openSNP | rs1045642

Links to SNPedia

Title	Summary
rs1045642 C/C	Increased risk of cannabis dependence, lower (normal) cancer risk
rs1045642 T/T	Altered drug metabolism and bioavailability; moderately increased risk for certain cancers }} this is the homozygous variant of c3435t, on the gene encoding p-glycoprotein (called mdr1 or abcb1). p-glycoprotein is a protein involved in pumping foreign substances out of cells. it mainly affects areas of the body that have a barrier or excretory function: blood-tissue barrier, the gastrointestinal tract, liver and kidney. poor functioning of this cellular defense mechanism can affect elimination of carcinogens and movement of drugs in the system. == drug treatment response & toxicity == '''abcb1 polymorphism as prognostic factor in breast cancer patients treated with docetaxel and doxorubicin neoadjuvant chemotherapy.''' (2014). among 216 patients, those with the 3435tt genotype had a longer overall survival than cc/ct. abcb1 3435tt genotype had a higher blood concentration than cc/ct for docetaxel. these higher values in the c3435tt were associated with increased toxicities of neutropenia (low count of a type of white blood cell) and diarrhea. this study showed that the genetic polymorphism of abcb1 c3435t might be associated with a longer overall survival. our results also suggest that the prediction of docetaxel toxicity might be possible for c3435t polymorphism. '''effect of polymorphisms within methotrexate pathway genes on methotrexate toxicity and plasma levels in adults with hematological malignancies.''' (2014). [http://www.ncbi.nlm.nih.gov/pubmed/25303299] individuals respond differently to the cancer drug methotrexate (mtx) and experience differences in toxicity. the authors evaluated the impact of snps within the mtx pathway genes on mtx-induced toxicity and mtx plasma levels at 48 hours following treatment in asian adults with acute lymphoblastic leukemia or non-hodgkin lymphoma. patients with mthfr c677t and abcb1 c3435t polymorphisms appear to have significantly higher mtx plasma concentrations (p < 0.05). hepatic toxicity was associated with slc19a1 g80a and abcb1 c3435t. '''snpwatch: variants associated with clopidogrel efficacy and stent thrombosis.''' [http://blog.23andme.com/2011/11/14/snpwatch-avoiding-blood-clot/] 2.6 times higher odds of developing early stent thrombosis in patients with a stent taking the anti-clotting drug clopidogrel, due to slow metabolism of clopidogrel. with the increasing incidence of coronary artery disease, knowledge of variations in anticoagulant metabolism may have in impact on drug therapy. this is particularly important in those undergoing stent placement. variants in the cyp2c19 gene affect how people metabolize clopidogrel and those that those who metabolize clopidogrel faster were less likely to develop early stent thrombosis. abcb1 gene encodes a protein that effects [[clopidogrel]] absorption; rs individuals with the aa genotype at rs1045642 in the abcb1 gene had 2.6 times higher odds of developing early stent thrombosis over individuals with the ag or gg genotypes. {{pmid\|22028352
rs1045642 C/T	Slower metaboliser for some drugs

Note: For some SNPs, testing providers detect the genotype from the opposite strand of DNA, so that the genotypes listed on openSNP don't appear here. In those cases, please replace "A" by "T" or "G" by "C" (and vice-versa).

Publications on this SNP on the Public Library of Science:

