openSNP | rs1076560

Links to SNPedia

Title	Summary
rs1076560 A/A	Influences working memory
rs1076560 C/C	Normal
rs1076560 A/C	1.3x increased risk for alcoholism

Note: For some SNPs, testing providers detect the genotype from the opposite strand of DNA, so that the genotypes listed on openSNP don't appear here. In those cases, please replace "A" by "T" or "G" by "C" (and vice-versa).

Publications on this SNP on the Public Library of Science:

First Author	Title	Year of Publication	# of readers
Didier Jutras-Aswad	Cannabis-Dependence Risk Relates to Synergism between Neuroticism and Proenkephalin SNPs Associated with Amygdala Gene Expression: Case-Control Study	2012	2503
Alessandro Bertolino	Genetically Determined Measures of Striatal D2 Signaling Predict Prefrontal Activity during Working Memory Performance	2010	6286
Patrick C. M. Wong	Linguistic Grammar Learning and DRD2-TAQ-IA Polymorphism	2013	3854
Annabella Di Giorgio	DRD2/CHRNA5 Interaction on Prefrontal Biology and Physiology during Working Memory	2014	3689
Thomas Yvert	Acyl Coenzyme A Synthetase Long-Chain 1 (ACSL1) Gene Polymorphism (rs6552828) and Elite Endurance Athletic Status: A Replication Study	2012	2900
Jonathan Savitz	The Functional DRD3 Ser9Gly Polymorphism (rs6280) Is Pleiotropic, Affecting Reward as Well as Movement	2013	3855
Neema Yazdani	Hnrnph1 Is A Quantitative Trait Gene for Methamphetamine Sensitivity	2015	6045

