openSNP | rs10830963

Links to SNPedia

Title	Summary
rs10830963 C/C	Normal risk of type-2 diabetes
rs10830963 C/G	Increased type-2 diabetes risk; higher gestational diabetes risk
rs10830963 G/G	Increased type-2 diabetes risk; higher gestational diabetes risk

Note: For some SNPs, testing providers detect the genotype from the opposite strand of DNA, so that the genotypes listed on openSNP don't appear here. In those cases, please replace "A" by "T" or "G" by "C" (and vice-versa).

Publications on this SNP on the Public Library of Science:

First Author	Title	Year of Publication	# of readers
Silke A. Herzberg-Schäfer	Evaluation of Fasting State-/Oral Glucose Tolerance Test-Derived Measures of Insulin Release for the Detection of Genetically Impaired β-Cell Function	2010	8521
Haoran Wang	Large Scale Meta-Analyses of Fasting Plasma Glucose Raising Variants in GCK, GCKR, MTNR1B and G6PC2 and Their Impacts on Type 2 Diabetes Mellitus Risk	2013	3846
Shunyao Liao	Association of Genetic Variants of Melatonin Receptor 1B with Gestational Plasma Glucose Level and Risk of Glucose Intolerance in Pregnant Chinese Women	2012	3311
Inga Prokopenko	A Central Role for GRB10 in Regulation of Islet Function in Man	2014	8990
Claudia Langenberg	Gene-Lifestyle Interaction and Type 2 Diabetes: The EPIC InterAct Case-Cohort Study	2014	20508
Anthony G. Comuzzie	Novel Genetic Loci Identified for the Pathophysiology of Childhood Obesity in the Hispanic Population	2012	15677
Amélie Bonnefond	What Is the Contribution of Two Genetic Variants Regulating VEGF Levels to Type 2 Diabetes Risk and to Microvascular Complications?	2013	3047
Katarzyna Linder	Allele Summation of Diabetes Risk Genes Predicts Impaired Glucose Tolerance in Female and Obese Individuals	2012	3246
Anders Borglykke	Genetic Variant SCL2A2 Is Associated with Risk of Cardiovascular Disease – Assessing the Individual and Cumulative Effect of 46 Type 2 Diabetes Related Genetic Variants	2012	2487
John R. B. Perry	Stratifying Type 2 Diabetes Cases by BMI Identifies Genetic Risk Variants in LAMA1 and Enrichment for Risk Variants in Lean Compared to Obese Cases	2012	19233
Harald Staiger	Polymorphisms within the Novel Type 2 Diabetes Risk Locus MTNR1B Determine β-Cell Function	2008	4738
Qing Xia	Association between the Melatonin Receptor 1B Gene Polymorphism on the Risk of Type 2 Diabetes, Impaired Glucose Regulation: A Meta-Analysis	2012	3527
Hongyan Mao	Meta-Analysis of the Relationship between Common Type 2 Diabetes Risk Gene Variants with Gestational Diabetes Mellitus	2012	7343
Birgit-Christiane Zyriax	The Association of Genetic Markers for Type 2 Diabetes with Prediabetic Status - Cross-Sectional Data of a Diabetes Prevention Trial	2013	4027
Robert Wagner	Glucose-Raising Genetic Variants in MADD and ADCY5 Impair Conversion of Proinsulin to Insulin	2011	4737
Claudia Ha Ting Tam	Common Polymorphisms in MTNR1B, G6PC2 and GCK Are Associated with Increased Fasting Plasma Glucose and Impaired Beta-Cell Function in Chinese Subjects	2010	4641
Min Xu	Combined Effects of 19 Common Variations on Type 2 Diabetes in Chinese: Results from Two Community-Based Studies	2010	5222
Toshihiko Ohshige	Association of New Loci Identified in European Genome-Wide Association Studies with Susceptibility to Type 2 Diabetes in the Japanese	2011	5213
Jose C. Florez	Effects of Genetic Variants Previously Associated with Fasting Glucose and Insulin in the Diabetes Prevention Program	2012	5101
Harald Staiger	Polymorphisms within the Novel Type 2 Diabetes Risk Locus MTNR1B Determine β-Cell Function	2008	6672
Qi Zhao	Cross-Sectional and Longitudinal Replication Analyses of Genome-Wide Association Loci of Type 2 Diabetes in Han Chinese	2014	2631
Ying Wang	Association of Six Single Nucleotide Polymorphisms with Gestational Diabetes Mellitus in a Chinese Population	2011	5772
Cheng Hu	Effects of GCK, GCKR, G6PC2 and MTNR1B Variants on Glucose Metabolism and Insulin Secretion	2010	4144
Cheng Hu	Variants from GIPR, TCF7L2, DGKB, MADD, CRY2, GLIS3, PROX1, SLC30A8 and IGF1 Are Associated with Glucose Metabolism in the Chinese	2010	5028
Simon D. Rees	Effects of 16 Genetic Variants on Fasting Glucose and Type 2 Diabetes in South Asians: ADCY5 and GLIS3 Variants May Predispose to Type 2 Diabetes	2011	5111
Xiaomu Kong	Association of Genetic Variants with Isolated Fasting Hyperglycaemia and Isolated Postprandial Hyperglycaemia in a Han Chinese Population	2013	3152
Jinghui Yang	Genetic Association Study with Metabolic Syndrome and Metabolic-Related Traits in a Cross-Sectional Sample and a 10-Year Longitudinal Sample of Chinese Elderly Population	2014	2701
Neelam Hassanali	Evaluation of Common Type 2 Diabetes Risk Variants in a South Asian Population of Sri Lankan Descent	2014	2404
Maria A. Matuszek	Increased Insulin following an Oral Glucose Load, Genetic Variation near the Melatonin Receptor MTNR1B, but No Biochemical Evidence of Endothelial Dysfunction in Young Asian Men and Women	2015	1455
Alicia Huerta-Chagoya	Genetic Determinants for Gestational Diabetes Mellitus and Related Metabolic Traits in Mexican Women	2015	5509
Celia G. Walker	Modelling the Interplay between Lifestyle Factors and Genetic Predisposition on Markers of Type 2 Diabetes Mellitus Risk	2015	3377
Momoko Horikoshi	Discovery and Fine-Mapping of Glycaemic and Obesity-Related Trait Loci Using High-Density Imputation	2015	5181
Xiaomu Kong	The Association of Type 2 Diabetes Loci Identified in Genome-Wide Association Studies with Metabolic Syndrome and Its Components in a Chinese Population with Type 2 Diabetes	2015	2999
Isak Sundberg	Salivary Melatonin in Relation to Depressive Symptom Severity in Young Adults	2016	636

