openSNP | rs10993994

Links to SNPedia

Title	Summary
rs10993994 C/C	No summary provided.
rs10993994 T/T	Increased prostate cancer risk (odds ratio 1.6)
rs10993994 C/T	Increased prostate cancer risk (odds ratio 1.2)

Note: For some SNPs, testing providers detect the genotype from the opposite strand of DNA, so that the genotypes listed on openSNP don't appear here. In those cases, please replace "A" by "T" or "G" by "C" (and vice-versa).

Publications on this SNP on the Public Library of Science:

First Author	Title	Year of Publication	# of readers
Stella Koutros	Genetic Susceptibility Loci, Pesticide Exposure and Prostate Cancer Risk	2013	3544
Ethan M. Lange	Genome-Wide Association Scan for Variants Associated with Early-Onset Prostate Cancer	2014	2533
Rafael C. Jimenez	myKaryoView: A Light-Weight Client for Visualization of Genomic Data	2011	3186
Sara Lindstrom	Characterizing Associations and SNP-Environment Interactions for GWAS-Identified Prostate Cancer Risk Markers—Results from BPC3	2011	7343
Unhee Lim	Pleiotropy of Cancer Susceptibility Variants on the Risk of Non-Hodgkin Lymphoma: The PAGE Consortium	2014	2465
Shusuke Akamatsu	Reproducibility, Performance, and Clinical Utility of a Genetic Risk Prediction Model for Prostate Cancer in Japanese	2012	3197
Dennis J. Hazelett	Comprehensive Functional Annotation of 77 Prostate Cancer Risk Loci	2014	17668
Christopher A. Haiman	Characterizing Genetic Risk at Known Prostate Cancer Susceptibility Loci in African Americans	2011	6481
Mark M. Pomerantz	Analysis of the 10q11 Cancer Risk Locus Implicates MSMB and NCOA4 in Human Prostate Tumorigenesis	2010	5113
Bi-Qing Li	Identification of Colorectal Cancer Related Genes with mRMR and Shortest Path in Protein-Protein Interaction Network	2012	5705
Hayley C. Whitaker	The rs10993994 Risk Allele for Prostate Cancer Results in Clinically Relevant Changes in Microseminoprotein-Beta Expression in Tissue and Urine	2010	9533
Ilir Agalliu	Characterization of SNPs Associated with Prostate Cancer in Men of Ashkenazic Descent from the Set of GWAS Identified SNPs: Impact of Cancer Family History and Cumulative SNP Risk Prediction	2013	3014
Hanibal Hani Adamo	Characterization of a Gene Expression Signature in Normal Rat Prostate Tissue Induced by the Presence of a Tumor Elsewhere in the Organ	2015	764
Rebecca Gilbert	Incorporating Known Genetic Variants Does Not Improve the Accuracy of PSA Testing to Identify High Risk Prostate Cancer on Biopsy	2015	1717
Liisa Sjöblom	Microseminoprotein-Beta Expression in Different Stages of Prostate Cancer	2016	712

