openSNP | rs1143634

Links to SNPedia

Title	Summary
rs1143634 C/C	Normal
rs1143634 T/T	Complex; see details
rs1143634 C/T	Complex; see details

Note: For some SNPs, testing providers detect the genotype from the opposite strand of DNA, so that the genotypes listed on openSNP don't appear here. In those cases, please replace "A" by "T" or "G" by "C" (and vice-versa).

Publications on this SNP on the Public Library of Science:

First Author	Title	Year of Publication	# of readers
Ying Zhang	IL1 Receptor Antagonist Gene IL1-RN Variable Number of Tandem Repeats Polymorphism and Cancer Risk: A Literature Review and Meta-Analysis	2012	3755
Michelle A. T. Hildebrandt	Genetic Variants in Inflammation-Related Genes Are Associated with Radiation-Induced Toxicity Following Treatment for Non-Small Cell Lung Cancer	2010	6708
Marcela Caleffi da Costa Lima Caniatti	Association of Cytokines in Individuals Sensitive and Insensitive to Dust Mites in a Brazilian Population	2014	1961
Joshua M. Shulman	Intermediate Phenotypes Identify Divergent Pathways to Alzheimer's Disease	2010	5052
María Asunción García-González	Prognostic Role of Host Cyclooxygenase and Cytokine Genotypes in a Caucasian Cohort of Patients with Gastric Adenocarcinoma	2012	3381
Guoliang Zhang	Allele-Specific Induction of IL-1β Expression by C/EBPβ and PU.1 Contributes to Increased Tuberculosis Susceptibility	2014	6005
Laura Ibáñez	HIV-Infection, Atherosclerosis and the Inflammatory Pathway: Candidate Gene Study in a Spanish HIV-Infected Population	2014	1872
Christine Miaskowski	Evidence of Associations between Cytokine Genes and Subjective Reports of Sleep Disturbance in Oncology Patients and Their Family Caregivers	2012	3949
Sebastian Okser	Genetic Variants and Their Interactions in the Prediction of Increased Pre-Clinical Carotid Atherosclerosis: The Cardiovascular Risk in Young Finns Study	2010	8490
Pasi J. Eskola	Genetic Association Studies in Lumbar Disc Degeneration: A Systematic Review	2012	7844
Nagafumi Doi	Persistence Criteria for Susceptibility Genes for Schizophrenia: a Discussion from an Evolutionary Viewpoint	2009	5377
Min-Li Chen	Association between the IL1B (-511), IL1B (+3954), IL1RN (VNTR) Polymorphisms and Graves' Disease Risk: A Meta-Analysis of 11 Case-Control Studies	2014	2907
Andrea Burri	A Genome-Wide Association Study of Female Sexual Dysfunction	2012	4344
Jiali Xu	Systematic Review and Meta-Analysis on the Association between IL-1B Polymorphisms and Cancer Risk	2013	4815
Esther Erdei	Cytokines and Tumor Metastasis Gene Variants in Oral Cancer and Precancer in Puerto Rico	2013	2522
Tobias O. Apinjoh	Association of Cytokine and Toll-Like Receptor Gene Polymorphisms with Severe Malaria in Three Regions of Cameroon	2013	3296
Ousmane Toure	Candidate Polymorphisms and Severe Malaria in a Malian Population	2012	3484
Daniel T. Barratt	Innate Immune Signalling Genetics of Pain, Cognitive Dysfunction and Sickness Symptoms in Cancer Pain Patients Treated with Transdermal Fentanyl	2015	2411
Shaofan Weng	Effects of the Interactions between Dust Exposure and Genetic Polymorphisms in Nalp3, Caspase-1, and IL-1β on the Risk of Silicosis: A Case-Control Study	2015	1530
Jung-Pil Jang	Multiplex Genotyping of Cytokine Gene SNPs Using Fluorescence Bead Array	2015	2246
Chi-Hui Cheng	Genetic Polymorphisms in Inflammasome-Dependent Innate Immunity among Pediatric Patients with Severe Renal Parenchymal Infections	2015	1854
Himanshu Rai	Interleukin-1 Gene Cluster Polymorphisms and Their Association with Coronary Artery Disease: Separate Evidences from the Largest Case-Control Study amongst North Indians and an Updated Meta-Analysis	2016	1584
Zheng Wang	Interleukin 1 Polymorphisms Contribute to Intervertebral Disc Degeneration Risk: A Meta-Analysis	2016	1717
Francisco Mesa	Polymorphism IL-1RN rs419598 reduces the susceptibility to generalized periodontitis in a population of European descent	2017	1252
Romain Shanil Perera	Variants of ACAN are associated with severity of lumbar disc herniation in patients with chronic low back pain	2017	1359
Romain Shanil Perera	Single Nucleotide Variants of Candidate Genes in Aggrecan Metabolic Pathway Are Associated with Lumbar Disc Degeneration and Modic Changes	2017	1825
Wen-Chien Fan	TLR4/CD14 Variants-Related Serologic and Immunologic Dys-Regulations Predict Severe Sepsis in Febrile De-Compensated Cirrhotic Patients	2016	1173

