openSNP | rs10811661

Links to SNPedia

Title	Summary
rs10811661 C/C	Normal
rs10811661 T/T	1.2x increased risk for type-2 diabetes
rs10811661 C/T	1.2x increased risk for type-2 diabetes

Note: For some SNPs, testing providers detect the genotype from the opposite strand of DNA, so that the genotypes listed on openSNP don't appear here. In those cases, please replace "A" by "T" or "G" by "C" (and vice-versa).

Publications on this SNP on the Public Library of Science:

First Author	Title	Year of Publication	# of readers
Xiao Ou Shu	Identification of New Genetic Risk Variants for Type 2 Diabetes	2010	12815
John R. B. Perry	Stratifying Type 2 Diabetes Cases by BMI Identifies Genetic Risk Variants in LAMA1 and Enrichment for Risk Variants in Lean Compared to Obese Cases	2012	19233
Slavica Pecioska	Association between Type 2 Diabetes Loci and Measures of Fatness	2010	16908
Anders Borglykke	Genetic Variant SCL2A2 Is Associated with Risk of Cardiovascular Disease – Assessing the Individual and Cumulative Effect of 46 Type 2 Diabetes Related Genetic Variants	2012	2487
Stéphane Cauchi	Post Genome-Wide Association Studies of Novel Genes Associated with Type 2 Diabetes Show Gene-Gene Interaction and High Predictive Value	2008	12155
Yan Liu	INK4/ARF Transcript Expression Is Associated with Chromosome 9p21 Variants Linked to Atherosclerosis	2009	9514
Vipin Gupta	Association Study of 25 Type 2 Diabetes Related Loci with Measures of Obesity in Indian Sib Pairs	2013	3049
Jie Wen	Investigation of Type 2 Diabetes Risk Alleles Support CDKN2A/B, CDKAL1, and TCF7L2 As Susceptibility Genes in a Han Chinese Cohort	2010	6722
Yi-Cheng Chang	Validation of Type 2 Diabetes Risk Variants Identified by Genome-Wide Association Studies in Han Chinese Population: A Replication Study and Meta-Analysis	2014	3877
Yun Qian	Cumulative Effect and Predictive Value of Genetic Variants Associated with Type 2 Diabetes in Han Chinese: A Case-Control Study	2015	2756
John P.A. Ioannidis	Heterogeneity in Meta-Analyses of Genome-Wide Association Investigations	2007	10623
Steven Haney	RNAi Screening in Primary Human Hepatocytes of Genes Implicated in Genome-Wide Association Studies for Roles in Type 2 Diabetes Identifies Roles for CAMK1D and CDKAL1, among Others, in Hepatic Glucose Regulation	2013	4518
Arne S. Schaefer	Identification of a Shared Genetic Susceptibility Locus for Coronary Heart Disease and Periodontitis	2009	14022
Raquel Villegas	Joint Effect of Genetic and Lifestyle Risk Factors on Type 2 Diabetes Risk among Chinese Men and Women	2012	3376
Claudia Langenberg	Gene-Lifestyle Interaction and Type 2 Diabetes: The EPIC InterAct Case-Cohort Study	2014	20508
Timothy R. Braun	A Replication Study of GWAS-Derived Lipid Genes in Asian Indians: The Chromosomal Region 11q23.3 Harbors Loci Contributing to Triglycerides	2012	5196
Min Xu	Combined Effects of 19 Common Variations on Type 2 Diabetes in Chinese: Results from Two Community-Based Studies	2010	5222
Christopher G. Bell	Integrated Genetic and Epigenetic Analysis Identifies Haplotype-Specific Methylation in the FTO Type 2 Diabetes and Obesity Susceptibility Locus	2010	20501
Xiaomu Kong	Association of Genetic Variants with Isolated Fasting Hyperglycaemia and Isolated Postprandial Hyperglycaemia in a Han Chinese Population	2013	3152
Claudia H. T. Tam	Use of Net Reclassification Improvement (NRI) Method Confirms The Utility of Combined Genetic Risk Score to Predict Type 2 Diabetes	2013	5559
Ying Wang	Association of Six Single Nucleotide Polymorphisms with Gestational Diabetes Mellitus in a Chinese Population	2011	5772
