openSNP | rs762551

Links to SNPedia

Title	Summary
rs762551 A/A	Fast caffeine metabolizer.
rs762551 C/C	Cyp1a2 slow caffeine metabolizer.
rs762551 A/C	*Carrier of one cyp1a21f allele; slow caffeine metabolizer.**

Note: For some SNPs, testing providers detect the genotype from the opposite strand of DNA, so that the genotypes listed on openSNP don't appear here. In those cases, please replace "A" by "T" or "G" by "C" (and vice-versa).

Publications on this SNP on the Public Library of Science:

First Author	Title	Year of Publication	# of readers
Yuan Zhao	Quantitative Assessment of the Influence of Cytochrome P450 1A2 Gene Polymorphism and Colorectal Cancer Risk	2013	1451
Qi Pei	Evaluation of the Highly Variable Agomelatine Pharmacokinetics in Chinese Healthy Subjects to Support Bioequivalence Study	2014	2771
Xiao-Feng He	Association between CYP1A2 and CYP1B1 Polymorphisms and Colorectal Cancer Risk: A Meta-Analysis	2014	1615
Yueshan Hu	Genotyping Performance between Saliva and Blood-Derived Genomic DNAs on the DMET Array: A Comparison	2012	6873
Richard A. Mushlin	Clique-Finding for Heterogeneity and Multidimensionality in Biomarker Epidemiology Research: The CHAMBER Algorithm	2009	2685
Dazhi Wang	Functional Evaluation of Genetic and Environmental Regulators of P450 mRNA Levels	2011	3506
Cosmin Sebastian Voican	Liver Function Test Abnormalities in Depressed Patients Treated with Antidepressants: A Real-World Systematic Observational Study in Psychiatric Settings	2016	4124

Publications on this SNP on Mendeley

First Author	Title	Pub. Year	# of Readers	DOI
U Ghoshal	Genetic polymorphism of cytochrome P450 (CYP) 1A1, CYP1A2, and CYP2E1 genes modulate susceptibility to gastric cancer in patients with Helicobacter pylori infection	2013	1
Sofia Pavanello	CYP1A2 polymorphisms, occupational and environmental exposures and risk of bladder cancer.	2010	3	-
Idris Guessous	Caffeine intake and CYP1A2 variants associated with high caffeine intake protect non-smokers from hypertension.	2012	16	10.1093/hmg/dds137
Idris Guessous	Caffeine intake and CYP1A2 variants associated with high caffeine intake protect non-smokers from hypertension.	2012	1	10.1093/hmg/dds137
H Wang	CYP1A2 rs762551 polymorphism contributes to cancer susceptibility: a meta-analysis from 19 case-control studies	2012	3	10.1186/1471-2407-12-528
H Wang	CYP1A2 rs762551 polymorphism contributes to cancer susceptibility: a meta-analysis from 19 case-control studies	2012	0	10.1186/1471-2407-12-528
B Laika	Pharmacogenetics and olanzapine treatment: CYP1A2*1F and serotonergic polymorphisms influence therapeutic outcome.	2010	0	10.1038/tpj.2009.32
Ulla Vogel	Role of CYP1A2 polymorphisms on lung cancer risk in a prospective study	2012	0	10.1016/j.cancergen.2012.02.004
Eng-King Tan	Association between caffeine intake and risk of Parkinson's disease among fast and slow metabolizers.	2007	4	-
L Song	Effect of CYP1A2 polymorphism on the pharmacokinetics of agomelatine in Chinese healthy male volunteers.	2014	2	10.1111/jcpt.12118
Hongge Wang	CYP1A2 rs762551 polymorphism contributes to cancer susceptibility: a meta-analysis from 19 case-control studies.	2012	5	10.1186/1471-2407-12-528
Sumitaka Kobayashi	Genetic association of aromatic hydrocarbon receptor (AHR) and cytochrome P450, family 1, subfamily A, polypeptide 1 (CYP1A1) polymorphisms with dioxin blood concentrations among pregnant Japanese women	2013	4	10.1016/j.toxlet.2013.03.013
Sofia Pavanello	Role of CYP1A2 polymorphisms in breast cancer risk in women	2012	0	10.3892/mmr.2012.1164
Zhong Tian	Role of CYP1A2 1F polymorphism in cancer risk: evidence from a meta-analysis of 46 case-control studies.	2013	3	10.1016/j.gene.2013.04.038
Idris Guessous	Caffeine intake and CYP1A2 variants associated with high caffeine intake protect non-smokers from hypertension.	2012	8	10.1093/hmg/dds137
Sofia Pavanello	CYP1A2 polymorphisms, occupational and environmental exposures and risk of bladder cancer.	2010	0	10.1007/s10654-010-9479-8
Sofia Pavanello	Role of CYP1A2 polymorphisms on lung cancer risk in a prospective study.	2012	2	10.1016/j.cancergen.2012.02.004
A. G. Uitterlinden	CYP1A2 and coffee intake and the modifying effect of sex, age, and smoking	2012	0	10.3945/ajcn.111.027102
S Kobayashi	Genetic association of aromatic hydrocarbon receptor (AHR) and cytochrome P450, family 1, subfamily A, polypeptide 1 (CYP1A1) polymorphisms with dioxin blood concentrations among pregnant Japanese women	2013	1	-
Sofia Pavanello	Role of CYP1A2 polymorphisms on lung cancer risk in a prospective study	2012	9	10.1016/j.cancergen.2012.02.004
Hongge Wang	CYP1A2 rs762551 polymorphism contributes to cancer susceptibility: a meta-analysis from 19 case-control studies	2012	4	10.1186/1471-2407-12-528
Eng-King Tan	Association between caffeine intake and risk of Parkinson's disease among fast and slow metabolizers.	2007	0	10.1097/FPC.0b013e3282f09265

Evidence compiled by the Personal Genome Project

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Publications listed by Genome.gov

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Name	rs762551
Chromosome	15
Position	74749576
Weight of evidence	51

SNP rs762551

Basic Information

Genotype Frequency

Allele Frequency

Additional Information

Links to SNPedia

Publications on this SNP on the Public Library of Science:

Publications on this SNP on Mendeley

Evidence compiled by the Personal Genome Project

Publications listed by Genome.gov

Users who share this SNP:

Genome Browser

Contacts