openSNP | rs10757274

Links to SNPedia

Title	Summary
rs10757274 G/G	~1.3x increased risk for heart disease
rs10757274 A/G	~1.2x increased risk for heart disease
rs10757274 A/A	Normal

Note: For some SNPs, testing providers detect the genotype from the opposite strand of DNA, so that the genotypes listed on openSNP don't appear here. In those cases, please replace "A" by "T" or "G" by "C" (and vice-versa).

Publications on this SNP on the Public Library of Science:

First Author	Title	Year of Publication	# of readers
Xiaoqing Ni	Association between 9p21 Genomic Markers and Ischemic Stroke Risk: Evidence Based on 21 Studies	2014	1896
Jianhui Zhuang	Methylation of p15INK4b and Expression of ANRIL on Chromosome 9p21 Are Associated with Coronary Artery Disease	2012	5265
Hsiu-Fen Lin	Sex Differential Genetic Effect of Chromosome 9p21 on Subclinical Atherosclerosis	2010	2784
Fang Xie	Replication of Putative Susceptibility Loci from Genome-Wide Association Studies Associated with Coronary Atherosclerosis in Chinese Han Population	2011	2690
Michael S. Cunnington	Chromosome 9p21 SNPs Associated with Multiple Disease Phenotypes Correlate with ANRIL Expression	2010	17779
Arne S. Schaefer	Identification of a Shared Genetic Susceptibility Locus for Coronary Heart Disease and Periodontitis	2009	18624
Frank Beutner	Rationale and Design of the Leipzig (LIFE) Heart Study: Phenotyping and Cardiovascular Characteristics of Patients with Coronary Artery Disease	2011	4272
Jussi A. Hernesniemi	Genetic Profiling Using Genome-Wide Significant Coronary Artery Disease Risk Variants Does Not Improve the Prediction of Subclinical Atherosclerosis: The Cardiovascular Risk in Young Finns Study, the Bogalusa Heart Study and the Health 2000 Survey – A Meta-Analysis of Three Independent Studies	2012	4242
Viktor Hamrefors	Smoking Modifies the Associated Increased Risk of Future Cardiovascular Disease by Genetic Variation on Chromosome 9p21	2014	2776
Arne S. Schaefer	Identification of a Shared Genetic Susceptibility Locus for Coronary Heart Disease and Periodontitis	2009	14022
Lasse Folkersen	Relationship between CAD Risk Genotype in the Chromosome 9p21 Locus and Gene Expression. Identification of Eight New ANRIL Splice Variants	2009	7191
Ron Do	The Effect of Chromosome 9p21 Variants on Cardiovascular Disease May Be Modified by Dietary Intake: Evidence from a Case/Control and a Prospective Study	2011	34110
Lesca M. Holdt	Alu Elements in ANRIL Non-Coding RNA at Chromosome 9p21 Modulate Atherogenic Cell Functions through Trans-Regulation of Gene Networks	2013	15227
Yangsoo Jang	Carriage of the V279F Null Allele within the Gene Encoding Lp-PLA₂ Is Protective from Coronary Artery Disease in South Korean Males	2011	3842
Katherine E. Beaney	Clinical Utility of a Coronary Heart Disease Risk Prediction Gene Score in UK Healthy Middle Aged Men and in the Pakistani Population	2015	2273
Themistocles L. Assimes	Genetics of Coronary Artery Disease in Taiwan: A Cardiometabochip Study by the Taichi Consortium	2016	1964
Dong Hoon Shin	Paleogenetic study on the 17^th century Korean mummy with atherosclerotic cardiovascular disease	2017	1466
Reza Jabbari	A Common Variant in SCN5A and the Risk of Ventricular Fibrillation Caused by First ST-Segment Elevation Myocardial Infarction	2017	2146
Michael S. Cunnington	Chromosome 9p21 SNPs Associated with Multiple Disease Phenotypes Correlate with ANRIL Expression	2010	17932

