risk of ischemic heart disease in the general population 2011 1 Oa logo
Zoltán Kutalik Association of eGFR-Related Loci Identified by GWAS with Incident CKD and ESRD 2011 13 10.1371/journal.pgen.1002292
Anette Varbo TRIB1 and GCKR polymorphisms, lipid levels, and risk of ischemic heart disease in the general population. 2011 2 10.1161/ATVBAHA.110.216333Oa logo
Nicola Santoro Variant in the glucokinase regulatory protein (GCKR) gene is associated with fatty liver in obese children and adolescents. 2012 6 10.1002/hep.24806
Wael Osman Association of common variants in TNFRSF13B, TNFSF13, and ANXA3 with serum levels of non-albumin protein and immunoglobulin isotypes in Japanese. 2012 2 10.1371/journal.pone.0032683
Pablo Perez-Martinez Glucokinase regulatory protein genetic variant interacts with Omega-3 PUFA to influence insulin resistance and inflammation in metabolic syndrome 2011 11 10.1371/journal.pone.0020555Oa logo
Anette Varbo TRIB1 and GCKR polymorphisms, lipid levels, and risk of ischemic heart disease in the general population. 2011 11 -
Sharon Wyatt Genetic Association for Renal Traits among Participants of African Ancestry Reveals New Loci for Renal Function 2011 7 10.1371/journal.pgen.1002264
A. Varbo TRIB1 and GCKR Polymorphisms, Lipid Levels, and Risk of Ischemic Heart Disease in the General Population 2011 1 10.1161/ATVBAHA.110.216333
W. Tang Genome-wide association study identifies novel loci for plasma levels of protein C: the ARIC study 2010 3 10.1182/blood-2010-05-283739
Tamuno Alfred Associations between a Polymorphism in the Pleiotropic GCKR and Age-Related Phenotypes: The HALCyon Programme. 2013 1 10.1371/journal.pone.0070045Oa logo
Jan Windholz Effects of genetic variants in ADCY5, GIPR, GCKR and VPS13C on early impairment of glucose and insulin metabolism in children. 2011 9 10.1371/journal.pone.0022101Oa logo
Nicola Santoro The Association Between Hepatic Fat Content and Liver Injury in Obese Children and Adolescents: Effects of ethnicity, insulin resistance, and common gene variants. 2012 3 10.2337/dc12-1791
Tamuno Alfred Associations between a Polymorphism in the Pleiotropic GCKR and Age-Related Phenotypes: The HALCyon Programme 2013 1 10.1371/journal.pone.0070045Oa logo
Weihong Tang Genome-wide association study identifies novel loci for plasma levels of protein C: the ARIC study. 2010 19 -
Martine Vaxillaire The common P446L polymorphism in GCKR inversely modulates fasting glucose and triglyceride levels and reduces type 2 diabetes risk in the DESIR prospective general French population. 2008 11 10.2337/db07-1807Oa logo
Wael Osman Association of common variants in TNFRSF13B, TNFSF13, and ANXA3 with serum levels of non-albumin protein and immunoglobulin isotypes in Japanese 2012 3 10.1371/journal.pone.0032683Oa logo
Anette Varbo TRIB1 and GCKR polymorphisms, lipid levels, and risk of ischemic heart disease in the general population. 2011 2 10.1161/ATVBAHA.110.216333Oa logo
Márton Mohás GCKR gene functional variants in type 2 diabetes and metabolic syndrome: do the rare variants associate with increased carotid intima-media thickness? 2010 5 10.1186/1475-2840-9-79Oa logo
Luca Járomi Functional variants of glucokinase regulatory protein and apolipoprotein A5 genes in ischemic stroke. 2010 5 -
Pablo Perez-Martinez Glucokinase regulatory protein genetic variant interacts with omega-3 PUFA to influence insulin resistance and inflammation in metabolic syndrome. 2011 10 10.1371/journal.pone.0020555Oa logo
H Q Shen Glucokinase regulatory protein gene polymorphism affects postprandial lipemic response in a dietary intervention study 2009 1 DOI 10.1007/s00439-009-0700-3Oa logo
Andrew Mente Causal relationship between adiponectin and metabolic traits: a Mendelian randomization study in a multiethnic population. 2013 5 10.1371/journal.pone.0066808Oa logo
R Saxena Genetic variation in GIPR influences the glucose and insulin responses to an oral glucose challenge 2010 47 10.1038/ng.521
Haiqing Shen Glucokinase regulatory protein gene polymorphism affects postprandial lipemic response in a dietary intervention study. 2009 2 10.1007/s00439-009-0700-3Oa logo
K Horvatovich Functional glucokinase regulator gene variants have inverse effects on triglyceride and glucose levels, and decrease the risk of obesity in children 2011 2 10.1016/j.diabet.2011.02.003
Weihong Tang Genome-wide association study identifies novel loci for plasma levels of protein C: The ARIC study 2010 19 10.1182/blood-2010-05-283739
A Varbo TRIB1 and GCKR polymorphisms, lipid levels, and risk of ischemic heart disease in the general population 2011 2 10.1161/atvbaha.110.216333
Carsten A. B??ger Association of eGFR-related loci identified by GWAS with incident CKD and ESRD 2011 15 10.1371/journal.pgen.1002292Oa logo
Toni I Pollin Triglyceride response to an intensive lifestyle intervention is enhanced in carriers of the GCKR Pro446Leu polymorphism. 2011 8 -
Haiqing Shen Glucokinase regulatory protein gene polymorphism affects postprandial lipemic response in a dietary intervention study. 2009 2 -
Pablo Perez-Martinez Glucokinase Regulatory Protein Genetic Variant Interacts with Omega-3 PUFA to Influence Insulin Resistance and Inflammation in Metabolic Syndrome 2011 5 10.1371/journal.pone.0020555Oa logo
Martine Vaxillaire The Common P446L Polymorphism in GCKR Inversely Modulates Fasting Glucose and Triglyceride Levels and Reduces Type 2 Diabetes Risk in the DESIR Prospective General French Population 2008 8 10.2337/db07-1807
Chiara Sabatti Genome-wide association analysis of metabolic traits in a birth cohort from a founder population. 2009 108 10.1038/ng.271Oa logo

