SNP rs10757274

Basic Information
Name rs10757274
Chromosome 9
Position 22096056
Weight of evidence 71
Additional Information

Links to SNPedia

Title Summary
rs10757274 G/G ~1.3x increased risk for heart disease
rs10757274 A/G ~1.2x increased risk for heart disease
rs10757274 A/A Normal
Note: For some SNPs, testing providers detect the genotype from the opposite strand of DNA, so that the genotypes listed on openSNP don't appear here. In those cases, please replace "A" by "T" or "G" by "C" (and vice-versa).

Publications on this SNP on the Public Library of Science:

First Author Title Year of Publication # of readers
Xiaoqing Ni Association between 9p21 Genomic Markers and Ischemic Stroke Risk: Evidence Based on 21 Studies 2014 1896
Jianhui Zhuang Methylation of p15INK4b and Expression of ANRIL on Chromosome 9p21 Are Associated with Coronary Artery Disease 2012 5265
Hsiu-Fen Lin Sex Differential Genetic Effect of Chromosome 9p21 on Subclinical Atherosclerosis 2010 2784
Fang Xie Replication of Putative Susceptibility Loci from Genome-Wide Association Studies Associated with Coronary Atherosclerosis in Chinese Han Population 2011 2690
Michael S. Cunnington Chromosome 9p21 SNPs Associated with Multiple Disease Phenotypes Correlate with ANRIL Expression 2010 17779
Arne S. Schaefer Identification of a Shared Genetic Susceptibility Locus for Coronary Heart Disease and Periodontitis 2009 18624
Frank Beutner Rationale and Design of the Leipzig (LIFE) Heart Study: Phenotyping and Cardiovascular Characteristics of Patients with Coronary Artery Disease 2011 4272
Jussi A. Hernesniemi Genetic Profiling Using Genome-Wide Significant Coronary Artery Disease Risk Variants Does Not Improve the Prediction of Subclinical Atherosclerosis: The Cardiovascular Risk in Young Finns Study, the Bogalusa Heart Study and the Health 2000 Survey – A Meta-Analysis of Three Independent Studies 2012 4242
Viktor Hamrefors Smoking Modifies the Associated Increased Risk of Future Cardiovascular Disease by Genetic Variation on Chromosome 9p21 2014 2776
Arne S. Schaefer Identification of a Shared Genetic Susceptibility Locus for Coronary Heart Disease and Periodontitis 2009 14022
Lasse Folkersen Relationship between CAD Risk Genotype in the Chromosome 9p21 Locus and Gene Expression. Identification of Eight New ANRIL Splice Variants 2009 7191
Ron Do The Effect of Chromosome 9p21 Variants on Cardiovascular Disease May Be Modified by Dietary Intake: Evidence from a Case/Control and a Prospective Study 2011 34110
Lesca M. Holdt Alu Elements in ANRIL Non-Coding RNA at Chromosome 9p21 Modulate Atherogenic Cell Functions through Trans-Regulation of Gene Networks 2013 15227
Yangsoo Jang Carriage of the V279F Null Allele within the Gene Encoding Lp-PLA2 Is Protective from Coronary Artery Disease in South Korean Males 2011 3842
Katherine E. Beaney Clinical Utility of a Coronary Heart Disease Risk Prediction Gene Score in UK Healthy Middle Aged Men and in the Pakistani Population 2015 2273
Themistocles L. Assimes Genetics of Coronary Artery Disease in Taiwan: A Cardiometabochip Study by the Taichi Consortium 2016 1964
Dong Hoon Shin Paleogenetic study on the 17th century Korean mummy with atherosclerotic cardiovascular disease 2017 1466
Reza Jabbari A Common Variant in SCN5A and the Risk of Ventricular Fibrillation Caused by First ST-Segment Elevation Myocardial Infarction 2017 2146
Michael S. Cunnington Chromosome 9p21 SNPs Associated with Multiple Disease Phenotypes Correlate with ANRIL Expression 2010 17932

Publications on this SNP on Mendeley

First Author Title Pub. Year # of Readers DOI
J Gustav Smith Common genetic variants on chromosome 9p21 confers risk of ischemic stroke: a large-scale genetic association study. 2009 2 -
Aaron R Folsom Effect of 9p21 genetic variation on coronary heart disease is not modified by other risk markers. The Atherosclerosis Risk in Communities (ARIC) Study. 2012 3 10.1016/j.atherosclerosis.2012.08.007
PJ Talmud Chromosome 9p21.3 coronary heart disease locus genotype and prospective risk of CHD in healthy middle-aged men 2008 18 -
Wenhui Peng Methylation of p15INK4b and Expression of ANRIL on Chromosome 9p21 Are Associated with Coronary Artery Disease 2012 5 10.1371/journal.pone.0047193
May M Luke Polymorphisms associated with both noncardioembolic stroke and coronary heart disease: vienna stroke registry. 2009 4 10.1159/000236914Oa logo
Nina P Paynter Cardiovascular disease risk prediction with and without knowledge of genetic variation at chromosome 9p21.3. 2009 24 -
Aaron R Folsom Effect of 9p21 genetic variation on coronary heart disease is not modified by other risk markers. The Atherosclerosis Risk in Communities (ARIC) Study. 2012 4 10.1016/j.atherosclerosis.2012.08.007Oa logo
Nina P Paynter Abstract 4992: Cardiovascular Disease Risk Prediction with and without Knowledge of Genetic Variation at Chromosome 9p21.3: The Women's Genome Health Study 2008 1 Oa logo
Nina P Paynter Cardiovascular disease risk prediction with and without knowledge of genetic variation at chromosome 9p21.3. 2009 23 10.7326/0003-4819-150-2-200901200-00003Oa logo
Francisco Rodríguez Esparragón Replication of relevant SNPs associated with cardiovascular disease susceptibility obtained from GWAs in a case-control study in a Canarian population. 2012 2 10.3233/DMA-2011-0879Oa logo
Aaron R. Folsom Effect of 9p21 genetic variation on coronary heart disease is not modified by other risk markers. The Atherosclerosis Risk in Communities (ARIC) Study 2012 4 10.1016/j.atherosclerosis.2012.08.007
J A Hubáček Association between a marker on chromosome 9 and acute coronary syndrome. confirmatory study on Czech population. 2012 1 Oa logo
May M. Luke Polymorphisms associated with both noncardioembolic stroke and coronary heart disease: Vienna stroke registry 2009 4 10.1159/000236914
Philippa J Talmud Chromosome 9p21.3 coronary heart disease locus genotype and prospective risk of CHD in healthy middle-aged men. 2008 19 10.1373/clinchem.2007.095489Oa logo
Ariel Brautbar Impact of adding a single allele in the 9p21 locus to traditional risk factors on reclassification of coronary heart disease risk and implications for lipid-modifying therapy in the Atherosclerosis Risk in Communities study. 2009 5 -
Kazumasa Yamagishi A genetic variant on chromosome 9p21 and incident heart failure in the ARIC study. 2009 3 10.1093/eurheartj/ehp087

Evidence compiled by the Personal Genome Project

There are no results from the Personal Genome Project yet. Please come back later.

Publications listed by Genome.gov

First Author Title Journal Publication Date Trait p-value Confidence Interval
Lu X Genome-wide association study in Han Chinese identifies four new susceptibility loci for coronary artery disease. Nat Genet 07/01/2012 Coronary heart disease 8.0e-45 [1.31-1.43]

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