openSNP | rs11136000

Links to SNPedia

Title	Summary
rs11136000 C/T	0.84x decreased risk for alzheimer's disease
rs11136000 T/T	0.84x decreased risk for alzheimer's disease
rs11136000 C/C	Normal

Note: For some SNPs, testing providers detect the genotype from the opposite strand of DNA, so that the genotypes listed on openSNP don't appear here. In those cases, please replace "A" by "T" or "G" by "C" (and vice-versa).

Publications on this SNP on the Public Library of Science:

First Author	Title	Year of Publication	# of readers
Yuan Zhou	Intracellular Clusterin Interacts with Brain Isoforms of the Bridging Integrator 1 and with the Microtubule-Associated Protein Tau in Alzheimer's Disease	2014	4533
Akinori Miyashita	SORL1 Is Genetically Associated with Late-Onset Alzheimer’s Disease in Japanese, Koreans and Caucasians	2013	11460
Perry G. Ridge	Alzheimer’s Disease: Analyzing the Missing Heritability	2013	10824
Xiaoyan Liu	Association Study of Candidate Gene Polymorphisms with Amnestic Mild Cognitive Impairment in a Chinese Population	2012	2464
Lesley Jones	Genetic Evidence Implicates the Immune System and Cholesterol Metabolism in the Aetiology of Alzheimer's Disease	2010	15759
I-Fang Ling	Genetics of Clusterin Isoform Expression and Alzheimer's Disease Risk	2012	5133
Adam C. Naj	Dementia Revealed: Novel Chromosome 6 Locus for Late-Onset Alzheimer Disease Provides Genetic Evidence for Folate-Pathway Abnormalities	2010	11080
John S. K. Kauwe	Fine Mapping of Genetic Variants in BIN1, CLU, CR1 and PICALM for Association with Cerebrospinal Fluid Biomarkers for Alzheimer's Disease	2011	6623
Timothy J. Hohman	Epistatic Genetic Effects among Alzheimer’s Candidate Genes	2013	5263
Karen A. Mather	Investigating the Genetics of Hippocampal Volume in Older Adults without Dementia	2015	2113
Jonas Mengel-From	CLU Genetic Variants and Cognitive Decline among Elderly and Oldest Old	2013	1820
Fanggeng Zou	Linking Protective GAB2 Variants, Increased Cortical GAB2 Expression and Decreased Alzheimer’s Disease Pathology	2013	2170
Rita J. Guerreiro	Genetic Variability in CLU and Its Association with Alzheimer's Disease	2010	6992
Catherine Féart	Association between IgM Anti-Herpes Simplex Virus and Plasma Amyloid-Beta Levels	2011	4655
Zongqi Xia	A Putative Alzheimer's Disease Risk Allele in PCK1 Influences Brain Atrophy in Multiple Sclerosis	2010	2915
Lyzel S. Elias-Sonnenschein	Genetic Loci Associated with Alzheimer’s Disease and Cerebrospinal Fluid Biomarkers in a Finnish Case-Control Cohort	2013	4509
Ellen M. Wijsman	Genome-Wide Association of Familial Late-Onset Alzheimer's Disease Replicates BIN1 and CLU and Nominates CUGBP2 in Interaction with APOE	2011	13243
Christine Herold	A One-Degree-of-Freedom Test for Supra-Multiplicativity of SNP Effects	2013	1487
Jianjun Gao	An Exploratory Study on CLU, CR1 and PICALM and Parkinson Disease	2011	3303
Xiaolan Hu	Meta-Analysis for Genome-Wide Association Study Identifies Multiple Variants at the BIN1 Locus Associated with Late-Onset Alzheimer's Disease	2011	9642
Li Zhao	Association between the European GWAS-Identified Susceptibility Locus at Chromosome 4p16 and the Risk of Atrial Septal Defect: A Case-Control Study in Southwest China and a Meta-Analysis	2015	1369
Gonçalo da Costa	Transthyretin Amyloidosis: Chaperone Concentration Changes and Increased Proteolysis in the Pathway to Disease	2015	2501
Bin Jiao	Polygenic Analysis of Late-Onset Alzheimer’s Disease from Mainland China	2015	2882
Venugopalan Y. Vishnu	Role of Plasma Clusterin in Alzheimer’s Disease—A Pilot Study in a Tertiary Hospital in Northern India	2016	1256
Thaddeus Haight	Associations of plasma clusterin and Alzheimer’s disease-related MRI markers in adults at mid-life: The CARDIA Brain MRI sub-study	2018	602

