Spinal Degenerative bone or disc disease, resulting in debilitating pain, nerve damage/pain, physical issues, etc. Specifically resulting in surgery or disc replacement before the age of 40; or disability before the age of 30, without any physical injury or explained cause. (Except genetics).
https://www.spineuniverse.com/conditions/degenerative-disc-disease
https://www.aans.org/Patients/Neurosurgical-Conditions-and-Treatments/Osteoarthritis