openSNP | rs1044396

Links to SNPedia

Title	Summary
rs1044396 C/C	Increased risk of nicotine dependence among males

Note: For some SNPs, testing providers detect the genotype from the opposite strand of DNA, so that the genotypes listed on openSNP don't appear here. In those cases, please replace "A" by "T" or "G" by "C" (and vice-versa).

Publications on this SNP on the Public Library of Science:

First Author	Title	Year of Publication	# of readers
Judit Lazary	Massive Withdrawal Symptoms and Affective Vulnerability Are Associated with Variants of the CHRNA4 Gene in a Subgroup of Smokers	2014	2240
Thomas Espeseth	Nicotinic Receptor Gene CHRNA4 Interacts with Processing Load in Attention	2010	3031
Robert B. Weiss	A Candidate Gene Approach Identifies the CHRNA5-A3-B4 Region as a Risk Factor for Age-Dependent Nicotine Addiction	2008	15480
Annabella Di Giorgio	DRD2/CHRNA5 Interaction on Prefrontal Biology and Physiology during Working Memory	2014	3689
Thomas P. K. Breckel	Nicotinergic Modulation of Attention-Related Neural Activity Differentiates Polymorphisms of DRD2 and CHRNA4 Receptor Genes	2015	1683
A. Mobascher	Association of Common Polymorphisms in the Nicotinic Acetylcholine Receptor Alpha4 Subunit Gene with an Electrophysiological Endophenotype in a Large Population-Based Sample	2016	1536
Jo-Eun Jeong	The association between the nicotinic acetylcholine receptor α4 subunit gene (CHRNA4) rs1044396 and Internet gaming disorder in Korean male adults	2017	520