Publications on this SNP on Mendeley

First Author	Title	Pub. Year	# of Readers	DOI
Mary Dawn Hennessy	Polymorphisms of Interleukin-1 Beta and Interleukin-17Alpha Genes Are Associated With Restless Legs Syndrome.	2014	2	10.1177/1099800413478827
Daniel Torres-Moreno	Influence of polymorphisms and TNF and IL1β serum concentration on the infliximab response in Crohn’s disease and ulcerative colitis	2012	5	10.1007/s00228-012-1389-0
K. S. Benke	The association of genetic variants in interleukin-1 genes with cognition: Findings from the cardiovascular health study	2011	7	10.1016/j.exger.2011.09.005
Mingqing Xu	Convergent evidence shows a positive association of interleukin-1 gene complex locus with susceptibility to schizophrenia in the Caucasian population.	2010	8	10.1016/j.schres.2010.02.1031
Hara Levy	IL1B polymorphisms modulate cystic fibrosis lung disease.	2009	5	10.1002/ppul.21026
K S Benke	The association of genetic variants in interleukin-1 genes with cognition : Findings from the cardiovascular health study	2011	4	10.1016/j.exger.2011.09.005
So-Hee Kim	Association of -31T>C and -511 C>T polymorphisms in the interleukin 1 beta (IL1B) promoter in Korean keratoconus patients.	2008	7
E. Jacobi-Gresser	Genetic and immunological markers predict titanium implant failure: a retrospective study	2012	20	10.1016/j.ijom.2012.07.018
Xiaoan Liu	XPC gene polymorphisms and breast cancer susceptibility: appraisal of a recent meta-analysis.	2010	3	-
Ibrahim Arda Yilmaz	Cytokine polymorphism in patients with migraine: some suggestive clues of migraine and inflammation.	2010	3	-
Y Zhang	IL1 receptor antagonist gene IL1-RN variable number of tandem repeats polymorphism and cancer risk: a literature review and meta-analysis	2012	2	10.1371/journal.pone.0046017
E Jacobi-Gresser	Genetic and immunological markers predict titanium implant failure: a retrospective study.	2012	1	10.1016/j.ijom.2012.07.018
Svetlana Solovieva	Association between interleukin 1 gene cluster polymorphisms and bilateral distal interphalangeal osteoarthritis.	2009	1	10.3899/jrheum.081238
Jamal M. Stein	Single nucleotide polymorphisms in interleukin-1gene cluster and subgingival colonization with Aggregatibacter actinomycetemcomitans in patients with aggressive periodontitis	2011	4	10.1016/j.humimm.2011.05.009
A Iglesias-Linares	Interleukin 1 gene cluster SNPs (rs1800587, rs1143634) influences post-orthodontic root resorption in endodontic and their contralateral vital control teeth differently	2012	3	-
Y Tomoyasu	External apical root resorption and the interleukin-1B gene polymorphism in the Japanese population	2009	1	-
Koutaro Maki	External apical root resorption and the interleukin-1B gene polymorphism in the Japanese population	2009	6	10.1016/j.odw.2009.05.002
M P Amaya	Polymorphisms of pro-inflammatory cytokine genes and the risk for acute suppurative or chronic nonsuppurative apical periodontitis in a Colombian population.	2012	1	10.1111/j.1365-2591.2012.02097.x
Y Zhang	IL1 Receptor Antagonist Gene IL1-RN Variable Number of Tandem Repeats Polymorphism and Cancer Risk: A Literature Review and Meta-Analysis	2012	2	10.1371/journal.pone.0046017
Ying Zhang	IL1 receptor antagonist gene IL1-RN variable number of tandem repeats polymorphism and cancer risk: a literature review and meta-analysis.	2012	3	10.1371/journal.pone.0046017
Suddhasil Mookherjee	Association of IL1A and IL1B loci with primary open angle glaucoma.	2010	1	10.1186/1471-2350-11-99
Alessandra Pontillo	Polymorphisms in inflammasome' genes and susceptibility to HIV-1 infection.	2012	11	10.1097/QAI.0b013e3182392ebe
I Borzani	The interleukin-1 cluster gene region is associated with multiple sclerosis in an Italian Caucasian population.	2010	2	10.1111/j.1468-1331.2010.02952.x
