openSNP | rs1042522

Links to SNPedia

Title	Summary
rs1042522 C/C	Live 3 years longer. chemotherapy is more effective.
rs1042522 G/G	Common variant. slightly shorter lifespan. }} chemotherapy is less effective. accelerated lung decline in smokers. {{pmid\|19521721\|oa=1
rs1042522 C/G	Slightly increased lifespan?

Note: For some SNPs, testing providers detect the genotype from the opposite strand of DNA, so that the genotypes listed on openSNP don't appear here. In those cases, please replace "A" by "T" or "G" by "C" (and vice-versa).

Publications on this SNP on the Public Library of Science:

First Author	Title	Year of Publication	# of readers
Ali Rihani	CASP8 SNP D302H (rs1045485) Is Associated with Worse Survival in MYCN-Amplified Neuroblastoma Patients	2014	1642
Kristoffer Sølvsten Burgdorf	Studies of the Association of Arg72Pro of Tumor Suppressor Protein p53 with Type 2 Diabetes in a Combined Analysis of 55,521 Europeans	2011	2690
Yu Weng	p53 codon 72 polymorphism and Hematological Cancer Risk: An Update Meta-Analysis	2012	3905
Yasuki Hori	Impact of TP53 Codon 72 and MDM2 SNP 309 Polymorphisms in Pancreatic Ductal Adenocarcinoma	2015	1115
Nagafumi Doi	Persistence Criteria for Susceptibility Genes for Schizophrenia: a Discussion from an Evolutionary Viewpoint	2009	5377
Jeffrey J. W. Verschuren	Systematic Testing of Literature Reported Genetic Variation Associated with Coronary Restenosis: Results of the GENDER Study	2012	2110
Anida Sarajlić	Network Topology Reveals Key Cardiovascular Disease Genes	2013	3256
Rosa Maria Corbo	How Contemporary Human Reproductive Behaviors Influence the Role of Fertility-Related Genes: The Example of the P53 Gene	2012	2548
Carolina Cavaliéri Gomes	Assessment of TP53 Mutations in Benign and Malignant Salivary Gland Neoplasms	2012	3852
Dongmei Wu	Intron 3 Sixteen Base Pairs Duplication Polymorphism of P53 Contributes to Breast Cancer Susceptibility: Evidence from Meta-Analysis	2013	2253
Ranjan Chrisanthar	Predictive and Prognostic Impact of TP53 Mutations and MDM2 Promoter Genotype in Primary Breast Cancer Patients Treated with Epirubicin or Paclitaxel	2011	4373
Xiaoai Zhang	Combined Effects of Genetic Variants of the PTEN, AKT1, MDM2 and p53 Genes on the Risk of Nasopharyngeal Carcinoma	2014	3120
Isabelle Bergiers	The Homeodomain Transcription Factor Hoxa2 Interacts with and Promotes the Proteasomal Degradation of the E3 Ubiquitin Protein Ligase RCHY1	2013	1562
Silvia Pineda	Genetic Variation in the TP53 Pathway and Bladder Cancer Risk. A Comprehensive Analysis	2014	3170
Fernando Pires Hartwig	Evidence for an Epistatic Effect between TP53 R72P and MDM2 T309G SNPs in HIV Infection: A Cross-Sectional Study in Women from South Brazil	2014	1562
Salvador Pastor-Idoate	The T309G MDM2 Gene Polymorphism Is a Novel Risk Factor for Proliferative Vitreoretinopathy	2013	1994
Janey L. Wiggs	The p53 Codon 72 PRO/PRO Genotype May Be Associated with Initial Central Visual Field Defects in Caucasians with Primary Open Angle Glaucoma	2012	1670
Liang Zheng	p21 rs3176352 G>C and p73 rs1801173 C>T Polymorphisms Are Associated with an Increased Risk of Esophageal Cancer in a Chinese Population	2014	1460
Yongwook Choi	Predicting the Functional Effect of Amino Acid Substitutions and Indels	2012	24849
