openSNP | rs1260326

Links to SNPedia

Title	Summary
rs1260326 T/T	Slightly higher risk for gout
rs1260326 C/T	Slightly higher risk for gout
rs1260326 C/C	No summary provided.

Note: For some SNPs, testing providers detect the genotype from the opposite strand of DNA, so that the genotypes listed on openSNP don't appear here. In those cases, please replace "A" by "T" or "G" by "C" (and vice-versa).

Publications on this SNP on the Public Library of Science:

First Author	Title	Year of Publication	# of readers
Michael Inouye	An Immune Response Network Associated with Blood Lipid Levels	2010	11382
Rajkumar Dorajoo	Are C-Reactive Protein Associated Genetic Variants Associated with Serum Levels and Retinal Markers of Microvascular Pathology in Asian Populations from Singapore?	2013	3275
Carsten A. Böger	Association of eGFR-Related Loci Identified by GWAS with Incident CKD and ESRD	2011	10977
Yue Shen	GCKR Variants Increase Triglycerides While Protecting from Insulin Resistance in Chinese Children	2013	1947
Ching-Ti Liu	Genetic Association for Renal Traits among Participants of African Ancestry Reveals New Loci for Renal Function	2011	10846
Tamuno Alfred	Associations between a Polymorphism in the Pleiotropic GCKR and Age-Related Phenotypes: The HALCyon Programme	2013	1978
Ying Wu	Trans-Ethnic Fine-Mapping of Lipid Loci Identifies Population-Specific Signals and Allelic Heterogeneity That Increases the Trait Variance Explained	2013	9854
Elizabeth K. Speliotes	Genome-Wide Association Analysis Identifies Variants Associated with Nonalcoholic Fatty Liver Disease That Have Distinct Effects on Metabolic Traits	2011	29814
Andreas Leiherer	Genome-Wide Association Study Reveals a Polymorphism in the Podocyte Receptor RANK for the Decline of Renal Function in Coronary Patients	2014	1149
Molly A. Hall	Detection of Pleiotropy through a Phenome-Wide Association Study (PheWAS) of Epidemiologic Data as Part of the Environmental Architecture for Genes Linked to Environment (EAGLE) Study	2014	4663
Clara C. Elbers	Gene-Centric Meta-Analysis of Lipid Traits in African, East Asian and Hispanic Populations	2012	4600
Salvatore Petta	Glucokinase Regulatory Protein Gene Polymorphism Affects Liver Fibrosis in Non-Alcoholic Fatty Liver Disease	2014	3370
Conall M. O'Seaghdha	Meta-Analysis of Genome-Wide Association Studies Identifies Six New Loci for Serum Calcium Concentrations	2013	11398
Logan Dumitrescu	Genetic Determinants of Lipid Traits in Diverse Populations from the Population Architecture using Genomics and Epidemiology (PAGE) Study	2011	8335
Claudia Ha Ting Tam	Common Polymorphisms in MTNR1B, G6PC2 and GCK Are Associated with Increased Fasting Plasma Glucose and Impaired Beta-Cell Function in Chinese Subjects	2010	4641
Mathew J. Barber	Genome-Wide Association of Lipid-Lowering Response to Statins in Combined Study Populations	2010	12129
Jan Windholz	Effects of Genetic Variants in ADCY5, GIPR, GCKR and VPS13C on Early Impairment of Glucose and Insulin Metabolism in Children	2011	2672
Susan K. Service	Re-sequencing Expands Our Understanding of the Phenotypic Impact of Variants at GWAS Loci	2014	10793
Wael Osman	Association of Common Variants in TNFRSF13B, TNFSF13, and ANXA3 with Serum Levels of Non-Albumin Protein and Immunoglobulin Isotypes in Japanese	2012	2839
Gleb Kichaev	Integrating Functional Data to Prioritize Causal Variants in Statistical Fine-Mapping Studies	2014	17389
Claudia Giambartolomei	Bayesian Test for Colocalisation between Pairs of Genetic Association Studies Using Summary Statistics	2014	9447
Kiran Musunuru	Multi-Ethnic Analysis of Lipid-Associated Loci: The NHLBI CARe Project	2012	3096
Rahul C. Deo	Genetic Differences between the Determinants of Lipid Profile Phenotypes in African and European Americans: The Jackson Heart Study	2009	8916
Simon D. Rees	Effects of 16 Genetic Variants on Fasting Glucose and Type 2 Diabetes in South Asians: ADCY5 and GLIS3 Variants May Predispose to Type 2 Diabetes	2011	5111
Christy L. Avery	A Phenomics-Based Strategy Identifies Loci on APOC1, BRAP, and PLCG1 Associated with Metabolic Syndrome Phenotype Domains	2011	7998
Mark Bi	Association of rs780094 in GCKR with Metabolic Traits and Incident Diabetes and Cardiovascular Disease: The ARIC Study	2010	3657
Xiaomu Kong	Association of Genetic Variants with Isolated Fasting Hyperglycaemia and Isolated Postprandial Hyperglycaemia in a Han Chinese Population	2013	3152
Daniel Shriner	Multiple Loci Associated with Renal Function in African Americans	2012	1921
Paul F. O’Reilly	MultiPhen: Joint Model of Multiple Phenotypes Can Increase Discovery in GWAS	2012	13525
Gareth J. McKay	Association Analysis of Dyslipidemia-Related Genes in Diabetic Nephropathy	2013	3408
Tibor V. Varga	Genetic Determinants of Long-Term Changes in Blood Lipid Concentrations: 10-Year Follow-Up of the GLACIER Study	2014	4595
Andrew Mente	Causal Relationship between Adiponectin and Metabolic Traits: A Mendelian Randomization Study in a Multiethnic Population	2013	2136
Michael Inouye	Novel Loci for Metabolic Networks and Multi-Tissue Expression Studies Reveal Genes for Atherosclerosis	2012	10555
Pablo Perez-Martinez	Glucokinase Regulatory Protein Genetic Variant Interacts with Omega-3 PUFA to Influence Insulin Resistance and Inflammation in Metabolic Syndrome	2011	4862
Dov Shiffman	A Gene Variant in CERS2 Is Associated with Rate of Increase in Albuminuria in Patients with Diabetes from ONTARGET and TRANSCEND	2014	2056
Yann C. Klimentidis	Triglyceride-Increasing Alleles Associated with Protection against Type-2 Diabetes	2015	3254
Symen Ligthart	Pleiotropy among Common Genetic Loci Identified for Cardiometabolic Disorders and C-Reactive Protein	2015	2172
Momoko Horikoshi	Discovery and Fine-Mapping of Glycaemic and Obesity-Related Trait Loci Using High-Density Imputation	2015	5181
Marte C. Liefaard	Vitamin D and C-Reactive Protein: A Mendelian Randomization Study	2015	4453