Ying Zhang	IL1 receptor antagonist gene IL1-RN variable number of tandem repeats polymorphism and cancer risk: a literature review and meta-analysis.	2012	1	10.1371/journal.pone.0046017
Yoko Tomoyasu	External apical root resorption and the interleukin-1B gene polymorphism in the Japanese population	2009	6	10.1016/j.odw.2009.05.002
M H Kaarvatn	Associations of the interleukin-1 gene locus polymorphisms with risk to hip and knee osteoarthritis: gender and subpopulation differences.	2013	2	10.1111/sji.12016
Xiaoan Liu	Three polymorphisms in interleukin-1beta gene and risk for breast cancer: a meta-analysis.	2010	2	10.1007/s10549-010-0910-3
M D Hennessy	Polymorphisms of Interleukin-1 Beta and Interleukin-17Alpha Genes Are Associated With Restless Legs Syndrome	2013	1	10.1177/1099800413478827
Bernhard T Baune	The interleukin 1 beta (IL1B) gene is associated with failure to achieve remission and impaired emotion processing in major depression.	2010	37	10.1016/j.biopsych.2009.11.004
M Mahmoudi	Association of IL1R polymorphism with HLA-B27 positive in Iranian patients with ankylosing spondylitis.	2011	3	10.1684/ecn.2011.0293
Kim Carter	Association of Interleukin-1 gene polymorphisms with central obesity and metabolic syndrome in a coronary heart disease population	2008	2	10.1007/s00439-008-0540-6
Ibrahim Arda Yilmaz	Cytokine polymorphism in patients with migraine: some suggestive clues of migraine and inflammation.	2010	4	10.1111/j.1526-4637.2009.00791.x
Daimei Sasayama	Association of interleukin-1β genetic polymorphisms with cognitive performance in elderly females without dementia.	2011	2	10.1038/jhg.2011.56
Svetlana Solovieva	Association between interleukin 1 gene cluster polymorphisms and bilateral distal interphalangeal osteoarthritis.	2009	0	-
Ying Zhang	IL1 Receptor Antagonist Gene IL1-RN Variable Number of Tandem Repeats Polymorphism and Cancer Risk: A Literature Review and Meta-Analysis	2012	7	10.1371/journal.pone.0046017
a Iglesias-Linares	Interleukin 1 gene cluster SNPs (rs1800587, rs1143634) influences post-orthodontic root resorption in endodontic and their contralateral vital control teeth differently.	2012	4	10.1111/j.1365-2591.2012.02065.x
Kari Luotola	Association of variation in the interleukin-1 gene family with diabetes and glucose homeostasis.	2009	9	10.1210/jc.2009-0666
Kim W Carter	Association of Interleukin-1 gene polymorphisms with central obesity and metabolic syndrome in a coronary heart disease population.	2008	4	10.1007/s00439-008-0540-6
M Mahmoudi	Association of IL1R polymorphism with HLA-B27 positive in Iranian patients with ankylosing spondylitis.	2011	3	10.1684/ecn.2011.0293
Su Kang Kim	Coding single-nucleotide polymorphisms of interleukin-1 gene cluster are not associated with Kawasaki disease in the Korean population.	2011	1	10.1007/s00246-010-9858-7
S Pereira	Polymorphisms of genes encoding P2X7R, IL-1B, OPG and RANK in orthodontic-induced apical root resorption.	2013	3	10.1111/odi.12185
Monica Ter-Minassian	Apoptosis gene polymorphisms, age, smoking and the risk of non-small cell lung cancer.	2008	2	10.1093/carcin/bgn205
A Iglesias-Linares	Interleukin 1 gene cluster SNPs (rs1800587, rs1143634) influences post-orthodontic root resorption in endodontic and their contralateral vital control teeth differently.	2012	8	10.1111/j.1365-2591.2012.02065.x
M P Amaya	Polymorphisms of pro-inflammatory cytokine genes and the risk for acute suppurative or chronic nonsuppurative apical periodontitis in a Colombian population.	2013	2	10.1111/j.1365-2591.2012.02097.x
K S Benke	The association of genetic variants in interleukin-1 genes with cognition: Findings from the cardiovascular health study.	2011	2	-
J.D. Walston	The association of genetic variants in interleukin-1 genes with cognition: Findings from the cardiovascular health study	2011	7	10.1016/j.exger.2011.09.005
Maximilian Schmid	Interleukin-1 beta gene polymorphisms and preterm birth.	2012	3	10.1016/j.ejogrb.2012.07.013