First Author	Title	Year of Publication	# of readers
Yi-kuan Chen	Personalized Tacrolimus Dose Requirement by CYP3A5 but Not ABCB1 or ACE Genotyping in Both Recipient and Donor after Pediatric Liver Transplantation	2014	2691
Eugenia Ulzurrun	Selected ABCB1, ABCB4 and ABCC2 Polymorphisms Do Not Enhance the Risk of Drug-Induced Hepatotoxicity in a Spanish Cohort	2014	2314
Beate Beer	Association of Polymorphisms in Pharmacogenetic Candidate Genes (OPRD1, GAL, ABCB1, OPRM1) with Opioid Dependence in European Population: A Case-Control Study	2013	3561
Wang-Qing Chen	Polymorphism of ORM1 Is Associated with the Pharmacokinetics of Telmisartan	2013	3304
Chin-Chuan Hung	Functional Impact of ABCB1 Variants on Interactions between P-Glycoprotein and Methadone	2013	3408
Brittany B. Dennis	Impact of ABCB1 and CYP2B6 Genetic Polymorphisms on Methadone Metabolism, Dose and Treatment Response in Patients with Opioid Addiction: A Systematic Review and Meta-Analysis	2014	5757
Yan Du	Associations of Polymorphisms in DNA Repair Genes and MDR1 Gene with Chemotherapy Response and Survival of Non-Small Cell Lung Cancer	2014	2632
Getnet Yimer	Pharmacogenetic & Pharmacokinetic Biomarker for Efavirenz Based ARV and Rifampicin Based Anti-TB Drug Induced Liver Injury in TB-HIV Infected Patients	2011	7883
Laura W. Goff	Thymidylate Synthase Genotype-Directed Chemotherapy for Patients with Gastric and Gastroesophageal Junction Cancers	2014	1884
Géraldine Dessilly	ABCB1 1199G>A Genetic Polymorphism (Rs2229109) Influences the Intracellular Accumulation of Tacrolimus in HEK293 and K562 Recombinant Cell Lines	2014	2750
Soobitha Subenthiran	Linkage Disequilibrium between Polymorphisms of ABCB1 and ABCC2 to Predict the Treatment Outcome of Malaysians with Complex Partial Seizures on Treatment with Carbamazepine Mono-Therapy at the Kuala Lumpur Hospital	2013	2615
George Fountzilas	Ixabepilone Administered Weekly or Every Three Weeks in HER2-Negative Metastatic Breast Cancer Patients; A Randomized Non-Comparative Phase II Trial	2013	2636
Onkar Singh	SLC22A1-ABCB1 Haplotype Profiles Predict Imatinib Pharmacokinetics in Asian Patients with Chronic Myeloid Leukemia	2012	4078
Konrad J. Karczewski	Chapter 7: Pharmacogenomics	2012	25648
Daniela Caronia	Effect of ABCB1 and ABCC3 Polymorphisms on Osteosarcoma Survival after Chemotherapy: A Pharmacogenetic Study	2011	4951
Peng Zhu	ABCB1 Variation and Treatment Response in AIDS Patients: Initial Results of the Henan Cohort	2013	2742
Huai Liu	Genetic Variations in Radiation and Chemotherapy Drug Action Pathways and Survival in locoregionally Advanced Nasopharyngeal Carcinoma Treated with Chemoradiotherapy	2013	2035
Xiaobo Yu	Association of MDR1 Gene SNPs and Haplotypes with the Tacrolimus Dose Requirements in Han Chinese Liver Transplant Recipients	2011	4636
Daniele Campa	A Comprehensive Investigation on Common Polymorphisms in the MDR1/ABCB1 Transporter Gene and Susceptibility to Colorectal Cancer	2012	3627
Shabeesh Balan	Genetic Association Analysis of ATP Binding Cassette Protein Family Reveals a Novel Association of ABCB1 Genetic Variants with Epilepsy Risk, but Not with Drug-Resistance	2014	3784
Vibeke Andersen	Low ABCB1 Gene Expression Is an Early Event in Colorectal Carcinogenesis	2013	2465
Pascaline Boudou-Rouquette	Early Sorafenib-Induced Toxicity Is Associated with Drug Exposure and UGTIA9 Genetic Polymorphism in Patients with Solid Tumors: A Preliminary Study	2012	5028
Dong-Yi Chen	Paraoxonase-1 Is Not a Major Determinant of Stent Thrombosis in a Taiwanese Population	2012	2329
Jolanta M. Siller-Matula	Interplay between Genetic and Clinical Variables Affecting Platelet Reactivity and Cardiac Adverse Events in Patients Undergoing Percutaneous Coronary Intervention	2014	2482
Lauren E. Kelly	A Clinical Tool for Reducing Central Nervous System Depression among Neonates Exposed to Codeine through Breast Milk	2013	3965