Publications on this SNP on Mendeley

First Author	Title	Pub. Year	# of Readers	DOI
H Y Tan	Effective connectivity of akt1-mediated dopaminergic working memory networks and its relationship to the pharmacogenetics of cognition in schizophrenia	2011	1
Robert A Moyer	Intronic polymorphisms affecting alternative splicing of human dopamine D2 receptor are associated with cocaine abuse.	2011	9	10.1038/npp.2010.208
Alessandro Bertolino	Genetically determined measures of striatal D2 signaling predict prefrontal activity during working memory performance	2010	40	10.1371/journal.pone.0009348
Robert A Moyer	Intronic polymorphisms affecting alternative splicing of human dopamine D2 receptor are associated with cocaine abuse.	2011	1	10.1038/npp.2010.208
Alessandro Bertolino	Functional variants of the dopamine receptor D2 gene modulate prefronto-striatal phenotypes in schizophrenia.	2009	38	10.1093/brain/awn248
Fabio Sambataro	DRD2 genotype-based variation of default mode network activity and of its relationship with striatal DAT binding.	2013	26	10.1093/schbul/sbr128
Giuseppe Blasi	Functional variation of the dopamine D2 receptor gene is associated with emotional control as well as brain activity and connectivity during emotion processing in humans.	2009	41	-
Alessandro Bertolino	Genetically Determined Measures of Striatal D2 Signaling Predict Prefrontal Activity during Working Memory Performance	2010	28	10.1371/journal.pone.0009348
Y Zhang	Polymorphisms in human dopamine D2 receptor gene affect gene expression, splicing, and neuronal activity during working memory	2007	7	0707106104 [pii]\r10.1073/pnas.0707106104
Toshikazu Sasabe	Association analysis of the dopamine receptor D2 (DRD2) SNP rs1076560 in alcoholic patients	2007	12	10.1016/j.neulet.2006.10.064
Giuseppe Blasi	DRD2/AKT1 interaction on D2 c-AMP independent signaling, attentional processing, and response to olanzapine treatment in schizophrenia.	2011	31	10.1073/pnas.1013535108
Robert A Moyer	Intronic polymorphisms affecting alternative splicing of human dopamine D2 receptor are associated with cocaine abuse.	2011	8	-
Chunming Zheng	Rs1076560, a functional variant of the dopamine D2 receptor gene, confers risk of schizophrenia in Han Chinese	2012	2	10.1016/j.neulet.2012.04.052
R A Moyer	Intronic polymorphisms affecting alternative splicing of human dopamine D2 receptor are associated with cocaine abuse	2011	2	npp2010208 [pii]\n10.1038/npp.2010.208
Y Zhang	Polymorphisms in human dopamine D2 receptor gene affect gene expression, splicing, and neuronal activity during working memory	2007	3	10.1073/pnas.0707106104
Y Zhang	Polymorphisms in human dopamine D2 receptor gene affect gene expression, splicing, and neuronal activity during working memory	2007	1
S S Kaalund	Contrasting changes in DRD1 and DRD2 splice variant expression in schizophrenia and affective disorders, and associations with SNPs in postmortem brain.	2013	6	10.1038/mp.2013.165
Chunming Zheng	Rs1076560, a functional variant of the dopamine D2 receptor gene, confers risk of schizophrenia in Han Chinese.	2012	2	10.1016/j.neulet.2012.04.052
Giuseppe Blasi	Functional variation of the dopamine D2 receptor gene is associated with emotional control as well as brain activity and connectivity during emotion processing in humans.	2009	50	10.1523/JNEUROSCI.3609-09.2009
Barbara Gelao	DRD2 genotype predicts prefrontal activity during working memory after stimulation of D2 receptors with bromocriptine.	2014	3	10.1007/s00213-013-3398-9
Leonardo Fazio	D2 receptor genotype and striatal dopamine signaling predict motor cortical activity and behavior in humans.	2011	18	10.1016/j.neuroimage.2010.11.034
Ying Zhang	Polymorphisms in human dopamine D2 receptor gene affect gene expression, splicing, and neuronal activity during working memory.	2007	48	10.1073/pnas.0707106104
Alessandro Bertolino	Genetically determined interaction between the dopamine transporter and the D2 receptor on prefronto-striatal activity and volume in humans.	2009	35	10.1523/JNEUROSCI.4858-08.2009
Ying Zhang	Polymorphisms in human dopamine D2 receptor gene affect gene expression, splicing, and neuronal activity during working memory.	2007	2	10.1073/pnas.0707106104
Giuseppe Blasi	DRD2/AKT1 interaction on D2 c-AMP independent signaling, attentional processing, and response to olanzapine treatment in schizophrenia.	2011	29	10.1073/pnas.1013535108
Fabio Sambataro	DRD2 Genotype-Based Variation of Default Mode Network Activity and of Its Relationship with Striatal DAT Binding.	2011	16	10.1093/schbul/sbr128
Toshikazu Sasabe	Association analysis of the dopamine receptor D2 (DRD2) SNP rs1076560 in alcoholic patients.	2007	10	-
Leonardo Fazio	D2 receptor genotype and striatal dopamine signaling predict motor cortical activity and behavior in humans	2011	21	10.1016/j.neuroimage.2010.11.034
Chunming Zheng	Rs1076560, a functional variant of the dopamine D2 receptor gene, confers risk of schizophrenia in Han Chinese	2012	2	10.1016/j.neulet.2012.04.052
Alessandro Bertolino	Genetically determined measures of striatal D2 signaling predict prefrontal activity during working memory performance.	2010	37	10.1371/journal.pone.0009348
Ying Zhang	Polymorphisms in human dopamine D2 receptor gene affect gene expression, splicing, and neuronal activity during working memory	2007	2	10.1073/pnas.0707106104
L Fazio	D2 receptor genotype and striatal dopamine signaling predict motor cortical activity and behavior in humans.	2006	4	10.1117/12.664838
Toshikazu Sasabe	Association analysis of the dopamine receptor D2 (DRD2) SNP rs1076560 in alcoholic patients.	2007	13	10.1016/j.neulet.2006.10.064
Leonardo Fazio	D2 receptor genotype and striatal dopamine signaling predict motor cortical activity and behavior in humans.	2011	0	-
Leonardo Fazio	D2 receptor genotype and striatal dopamine signaling predict motor cortical activity and behavior in humans.	2011	15	10.1016/j.neuroimage.2010.11.034
Alessandro Bertolino	Genetically determined interaction between the dopamine transporter and the D2 receptor on prefronto-striatal activity and volume in humans.	2009	35	10.1523/JNEUROSCI.4858-08.2009
Fabio Sambataro	DRD2 genotype-based variation of default mode network activity and of its relationship with striatal DAT binding.	2013	20	10.1093/schbul/sbr128
Saskia Koehler	Resting posterior minus frontal EEG slow oscillations is associated with extraversion and DRD2 genotype	2011	7	10.1016/j.biopsycho.2011.05.006

Evidence compiled by the Personal Genome Project

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Publications listed by Genome.gov

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Name	rs1076560
Chromosome	11
Position	113412966
Weight of evidence	67

SNP rs1076560

Basic Information

Genotype Frequency

Allele Frequency

Additional Information

Links to SNPedia

Publications on this SNP on the Public Library of Science:

Publications on this SNP on Mendeley

Evidence compiled by the Personal Genome Project

Publications listed by Genome.gov

Users who share this SNP:

Genome Browser

Contacts