SNP rs10757278

Basic Information
Name rs10757278
Chromosome 9
Position 22124478
Weight of evidence 129
Additional Information

Links to SNPedia

Title Summary
rs10757278 A/A 0.78x reduced risk for coronary heart disease. 0.77x reduced risk for brain aneurysm and abdominal aortic aneurysm.
rs10757278 G/G 1.6x risk for heart attack; 1.3x risk for abdominal aortic aneurysm and brain aneurysm.
rs10757278 A/G 1.3x risk for heart attack. normal risk for abdominal aortic aneurysm and brain aneurysm.
Note: For some SNPs, testing providers detect the genotype from the opposite strand of DNA, so that the genotypes listed on openSNP don't appear here. In those cases, please replace "A" by "T" or "G" by "C" (and vice-versa).

Publications on this SNP on the Public Library of Science:

First Author Title Year of Publication # of readers
Arne S. Schaefer Identification of a Shared Genetic Susceptibility Locus for Coronary Heart Disease and Periodontitis 2009 14022
Sarah A. Pendergrass Phenome-Wide Association Study (PheWAS) for Detection of Pleiotropy within the Population Architecture using Genomics and Epidemiology (PAGE) Network 2013 14487
Ron Do The Effect of Chromosome 9p21 Variants on Cardiovascular Disease May Be Modified by Dietary Intake: Evidence from a Case/Control and a Prospective Study 2011 34110
Lasse Folkersen Relationship between CAD Risk Genotype in the Chromosome 9p21 Locus and Gene Expression. Identification of Eight New ANRIL Splice Variants 2009 7191
Yan Liu INK4/ARF Transcript Expression Is Associated with Chromosome 9p21 Variants Linked to Atherosclerosis 2009 9514
Lesca M. Holdt Alu Elements in ANRIL Non-Coding RNA at Chromosome 9p21 Modulate Atherogenic Cell Functions through Trans-Regulation of Gene Networks 2013 15227
Frank Beutner Rationale and Design of the Leipzig (LIFE) Heart Study: Phenotyping and Cardiovascular Characteristics of Patients with Coronary Artery Disease 2011 4272
Christin E. Burd Expression of Linear and Novel Circular Forms of an INK4/ARF-Associated Non-Coding RNA Correlates with Atherosclerosis Risk 2010 15860
Anna Szpakowicz Polymorphism of 9p21.3 Locus Is Associated with 5-Year Survival in High-Risk Patients with Myocardial Infarction 2014 1806
Hsiu-Fen Lin Sex Differential Genetic Effect of Chromosome 9p21 on Subclinical Atherosclerosis 2010 2784
Fang Xie Replication of Putative Susceptibility Loci from Genome-Wide Association Studies Associated with Coronary Atherosclerosis in Chinese Han Population 2011 2690
Xiaoqing Ni Association between 9p21 Genomic Markers and Ischemic Stroke Risk: Evidence Based on 21 Studies 2014 1896
Anna Szpakowicz Polymorphism of 9p21.3 Locus Is Associated with 5-Year Survival in High-Risk Patients with Myocardial Infarction 2013 1873
Michael S. Cunnington Chromosome 9p21 SNPs Associated with Multiple Disease Phenotypes Correlate with ANRIL Expression 2010 17779
Melinda Butsch Kovacic Identification of KIF3A as a Novel Candidate Gene for Childhood Asthma Using RNA Expression and Population Allelic Frequencies Differences 2011 3933
Arne S. Schaefer Identification of a Shared Genetic Susceptibility Locus for Coronary Heart Disease and Periodontitis 2009 18624
Perttu P. Salo Genetic Variants on Chromosome 1p13.3 Are Associated with Non-ST Elevation Myocardial Infarction and the Expression of DRAM2 in the Finnish Population 2015 1938
Hirofumi Nakaoka Allelic Imbalance in Regulation of ANRIL through Chromatin Interaction at 9p21 Endometriosis Risk Locus 2016 4299