Raju S. R. Adduri	TP53 Pro72 Allele Is Enriched in Oral Tongue Cancer and Frequently Mutated in Esophageal Cancer in India	2014	1144
Qiliu Peng	TP53 and MDM2 Gene Polymorphisms, Gene-Gene Interaction, and Hepatocellular Carcinoma Risk: Evidence from an Updated Meta-Analysis	2013	1741
Dale L. Bodian	Germline Variation in Cancer-Susceptibility Genes in a Healthy, Ancestrally Diverse Cohort: Implications for Individual Genome Sequencing	2014	27637
Gabrielle C. Nickel	Characterizing Mutational Heterogeneity in a Glioblastoma Patient with Double Recurrence	2012	6135
Goar Mosoyan	Multiple Breast Cancer Cell-Lines Derived from a Single Tumor Differ in Their Molecular Characteristics and Tumorigenic Potential	2013	6302
Sirkku Karinen	Data Integration Workflow for Search of Disease Driving Genes and Genetic Variants	2011	4184
Agnès Marchio	A Peculiar Mutation Spectrum Emerging from Young Peruvian Patients with Hepatocellular Carcinoma	2014	2111
Katharina Proestling	The Pro Allele of the p53 Codon 72 Polymorphism Is Associated with Decreased Intratumoral Expression of BAX and p21, and Increased Breast Cancer Risk	2012	3003
Kumaraswamy Naidu Chitrala	Computational Screening and Molecular Dynamic Simulation of Breast Cancer Associated Deleterious Non-Synonymous Single Nucleotide Polymorphisms in TP53 Gene	2014	4507
Luis Alberto Henríquez-Hernández	Polymorphisms in DNA-Repair Genes in a Cohort of Prostate Cancer Patients from Different Areas in Spain: Heterogeneity between Populations as a Confounding Factor in Association Studies	2013	2563
Chuanbo Fan	The Functional TP53 rs1042522 and MDM4 rs4245739 Genetic Variants Contribute to Non-Hodgkin Lymphoma Risk	2014	2148
René L. Warren	Targeted Assembly of Short Sequence Reads	2011	7231
Chih-Hsiung Lai	Clinical Significance in Oral Cavity Squamous Cell Carcinoma of Pathogenic Somatic Mitochondrial Mutations	2013	1627
Suzhen Jiang	Re-evaluation of the Carcinogenic Significance of Hepatitis B Virus Integration in Hepatocarcinogenesis	2012	3748
Stephen D. Walter	Accuracy of p53 Codon 72 Polymorphism Status Determined by Multiple Laboratory Methods: A Latent Class Model Analysis	2013	1491
Mariana Maschietto	TP53 Mutational Status Is a Potential Marker for Risk Stratification in Wilms Tumour with Diffuse Anaplasia	2014	1445
Veronika Vymetalkova	Genotype and Haplotype Analyses of TP53 Gene in Breast Cancer Patients: Association with Risk and Clinical Outcomes	2015	2201
Vanessa Cristina Jacovas	Genetic Variations in the TP53 Pathway in Native Americans Strongly Suggest Adaptation to the High Altitudes of the Andes	2015	2400
Ronghai Cheng	Virtual Pharmacist: A Platform for Pharmacogenomics	2015	4022
Ana Luiza Seidinger	Occurrence of Neuroblastoma among TP53 p.R337H Carriers	2015	2150
Feng Gao	A Regulatory MDM4 Genetic Variant Locating in the Binding Sequence of Multiple MicroRNAs Contributes to Susceptibility of Small Cell Lung Cancer	2015	2722
Vassiliki Kotoula	Evaluation of Two Highly-Multiplexed Custom Panels for Massively Parallel Semiconductor Sequencing on Paraffin DNA	2015	1102
Chaoyong Tian	Comparison of Genetic Variants in Cancer-Related Genes between Chinese Hui and Han Populations	2015	2157
Gloria López Valverde	Study of Association between Pre-Senile Cataracts and the Polymorphisms rs2228000 in XPC and rs1042522 in p53 in Spanish Population	2016	1472