Publications on this SNP on Mendeley

First Author	Title	Pub. Year	# of Readers	DOI
Zheng Xiaofeng	Effect of Xiaoke Antang Formula on Insulin Receptors in Patients with Type 2 Diabetes Mellitus	2009	4	-
Margarita Vlassi	The rs10830963 variant of melatonin receptor MTNR1B is associated with increased risk for gestational diabetes mellitus in a Greek population.	2012	1
Harald Staiger	Polymorphisms within the Novel Type 2 Diabetes Risk Locus MTNR1B Determine β-Cell Function	2008	15	10.1371/journal.pone.0003962
Laura J Rasmussen-Torvik	Fasting Glucose GWAS Candidate Region Analysis Across Ethnic Groups in the Multiethnic Study of Atherosclerosis (MESA).	2012	6	10.1002/gepi.21632
Harald Staiger	Polymorphisms within the novel type 2 diabetes risk locus MTNR1B determine beta-cell function.	2008	17	10.1371/journal.pone.0003962
Renuka Natarajan	Melatonin pathway genes are associated with progressive subtypes and disability status in multiple sclerosis among Finnish patients.	2012	5	10.1016/j.jneuroim.2012.05.014
Jason Y Kim	Melatonin receptor 1 B polymorphisms associated with the risk of gestational diabetes mellitus.	2011	9	10.1186/1471-2350-12-82
Claudia Ha Ting Tam	Common polymorphisms in MTNR1B, G6PC2 and GCK are associated with increased fasting plasma glucose and impaired beta-cell function in Chinese subjects.	2010	6	10.1371/journal.pone.0011428
M Y Kan	Two susceptible diabetogenic variants near/in MTNR1B are associated with fasting plasma glucose in a Han Chinese cohort.	2010	1	10.1111/j.1464-5491.2010.02975.x
Lesa M Nelson	Genetic variants in melatonin synthesis and signaling pathway are not associated with adolescent idiopathic scoliosis.	2011	3	10.1097/BRS.0b013e3181e8755b
Jie Yun Song	Association of the rs10830963 polymorphism in MTNR1B with fasting glucose levels in Chinese children and adolescents	2011	3	10.1159/000329306
Jie-Yun Song	Association of the rs10830963 polymorphism in MTNR1B with fasting glucose levels in Chinese children and adolescents.	2011	3	-
Angeliki Karamitri	[Involvement of melatonin MT2 receptor mutants in type 2 diabetes development].	2013	1	-
C Langenberg	Common genetic variation in the melatonin receptor 1B gene (MTNR1B) is associated with decreased early-phase insulin response.	2009	10	10.1007/s00125-009-1392-x
John C Chambers	Common genetic variation near melatonin receptor MTNR1B contributes to raised plasma glucose and increased risk of type 2 diabetes among Indian Asians and European Caucasians.	2009	19	10.2337/db08-1805
Harald Staiger	Polymorphisms within the Novel Type 2 Diabetes Risk Locus MTNR1B Determine β-Cell Function	2008	0	10.1371/journal.pone.0003962
Thomas Reinehr	Relationship between MTNR1B (melatonin receptor 1B gene) polymorphism rs10830963 and glucose levels in overweight children and adolescents.	2011	5	10.1111/j.1399-5448.2010.00738.x
Clara Kelliny	Common Genetic Determinants of Glucose Homeostasis in Healthy Children	2009	3	10.2337/db09-0374
De Jonghe A.; De Rooij S.; Van Munster B.	Melatonin receptor 1b and risk of delirium	2011	4	10.1016/j.eurger.2011.06.002
F Takeuchi	Common variants at the GCK, GCKR, G6PC2-ABCB11 and MTNR1B loci are associated with fasting glucose in two Asian populations.	2010	6	10.1007/s00125-009-1595-1
K Dietrich	Association and evolutionary studies of the melatonin receptor 1B gene (MTNR1B) in the self-contained population of Sorbs from Germany.	2011	1	10.1111/j.1464-5491.2011.03374.x
C Langenberg	Common genetic variation in the melatonin receptor 1B gene (MTNR1B) is associated with decreased early-phase insulin response.	2009	8	-
Thomas Sparsø	G-allele of Intronic rs10830963 in MTNR1B Confers Increased Risk of Impaired Fasting Glycemia and Type 2 Diabetes Through an Impaired Glucose-Stimulated Insulin Release	2009	6	10.2337/db08-1660
Cheng Hu	Effects of GCK, GCKR, G6PC2 and MTNR1B variants on glucose metabolism and insulin secretion.	2010	8	10.1371/journal.pone.0011761
Simon D Rees	Effects of 16 genetic variants on fasting glucose and type 2 diabetes in South Asians : ADCY5 and GLIS3 variants may predispose to type 2 diabetes	2011	5	10.1371/journal.pone.0024710