Publications on this SNP on Mendeley

First Author	Title	Pub. Year	# of Readers	DOI
Jan Windholz	Effects of genetic variants in ADCY5, GIPR, GCKR and VPS13C on early impairment of glucose and insulin metabolism in children	2011	10	10.1371/journal.pone.0022101
B Køster	Novel polymorphisms in the GCKR gene and their influence on glucose and insulin levels in a Danish twin population.	2005	4	10.1111/j.1464-5491.2005.01700.x
Anette Varbo	TRIB1 and GCKR Polymorphisms, Lipid Levels, and Risk of Ischemic Heart Disease in the General Population.	2010	9	10.1161/ATVBAHA.110.216333
E Reiling	Combined effects of single-nucleotide polymorphisms in GCK, GCKR, G6PC2 and MTNR1B on fasting plasma glucose and type 2 diabetes risk.	2009	8	10.1007/s00125-009-1413-9
Ching Ti Liu	Genetic association for renal traits among participants of African Ancestry reveals new loci for renal function	2011	12	10.1371/journal.pgen.1002264
A Varbo	TRIB1 and GCKR polymorphisms, lipid levels, and risk of ischemic heart disease in the general population	2011	1	-
Anna Kottgen	New loci associated with kidney function and chronic kidney disease.	2010	1
Abbas Dehghan	Meta-analysis of genome-wide association studies in >80 000 subjects identifies multiple loci for C-reactive protein levels.	2011	41	10.1161/CIRCULATIONAHA.110.948570
A Varbo	TRIB1 and GCKR polymorphisms, lipid levels, and risk of ischemic heart disease in the general population	2011	1	ATVBAHA.110.216333 [pii]\r10.1161/ATVBAHA.110.216333
Varbo A.	TRIB1 and GCKR polymorphisms, lipid levels, and risk of ischemic heart disease in the general population	2011	1
Zoltán Kutalik	Association of eGFR-Related Loci Identified by GWAS with Incident CKD and ESRD	2011	13	10.1371/journal.pgen.1002292
Anette Varbo	TRIB1 and GCKR polymorphisms, lipid levels, and risk of ischemic heart disease in the general population.	2011	2	10.1161/ATVBAHA.110.216333
Nicola Santoro	Variant in the glucokinase regulatory protein (GCKR) gene is associated with fatty liver in obese children and adolescents.	2012	6	10.1002/hep.24806
Wael Osman	Association of common variants in TNFRSF13B, TNFSF13, and ANXA3 with serum levels of non-albumin protein and immunoglobulin isotypes in Japanese.	2012	2	10.1371/journal.pone.0032683
Pablo Perez-Martinez	Glucokinase regulatory protein genetic variant interacts with Omega-3 PUFA to influence insulin resistance and inflammation in metabolic syndrome	2011	11	10.1371/journal.pone.0020555
Anette Varbo	TRIB1 and GCKR polymorphisms, lipid levels, and risk of ischemic heart disease in the general population.	2011	11	-
Sharon Wyatt	Genetic Association for Renal Traits among Participants of African Ancestry Reveals New Loci for Renal Function	2011	7	10.1371/journal.pgen.1002264
A. Varbo	TRIB1 and GCKR Polymorphisms, Lipid Levels, and Risk of Ischemic Heart Disease in the General Population	2011	1	10.1161/ATVBAHA.110.216333
W. Tang	Genome-wide association study identifies novel loci for plasma levels of protein C: the ARIC study	2010	3	10.1182/blood-2010-05-283739
Tamuno Alfred	Associations between a Polymorphism in the Pleiotropic GCKR and Age-Related Phenotypes: The HALCyon Programme.	2013	1	10.1371/journal.pone.0070045
Jan Windholz	Effects of genetic variants in ADCY5, GIPR, GCKR and VPS13C on early impairment of glucose and insulin metabolism in children.	2011	9	10.1371/journal.pone.0022101
Nicola Santoro	The Association Between Hepatic Fat Content and Liver Injury in Obese Children and Adolescents: Effects of ethnicity, insulin resistance, and common gene variants.	2012	3	10.2337/dc12-1791