Weihua Shou	Gene-Wide Characterization of Common Quantitative Trait Loci for ABCB1 mRNA Expression in Normal Liver Tissues in the Chinese Population	2012	1970
Hua Wei	Association of Polymorphisms in Oxidative Stress Genes with Clinical Outcomes for Bladder Cancer Treated with Bacillus Calmette-Guérin	2012	3367
Sabina Mugusi	Liver Enzyme Abnormalities and Associated Risk Factors in HIV Patients on Efavirenz-Based HAART with or without Tuberculosis Co-Infection in Tanzania	2012	4538
Caitrin W. McDonough	Atenolol Induced HDL-C Change in the Pharmacogenomic Evaluation of Antihypertensive Responses (PEAR) Study	2013	2703
Daniel H. Johnson	Genetic and Non-Genetic Determinants of Raltegravir Penetration into Cerebrospinal Fluid: A Single Arm Pharmacokinetic Study	2013	3394
Eliford Ngaimisi	Importance of Ethnicity, CYP2B6 and ABCB1 Genotype for Efavirenz Pharmacokinetics and Treatment Outcomes: A Parallel-Group Prospective Cohort Study in Two Sub-Saharan Africa Populations	2013	4368
Ji-Ye Yin	Meta-Analysis on Pharmacogenetics of Platinum-Based Chemotherapy in Non Small Cell Lung Cancer (NSCLC) Patients	2012	5268
Jia Su	ABCB1 C3435T Polymorphism and Response to Clopidogrel Treatment in Coronary Artery Disease (CAD) Patients: A Meta-Analysis	2012	4909
Armond Daci	Polymorphic Variants of SCN1A and EPHX1 Influence Plasma Carbamazepine Concentration, Metabolism and Pharmacoresistance in a Population of Kosovar Albanian Epileptic Patients	2015	2341
Roshan Mascarenhas	Allele-Selective Transcriptome Recruitment to Polysomes Primed for Translation: Protein-Coding and Noncoding RNAs, and RNA Isoforms	2015	2707
Daniel T. Barratt	Innate Immune Signalling Genetics of Pain, Cognitive Dysfunction and Sickness Symptoms in Cancer Pain Patients Treated with Transdermal Fentanyl	2015	2411
Hui Li	The Roles of Variants in Human Multidrug Resistance (MDR1) Gene and Their Haplotypes on Antiepileptic Drugs Response: A Meta-Analysis of 57 Studies	2015	1866
Ying-Hsia Chu	Association of ABCB1 and FLT3 Polymorphisms with Toxicities and Survival in Asian Patients Receiving Sunitinib for Renal Cell Carcinoma	2015	1769
Xiao-Qing Li	Association of PON1, P2Y12 and COX1 with Recurrent Ischemic Events in Patients with Extracranial or Intracranial Stenting	2016	2200
Seung Seok Han	Monitoring the Intracellular Tacrolimus Concentration in Kidney Transplant Recipients with Stable Graft Function	2016	2419
Jia Su	The risk of clopidogrel resistance is associated with ABCB1 polymorphisms but not promoter methylation in a Chinese Han population	2017	1714
Himanshu Gupta	Genetic and epigenetic changes in host ABCB1 influences malaria susceptibility to Plasmodium falciparum	2017	1846
Tomas Pascual	Polymorphisms associated with everolimus pharmacokinetics, toxicity and survival in metastatic breast cancer	2017	1608
Haifa Jmel	Pharmacogenetic landscape of Metabolic Syndrome components drug response in Tunisia and comparison with worldwide populations	2018	67
Mariana S. Silva-Alves	A Prediction Algorithm for Drug Response in Patients with Mesial Temporal Lobe Epilepsy Based on Clinical and Genetic Information	2017	2889
Dragana Mijac	MDR1 gene polymorphisms are associated with ulcerative colitis in a cohort of Serbian patients with inflammatory bowel disease	2018	374
Kalluri Thishya	Artificial neural network model for predicting the bioavailability of tacrolimus in patients with renal transplantation	2018	235
Si Sun	Prognostic Value and Implication for Chemotherapy Treatment of ABCB1 in Epithelial Ovarian Cancer: A Meta-Analysis	2016	2004
Catharina Scholl	Population nutrikinetics of green tea extract	2018	439
Sandra Soeria-Atmadja	Genetic variants in CYP2B6 and CYP2A6 explain interindividual variation in efavirenz plasma concentrations of HIV-infected children with diverse ethnic origin	2017	1369