Publications on this SNP on Mendeley

First Author	Title	Pub. Year	# of Readers	DOI
Hong Lou	Fine mapping and functional analysis of a common variant in MSMB on chromosome 10q11.2 associated with prostate cancer susceptibility	2009	18	10.1073/pnas.0902104106
Kevin M Waters	A common prostate cancer risk variant 5' of microseminoprotein-beta (MSMB) is a strong predictor of circulating beta-microseminoprotein (MSP) levels in multiple populations.	2010	3	-
Kevin M Waters	A common prostate cancer risk variant 5' of microseminoprotein-beta (MSMB) is a strong predictor of circulating beta-microseminoprotein (MSP) levels in multiple populations.	2010	0	10.1158/1055-9965.EPI-10-0427
Liesel M FitzGerald	Investigation of the relationship between prostate cancer and MSMB and NCOA4 genetic variants and protein expression.	2013	1	10.1002/humu.22176
Meredith Yeager	Comprehensive resequence analysis of a 97 kb region of chromosome 10q11.2 containing the MSMB gene associated with prostate cancer.	2009	12	10.1007/s00439-009-0723-9
Hayley C. Whitaker	The rs10993994 risk allele for prostate cancer results in clinically relevant changes in microseminoprotein-beta expression in tissue and urine	2010	17	10.1371/journal.pone.0013363
Hong Lou	Fine mapping and functional analysis of a common variant in MSMB on chromosome 10q11.2 associated with prostate cancer susceptibility.	2009	21	10.1073/pnas.0902104106
Mark M Pomerantz	Analysis of the 10q11 Cancer Risk Locus Implicates MSMB and NCOA4 in Human Prostate Tumorigenesis	2010	8	10.1371/journal.pgen.1001204
Kevin M Waters	A common prostate cancer risk variant 5' of MSMB (microseminoprotein-beta) is a strong predictor of circulating MSP (microseminoprotein) in multiple populations.	2010	6	10.1158/1055-9965.EPI-10-0427
Z Kote-Jarai	Mutation analysis of the MSMB gene in familial prostate cancer.	2010	6	10.1038/sj.bjc.6605485
Bin Xu	A functional polymorphism in MSMB gene promoter is associated with prostate cancer risk and serum MSMB expression.	2010	2	-
Nicola J Camp	Replication of the 10q11 and Xp11 prostate cancer risk variants: results from a Utah pedigree-based study.	2009	2	10.1158/1055-9965.EPI-08-0327
Bin Xu	A functional polymorphism in MSMB gene promoter is associated with prostate cancer risk and serum MSMB expression.	2010	3	10.1002/pros.21149
Christopher a Haiman	Levels of beta-microseminoprotein in blood and risk of prostate cancer in multiple populations.	2013	1	10.1093/jnci/djs486
Hayley C Whitaker	The rs10993994 risk allele for prostate cancer results in clinically relevant changes in microseminoprotein-beta expression in tissue and urine.	2010	14	10.1371/journal.pone.0013363
Hong Lou	Fine mapping and functional analysis of a common variant in MSMB on chromosome 10q11.2 associated with prostate cancer susceptibility.	2009	1	10.1073/pnas.0902104106
Mark M Pomerantz	Analysis of the 10q11 cancer risk locus implicates MSMB and NCOA4 in human prostate tumorigenesis.	2010	8	10.1371/journal.pgen.1001204
Bao-Li Chang	Fine mapping association study and functional analysis implicate a SNP in MSMB at 10q11 as a causal variant for prostate cancer risk	2009	8	10.1093/hmg/ddp035
Simon M Collin	Associations of folate, vitamin B12, homocysteine, and folate-pathway polymorphisms with prostate-specific antigen velocity in men with localized prostate cancer.	2010	2	-
Xing Xu	Polymorphisms at the Microseminoprotein-beta locus associated with physiologic variation in beta-microseminoprotein and prostate-specific antigen levels.	2010	1	10.1158/1055-9965.EPI-10-0431
Christopher A Haiman	Levels of beta-microseminoprotein in blood and risk of prostate cancer in multiple populations.	2013	1	10.1093/jnci/djs486
Z Kote-Jarai	Mutation analysis of the MSMB gene in familial prostate cancer.	2010	8	10.1038/sj.bjc.6605485
Meredith Yeager	Comprehensive resequence analysis of a 97 kb region of chromosome 10q11.2 containing the MSMB gene associated with prostate cancer	2009	12	10.1007/s00439-009-0723-9
Bao-Li Chang	Fine mapping association study and functional analysis implicate a SNP in MSMB at 10q11 as a causal variant for prostate cancer risk.	2009	10	10.1093/hmg/ddp035
Liesel M FitzGerald	Investigation of the relationship between prostate cancer and MSMB and NCOA4 genetic variants and protein expression.	2013	3	10.1002/humu.22176
Hayley C Whitaker	The rs10993994 Risk Allele for Prostate Cancer Results in Clinically Relevant Changes in Microseminoprotein-Beta Expression in Tissue and Urine	2010	12	10.1371/journal.pone.0013363
A Dahlman	Effect of androgen deprivation therapy on the expression of prostate cancer biomarkers MSMB and MSMB-binding protein CRISP3.	2010	4	-
Wei Wu	Association of prostate cancer susceptibility variant (MSMB) rs10993994 with risk of spermatogenic failure	2013	1	10.1016/j.gene.2013.03.142
Wei Wu	Association of prostate cancer susceptibility variant (MSMB) rs10993994 with risk of spermatogenic failure.	2013	1	10.1016/j.gene.2013.03.142
Nicola J Camp	Replication of the 10q11 and Xp11 prostate cancer risk variants: results from a Utah pedigree-based study.	2009	2	-
A Dahlman	Effect of androgen deprivation therapy on the expression of prostate cancer biomarkers MSMB and MSMB-binding protein CRISP3.	2010	5	10.1038/pcan.2010.25

Evidence compiled by the Personal Genome Project

There are no results from the Personal Genome Project yet. Please come back later.

Publications listed by Genome.gov

First Author	Title	Journal	Publication Date	Trait	p-value	Confidence Interval
Thomas G	Multiple loci identified in a genome-wide association study of prostate cancer.	Nat Genet	02/10/2008	Prostate cancer	7.0e-13	[1.04-1.29]
Eeles RA	Multiple newly identified loci associated with prostate cancer susceptibility.	Nat Genet	02/10/2008	Prostate cancer	9.0e-29	[1.17-1.34]
Gudmundsson J	Genetic correction of PSA values using sequence variants associated with PSA levels.	Sci Transl Med	12/15/2010	Prostate-specific antigen levels	7.0e-13	[NR] % increase

Name	rs10993994
Chromosome	10
Position	46046326
Weight of evidence	82

SNP rs10993994

Basic Information

Genotype Frequency

Allele Frequency

Additional Information

Links to SNPedia

Publications on this SNP on the Public Library of Science:

Publications on this SNP on Mendeley

Evidence compiled by the Personal Genome Project

Publications listed by Genome.gov

Users who share this SNP:

Genome Browser

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