openSNP | rs1137101

Links to SNPedia

Title	Summary
rs1137101 A/A	Common in clinvar

Note: For some SNPs, testing providers detect the genotype from the opposite strand of DNA, so that the genotypes listed on openSNP don't appear here. In those cases, please replace "A" by "T" or "G" by "C" (and vice-versa).

Publications on this SNP on the Public Library of Science:

First Author	Title	Year of Publication	# of readers
Antti Huuskonen	Aerobic Fitness Does Not Modify the Effect of FTO Variation on Body Composition Traits	2012	4339
Lijun Jing	Ethnic Background and Genetic Variation in the Evaluation of Cancer Risk: A Systematic Review	2014	4020
Li-Jun Tan	Replication of 6 Obesity Genes in a Meta-Analysis of Genome-Wide Association Studies from Diverse Ancestries	2014	4826
Yan Zhang	Tumor Necrosis Factor-α Induced Protein 8 Polymorphism and Risk of Non-Hodgkin’s Lymphoma in a Chinese Population: A Case-Control Study	2012	2906
Hans Verkerke	Kinetics of Leptin Binding to the Q223R Leptin Receptor	2014	2175
Jingping Niu	The Association between Leptin Level and Breast Cancer: A Meta-Analysis	2013	5254
Jing He	Association of LEP G2548A and LEPR Q223R Polymorphisms with Cancer Susceptibility: Evidence from a Meta-Analysis	2013	3712
Paola León-Mimila	Contribution of Common Genetic Variants to Obesity and Obesity-Related Traits in Mexican Children and Adults	2013	8826
Margrit Urbanek	The Role of Inflammatory Pathway Genetic Variation on Maternal Metabolic Phenotypes during Pregnancy	2012	4645
Sven Knüppel	Evaluation of 41 Candidate Gene Variants for Obesity in the EPIC-Potsdam Cohort by Multi-Locus Stepwise Regression	2013	3216
Huaidong Du	Genetic Polymorphisms in the Hypothalamic Pathway in Relation to Subsequent Weight Change – The DiOGenes Study	2011	4180
Ching-Jung Hsieh	Association of Adiponectin Gene Polymorphism with Nonalcoholic Fatty Liver Disease in Taiwanese Patients with Type 2 Diabetes	2015	2305
Yunzhong Yang	A meta-analysis of associations of LEPR Q223R and K109R polymorphisms with Type 2 diabetes risk	2018	451