Tamuno Alfred	Associations between a Polymorphism in the Pleiotropic GCKR and Age-Related Phenotypes: The HALCyon Programme	2013	1	10.1371/journal.pone.0070045
Weihong Tang	Genome-wide association study identifies novel loci for plasma levels of protein C: the ARIC study.	2010	19	-
Martine Vaxillaire	The common P446L polymorphism in GCKR inversely modulates fasting glucose and triglyceride levels and reduces type 2 diabetes risk in the DESIR prospective general French population.	2008	11	10.2337/db07-1807
Wael Osman	Association of common variants in TNFRSF13B, TNFSF13, and ANXA3 with serum levels of non-albumin protein and immunoglobulin isotypes in Japanese	2012	3	10.1371/journal.pone.0032683
Anette Varbo	TRIB1 and GCKR polymorphisms, lipid levels, and risk of ischemic heart disease in the general population.	2011	2	10.1161/ATVBAHA.110.216333
Márton Mohás	GCKR gene functional variants in type 2 diabetes and metabolic syndrome: do the rare variants associate with increased carotid intima-media thickness?	2010	5	10.1186/1475-2840-9-79
Luca Járomi	Functional variants of glucokinase regulatory protein and apolipoprotein A5 genes in ischemic stroke.	2010	5	-
Pablo Perez-Martinez	Glucokinase regulatory protein genetic variant interacts with omega-3 PUFA to influence insulin resistance and inflammation in metabolic syndrome.	2011	10	10.1371/journal.pone.0020555
H Q Shen	Glucokinase regulatory protein gene polymorphism affects postprandial lipemic response in a dietary intervention study	2009	1	DOI 10.1007/s00439-009-0700-3
Andrew Mente	Causal relationship between adiponectin and metabolic traits: a Mendelian randomization study in a multiethnic population.	2013	5	10.1371/journal.pone.0066808
R Saxena	Genetic variation in GIPR influences the glucose and insulin responses to an oral glucose challenge	2010	47	10.1038/ng.521
Haiqing Shen	Glucokinase regulatory protein gene polymorphism affects postprandial lipemic response in a dietary intervention study.	2009	2	10.1007/s00439-009-0700-3
K Horvatovich	Functional glucokinase regulator gene variants have inverse effects on triglyceride and glucose levels, and decrease the risk of obesity in children	2011	2	10.1016/j.diabet.2011.02.003
Weihong Tang	Genome-wide association study identifies novel loci for plasma levels of protein C: The ARIC study	2010	19	10.1182/blood-2010-05-283739
A Varbo	TRIB1 and GCKR polymorphisms, lipid levels, and risk of ischemic heart disease in the general population	2011	2	10.1161/atvbaha.110.216333
Carsten A. B??ger	Association of eGFR-related loci identified by GWAS with incident CKD and ESRD	2011	15	10.1371/journal.pgen.1002292
Toni I Pollin	Triglyceride response to an intensive lifestyle intervention is enhanced in carriers of the GCKR Pro446Leu polymorphism.	2011	8	-
Haiqing Shen	Glucokinase regulatory protein gene polymorphism affects postprandial lipemic response in a dietary intervention study.	2009	2	-
Pablo Perez-Martinez	Glucokinase Regulatory Protein Genetic Variant Interacts with Omega-3 PUFA to Influence Insulin Resistance and Inflammation in Metabolic Syndrome	2011	5	10.1371/journal.pone.0020555
Martine Vaxillaire	The Common P446L Polymorphism in GCKR Inversely Modulates Fasting Glucose and Triglyceride Levels and Reduces Type 2 Diabetes Risk in the DESIR Prospective General French Population	2008	8	10.2337/db07-1807
Chiara Sabatti	Genome-wide association analysis of metabolic traits in a birth cohort from a founder population.	2009	108	10.1038/ng.271