Thomas Sparsø	G-allele of intronic rs10830963 in MTNR1B confers increased risk of impaired fasting glycemia and type 2 diabetes through an impaired glucose-stimulated insulin release: studies involving 19,605 Europeans.	2009	10	10.2337/db08-1660
Chen Liu	MTNR1B rs10830963 is associated with fasting plasma glucose, HbA1C and impaired beta-cell function in Chinese Hans from Shanghai.	2010	9	10.1186/1471-2350-11-59
Chen Liu	MTNR1B rs10830963 is associated with fasting plasma glucose, HbA1C and impaired beta-cell function in Chinese Hans from Shanghai	2010	7	10.1186/1471-2350-11-59
Irina Elovaara	Melatonin pathway genes are associated with progressive subtypes and disability status in multiple sclerosis among Finnish patients	2012	8	10.1016/j.jneuroim.2012.05.014
Thomas Reinehr	Relationship between MTNR1B (melatonin receptor 1B gene) polymorphism rs10830963 and glucose levels in overweight children and adolescents.	2011	4	10.1111/j.1399-5448.2010.00738.x
Kazuyuki Tobe	Variations with modest effects have an important role in the genetic background of type 2 diabetes and diabetes-related traits	2012	4	10.1038/jhg.2012.110
Laura J Rasmussen-Torvik	Fasting glucose GWAS candidate region analysis across ethnic groups in the Multiethnic Study of Atherosclerosis (MESA).	2012	8	10.1002/gepi.21632
Laura J Rasmussen-Torvik	Fasting glucose GWAS candidate region analysis across ethnic groups in the Multiethnic Study of Atherosclerosis (MESA).	2012	6	10.1002/gepi.21632
S. de Rooija	Polymorphisms in the Melatonin Receptor 1B Gene and the Risk of Delirium	2012	2	10.1159/000339231
Jie-Yun Song	Association of the rs10830963 polymorphism in MTNR1B with fasting glucose levels in Chinese children and adolescents.	2011	3	10.1159/000329306
Yan Ling	A common polymorphism rs3781637 in MTNR1B is associated with type 2 diabetes and lipids levels in Han Chinese individuals	2011	3	10.1186/1475-2840-10-27
L Olsson	No effect by the common gene variant rs10830963 of the melatonin receptor 1B on the association between sleep disturbances and type 2 diabetes: results from the Nord-Trøndelag Health Study.	2011	3	-
T Rönn	A common variant in MTNR1B, encoding melatonin receptor 1B, is associated with type 2 diabetes and fasting plasma glucose in Han Chinese individuals.	2009	6	-
Margarita Vlassi	The rs10830963 variant of melatonin receptor MTNR1B is associated with increased risk for gestational diabetes mellitus in a Greek population.	2012	1	-
M Y Kan	Two susceptible diabetogenic variants near/in MTNR1B are associated with fasting plasma glucose in a Han Chinese cohort.	2010	1	-
Inga Prokopenko	Variants in MTNR1B influence fasting glucose levels.	2009	76	10.1038/ng.290
Christina Holzapfel	Association of a melatonin receptor 1B (MTNR1B) gene variant with fasting glucose and 3 HOMA-B in children and adolescents of high BMI-SDS groups	2010	1
Chao Li	Association of rs10830963 and rs10830962 SNPs in the melatonin receptor (MTNR1B) gene among Han Chinese women with polycystic ovary syndrome.	2011	4	10.1093/molehr/gaq087
Anna Maria Siega-Riz	74: Maternal genotype and gestational diabetes	2012	1	10.1016/j.ajog.2011.10.100
T Rönn	A common variant in MTNR1B, encoding melatonin receptor 1B, is associated with type 2 diabetes and fasting plasma glucose in Han Chinese individuals.	2009	7	10.1007/s00125-009-1297-8
J.J. Mulvihill	A low frequency variant within the GWAS locus of MTNR1B affects fasting glucose concentrations: Genetic risk is modulated by obesity	2012	4	10.1016/j.numecd.2011.01.006
Stephanie C E Schuit	Estrogen Receptor {alpha} Gene Polymorphisms and Risk of Myocardial Infarction	2004	1
Hayato Fujita	Variations with modest effects have an important role in the genetic background of type 2 diabetes and diabetes-related traits.	2012	3	10.1038/jhg.2012.110
L J Rasmussen-Torvik	Association of a fasting glucose genetic risk score with subclinical atherosclerosis: The Atherosclerosis Risk in Communities (ARIC) study	2011	2	db10-0839 [pii]\r10.2337/db10-0839
J Y Kim	Melatonin receptor 1 B polymorphisms associated with the risk of gestational diabetes mellitus	2011	1	Artn 82\nDoi 10.1186/1471-2350-12-82