Publications on this SNP on Mendeley

First Author	Title	Pub. Year	# of Readers	DOI
Marcos Antonio Mauricio Scheiner	ABCB1 single nucleotide polymorphisms in the Brazilian population.	2010	3	10.1007/s11033-009-9547-x
Darinka Todorova Petrova	No association between MDR1 (ABCB1) 2677G>T and 3435C>T polymorphism and sporadic colorectal cancer among Bulgarian patients.	2008	1	-
M. C. F. J. de ROTTE	ABCB1 and ABCC3 Gene Polymorphisms Are Associated with First-year Response to Methotrexate in Juvenile Idiopathic Arthritis	2012	12	10.3899/jrheum.111593
C. Cass	552 CYP3A5*3 (rs776746) is associated with docetaxel-specific toxicities during adjuvant breast cancer chemotherapy	2010	1	10.1016/S1359-6349(10)72259-X
Xiaobo Yu	Association of MDR1 Gene SNPs and Haplotypes with the Tacrolimus Dose Requirements in Han Chinese Liver Transplant Recipients.	2011	3	10.1371/journal.pone.0025933
Stephen Drain	ABCB1 (MDR1) rs1045642 is associated with increased overall survival in plasma cell myeloma.	2009	2	10.1080/10428190902853144
K Buathet	Association of ABCB1 polymorphism with lamotrigine-resistant epilepsy in Thais	2013	1
H J Choi	Polymorphisms of the MDR1 and MIF genes in children with nephrotic syndrome	2011	3	10.1007/s00467-011-1903-0
Christoph Grimm	Two multidrug-resistance (ABCB1) gene polymorphisms as prognostic parameters in women with ovarian cancer.	2010	0	-
M A Scheiner	ABCB1 single nucleotide polymorphisms in the Brazilian population	2010	3	10.1007/s11033-009-9547-x
S Sadhasivam	Pharmacogenetics and personalizing perioperative analgesia in children	2010	2	10.1016/j.jpain.2010.01.207
L Zhang	Variants in ABCB1, TGFB1, and XRCC1 genes and susceptibility to viral hepatitis A infection in Mexican Americans	2012	4	10.1002/hep.25513
Abhijit Das	Corpora amylacea deposition in the hippocampus of patients with mesial temporal lobe epilepsy: A new role for an old gene?	2011	2	10.4103/0971-6866.80358
Patrick Menu	Antidepressants and ABCB1 gene C3435T functional polymorphism: a naturalistic study.	2010	7	-
Daniele Campa	A comprehensive investigation on common polymorphisms in the mdr1/abcb1 transporter gene and susceptibility to colorectal cancer	2012	4	10.1371/journal.pone.0032784
Marcos Antonio Mauricio Scheiner	ABCB1 single nucleotide polymorphisms in the Brazilian population.	2010	1	10.1007/s11033-009-9547-x
Georgina P Sava	Candidate gene association studies and risk of chronic lymphocytic leukemia: a systematic review and meta-analysis.	2013	3	10.3109/10428194.2013.800197
Daniele Campa	A comprehensive investigation on common polymorphisms in the MDR1/ABCB1 transporter gene and susceptibility to colorectal cancer.	2012	1	10.1371/journal.pone.0032784
Douglas Vivona	ABCB1 haplotype is associated with major molecular response in chronic myeloid leukemia patients treated with standard-dose of imatinib.	2011	2	10.1016/j.bcmd.2011.11.001
Hairong Qiu	The single nucleotide polymorphism and haplotype analysis of MDR1 in Jiangsu Han population of China.	2012	1	10.1016/j.biopha.2012.03.007
Stephen Drain	ABCB1 (MDR1) rs1045642 is associated with increased overall survival in plasma cell myeloma.	2009	0	-
Tomihisa Niitsu	Pharmacogenetics in major depression: a comprehensive meta-analysis.	2013	3	10.1016/j.pnpbp.2013.05.011
O F Khabour	Frequency of MDR1 single nucleotide polymorphisms in a Jordanian population, including a novel variant.	2013	2	10.4238/2013.March.13.9