Publications on this SNP on Mendeley

First Author Title Pub. Year # of Readers DOI
Andrzej Bochenek The rs10757278 Polymorphism of the 9p21.3 Locus Is Associated with Premature Coronary Artery Disease in Polish Patients 2012 1 10.1089/gtmb.2012.0046
Olivier Harismendy 9p21 DNA variants associated with coronary artery disease impair interferon-gamma singalling response 2011 1 10.1038/nature09753Oa logo
W. Zhang Variants on Chromosome 9p21.3 Correlated With ANRIL Expression Contribute to Stroke Risk and Recurrence in a Large Prospective Stroke Population 2012 2 10.1161/STROKEAHA.111.625442
John Mackay Longitudinal study of a 9p21.3 SNP using a national electronic healthcare database 2010 1 10.2217/pme.10.34
W Zhang Variants on chromosome 9p21.3 correlated with ANRIL expression contribute to stroke risk and recurrence in a large prospective stroke population 2012 1 10.1161/STROKEAHA.111.625442
Anna Helgadottir The same sequence variant on 9p21 associates with myocardial infarction, abdominal aortic aneurysm and intracranial aneurysm. 2008 76 10.1038/ng.72Oa logo
Luciana Gioli-Pereira Higher incidence of death in multi-vessel coronary artery disease patients associated with polymorphisms in chromosome 9p21. 2012 1 10.1186/1471-2261-12-61
Li Ting Zhou Meta-analysis of genetic association of chromosome 9p21 with early-onset coronary artery disease 2012 3 10.1016/j.gene.2012.09.003
O Harismendy 9p21 DNA variants associated with coronary artery disease impair interferon-gamma signalling response 2011 3 Doi 10.1038/Nature09753Oa logo
Christie Cluett The 9p21 myocardial infarction risk allele increases risk of peripheral artery disease in older people. 2009 5 10.1161/CIRCGENETICS.108.825935Oa logo
Christie Cluett The 9p21 myocardial infarction risk allele increases risk of peripheral artery disease in older people. 2009 5 -
Whady Hueb Higher incidence of death in multi-vessel coronary artery disease patients associated with polymorphisms in chromosome 9p21 2012 2 10.1186/1471-2261-12-61
Kaisa Silander Worldwide patterns of haplotype diversity at 9p21.3, a locus associated with type 2 diabetes and coronary heart disease. 2009 5 10.1186/gm51Oa logo
Abbas Dehghan Lack of association of two common polymorphisms on 9p21 with risk of coronary heart disease and myocardial infarction; results from a prospective cohort study 2008 8 10.1186/1741-7015-6-30Oa logo
C Cluett The 9p21 myocardial infarction risk allele increases risk of peripheral artery disease in older people 2009 1 Oa logo
Seamus C Harrison Association of a sequence variant in DAB2IP with coronary heart disease. 2012 1 10.1093/eurheartj/ehr075
Jiaping Chen Genetic variants at chromosome 9p21, 10p15 and 10q22 and breast cancer susceptibility in a Chinese population. 2012 0 10.1007/s10549-011-1927-yOa logo
Olivier Harismendy 9p21 DNA variants associated with coronary artery disease impair interferon-γ signalling response. 2011 106 -
G W D Landman Two common variants on 9p21 affect mortality risk in type 2 diabetes patients (ZODIAC-15) 2010 1 Oa logo
Gijs Wd Landman Association between 9p21 genetic variants and mortality risk in a prospective cohort of patients with type 2 diabetes (ZODIAC-15). 2012 1 Oa logo
C D Anderson Chromosome 9p21 in ischemic stroke: population structure and meta-analysis 2010 1 -
Abbas Dehghan Lack of association of two common polymorphisms on 9p21 with risk of coronary heart disease and myocardial infarction; results from a prospective cohort study. 2008 4 10.1186/1741-7015-6-30Oa logo
Gong-Qing Shen Association between four SNPs on chromosome 9p21 and myocardial infarction is replicated in an Italian population. 2008 7 10.1007/s10038-007-0230-6Oa logo
G W D Landman Two common variants on 9p21 affect mortality risk in type 2 diabetes patients (ZODIAC-15) 2010 1 -
Denis Tsygankov A quantitative model for age-dependent expression of the p16INK4a tumor suppressor. 2009 16 10.1073/pnas.0904405106
Robin Lemmens Variant on 9p21 strongly associates with coronary heart disease, but lacks association with common stroke. 2009 2 10.1038/ejhg.2009.42
Li-Ting Zhou Meta-analysis of genetic association of chromosome 9p21 with early-onset coronary artery disease. 2012 2 10.1016/j.gene.2012.09.003