Evidence compiled by the Personal Genome Project

There are no results from the Personal Genome Project yet. Please come back later.

Publications listed by Genome.gov

First Author Title Journal Publication Date Trait p-value Confidence Interval
Kettunen J Genome-wide association study identifies multiple loci influencing human serum metabolite levels. Nat Genet 01/29/2012 Metabolite levels 3.0e-18 (Ala, Gln) [0.11-0.19] unit decrease
Sabatti C Genome-wide association analysis of metabolic traits in a birth cohort from a founder population. Nat Genet 12/07/2008 Metabolic traits 4.0e-10 (TG) [0.06-0.12] mmol/l increase
Chambers JC Genome-wide association study identifies loci influencing concentrations of liver enzymes in plasma. Nat Genet 10/16/2011 Liver enzyme levels (gamma-glutamyl transferase) 4.0e-13 [2.40-4.0] % increase
Dehghan A Meta-analysis of genome-wide association studies in >80 000 subjects identifies multiple loci for C-reactive protein levels. Circulation 02/07/2011 C-reactive protein 5.0e-40 [0.06-0.08] unit increase
Saxena R Genetic variation in GIPR influences the glucose and insulin responses to an oral glucose challenge. Nat Genet 01/17/2010 Two-hour glucose challenge 3.0e-10 [0.05-0.09] mmol/L increase
Johansen CT Excess of rare variants in genes identified by genome-wide association study of hypertriglyceridemia. Nat Genet 07/25/2010 Hypertriglyceridemia 7.0e-09 [1.45-2.12]
Teslovich TM Biological, clinical and population relevance of 95 loci for blood lipids. Nature 08/05/2010 Triglycerides 1.0e-100 [7.98-9.54] mg/dL increase
Osman W Association of common variants in TNFRSF13B, TNFSF13, and ANXA3 with serum levels of non-albumin protein and immunoglobulin isotypes in Japanese. PLoS One 04/27/2012 Non-albumin protein levels 3.0e-09 (ALB) [0.053-0.107] unit decrease
Kathiresan S Common variants at 30 loci contribute to polygenic dyslipidemia. Nat Genet 12/07/2008 Triglycerides 2.0e-31 [0.08-0.16] s.d. increase
Kottgen A New loci associated with kidney function and chronic kidney disease. Nat Genet 04/11/2010 Chronic kidney disease 3.0e-14 (eGFRcrea) [0.007-0.011] ml/min/1.73 m2 increase

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