Patrick Menu	Antidepressants and ABCB1 gene C3435T functional polymorphism: a naturalistic study.	2010	9	10.1159/000319361
S Damaraju	CYP3A5null3 (rs776746) is associated with docetaxel-specific toxicities during adjuvant breast cancer chemotherapy	2010	1	-
Zhaoming Wang	Association between MDR1 C3435T polymorphism and risk of breast cancer	2013	2	10.1016/j.gene.2013.09.050
M. Ising	Polymorphisms of the drug transporter gene ABCB1 predict side effects of treatment with cabergoline in patients with PRL adenomas	2012	1	10.1530/EJE-12-0198
Et Al Menu P Gressier F Verstuyft C	essants and ABCB1 gene C3435T functional polymorphism: a naturalistic study. Neuropsychobiology	2010	1	-
Kevin Y Urayama	MDR1 gene variants, indoor insecticide exposure, and the risk of childhood acute lymphoblastic leukemia.	2007	5	-
Margherita Maffioli	Correlation between genetic polymorphisms of the hOCT1 and MDR1 genes and the response to imatinib in patients newly diagnosed with chronic-phase chronic myeloid leukemia	2011	2	10.1016/j.leukres.2010.12.004
Fayçal Mouaffak	Ultra-resistant schizophrenia is not associated with the multidrug-resistant transporter 1 (MDR1) gene rs1045642 variant.	2011	5	10.1097/JCP.0b013e31820f9152
R Lakhan	No association of ABCB1 polymorphisms with drug-refractory epilepsy in a north Indian population.	2009	6	-
Stephen Drain	Multidrug resistance gene expression and ABCB1 SNPs in plasma cell myeloma.	2011	3	10.1016/j.leukres.2011.05.033
Mehrzad Banihashemi	Association Between Tacrolimus Concentration and Genetic Polymorphisms of CYP3A5 and ABCB1 During the Early Stage After Liver Transplant in an Iranian Population	2012	3	10.6002/ect.2011.0093
M M Oros	Genetic performance criteria for valproate in patients with epilepsy	2011	2
Douglas Vivona	ABCB1 haplotype is associated with major molecular response in chronic myeloid leukemia patients treated with standard-dose of imatinib.	2011	5	10.1016/j.bcmd.2011.11.001
A B Singh	ABCB1 polymorphism predicts escitalopram dose needed for remission in major depression.	2012	8	10.1038/tp.2012.115
Vibeke Andersen	Polymorphisms in the xenobiotic transporter Multidrug Resistance 1 (MDR1) and interaction with meat intake in relation to risk of colorectal cancer in a Danish prospective case-cohort study.	2009	7	10.1186/1471-2407-9-407
M M Schwab	Impact of MDR1 (C3435T) polymorphism on lymph node regression in multimodality treatment of upper GI cancer: Comparative analysis of patients with gastric cancer and adenocarcinoma of the esophagus	2011	1
M C De Rotte	ABCB1 and ABCC3 gene polymorphisms are associated with first-year response to methotrexate in juvenile idiopathic arthritis	2012	0	10.3899/jrheum.111593;
P. B. Sumitha	Role of ABCB1 Variants on Postoperative Seizure Recurrence in Patients with AED-Resistant Temporal Lobe Epilepsy (P05.079)	2012	1	10.1212/WNL.78.1_MeetingAbstracts.P05.079
L Zhang	Variants in ABCB1, TGFB1, and XRCC1 genes and susceptibility to viral hepatitis A infection in Mexican Americans	2012	5	10.1002/hep.25513
E Gonzalez-Haba	ABCB1 gene polymorphisms are associated with adverse reactions in fluoropyrimidine-treated colorectal cancer patients	2010	1	10.2217/pgs.10.159
S. C. L. Gough	Donor ABCB1 Variant Associates with Increased Risk for Kidney Allograft Failure	2012	2	10.1681/ASN.2012030260