Publications on this SNP on Mendeley

First Author	Title	Pub. Year	# of Readers	DOI
Carolina C Gomes	TP53 rs1042522 SNP in salivary gland neoplasms.	2013	1	10.1002/hed.23513
Santos Alonso	The diversity profile of TP53 is influenced by positive selection on the immediately upstream locus WDR79	2009	7	10.1159/000243152
Robert J Hancox	Accelerated decline in lung function in cigarette smokers is associated with TP53/MDM2 polymorphisms.	2009	6	10.1007/s00439-009-0704-z
Xuemei Zhang	Genetic polymorphisms in cell cycle regulatory genes MDM2 and TP53 are associated with susceptibility to lung cancer.	2006	8	10.1002/humu.20277
Kshitij Srivastava	Candidate gene studies in gallbladder cancer: a systematic review and meta-analysis.	2011	7	10.1016/j.mrrev.2011.06.002
Salvador Pastor-Idoate	The T309G MDM2 gene polymorphism is a novel risk factor for proliferative vitreoretinopathy	2013	4	10.1371/journal.pone.0082283
KJ Kyle J Gaulton	Comprehensive Association Study of Type 2 Diabetes and Related Quantitative Traits with 222 Candidate Genes.	2008	1
Prerana Jha	TP53 polymorphisms in gliomas from Indian patients: Study of codon 72 genotype, rs1642785, rs1800370 and 16 base pair insertion in intron-3.	2011	5	10.1016/j.yexmp.2010.11.002
Joerg Bittenbring	MDM2 gene SNP309 T/G and p53 gene SNP72 G/C do not influence diffuse large B-cell non-Hodgkin lymphoma onset or survival in central European Caucasians.	2008	7	10.1186/1471-2407-8-116
Nelson Tang	Correlation of telomere length shortening with TP53 somatic mutations, polymorphisms and allelic loss in breast tumors and esophageal cancer	2012	3	10.3892/or.2012.2098
Leah E Mechanic	Common genetic variation in TP53 is associated with lung cancer risk and prognosis in African Americans and somatic mutations in lung tumors.	2007	1	10.1158/1055-9965.EPI-06-0790
Yifeng Yang	Tumor suppressor gene TP53 is genetically associated with schizophrenia in the Chinese population	2004	9	10.1016/j.neulet.2004.07.068
José Caamaño	TP53 codon 72 polymorphism is associated with coronary artery disease in Chilean subjects.	2011	0
Jill Koshiol	Common genetic variation in TP53 and risk of human papillomavirus persistence and progression to CIN3/cancer revisited.	2009	1	-
Katie A. Ashton	Polymorphisms in TP53 and MDM2 combined are associated with high grade endometrial cancer	2009	8	10.1016/j.ygyno.2008.12.036
Florian Ebner	The role of TP53 and p21 gene polymorphisms in breast cancer biology in a well specified and characterized German cohort.	2010	3	10.1007/s00432-010-0788-9
A Naccarati	Genotype and haplotype analysis of TP53 gene and the risk of pancreatic cancer: an association study in the Czech Republic.	2010	1	-
Surong Hu	The association between polymorphism of P53 codon 72 Arg/Pro and hepatocellular carcinoma susceptibility: Evidence from a meta-analysis of 15 studies with 3704 cases	2013	1	10.1016/j.mgene.2013.09.010
V Polakova	Genotype and haplotype analysis of cell cycle genes in sporadic colorectal cancer in the Czech Republic.	2009	2	10.1002/humu.20931
Sayeh Ezzikouri	Impact of TP53 codon 72 and MDM2 promoter 309 allelic dosage in a Moroccan population with hepatocellular carcinoma	2011	1	10.5301/JBM.2011.8881
Fumihiko Mabuchi	Lack of association between p53 gene polymorphisms and primary open angle glaucoma in the Japanese population	2009	3