Publications on this SNP on Mendeley

First Author	Title	Pub. Year	# of Readers	DOI
Jean-Charles Lambert	Supplementary Methods	2009	1	10.1038/ng.439
Jonas Mengel-From	Genetic variations in the CLU and PICALM genes are associated with cognitive function in the oldest old.	2011	0	-
M N Braskie	Common Alzheimer's Disease Risk Variant Within the CLU Gene Affects White Matter Microstructure in Young Adults	2011	1	10.1523/JNEUROSCI.5794-10.2011
T M Lancaster	Neural hyperactivation in carriers of the Alzheimer's risk variant on the clusterin gene	2011	1	-
S A Golenkina	[Analysis of clusterin gene (CLU/APOJ) polymorphism in Alzheimer's disease patients and in normal cohorts from Russian populations].	2011	3	-
Meredith N Braskie	Common Alzheimer's disease risk variant within the CLU gene affects white matter microstructure in young adults.	2011	43	10.1523/JNEUROSCI.5794-10.2011
Thomas M Lancaster	Neural hyperactivation in carriers of the Alzheimer's risk variant on the clusterin gene	2011	14	10.1016/j.euroneuro.2011.02.001
Yi Zhou	Association analysis between the rs11136000 single nucleotide polymorphism in clusterin gene, rs3851179 single nucleotide polymorphism in clathrin assembly lymphoid myeloid protein gene and the patients with schizophrenia in the Chinese population.	2010	0	-
Otto Pedraza	Evaluation of memory endophenotypes for association with CLU, CR1, and PICALM variants in black and white subjects	2013	1	10.1016/j.jalz.2013.01.016
J Mengel-From	Genetic variations in the CLU and PICALM genes are associated with cognitive function in the oldest old	2010	1
Minerva M Carrasquillo	Replication of BIN1 Association with Alzheimer's Disease and Evaluation of Genetic Interactions.	2011	6	10.3233/JAD-2011-101932
Jean-Charles Lambert	Genome-wide association study identifies variants at CLU and CR1 associated with Alzheimer's disease.	2009	183	10.1038/ng.439
T M Lancaster	Neural hyperactivation in carriers of the Alzheimer's risk variant on the clusterin gene	2011	1	-
David W. Fardo	Genetics of Clusterin Isoform Expression and Alzheimer's Disease Risk	2012	9	10.1371/journal.pone.0033923
Mohd Nazif Darawi	Allele-specific polymerase chain reaction for the detection of Alzheimer's disease-related single nucleotide polymorphisms.	2013	4	10.1186/1471-2350-14-27
Richard C. Dodel	Association of Clusterin Gene Polymorphisms with Late-Onset Alzheimer’s Disease	2011	1	10.1159/000331276
Joan S. Reisch	Implication of common and disease specific variants in CLU, CR1, and PICALM	2012	9	10.1016/j.neurobiolaging.2012.01.110
Elena H Martínez-Lapiscina	Genotype patterns at CLU, CR1, PICALM and APOE, cognition and Mediterranean diet: the PREDIMED-NAVARRA trial.	2014	6	10.1007/s12263-014-0393-7
Lu Hua Chen	Polymorphisms of CR1, CLU and PICALM confer susceptibility of Alzheimer's disease in a southern Chinese population	2012	16	10.1016/j.neurobiolaging.2011.09.016
Mohd Nazif Darawi	Allele-specific polymerase chain reaction for the detection of Alzheimer's disease-related single nucleotide polymorphisms.	2013	3	10.1186/1471-2350-14-27
D Harold	Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease	2009	15	10.1038/ng.440
Natalya Ponomareva	Age-Dependent Effect of Alzheimer's Risk Variant of CLU on EEG Alpha Rhythm in Non-Demented Adults	2013	4	10.3389/fnagi.2013.00086
Madhav Thambisetty	Alzheimer Risk Variant CLU and Brain Function During Aging.	2012	3	10.1016/j.biopsych.2012.05.026
Minerva M Carrasquillo	Replication of BIN1 Association with Alzheimer's Disease and Evaluation of Genetic Interactions	2011	1	10.3233/JAD-2011-101932
Denise Harold	Genome-wide association study identifies variants at CLU and CR1 associated with Alzheimer ’ s disease	2009	10	10.1038/ng.439
Madhav Thambisetty	Alzheimer risk variant CLU and brain function during aging	2013	10	10.1016/j.biopsych.2012.05.026
Jonas Mengel-From	Genetic variations in the CLU and PICALM genes are associated with cognitive function in the oldest old.	2011	10	-
Karolien Bettens	Both common variations and rare non-synonymous substitutions and small insertion/deletions in CLU are associated with increased Alzheimer risk	2012	5	10.1186/1750-1326-7-3