R. Barale	Single nucleotide polymorphism detection by optical DNA-based sensing coupled with whole genomic amplification	2012	3	10.1007/s00216-012-6345-4
S Balan	Role of ABCB1 variants on postoperative seizure recurrence in patients with aed-resistant temporal lobe epilepsy	2012	0	10.1212/WNL.78.1
Lu Y	Host pharmacogenetic factors significantly contribute to refinement of prognosis in children with Acute Lymphoblastic Leukemia (ALL): Result from the Malaysia-Singapore (Ma-Spore) ALL 2003 study	2011	1	-
M Onizuka	Cytochrome P450 genetic polymorphisms influence the serum concentration of calcineurin inhibitors in allogeneic hematopoietic SCT recipients.	2011	9	10.1038/bmt.2010.273
Jian Qu	ABCC2 Polymorphisms and Haplotype are Associated with Drug Resistance in Chinese Epileptic Patients.	2012	5	10.1111/j.1755-5949.2012.00336.x
R Vaclavikova	Detection of frequent ABCB1 polymorphisms by high-resolution melting curve analysis and their effect on breast carcinoma prognosis	2012	1	10.1515/cclm-2012-0103
S Damaraju	CYP3A5null3 (rs776746) is associated with docetaxel-specific toxicities during adjuvant breast cancer chemotherapy	2010	1	-
Georg Nikisch	Cytochrome P450 and ABCB1 genetics: association with quetiapine and norquetiapine plasma and cerebrospinal fluid concentrations and with clinical response in patients suffering from schizophrenia. A pilot study.	2011	5	-
Lu Y.	Host pharmacogenetic factors significantly contribute to refinement of prognosis in children with Acute Lymphoblastic Leukemia (ALL): Result from the Malaysia-Singapore (Ma-Spore) ALL 2003 study	2011	2	-
M L Ermini	Single nucleotide polymorphism detection by optical DNA-based sensing coupled with whole genomic amplification.	2013	3	10.1007/s00216-012-6345-4
M Liu	A functional common polymorphism of the ABCB1 gene is associated with chronic kidney disease and hypertension in Chinese	2013	2	10.1093/ajh/hpt126
Georgina P Sava	Candidate gene association studies and risk of chronic lymphocytic leukemia: a systematic review and meta-analysis.	2014	2	10.3109/10428194.2013.800197
J Jaitner	No association of ABCB1 C3435T genotype with clopidogrel response or risk of stent thrombosis in patients undergoing coronary stenting	2012	1	-
Youngil Koh	Polymorphisms in genes that regulate cyclosporine metabolism affect cyclosporine blood levels and clinical outcomes in patients who receive allogeneic hematopoietic stem cell transplantation.	2012	1	10.1016/j.bbmt.2011.08.019
Margherita Maffioli	Correlation between genetic polymorphisms of the hOCT1 and MDR1 genes and the response to imatinib in patients newly diagnosed with chronic-phase chronic myeloid leukemia.	2011	6	-
Lu Y	Host pharmacogenetic factors significantly contribute to refinement of prognosis in children with Acute Lymphoblastic Leukemia (ALL): Result from the Malaysia-Singapore (Ma-Spore) ALL 2003 study	2011	1	-
Fayçal Mouaffak	Ultra-resistant schizophrenia is not associated with the multidrug-resistant transporter 1 (MDR1) gene rs1045642 variant.	2011	1	-
M M Oros	Genetic performance criteria for valproate in patients with epilepsy	2011	1	-
M Maffioli	Correlation between genetic polymorphisms of the hOCT1 and MDR1 genes and the response to imatinib in patients newly diagnosed with chronic-phase chronic myeloid leukemia	2011	1	-
Federico Canzian	A Comprehensive Investigation on Common Polymorphisms in the MDR1/ABCB1 Transporter Gene and Susceptibility to Colorectal Cancer	2012	4	10.1371/journal.pone.0032784