Publications on this SNP on Mendeley

First Author	Title	Pub. Year	# of Readers	DOI
Li-qiang Wang	The association between polymorphisms in the leptin receptor gene and risk of breast cancer: a systematic review and pooled analysis.	2012	1	10.1007/s10549-012-2228-9
Shamsul Mohd Zain	The impact of LEPR variants on risk of non-alcoholic fatty liver disease and its interaction with PNPLA3 variant.	2012	1	10.1111/jgh.12104
Antti Huuskonen	Genetic variations of leptin and leptin receptor are associated with body composition changes in response to physical training.	2010	4	-
Natasha Favoretto Dias	Lack of mutations in the leptin receptor gene in severely obese children.	2012	3
P H Su	A polymorphism in the leptin receptor gene at position 223 is associated with growth hormone replacement therapy responsiveness in idiopathic short stature and growth hormone deficiency patients	2012	1	10.1016/j.ejmg.2012.09.003
Lynne R. Wilkens	Susceptibility Variants for Waist Size in Relation to Abdominal, Visceral, and Hepatic Adiposity in Postmenopausal Women	2012	2	10.1016/j.jand.2012.03.034
Marília Remuzzi Zandoná	Polymorphisms in LEPR, PPARG and APM1 genes: associations with energy intake and metabolic traits in young children	2013	2	-
Julie Anna Bienertová-Vasků	Association between variants in the genes for leptin, leptin receptor, and proopiomelanocortin with chronic heart failure in the Czech population.	2009	7	-
Samir Ben Ali	LEPR p.Q223R Polymorphism influences plasma leptin levels and body mass index in Tunisian obese patients.	2009	7	10.1016/j.arcmed.2009.02.008
Meiju Saukko	Leptin Receptor Lys109Arg and Gln223Arg Polymorphisms Are Associated with Early Atherosclerosis	2010	2	10.1089/met.2010.0004
S M Zain	Impact of leptin receptor gene variants on risk of non-alcoholic fatty liver disease and its interaction with adiponutrin gene	2013	4	10.1111/jgh.12104
K G Jackson	The leptin receptor Gln223Arg polymorphism (rs1137101) mediates the postprandial lipaemic response, but only in males	2012	1	-
Kim G. Jackson	The leptin receptor Gln223Arg polymorphism (rs1137101) mediates the postprandial lipaemic response, but only in males	2012	7	10.1016/j.atherosclerosis.2012.08.035
Antti Huuskonen	Aerobic Fitness Does Not Modify the Effect of FTO Variation on Body Composition Traits	2012	4	10.1371/journal.pone.0051635
Meiju Saukko	Leptin receptor Lys109Arg and Gln223Arg polymorphisms are associated with early atherosclerosis.	2010	5	10.1089/met.2010.0004
Jochem G Gregoor	Polymorphisms of the LEP- and LEPR gene and obesity in patients using antipsychotic medication.	2009	13	-
E. J. Brandl	Association study of polymorphisms in leptin and leptin receptor genes with antipsychotic-induced body weight gain	2012	13	10.1016/j.pnpbp.2012.03.001
Rajat Madan	Role of Leptin-Mediated Colonic Inflammation in Defense against Clostridium difficile Colitis.	2014	6	10.1128/IAI.00972-13
Natasha Favoretto Dias	Lack of mutations in the leptin receptor gene in severely obese children Ausência de mutação no gene receptor de leptina em crianças gravemente obesas	2012	3	-
Samir Ben Ali	LEPR p.Q223R Polymorphism influences plasma leptin levels and body mass index in Tunisian obese patients.	2009	5	-
L Gallicchio	Single nucleotide polymorphisms in obesity-related genes and all-cause and cause-specific mortality: a prospective cohort study	2009	2	10.1186/1471-2350-10-103
Pen-Hua Su	A polymorphism in the leptin receptor gene at position 223 is associated with growth hormone replacement therapy responsiveness in idiopathic short stature and growth hormone deficiency patients	2012	1	10.1016/j.ejmg.2012.09.003
Qi Sun	Genome-wide association study identifies polymorphisms in LEPR as determinants of plasma soluble leptin receptor levels.	2010	20	10.1093/hmg/ddq056
Shamsul Mohd Zain	Impact of leptin receptor gene variants on risk of non-alcoholic fatty liver disease and its interaction with adiponutrin gene.	2013	3	10.1111/jgh.12104
Shamsul Mohd Zain	Impact of leptin receptor gene variants on risk of non-alcoholic fatty liver disease and its interaction with adiponutrin gene.	2013		10.1111/jgh.12104
Samir Ben Ali	LEPR p.Q223R Polymorphism Influences Plasma Leptin Levels and Body Mass Index in Tunisian Obese Patients	2009	10	10.1016/j.arcmed.2009.02.008
S. Walsh	Leptin and leptin receptor genetic variants associate with habitual physical activity and the arm body composition response to resistance training	2012	4	10.1016/j.gene.2012.08.020
Catherine M Phillips	Leptin receptor polymorphisms interact with polyunsaturated fatty acids to augment risk of insulin resistance and metabolic syndrome in adults.	2010	9	10.3945/jn.109.115329
M Saukko	Leptin receptor Lys109Arg and Gln223Arg polymorphisms are associated with early atherosclerosis	2010	2	10.1089/met.2010.0004
Erdal Eren	Genetic variants of estrogen beta and leptin receptors may cause gynecomastia in adolescent	2014	1	10.1016/j.gene.2014.03.013
Marcel den Hoed	Postprandial responses in hunger and satiety are associated with the rs9939609 single nucleotide polymorphism in FTO.	2009	22	10.3945/ajcn.2009.28053
Siti Norsyuhada Roffeei	Association of FTO, LEPR and MTHFR gene polymorphisms with metabolic syndrome in schizophrenia patients receiving antipsychotics.	2014	1	10.2217/pgs.13.220
Tiago V Pereira	ADRB2 and LEPR gene polymorphisms: synergistic effects on the risk of obesity in Japanese.	2011	4	10.1038/oby.2010.322

Evidence compiled by the Personal Genome Project

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Publications listed by Genome.gov

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Name	rs1137101
Chromosome	1
Position	65592830
Weight of evidence	64

SNP rs1137101

Basic Information

Genotype Frequency

Allele Frequency

Additional Information

Links to SNPedia

Publications on this SNP on the Public Library of Science:

Publications on this SNP on Mendeley

Evidence compiled by the Personal Genome Project

Publications listed by Genome.gov

Users who share this SNP:

Genome Browser

Contacts