Christiane Winkler	Lack of Association of Type 2 Diabetes Susceptibility Genotypes and Body Weight on the Development of Islet Autoimmunity and Type 1 Diabetes	2012	3098
Cheng Hu	PPARG, KCNJ11, CDKAL1, CDKN2A-CDKN2B, IDE-KIF11-HHEX, IGF2BP2 and SLC30A8 Are Associated with Type 2 Diabetes in a Chinese Population	2009	8909
Yann C. Klimentidis	Identification of Allelic Heterogeneity at Type-2 Diabetes Loci and Impact on Prediction	2014	1964
André Gustavo P. Sousa	Genetic Variants of Diabetes Risk and Incident Cardiovascular Events in Chronic Coronary Artery Disease	2011	2482
Michael S. Cunnington	Chromosome 9p21 SNPs Associated with Multiple Disease Phenotypes Correlate with ANRIL Expression	2010	17779
Neelam Hassanali	Evaluation of Common Type 2 Diabetes Risk Variants in a South Asian Population of Sri Lankan Descent	2014	2404
Yudi Pawitan	How Many Genetic Variants Remain to Be Discovered?	2009	4574
Badri Padhukasahasram	Presymptomatic Risk Assessment for Chronic Non-Communicable Diseases	2010	9456
Jinghui Yang	Genetic Association Study with Metabolic Syndrome and Metabolic-Related Traits in a Cross-Sectional Sample and a 10-Year Longitudinal Sample of Chinese Elderly Population	2014	2701
Arne S. Schaefer	Identification of a Shared Genetic Susceptibility Locus for Coronary Heart Disease and Periodontitis	2009	18624
Marie Louise Max Andersen	Complex Multi-Block Analysis Identifies New Immunologic and Genetic Disease Progression Patterns Associated with the Residual β-Cell Function 1 Year after Diagnosis of Type 1 Diabetes	2013	2989
Birgit-Christiane Zyriax	The Association of Genetic Markers for Type 2 Diabetes with Prediabetic Status - Cross-Sectional Data of a Diabetes Prevention Trial	2013	4027
Guillaume Paré	Novel Association of HK1 with Glycated Hemoglobin in a Non-Diabetic Population: A Genome-Wide Evaluation of 14,618 Participants in the Women's Genome Health Study	2008	6594
Qi Zhao	Cross-Sectional and Longitudinal Replication Analyses of Genome-Wide Association Loci of Type 2 Diabetes in Han Chinese	2014	2631
Alicia Huerta-Chagoya	Genetic Determinants for Gestational Diabetes Mellitus and Related Metabolic Traits in Mexican Women	2015	5509
Fotios Drenos	Networks in Coronary Heart Disease Genetics As a Step towards Systems Epidemiology	2015	1763
Sameer D. Pant	Comparative Analyses of QTLs Influencing Obesity and Metabolic Phenotypes in Pigs and Humans	2015	3016
Xiaomu Kong	The Association of Type 2 Diabetes Loci Identified in Genome-Wide Association Studies with Metabolic Syndrome and Its Components in a Chinese Population with Type 2 Diabetes	2015	2999
Katherine Angela Benson	A HuGE Review and Meta-Analyses of Genetic Associations in New Onset Diabetes after Kidney Transplantation	2016	2223
Zahra N. Sohani	Risk Alleles in/near ADCY5, ADRA2A, CDKAL1, CDKN2A/B, GRB10, and TCF7L2 Elevate Plasma Glucose Levels at Birth and in Early Childhood: Results from the FAMILY Study	2016	1521
Nagaraja M. Phani	Replication and Relevance of Multiple Susceptibility Loci Discovered from Genome Wide Association Studies for Type 2 Diabetes in an Indian Population	2016	1419
Michael S. Cunnington	Chromosome 9p21 SNPs Associated with Multiple Disease Phenotypes Correlate with ANRIL Expression	2010	17932
Hadi Zarkoob	Utilization of genetic data can improve the prediction of type 2 diabetes incidence in a Swedish cohort	2017	1159
Sarah L. O’Beirne	Type 2 Diabetes Risk Allele Loci in the Qatari Population	2016	2145
Christoph Nowak	Effect of Insulin Resistance on Monounsaturated Fatty Acid Levels: A Multi-cohort Non-targeted Metabolomics and Mendelian Randomization Study	2016	3786