O M Sinilnikova	The TP53 Arg72Pro and MDM2 309G>T polymorphisms are not associated with breast cancer risk in BRCA1 and BRCA2 mutation carriers	2009	1	6605279 [pii]\r10.1038/sj.bjc.6605279
Mia M Gaudet	Genetic variation of TP53, polycyclic aromatic hydrocarbon-related exposures, and breast cancer risk among women on Long Island, New York.	2006	3	-
Pallavi Singhal	Association of MDM2 and p53 polymorphisms with the advancement of cervical carcinoma.	2013	5	10.1089/dna.2012.1718
Sharon A Savage	Germ-line genetic variation of TP53 in osteosarcoma.	2007	6	10.1002/pbc
V Polakova	Genotype and haplotype analysis of cell cycle genes in sporadic colorectal cancer in the Czech Republic	2009	2
Issa J Dahabreh	TP53 Arg72Pro polymorphism and colorectal cancer risk: a systematic review and meta-analysis.	2010	5	-
Bruna Gigante	NAMPT (visfatin) and AKT1 genetic variants associate with myocardial infarction	2012	2	10.1016/j.cca.2012.01.002
Myung Su Son	Promoter polymorphisms of pri-miR-34b/c are associated with hepatocellular carcinoma	2013	3	10.1016/j.gene.2013.04.042
Fabio Di Pietro	Genomic DNA extraction from whole blood stored from 15- to 30-years at -20 °C by rapid phenol-chloroform protocol: a useful tool for genetic epidemiology studies.	2011	8	-
Fabio Di Pietro	Genomic DNA extraction from whole blood stored from 15- to 30-years at -20 °C by rapid phenol-chloroform protocol: a useful tool for genetic epidemiology studies.	2011	15	10.1016/j.mcp.2010.10.003
Gian Andri Thun	The association of a variant in the cell cycle control gene CCND1 and obesity on the development of asthma in the Swiss SAPALDIA study.	2013	2	10.3109/02770903.2012.757776
Kristoffer Sølvsten Burgdorf	Studies of the Association of Arg72Pro of Tumor Suppressor Protein p53 with Type 2 Diabetes in a Combined Analysis of 55,521 Europeans	2011	1	-
Wa Xian	The Li-Fraumeni syndrome (LFS): a model for the initiation of p53 signatures in the distal Fallopian tube.	2010	6	-
Vincent Zimmer	Potential genotype-specific single nucleotide polymorphism interaction of common variation in p53 and its negative regulator mdm2 in cholangiocarcinoma susceptibility.	2012	0	10.3892/ol.2012.680
Bassam Lajin	Association Between Polymorphisms in the Genes for Tumor Suppressor Protein p53 and its Regulator NAD(P)H: Quinone Oxidoreductase 1 (NQO1) and Schizophrenia in a Syrian Study Cohort	2013	2	10.1016/j.arcmed.2012.12.009
Vincent Zimmer	Potential genotype-specific single nucleotide polymorphism interaction of common variation in p53 and its negative regulator mdm2 in cholangiocarcinoma susceptibility	2012	1	10.3892/ol.2012.680
Issa J Dahabreh	Genotype Misclassification in Genetic Association Studies of the rs1042522 TP53 (Arg72Pro) Polymorphism: A Systematic Review of Studies of Breast, Lung, Colorectal, Ovarian, and Endometrial Cancer.	2013	3	10.1093/aje/kws394
Hellen Silva Cintra	Investigation of genetic polymorphisms related to the outcome of radiotherapy for prostate cancer patients	2013	4	10.1155/2013/762685
Kshitij Srivastava	Candidate gene studies in gallbladder cancer: A systematic review and meta-analysis.	2011	6	-
L Ricks-Santi	p53 Pro72Arg polymorphism and prostate cancer in men of African descent.	2010	2	-