Ambarish Dutta The Coronary Artery Disease Associated 9p21 Variant and Later Life 20 Year Survival to Cohort Extinction. 2011 5 10.1161/CIRCGENETICS.111.960146
Jiaping Chen Genetic variants at chromosome 9p21, 10p15 and 10q22 and breast cancer susceptibility in a Chinese population 2012 4 10.1007/s10549-011-1927-y
S. Olsson Association between genetic variation on chromosome 9p21 and aneurysmal subarachnoid haemorrhage 2011 1 Oa logo
Burcu Bayoglu Chromosome 9p21 rs10757278 polymorphism is associated with the risk of metabolic syndrome. 2013 2 10.1007/s11010-013-1629-3
K G Abdullah Four SNPS on chromosome 9p21 confer risk to premature, familial CAD and MI in an American Caucasian population (GeneQuest). 2008 3 10.1111/j.1469-1809.2008.00454.xOa logo
Christopher D Anderson Chromosome 9p21 in ischemic stroke: population structure and meta-analysis. 2010 6 10.1161/STROKEAHA.110.580589Oa logo
Paulina Haas Genetic cardiovascular risk factors and age-related macular degeneration. 2011 0 10.1111/j.1755-3768.2009.01697.x
Denis Tsygankov A quantitative model for age-dependent expression of the p16INK4a tumor suppressor. 2009 16 10.1073/pnas.0904405106Oa logo
A Dehghan Lack of association of two common polymorphisms on 9p21 with risk of coronary heart disease and myocardial infarction; results from a prospective cohort study 2008 1 Artn 30\nDoi 10.1186/1741-7015-6-30Oa logo
S Olsson Association between genetic variation on chromosome 9p21 and aneurysmal subarachnoid haemorrhage 2010 1 jnnp.2009.187427 [pii]\n10.1136/jnnp.2009.187427Oa logo
O Liu Genetic analysis of six SNPs in candidate genes associated with high cross-race risk of development of thoracic aortic aneurysms and dissections in Chinese Han population 2010 1 10.1038/aps.2010.159Oa logo
Salim S Virani Chromosome 9p21 single nucleotide polymorphisms are not associated with recurrent myocardial infarction in patients with established coronary artery disease. 2012 1 Oa logo
Zhong Chen A common variant on chromosome 9p21 affects the risk of early-onset coronary artery disease. 2009 6 10.1007/s11033-008-9259-7Oa logo
Olivier Harismendy disease impair interferon-c signalling response 2011 5 10.1038/nature09753
Thomas Scheffold Six sequence variants on chromosome 9p21.3 are associated with a positive family history of myocardial infarction: a multicenter registry. 2011 7 10.1186/1471-2261-11-9Oa logo
Hirokuni Hashikata Confirmation of an association of single-nucleotide polymorphism rs1333040 on 9p21 with familial and sporadic intracranial aneurysms in Japanese patients. 2010 4 10.1161/STROKEAHA.109.576694
B Bayoglu Chromosome 9p21 rs10757278 polymorphism is associated with the risk of metabolic syndrome 2013 1 10.1007/s11010-013-1629-3Oa logo
Ambarish Dutta The Coronary Artery Disease Associated 9p21 Variant and Later Life 20 Year Survival to Cohort Extinction. 2011 4 10.1161/CIRCGENETICS.111.960146Oa logo
X Zhang Association of Genetic Variation on Chromosome 9p21 with Polypoidal Choroidal Vasculopathy and Neovascular Age-Related Macular Degeneration 2011 0 10.1167/iovs.11-7820
Hu Ding 9p21 is a shared susceptibility locus strongly for coronary artery disease and weakly for ischemic stroke in Chinese Han population. 2009 5 -
C Cluett The 9p21 myocardial infarction risk allele increases risk of peripheral artery disease in older people 2009 2 CIRCGENETICS.108.825935 [pii]\n10.1161/CIRCGENETICS.108.825935Oa logo
Gong-Qing Shen Four SNPs on chromosome 9p21 in a South Korean population implicate a genetic locus that confers high cross-race risk for development of coronary artery disease. 2008 6 10.1161/ATVBAHA.107.157248Oa logo
Hirokuni Hashikata Confirmation of an association of single-nucleotide polymorphism rs1333040 on 9p21 with familial and sporadic intracranial aneurysms in Japanese patients. 2010 5 10.1161/STROKEAHA.109.576694Oa logo
B Bayoglu Chromosome 9p21 rs10757278 polymorphism is associated with the risk of metabolic syndrome 2013 0 10.1007/s11010-013-1629-3
Yan Liu INK4/ARF Transcript Expression Is Associated with Chromosome 9p21 Variants Linked to Atherosclerosis 2009 33 10.1371/journal.pone.0005027Oa logo
Burcu Bayoglu Chromosome 9p21 rs10757278 polymorphism is associated with the risk of metabolic syndrome. 2013 2 10.1007/s11010-013-1629-3
Riyaz S Patel The chromosome 9p21 risk locus is associated with angiographic severity and progression of coronary artery disease. 2010 10 10.1093/eurheartj/ehq272Oa logo