Publications on this SNP on Mendeley

First Author	Title	Pub. Year	# of Readers	DOI
Ying Wu	Common variants in CDKAL1, CDKN2A/B, IGF2BP2, SLC30A8, and HHEX/IDE genes are associated with type 2 diabetes and impaired fasting glucose in a Chinese Han population.	2008	10	10.2337/db08-0047
K A Langberg	Single nucleotide polymorphisms in JAZF1 and BCL11A gene are nominally associated with type 2 diabetes in African-American families from the GENNID study	2012	1	-
Ping An	Epistatic interactions of CDKN2B-TCF7L2 for risk of type 2 diabetes and of CDKN2B-JAZF1 for triglyceride/high-density lipoprotein ratio longitudinal change: evidence from the Framingham Heart Study.	2009	5	10.1186/1753-6561-3-s7-s71
A. J. McKnight	SNP in the genome-wide association study hotspot on chromosome 9p21 confers susceptibility to diabetic nephropathy in type 1 diabetes	2012	2	10.1007/s00125-012-2587-0
M L Hribal	Glucose tolerance, insulin sensitivity and insulin release in European non-diabetic carriers of a polymorphism upstream of CDKN2A and CDKN2B.	2011	8	10.1007/s00125-010-2038-8
Fagerholm E	SNP in the genome-wide association study hotspot on chromosome 9p21 confers susceptibility to diabetic nephropathy in type 1 diabetes	2012	0	-
Francesca Gori	Common genetic variants on chromosome 9p21 are associated with myocardial infarction and type 2 diabetes in an Italian population.	2010	3	10.1186/1471-2350-11-60
Dharambir K Sanghera	Impact of nine common type 2 diabetes risk polymorphisms in Asian Indian Sikhs: PPARG2 (Pro12Ala), IGF2BP2, TCF7L2 and FTO variants confer a significant risk.	2008	32	10.1186/1471-2350-9-59
H M Björck	Association of genetic variation on chromosome 9p21.3 and arterial stiffness.	2009	2	JIM2020 [pii]\r10.1111/j.1365-2796.2008.02020.x
Fagerholm E	SNP in the genome-wide association study hotspot on chromosome 9p21 confers susceptibility to diabetic nephropathy in type 1 diabetes	2012	2	-
Yukio Horikawa	Replication of genome-wide association studies of type 2 diabetes susceptibility in Japan.	2008	20	10.1210/jc.2008-0452
Anna Helgadottir	The same sequence variant on 9p21 associates with myocardial infarction, abdominal aortic aneurysm and intracranial aneurysm.	2008	58	-
H M Björck	Association of genetic variation on chromosome 9p21.3 and arterial stiffness.	2009	2	-
Rita Nemr	Replication study of common variants in CDKAL1 and CDKN2A/2B genes associated with type 2 diabetes in Lebanese Arab population	2012	1	10.1016/j.diabres.2011.11.002
Ying Wu	Common Variants in CDKAL1, CDKN2A/B, IGF2BP2, SLC30A8, and HHEX/IDE Genes Are Associated With Type 2 Diabetes and Impaired Fasting Glucose in a Chinese Han Population	2008	0	10.2337/db08-0047
Steven C Elbein	Single nucleotide polymorphisms in JAZF1 and BCL11A gene are nominally associated with type 2 diabetes in African-American families from the GENNID study	2012	6	10.1038/jhg.2011.133
Y Wu	Common variants in CDKAL1, CDKN2A/B, IGF2BP2, SLC30A8, and HHEX/IDE genes are associated with type 2 diabetes and impaired fasting glucose in a Chinese Han population	2008	3
M Horikoshi	Variations in the HHEX gene are associated with increased risk of type 2 diabetes in the Japanese population.	2007	21	10.1007/s00125-007-0827-5
M L Hribal	Glucose tolerance, insulin sensitivity and insulin release in European non-diabetic carriers of a polymorphism upstream of CDKN2A and CDKN2B.	2011	7	-
Qian Ren	Search for genetic determinants of sulfonylurea efficacy in type 2 diabetic patients from China.	2014	1	10.1007/s00125-013-3146-z
Kaisa Silander	Worldwide patterns of haplotype diversity at 9p21.3, a locus associated with type 2 diabetes and coronary heart disease	2009	4	10.1186/gm51

Evidence compiled by the Personal Genome Project

There are no results from the Personal Genome Project yet. Please come back later.

Publications listed by Genome.gov

First Author	Title	Journal	Publication Date	Trait	p-value	Confidence Interval
Scott LJ	A genome-wide association study of type 2 diabetes in Finns detects multiple susceptibility variants.	Science	04/26/2007	Type 2 diabetes	8.0e-15 (DGI+FUSION+WTCCC)	[1.14-1.25]

Users who share this SNP:

John Lloyd Scharf

TT is risk allele

03.12.2011 16:56

rs10811661 CDKN2A/B 9 T 1.20 7.80E-15 0.023 7.76

Genotype Score in Addition to Common Risk Factors for Prediction of Type 2 Diabetes
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2746946/
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2746946/bin/NIHMS89176-supplement-supplement.pdf
Supplementary Table 4. SNPs Ranked by SNP Weight for Weighted Genotype Score

Name	rs10811661
Chromosome	9
Position	22134095
Weight of evidence	130

SNP rs10811661

Basic Information

Genotype Frequency

Allele Frequency

Additional Information