Fabio Di Pietro	Genomic DNA extraction from whole blood stored from 15- to 30-years at -20 ??C by rapid phenol-chloroform protocol: A useful tool for genetic epidemiology studies	2011	21	10.1016/j.mcp.2010.10.003
Evgeny V Denisov	Coordination of TP53 Abnormalities in Breast Cancer: Data from Analysis of TP53 Polymorphisms, Loss of Heterozygosity, Methylation, and Mutations.	2011	3	10.1089/gtmb.2011.0038
Thuy N Do	TP53 R72P and MDM2 SNP309 polymorphisms in modification of childhood acute lymphoblastic leukemia susceptibility.	2009	0	-
Fumihiko Mabuchi	Lack of association between p53 gene polymorphisms and primary open angle glaucoma in the Japanese population.	2009	3
Xiaoai Zhang	Combined Effects of Genetic Variants of the PTEN, AKT1, MDM2 and p53 Genes on the Risk of Nasopharyngeal Carcinoma.	2014	2	10.1371/journal.pone.0092135
Mia M Gaudet	Genetic variation of TP53, polycyclic aromatic hydrocarbon-related exposures, and breast cancer risk among women on Long Island, New York.	2008	2	10.1007/s10549-007-9573-0
Abul Kalam Azad	Validation of Genetic Sequence Variants as Prognostic Factors in Early-Stage Head and Neck Squamous Cell Cancer Survival	2012	1	10.1158/1078-0432.CCR-11-1759
M Brunotto	Risk genes in head and neck cancer: A systematic review and meta-analysis of last 5years.	2014	6	10.1016/j.oraloncology.2013.12.007
Kyle J J Gaulton	Comprehensive Association Study of Type 2 Diabetes and Related Quantitative Traits with 222 Candidate Genes.	2008	1	10.2337/db07-1731
Thuy N Do	TP53 R72P and MDM2 SNP309 polymorphisms in modification of childhood acute lymphoblastic leukemia susceptibility.	2009	0	10.1016/j.cancergencyto.2009.05.009
Jill Koshiol	Common genetic variation in TP53 and risk of human papillomavirus persistence and progression to CIN3/cancer revisited.	2009	1	-
Xin Zhou	Association between p53 codon 72 polymorphism and cervical cancer risk among Asians: a HuGE review and meta-analysis.	2012	4	-
Stefanie J Klug	TP53 codon 72 polymorphism and cervical cancer: a pooled analysis of individual data from 49 studies.	2009	13	-
Salvador Pastor-Idoate	The p53 codon 72 polymorphism (rs1042522) is associated with proliferative vitreoretinopathy: The retina 4 project	2013	2	10.1016/j.ophtha.2012.08.019
Mei-Li Wang	[Association of murine double minute 2 and P53 polymorphisms with breast cancer susceptibility].	2013	1
Y J Huang	A novel functional DEC1 promoter polymorphism -249T>C reduces risk of squamous cell carcinoma of the head and neck	2010	1	10.1093/carcin/bgq198
Yoshimoto N.	Genetic and environmental predictors, endogenous hormones and growth factors, and risk of estrogen receptor-positive breast cancer in Japanese women	2011	1	-
Haibo Zhang	Common Genetic Variants in 53BP1 Associated with Non-small Cell Lung Cancer Risk in Han Chinese.	2013	2	10.1016/j.arcmed.2013.10.011
Lili Qu	Association between polymorphisms in RAPGEF1, TP53, NRF1 and type 2 diabetes in Chinese Han population	2011	4	10.1016/j.diabres.2010.11.019
Fabio Di Pietro	Genomic DNA Extraction From	2004	1	10.1016/j.mcp.2010.10.003
X Zhou	Association Between p53 codon 72 Polymorphism and Cervical Cancer Risk Among Asians: a Huge Review and Meta-analysis	2012	2	-
Kshitij Srivastava	Candidate gene studies in gallbladder cancer: a systematic review and meta-analysis.	2011	2	10.1016/j.mrrev.2011.06.002