M. Carrasquillo	Novel Late-Onset Alzheimer's Disease Loci Variants Associate with Brain Gene Expression (S54.001)	2012	14	10.1212/WNL.78.1_MeetingAbstracts.S54.001
S Erk	Hippocampal Function in Healthy Carriers of the CLU Alzheimer's Disease Risk Variant	2011	14	10.1523/JNEUROSCI.4960-11.2011
J F Ma	Association study of clusterin polymorphism rs11136000 with late onset Alzheimer's disease in Chinese Han population	2011	1	10.1177/1533317511432735\r1533317511432735 [pii]
Simon Lovestone	Alzheimer Risk Variant Clusterin (CLU) and Brain Function During Aging	2011	4	10.1016/j.jalz.2011.05.547
Hong-Lei Li	PICALM and CR1 Variants are not Associated with Sporadic Alzheimer's Disease in Chinese Patients.	2011	2	10.3233/JAD-2011-101917
Minerva M Carrasquillo	Late-onset Alzheimer disease genetic variants in posterior cortical atrophy and posterior AD.	2014	2	10.1212/WNL.0000000000000335
B Schurmann	Association of the Alzheimer's disease clusterin risk allele with plasma clusterin concentration	2011	2	-
I-Fang Ling	Genetics of clusterin isoform expression and Alzheimer's disease risk.	2012	8	10.1371/journal.pone.0033923
I. Fang Ling	Genetics of clusterin isoform expression and Alzheimer's disease risk	2012	13	10.1371/journal.pone.0033923
Meredith N Braskie	Common Alzheimer's Disease Risk Variant Within the CLU Gene Affects White Matter Microstructure in Young Adults	2011	41	10.1523/JNEUROSCI.5794-10.2011
Gina Bisceglio	The genetics of cognitively healthy aging	2012	1	10.1016/j.jalz.2012.05.1826
Mariet Allen	Novel late-onset Alzheimer disease loci variants associate with brain gene expression.	2012	10	10.1212/WNL.0b013e3182605801
Hong-Lei Li	PICALM and CR1 variants are not associated with sporadic Alzheimer's disease in Chinese patients	2011	1
J Mengel-From	Genetic variations in the CLU and PICALM genes are associated with cognitive function in the oldest old	2011	1
Britta Schürmann	Association of the Alzheimer's disease clusterin risk allele with plasma clusterin concentration.	2011	5	10.3233/JAD-2011-110251
Beata Ferencz	The Benefits of Staying Active in Old Age: Physical Activity Counteracts the Negative Influence of PICALM, BIN1, and CLU Risk Alleles on Episodic Memory Functioning.	2014	2	10.1037/a0035465
T. W. Muhleisen	Hippocampal Function in Healthy Carriers of the CLU Alzheimer's Disease Risk Variant	2011	18	10.1523/JNEUROSCI.4960-11.2011
Jonas Mengel-From	Genetic variations in the CLU and PICALM genes are associated with cognitive function in the oldest old.	2010	2	10.1016/j.neurobiolaging.2010.07.016
Huiying Gu	Association of clusterin gene polymorphisms with late-onset Alzheimer's disease	2011	1	10.1159/000331276
Lu Hua Chen	Polymorphisms of CR1, CLU and PICALM confer susceptibility of Alzheimer's disease in a southern Chinese population.	2011	11	10.1016/j.neurobiolaging.2011.09.016
Jonas Mengel-From	Genetic variations in the CLU and PICALM genes are associated with cognitive function in the oldest old.	2011	10	10.1016/j.neurobiolaging.2010.07.016
G M Mullan	Plasma Clusterin Levels and the rs11136000 Genotype in Individuals with Mild Cognitive Impairment and Alzheimer's Disease.	2013	1
Thomas M. Lancaster	Neural hyperactivation in carriers of the Alzheimer's risk variant on the clusterin gene	2011	21	10.1016/j.euroneuro.2011.02.001
Britta Schürmann	Association of the Alzheimer's disease clusterin risk allele with plasma clusterin concentration.	2011	0	-

Evidence compiled by the Personal Genome Project

There are no results from the Personal Genome Project yet. Please come back later.

Publications listed by Genome.gov

First Author	Title	Journal	Publication Date	Trait	p-value	Confidence Interval
Harold D	Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease.	Nat Genet	09/06/2009	Alzheimer's disease	9.0e-10	[1.11-1.22]

Name	rs11136000
Chromosome	8
Position	27607002
Weight of evidence	119

SNP rs11136000

Basic Information

Genotype Frequency

Allele Frequency

Additional Information

Links to SNPedia

Publications on this SNP on the Public Library of Science:

Publications on this SNP on Mendeley

Evidence compiled by the Personal Genome Project

Publications listed by Genome.gov

Users who share this SNP:

Genome Browser

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