Publications on this SNP on Mendeley

First Author	Title	Pub. Year	# of Readers	DOI
J Gustav Smith	Common genetic variants on chromosome 9p21 confers risk of ischemic stroke: a large-scale genetic association study.	2009	2	-
Aaron R Folsom	Effect of 9p21 genetic variation on coronary heart disease is not modified by other risk markers. The Atherosclerosis Risk in Communities (ARIC) Study.	2012	3	10.1016/j.atherosclerosis.2012.08.007
PJ Talmud	Chromosome 9p21.3 coronary heart disease locus genotype and prospective risk of CHD in healthy middle-aged men	2008	18	-
Wenhui Peng	Methylation of p15INK4b and Expression of ANRIL on Chromosome 9p21 Are Associated with Coronary Artery Disease	2012	5	10.1371/journal.pone.0047193
May M Luke	Polymorphisms associated with both noncardioembolic stroke and coronary heart disease: vienna stroke registry.	2009	4	10.1159/000236914
Nina P Paynter	Cardiovascular disease risk prediction with and without knowledge of genetic variation at chromosome 9p21.3.	2009	24	-
Aaron R Folsom	Effect of 9p21 genetic variation on coronary heart disease is not modified by other risk markers. The Atherosclerosis Risk in Communities (ARIC) Study.	2012	4	10.1016/j.atherosclerosis.2012.08.007
Nina P Paynter	Abstract 4992: Cardiovascular Disease Risk Prediction with and without Knowledge of Genetic Variation at Chromosome 9p21.3: The Women's Genome Health Study	2008	1
Nina P Paynter	Cardiovascular disease risk prediction with and without knowledge of genetic variation at chromosome 9p21.3.	2009	23	10.7326/0003-4819-150-2-200901200-00003
Francisco Rodríguez Esparragón	Replication of relevant SNPs associated with cardiovascular disease susceptibility obtained from GWAs in a case-control study in a Canarian population.	2012	2	10.3233/DMA-2011-0879
Aaron R. Folsom	Effect of 9p21 genetic variation on coronary heart disease is not modified by other risk markers. The Atherosclerosis Risk in Communities (ARIC) Study	2012	4	10.1016/j.atherosclerosis.2012.08.007
J A Hubáček	Association between a marker on chromosome 9 and acute coronary syndrome. confirmatory study on Czech population.	2012	1
May M. Luke	Polymorphisms associated with both noncardioembolic stroke and coronary heart disease: Vienna stroke registry	2009	4	10.1159/000236914
Philippa J Talmud	Chromosome 9p21.3 coronary heart disease locus genotype and prospective risk of CHD in healthy middle-aged men.	2008	19	10.1373/clinchem.2007.095489
Ariel Brautbar	Impact of adding a single allele in the 9p21 locus to traditional risk factors on reclassification of coronary heart disease risk and implications for lipid-modifying therapy in the Atherosclerosis Risk in Communities study.	2009	5	-
Kazumasa Yamagishi	A genetic variant on chromosome 9p21 and incident heart failure in the ARIC study.	2009	3	10.1093/eurheartj/ehp087

Evidence compiled by the Personal Genome Project

There are no results from the Personal Genome Project yet. Please come back later.

Publications listed by Genome.gov

First Author	Title	Journal	Publication Date	Trait	p-value	Confidence Interval
Lu X	Genome-wide association study in Han Chinese identifies four new susceptibility loci for coronary artery disease.	Nat Genet	07/01/2012	Coronary heart disease	8.0e-45	[1.31-1.43]

Name	rs10757274
Chromosome	9
Position	22096056
Weight of evidence	71

SNP rs10757274

Basic Information

Genotype Frequency

Allele Frequency

Additional Information

Links to SNPedia

Publications on this SNP on the Public Library of Science:

Publications on this SNP on Mendeley

Evidence compiled by the Personal Genome Project

Publications listed by Genome.gov

Users who share this SNP:

Genome Browser

Contacts