Thuy N. Do	TP53 R72P and MDM2 SNP309 polymorphisms in modification of childhood acute lymphoblastic leukemia susceptibility	2009	1	10.1016/j.cancergencyto.2009.05.009
Mei-li Wang	[Association of murine double minute 2 and P53 polymorphisms with breast cancer susceptibility].	2013	1	-
Erwin Reiling	Codon 72 polymorphism (rs1042522) of TP53 is associated with changes in diastolic blood pressure over time	2012	2	10.1038/ejhg.2011.240
Sher-ullah Shahnoo Sulliman Khoyratty	Genomic DNA Extraction From	2004	9	10.1016/j.mcp.2010.10.003
Christopher L Daugherty	Primary open angle glaucoma in a Caucasian population is associated with the p53 codon 72 polymorphism.	2009	3
Won Yong Lee	I. Extraction of Genomic DNA	2010	2	10.1016/j.mcp.2010.10.003
Valeria Di Vuolo	TP53 and MDM2 gene polymorphisms and risk of hepatocellular carcinoma in Italian patients.	2011	1	10.1186/1750-9378-6-13
Jill Koshiol	Common genetic variation in TP53 and risk of human papillomavirus persistence and progression to CIN3/cancer revisited.	2009	0	-
Li Liu	Combined effect of genetic polymorphisms in P53, P73, and MDM2 on non-small cell lung cancer survival.	2011	2	10.1097/JTO.0b013e3182272273
Issa J Dahabreh	TP53 Arg72Pro polymorphism and colorectal cancer risk: a systematic review and meta-analysis.	2010	6	10.1158/1055-9965.EPI-10-0156
M M Gaudet	Genetic variation of TP53, polycyclic aromatic hydrocarbon-related exposures, and breast cancer risk among women on Long Island, New York	2008	1
L Ricks-Santi	p53 Pro72Arg polymorphism and prostate cancer in men of African descent.	2010	3	10.1002/pros.21209
Lili Qu	Association between polymorphisms in RAPGEF1, TP53, NRF1 and type 2 diabetes in Chinese Han population.	2011	10	-
Yanli Li	TP53 genetic polymorphisms, interactions with lifestyle factors and lung cancer risk: a case control study in a Chinese population.	2013	3	10.1186/1471-2407-13-607
Fabio Di Pietro	TP53*P72 allele influences negatively female life expectancy in a population of central Italy: cross-sectional study and genetic-demographic approach analysis.	2013	3	10.1093/gerona/gls223
Kyle J Gaulton	Comprehensive association study of type 2 diabetes and related quantitative traits with 222 candidate genes.	2008	10	10.2337/db07-1731
Stefanie J Klug	TP53 codon 72 polymorphism and cervical cancer: a pooled analysis of individual data from 49 studies.	2009	17	10.1016/S1470-2045(09)70187-1
Kshitij Srivastava	Candidate gene studies in gallbladder cancer: a systematic review and meta-analysis.	2011	9	10.1016/j.mrrev.2011.06.002
Peng Zhang	Association study between P53 and P73 gene polymorphisms and the sporadic late-onset form of Alzheimer's disease.	2003	3	-
E V Denisov	TP53 Gene Polymorphisms in Cancer Risk: The Modulating Effect of Ageing, Ethnicity and TP53 Somatic Abnormalities	2012	2
Nandita Mitra	Investigation of the Effect of MDM2 SNP309 and TP53 Arg72Pro Polymorphisms on the Age of Onset of Cutaneous Melanoma	2012	4	10.1038/jid.2012.15
Ju Yang	Association of p53 and MDM2 polymorphisms with risk of human papillomavirus (HPV)-related esophageal squamous cell carcinoma (ESCC)	2013	5	10.1016/j.canep.2013.06.001
Ju Yang	Association of p53 and MDM2 polymorphisms with risk of human papillomavirus (HPV)-related esophageal squamous cell carcinoma (ESCC)	2013	3	10.1016/j.canep.2013.06.001