Evidence compiled by the Personal Genome Project

There are no results from the Personal Genome Project yet. Please come back later.

Publications listed by Genome.gov

First Author	Title	Journal	Publication Date	Trait	p-value	Confidence Interval
Rasmussen-Torvik LJ	Fasting glucose GWAS candidate region analysis across ethnic groups in the Multiethnic Study of Atherosclerosis (MESA).	Genet Epidemiol	04/16/2012	Fasting plasma glucose	1.0e-12 (Fasting glucose)	[1.01-1.75] mg/dL increase
Dupuis J	New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk.	Nat Genet	01/17/2010	Fasting glucose-related traits	1.0e-100 (FPG)	NR
Kettunen J	Genome-wide association study identifies multiple loci influencing human serum metabolite levels.	Nat Genet	01/29/2012	Metabolite levels	3.0e-11 (Glc)	[0.1-0.18] unit increase
Manning AK	A genome-wide approach accounting for body mass index identifies genetic variants influencing fasting glycemic traits and insulin resistance.	Nat Genet	05/13/2012	Fasting glucose-related traits (interaction with BMI)	1.0e-100	NR
Prokopenko I	Variants in MTNR1B influence fasting glucose levels.	Nat Genet	12/01/2008	Fasting plasma glucose	3.0e-50	[0.06-0.08] mmol/l increase

Name	rs10830963
Chromosome	11
Position	92975544
Weight of evidence	143

SNP rs10830963

Basic Information

Genotype Frequency

Allele Frequency

Additional Information

Links to SNPedia

Publications on this SNP on the Public Library of Science:

Publications on this SNP on Mendeley

Evidence compiled by the Personal Genome Project

Publications listed by Genome.gov

Users who share this SNP:

Genome Browser

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