Qiang Zeng Polymorphisms on chromosome 9p21 confer a risk for acute coronary syndrome in a Chinese Han population. 2013 1 10.1016/j.cjca.2012.11.028Oa logo
O Harismendy 9p21 DNA variants associated with coronary artery disease impair interferon-gamma signalling response 2011 4 10.1038/nature09753
K G Abdullah Four SNPS on chromosome 9p21 confer risk to premature, familial CAD and MI in an American Caucasian population (GeneQuest). 2008 2 -
Jin Guo Association between 9p21.3 genomic markers and coronary artery disease in East Asians: a meta-analysis involving 9,813 cases and 10,710 controls 2012 2 10.1007/s11033-012-2066-1
Gijs W D Landman Association between 9p21 genetic variants and mortality risk in a prospective cohort of patients with type 2 diabetes (ZODIAC-15). 2012 1 10.1186/1475-2840-11-138Oa logo
A Dehghan Lack of association of two common polymorphisms on 9p21 with risk of coronary heart disease and myocardial infarction; results from a prospective cohort study 2008 1 Oa logo
A Fedson The association of obstructive sleep apnea with single nucleotide polymorphisms located near the CDKN2A/2B loci on chromosome 9P21 2011 1 10.1111/j.1479-8425.2011.00518.x
I. A. Lang The Coronary Artery Disease-Associated 9p21 Variant and Later Life 20-Year Survival to Cohort Extinction 2011 3 10.1161/CIRCGENETICS.111.960146
Hu Ding 9p21 is a shared susceptibility locus strongly for coronary artery disease and weakly for ischemic stroke in Chinese Han population. 2009 5 10.1161/CIRCGENETICS.108.810226Oa logo
A Fedson The association of obstructive sleep apnea with single nucleotide polymorphisms located near the CDKN2A/2B loci on chromosome 9P21 2011 3 10.1111/j.1479-8425.2011.00518.x
Andrew R Thompson Sequence variant on 9p21 is associated with the presence of abdominal aortic aneurysm disease but does not have an impact on aneurysmal expansion. 2009 6 10.1038/ejhg.2008.196Oa logo
Abbas Dehghan Lack of association of two common polymorphisms on 9p21 with risk of coronary heart disease and myocardial infarction; results from a prospective cohort study 2008 3 10.1186/1741-7015-6-30Oa logo
C Cluett The 9p21 myocardial infarction risk allele increases risk of peripheral artery disease in older people 2009 1 10.1161/CIRCGENETICS.108.825935Oa logo
Olivier Harismendy 9p21 DNA variants associated with coronary artery disease impair interferon-γ signalling response. 2011 135 10.1038/nature09753Oa logo
Aparna Amarendra Bhanushali Variant on 9p21 Is Strongly Associated with Coronary Artery Disease but Lacks Association with Myocardial Infarction and Disease Severity in a Population in Western India 2011 2 10.1016/j.arcmed.2011.09.003
Andrew R Thompson Sequence variant on 9p21 is associated with the presence of abdominal aortic aneurysm disease but does not have an impact on aneurysmal expansion 2009 0 10.1038/ejhg.2008.196Oa logo
Björn Wahlstrand The myocardial infarction associated CDKN2A/CDKN2B locus on chromosome 9p21 is associated with stroke independently of coronary events in patients with hypertension. 2009 4 10.1097/HJH.0b013e328326f7ebOa logo
Gijs Wd Landman Association between 9p21 genetic variants and mortality risk in a prospective cohort of patients with type 2 diabetes (ZODIAC-15). 2012 3 -
Gong-Qing Shen Association between four SNPs on chromosome 9p21 and myocardial infarction is replicated in an Italian population. 2008 5 -
Robin Lemmens Variant on 9p21 strongly associates with coronary heart disease, but lacks association with common stroke. 2009 3 10.1038/ejhg.2009.42Oa logo
Riyaz S Patel The chromosome 9p21 risk locus is associated with angiographic severity and progression of coronary artery disease. 2010 8 -
D. Cugino Type 2 diabetes and polymorphisms on chromosome 9p21: A meta-analysis 2012 9 10.1016/j.numecd.2010.11.010

Evidence compiled by the Personal Genome Project

There are no results from the Personal Genome Project yet. Please come back later.

Publications listed by Genome.gov

First Author Title Journal Publication Date Trait p-value Confidence Interval
Helgadottir A A common variant on chromosome 9p21 affects the risk of myocardial infarction. Science 05/03/2007 Myocardial infarction 1.0e-20 [1.22-1.35]

Users who share this SNP:

Genome Browser