Li Liu	Combined effect of genetic polymorphisms in P53, P73, and MDM2 on non-small cell lung cancer survival.	2011	3	10.1097/JTO.0b013e3182272273
Valeria Di Vuolo	TP53 and MDM2 gene polymorphisms and risk of hepatocellular carcinoma in Italian patients	2011	1	10.1186/1750-9378-6-13
Xin Zhou	Association between p53 codon 72 polymorphism and cervical cancer risk among Asians: a HuGE review and meta-analysis.	2012	2
Lili Qu	Association between polymorphisms in RAPGEF1, TP53, NRF1 and type 2 diabetes in Chinese Han population.	2011	2	10.1016/j.diabres.2010.11.019
Tianbo Jin	TP53 and RPA3 gene variations were associated with risk of glioma in a Chinese Han population.	2013	3	10.1089/cbr.2012.1291
Leah E Mechanic	Common genetic variation in TP53 is associated with lung cancer risk and prognosis in African Americans and somatic mutations in lung tumors.	2007	5	10.1158/1055-9965.EPI-06-0790
Xiaoyi Zhou	Polymorphisms in HPV E6/E7 protein interacted genes and risk of cervical cancer in Chinese women: a case-control analysis.	2009	10	-
Nadezhda V Cherdyntseva	Crosstalk Between the FGFR2 and TP53 Genes in Breast Cancer: Data from an Association Study and Epistatic Interaction Analysis.	2011	3	10.1089/dna.2011.1351
Yu-Jing Huang	A novel functional DEC1 promoter polymorphism -249T>C reduces risk of squamous cell carcinoma of the head and neck.	2010	2	-
Christopher L Daugherty	Primary open angle glaucoma in a Caucasian population is associated with the p53 codon 72 polymorphism	2009	3
X M Zhang	Genetic polymorphisms in cell cycle regulatory genes MDM2 and TP53 are associated with susceptibility to lung cancer	2006	1	Doi 10.1002/Humu.20277
Kristoffer Sølvsten Burgdorf	Studies of the Association of Arg72Pro of Tumor Suppressor Protein p53 with Type 2 Diabetes in a Combined Analysis of 55,521 Europeans	2011	4	10.1371/journal.pone.0015813
Pin Sun	Association of genetic polymorphisms, mRNA expression of p53 and p21 with chronic benzene poisoning in a chinese occupational population.	2009	1	10.1158/1055-9965.EPI-09-0140
Joerg Bittenbring	MDM2 gene SNP309 T/G and p53 gene SNP72 G/C do not influence diffuse large B-cell non-Hodgkin lymphoma onset or survival in central European Caucasians	2008	7	10.1186/1471-2407-8-116

Evidence compiled by the Personal Genome Project

Gene	Impact	Trait	Summary	Inheritance
TP53	Low clinical importance, Uncertain pathogenic		This is a common variant was first reported as a polymorphism. It has since had mixed associations with cancer: Storey et al. conclude a 7x increased risk of HPV cancer for homozygotes vs hets, but Jones et al. find a 1.98x decreased risk for colorectal cancer. This variant may have significant impact on particular cancers, but it is unclear what effect it has on the overall burden of cancer.	unknown

Publications listed by Genome.gov

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Name	rs1042522
Chromosome	17
Position	7676154
Weight of evidence	283

SNP rs1042522

Basic Information

Genotype Frequency

Allele Frequency

Additional Information

Links to SNPedia

Publications on this SNP on the Public Library of Science:

Publications on this SNP on Mendeley

Evidence compiled by the Personal Genome Project

Publications listed by Genome.gov

Users who share this SNP:

Genome Browser

Contacts