D Lacruz-Guzman	Influence of polymorphisms and TNF and IL1(beta) serum concentration on the infliximab response in Crohn's disease and ulcerative colitis	2013	1
G Moxley	Potential influence of IL1B haplotype and IL1A-IL1B-IL1RN extended haplotype on hand osteoarthritis risk.	2007	1	S1063-4584(07)00128-8 [pii]\r10.1016/j.joca.2007.03.022
Walter P Maksymowych	Association of the IL1 gene cluster with susceptibility to ankylosing spondylitis: an analysis of three Canadian populations.	2006	4	10.1002/art.21642
X Liu	Three polymorphisms in interleukin-1beta gene and risk for breast cancer: a meta-analysis	2010	2	-
Marikken Heiland Kaarvatn	Associations of the Interleukin-1 Gene Locus Polymorphisms with Risk to Hip and Knee Osteoarthritis: Gender and Subpopulation Differences.	2012	1	10.1111/sji.12016
K W Carter	Association of Interleukin-1 gene polymorphisms with central obesity and metabolic syndrome in a coronary heart disease population	2008	2	10.1007/s00439-008-0540-6
C Kiyohara	IL1B rs1143634 polymorphism, cigarette smoking, alcohol use, and lung cancer risk in a Japanese population	2010	1	10.1097/JTO.0b013e3181c8cae3
Suddhasil Mookherjee	Association of IL1A and IL1B loci with primary open angle glaucoma	2010	1	10.1186/1471-2350-11-99
Suddhasil Mookherjee	Association of IL1A and IL1B loci with primary open angle glaucoma	2010	1	-
Susanne Schulz	Single nucleotide polymorphisms in interleukin-1gene cluster and subgingival colonization with Aggregatibacter actinomycetemcomitans in patients with aggressive periodontitis	2011	3	10.1016/j.humimm.2011.05.009
Rong-Bin Lu	Association of interleukin-1 gene polymorphisms with multiple sclerosis: a meta-analysis	2012	1	10.1007/s00011-012-0556-1
Chikako Kiyohara	IL1B rs1143634 polymorphism, cigarette smoking, alcohol use, and lung cancer risk in a Japanese population.	2010	4	10.1097/JTO.0b013e3181c8cae3
Xiaoan Liu	Three polymorphisms in interleukin-1β gene and risk for breast cancer: a meta-analysis.	2010	2	10.1007/s10549-010-0910-3
Robert Y L Zee	An evaluation of candidate genes of inflammation and thrombosis in relation to the risk of venous thromboembolism: The Women's Genome Health Study.	2009	2	10.1161/CIRCGENETICS.108.801969
a Iglesias-Linares	Postorthodontic external root resorption is associated with IL1 receptor antagonist gene variations.	2012	7	10.1111/j.1601-0825.2011.01865.x
Alejandro Iglesias-Linares	Postorthodontic external root resorption in root-filled teeth is influenced by interleukin-1?? polymorphism	2012	21	10.1016/j.joen.2011.12.022
Y Zhang	IL1 receptor antagonist gene IL1-RN variable number of tandem repeats polymorphism and cancer risk: a literature review and meta-analysis	2012	3	10.1371/journal.pone.0046017; 10.1371/journal.pone.0046017
Daimei Sasayama	Association of interleukin-1β genetic polymorphisms with cognitive performance in elderly females without dementia.	2011	2	10.1038/jhg.2011.56
Alessandra Pontillo	Polymorphisms in Inflammasomeʼ Genes and Susceptibility to HIV-1 Infection	2012	13	10.1097/QAI.0b013e3182392ebe
Chikako Kiyohara	IL1B rs1143634 polymorphism, cigarette smoking, alcohol use, and lung cancer risk in a Japanese population.	2010	3	-

Evidence compiled by the Personal Genome Project

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Publications listed by Genome.gov

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Name	rs1143634
Chromosome	2
Position	112832813
Weight of evidence	136

SNP rs1143634

Basic Information

Genotype Frequency

Allele Frequency

Additional Information

Links to SNPedia

Publications on this SNP on the Public Library of Science:

Publications on this SNP on Mendeley

Evidence compiled by the Personal Genome Project

Publications listed by Genome.gov

Users who share this SNP:

Genome Browser

Contacts