Publications on this SNP on Mendeley

First Author	Title	Pub. Year	# of Readers	DOI
Pamela M Greenwood	Both a nicotinic single nucleotide polymorphism (SNP) and a noradrenergic SNP modulate working memory performance when attention is manipulated.	2009	0
P M Greenwood	Synergistic effects of genetic variation in nicotinic and muscarinic receptors on visual attention but not working memory.	2009	1	10.1073/pnas.0807891106
Ivar Reinvang	Individual variation in a cholinergic receptor gene modulates attention.	2009	8	10.1016/j.neulet.2009.02.029
Hema Tharoor	Association of dopamine, serotonin, and nicotinic gene polymorphisms with methylphenidate response in ADHD.	2008	9	-
Sebastian Markett	The nicotinic acetylcholine receptor gene CHRNA4 i... [Emotion. 2011] - PubMed result	2011	1	10.1037/a0021784
Sebastian Markett	The nicotinic acetylcholine receptor gene CHRNA4 i... [Emotion. 2011] - PubMed result	2011	1	10.1037/a0021784
S J Tsai	Association of CHRNA4 polymorphism with depression and loneliness in elderly males.	2012	1	-
Ming D Li	Ethnic- and gender-specific association of the nicotinic acetylcholine receptor alpha4 subunit gene (CHRNA4) with nicotine dependence.	2005	11	10.1093/hmg/ddi132
L P Breitling	Association of nicotinic acetylcholine receptor subunit alpha4 polymorphisms with nicotine dependence in 5500 Germans.	2009	1	10.1038/tpj.2009.6
P M Greenwood	Synergistic effects of genetic variation in nicotinic and muscarinic receptors on visual attention but not working memory.	2009	2	10.1073/pnas.0807891106
P M Greenwood	Synergistic effects of genetic variation in nicotinic and muscarinic receptors on visual attention but not working memory.	2009	20	10.1073/pnas.0807891106
P M Greenwood	A cognitive phenotype for a polymorphism in the nicotinic receptor gene CHRNA4.	2012	6	10.1016/j.neubiorev.2012.02.010
P.M. Greenwood	A cognitive phenotype for a polymorphism in the nicotinic receptor gene CHRNA4	2012	10	10.1016/j.neubiorev.2012.02.010
Hema Tharoor	Association of dopamine, serotonin, and nicotinic gene polymorphisms with methylphenidate response in ADHD.	2008	10	10.1002/ajmg.b.30637
Sebastian Markett	The nicotinic acetylcholine receptor gene CHRNA4 is associated with negative emotionality.	2011	11	-
P M Greenwood	Synergistic effects of genetic variation in nicotinic and muscarinic receptors on visual attention but not working memory 10.1073/pnas.0807891106	2009	0	-
Y Feng	A common haplotype of the nicotine acetylcholine receptor alpha 4 subunit gene is associated with vulnerability to nicotine addiction in men	2004	0	10.1086/422194
Gavin Hudson	Genetic variation of CHRNA4 does not modulate attention in Parkinson's disease.	2010	0	-
Rachael G Grazioplene	A novel differential susceptibility gene: CHRNA4 and moderation of the effect of maltreatment on child personality.	2012	6	10.1111/jcpp.12031
Sebastian A Markett	The association between dopamine DRD2 polymorphisms and working memory capacity is modulated by a functional polymorphism on the nicotinic receptor gene CHRNA4.	2010	22	-
Ivar Reinvang	Individual variation in a cholinergic receptor gene modulates attention.	2009	8	-
Sebastian Markett	Interaction of the cholinergic system and the hypothalamic–pituitary–adrenal axis as a risk factor for depression	2012	2	10.1097/WNR.0b013e32835671ba
Cheng-Jing Chu	Association of nicotinic acetylcholine receptor subunit alpha-4 polymorphisms with smoking behaviors in Chinese male smokers.	2011	0
L P Breitling	Association of nicotinic acetylcholine receptor subunit alpha 4 polymorphisms with nicotine dependence in 5500 Germans.	2009	6	10.1038/tpj.2009.6
S-J Tsai	Association of CHRNA4 polymorphism with depression and loneliness in elderly males.	2012	11	10.1111/j.1601-183X.2011.00741.x
Rachael G Grazioplene	A novel differential susceptibility gene: CHRNA4 and moderation of the effect of maltreatment on child personality.	2012	8	10.1111/jcpp.12031
Yan Feng	A common haplotype of the nicotine acetylcholine receptor alpha 4 subunit gene is associated with vulnerability to nicotine addiction in men.	2004	13	-
Gavin Hudson	Genetic variation of CHRNA4 does not modulate attention in Parkinson's disease.	2010	0	10.1016/j.neulet.2010.05.041
S J Tsai	Association of CHRNA4 polymorphism with depression and loneliness in elderly males	2011	6	10.1111/j.1601-183X.2011.00741.x
Christian Montag	The role of the CHRNA4 gene in Internet addiction: A case-control study.	2012	8	10.1097/ADM.0b013e31825ba7e7
Martin Reuter	Interaction of the cholinergic system and the hypothalamic-pituitary-adrenal axis as a risk factor for depression: evidence from a genetic association study.	2012	1	10.1097/WNR.0b013e32835671ba
Carina Sauer	The Role of the CHRNA4 Gene in Internet Addiction	2012	11	10.1097/ADM.0b013e31825ba7e7
P M Greenwood	Synergistic effects of genetic variation in nicotinic and muscarinic receptors on visual attention but not working memory	2009	1	10.1073/pnas.0807891106
Sebastian Markett	The nicotinic acetylcholine receptor gene CHRNA4 is associated with negative emotionality.	2011	13	10.1037/a0021784
Yan Feng	A common haplotype of the nicotine acetylcholine receptor alpha 4 subunit gene is associated with vulnerability to nicotine addiction in men.	2004	18	10.1086/422194
L P Breitling	Association of nicotinic acetylcholine receptor subunit alpha 4 polymorphisms with nicotine dependence in 5500 Germans	2009	3	-
Georg Winterer	Association of attentional network function with exon 5 variations of the CHRNA4 gene.	2007	12	-
P M Greenwood	Synergistic effects of genetic variation in nicotinic and muscarinic receptors on visual attention but not working memory\r10.1073/pnas.0807891106	2009	1
P M Greenwood	Synergistic effects of genetic variation in nicotinic and muscarinic receptors on visual attention but not working memory.	2009	18	10.1073/pnas.0807891106

Evidence compiled by the Personal Genome Project

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Publications listed by Genome.gov

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Name	rs1044396
Chromosome	20
Position	63349782
Weight of evidence	58

SNP rs1044396

Basic Information

Genotype Frequency

Allele Frequency

Additional Information

Links to SNPedia

Publications on this SNP on the Public Library of Science:

Publications on this SNP on Mendeley

Evidence compiled by the Personal Genome Project

Publications listed by Genome.gov

Users who share this SNP:

Genome Browser

Contacts