Douglas Vivona	ABCB1 haplotype is associated with major molecular response in chronic myeloid leukemia patients treated with standard-dose of imatinib.	2012	4	10.1016/j.bcmd.2011.11.001
Brittany B. Dennis	Impact of ABCB1 and CYP2B6 Genetic Polymorphisms on Methadone Metabolism, Dose and Treatment Response in Patients with Opioid Addiction: A Systematic Review and Meta-Analysis	2014	2	10.1371/journal.pone.0086114
M Maffioli	Correlation between genetic polymorphisms of the hOCT1 and MDR1 genes and the response to imatinib in patients newly diagnosed with chronic-phase chronic myeloid leukemia	2011	1	-
C J De Luna	Pharmacogenetic Study of ABCB1 and CYP3A5 Genes During the First Year Following Heart Transplantation Regarding Tacrolimus or Cyclosporine Levels	2011	2	10.1016/j.transproceed.2011.05.008
Min Xu	MDR1 C3435T polymorphism and cancer risk: a meta-analysis based on 39 case–control studies	2012	1	10.1007/s11033-012-1554-7
Patrick Menu	Antidepressants and ABCB1 gene C3435T functional polymorphism: A naturalistic study	2010	8	10.1159/000319361
Shabeesh Balan	Genetic association analysis of ATP binding cassette protein family reveals a novel association of ABCB1 genetic variants with epilepsy risk, but not with drug-resistance	2014	1	10.1371/journal.pone.0089253
M.M. Oros	P.5.c.003 Association of ABCB1 and SCN1A gene polymorphisms with response to sodium valproate and carbamazepine in Ukrainian patients with epilepsy	2012	1	10.1016/S0924-977X(12)70600-4
M Maffioli	Correlation between genetic polymorphisms of the hOCT1 and MDR1 genes and the response to imatinib in patients newly diagnosed with chronic-phase chronic myeloid leukemia	2011	1	-
M M Schwab	Impact of MDR1 (C3435T) polymorphism on lymph node regression in multimodality treatment of upper GI cancer: Comparative analysis of patients with gastric cancer and adenocarcinoma of the esophagus	2011	1	-
G P Sava	Candidate gene association studies and risk of chronic lymphocytic leukemia: a systematic review and meta-analysis	2013	1	10.3109/10428194.2013.800197
M A Scheiner	ABCB1 single nucleotide polymorphisms in the Brazilian population	2010	1	-
Lu Y.	Host pharmacogenetic factors significantly contribute to refinement of prognosis in children with Acute Lymphoblastic Leukemia (ALL): Result from the Malaysia-Singapore (Ma-Spore) ALL 2003 study	2011	2
Jian Qu	ABCC2 polymorphisms and haplotype are associated with drug resistance in Chinese epileptic patients.	2012	8	10.1111/j.1755-5949.2012.00336.x
S. Braun	No Association of ABCB1 C3435T Genotype With Clopidogrel Response or Risk of Stent Thrombosis in Patients Undergoing Coronary Stenting	2012	5	10.1161/CIRCINTERVENTIONS.111.965400

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Publications listed by Genome.gov

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Name	rs1045642
Chromosome	7
Position	87509329
Weight of evidence	194

SNP rs1045642

Basic Information

Genotype Frequency

Allele Frequency

Additional Information

Links to SNPedia

Publications on this SNP on the Public Library of Science:

Publications on this SNP on Mendeley

Evidence compiled by the Personal Genome Project

Publications listed by Genome.gov

Users who share this SNP:

Genome Browser

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