Evidence compiled by the Personal Genome Project

There are no results from the Personal Genome Project yet. Please come back later.

Publications listed by Genome.gov

First Author	Title	Journal	Publication Date	Trait	p-value	Confidence Interval
Kettunen J	Genome-wide association study identifies multiple loci influencing human serum metabolite levels.	Nat Genet	01/29/2012	Metabolite levels	3.0e-18 (Ala, Gln)	[0.11-0.19] unit decrease
Sabatti C	Genome-wide association analysis of metabolic traits in a birth cohort from a founder population.	Nat Genet	12/07/2008	Metabolic traits	4.0e-10 (TG)	[0.06-0.12] mmol/l increase
Chambers JC	Genome-wide association study identifies loci influencing concentrations of liver enzymes in plasma.	Nat Genet	10/16/2011	Liver enzyme levels (gamma-glutamyl transferase)	4.0e-13	[2.40-4.0] % increase
Dehghan A	Meta-analysis of genome-wide association studies in >80 000 subjects identifies multiple loci for C-reactive protein levels.	Circulation	02/07/2011	C-reactive protein	5.0e-40	[0.06-0.08] unit increase
Saxena R	Genetic variation in GIPR influences the glucose and insulin responses to an oral glucose challenge.	Nat Genet	01/17/2010	Two-hour glucose challenge	3.0e-10	[0.05-0.09] mmol/L increase
Johansen CT	Excess of rare variants in genes identified by genome-wide association study of hypertriglyceridemia.	Nat Genet	07/25/2010	Hypertriglyceridemia	7.0e-09	[1.45-2.12]
Teslovich TM	Biological, clinical and population relevance of 95 loci for blood lipids.	Nature	08/05/2010	Triglycerides	1.0e-100	[7.98-9.54] mg/dL increase
Osman W	Association of common variants in TNFRSF13B, TNFSF13, and ANXA3 with serum levels of non-albumin protein and immunoglobulin isotypes in Japanese.	PLoS One	04/27/2012	Non-albumin protein levels	3.0e-09 (ALB)	[0.053-0.107] unit decrease
Kathiresan S	Common variants at 30 loci contribute to polygenic dyslipidemia.	Nat Genet	12/07/2008	Triglycerides	2.0e-31	[0.08-0.16] s.d. increase
Kottgen A	New loci associated with kidney function and chronic kidney disease.	Nat Genet	04/11/2010	Chronic kidney disease	3.0e-14 (eGFRcrea)	[0.007-0.011] ml/min/1.73 m2 increase

Name	rs1260326
Chromosome	2
Position	27508073
Weight of evidence	156

SNP rs1260326

Basic Information

Genotype Frequency

Allele Frequency

Additional Information

Links to SNPedia

Publications on this SNP on the Public Library of Science:

Publications on this SNP on Mendeley

Evidence compiled by the Personal Genome Project

Publications listed by Genome.gov

Users who share this SNP:

Genome Browser

Contacts