openSNP | rs10455872

Links to SNPedia

Title	Summary
rs10455872 G/G	Increased coronary heart disease risk
rs10455872 A/G	Increased coronary heart disease risk
rs10455872 A/A	Common/normal

Note: For some SNPs, testing providers detect the genotype from the opposite strand of DNA, so that the genotypes listed on openSNP don't appear here. In those cases, please replace "A" by "T" or "G" by "C" (and vice-versa).

Publications on this SNP on the Public Library of Science:

First Author	Title	Year of Publication	# of readers
Andrew R. Wood	Imputation of Variants from the 1000 Genomes Project Modestly Improves Known Associations and Can Identify Low-frequency Variant - Phenotype Associations Undetected by HapMap Based Imputation	2013	4719
Andrea S. Foulkes	Mixed Modeling of Meta-Analysis P-Values (MixMAP) Suggests Multiple Novel Gene Loci for Low Density Lipoprotein Cholesterol	2013	3857
The IBC 50K CAD Consortium	Large-Scale Gene-Centric Analysis Identifies Novel Variants for Coronary Artery Disease	2011	20564
Rahul C. Deo	Single-Nucleotide Polymorphisms in LPA Explain Most of the Ancestry-Specific Variation in Lp(a) Levels in African Americans	2011	4223
Logan Dumitrescu	Variation in LPA Is Associated with Lp(a) Levels in Three Populations from the Third National Health and Nutrition Examination Survey	2011	4107
Kiran Musunuru	Multi-Ethnic Analysis of Lipid-Associated Loci: The NHLBI CARe Project	2012	3096
Katherine E. Beaney	Clinical Utility of a Coronary Heart Disease Risk Prediction Gene Score in UK Healthy Middle Aged Men and in the Pakistani Population	2015	2273
Heejung Shim	A Multivariate Genome-Wide Association Analysis of 10 LDL Subfractions, and Their Response to Statin Treatment, in 1868 Caucasians	2015	3434
Yong An	IL-10 Genetic Polymorphisms Were Associated with Valvular Calcification in Han, Uygur and Kazak Populations in Xinjiang, China	2015	555
Kristen Fortney	Genome-Wide Scan Informed by Age-Related Disease Identifies Loci for Exceptional Human Longevity	2015	24433
Elena Sticchi	Apolipoprotein(a) Kringle-IV Type 2 Copy Number Variation Is Associated with Venous Thromboembolism	2016	358

Publications on this SNP on Mendeley

First Author	Title	Pub. Year	# of Readers	DOI
George Thanassoulis	Genetic associations with valvular calcification and aortic stenosis.	2013	35	10.1056/NEJMoa1109034
Zheng Ye	The association between circulating lipoprotein(a) and type 2 diabetes: is it causal?	2013	1	10.2337/db13-1144
Jemma C Hopewell	Lipoprotein(a) Genetic Variants Associated with Coronary and Peripheral Vascular Disease, But Not with Stroke Risk in the Heart Protection Study.	2011	1	10.1161/CIRCGENETICS.110.958371
Jeffrey L Anderson	Validation and Quantification of Genetic Determinants of Lipoprotein-a Levels and Predictive Value for Angiographic Coronary Artery Disease.	2013	2	10.1016/j.amjcard.2013.05.009
Jemma C Hopewell	Lipoprotein(a) genetic variants associated with coronary and peripheral vascular disease but not with stroke risk in the Heart Protection Study.	2011	5	10.1161/CIRCGENETICS.110.958371
Qibin Qi	Genetic variants, plasma lipoprotein(a) levels, and risk of cardiovascular morbidity and mortality among two prospective cohorts of type 2 diabetes.	2012	10	10.1093/eurheartj/ehr350
Zheng Ye	The Association Between Circulating Lipoprotein(a) and Type 2 Diabetes: Is It Causal?	2014	5	10.2337/db13-1144
Robert Clarke	Genetic variants associated with Lp(a) lipoprotein level and coronary disease.	2009	85	10.1056/NEJMoa0902604
Jemma C Hopewell	Lipoprotein(a) genetic variants associated with coronary and peripheral vascular disease but not with stroke risk in the Heart Protection Study	2011	5	10.1161/CIRCGENETICS.110.958371
Q Qi	Genetic variants, plasma lipoprotein(a) levels, and risk of cardiovascular morbidity and mortality among two prospective cohorts of type 2 diabetes1522	2012	1
Qibin Qi	Genetic variants, plasma lipoprotein(a) levels, and risk of cardiovascular morbidity and mortality among two prospective cohorts of type 2 diabetes.	2012	6	10.1093/eurheartj/ehr350
Pia R Kamstrup	Extreme Lipoprotein(a) Levels and Improved Cardiovascular Risk Prediction.	2013	4	10.1016/j.jacc.2012.12.023
Q Qi	Genetic variants, plasma lipoprotein(a) levels, and risk of cardiovascular morbidity and mortality among two prospective cohorts of type 2 diabetes	2012	1	-
George Thanassoulis	Genetic associations with valvular calcification and aortic stenosis.	2013	52	10.1056/NEJMoa1109034
J C Hopewell	Lipoprotein(a) genetic variants associated with coronary and peripheral vascular disease but not with stroke risk in the Heart Protection Study	2011	3	10.1161/CIRCGENETICS.110.958371
Pia R. Kamstrup	Lipoprotein(a) concentrations, isoform size, and risk of type 2 diabetes: A Mendelian randomisation study	2013	5	10.1016/S2213-8587(13)70064-0
W Koch	Two rare variants explain association with acute myocardial infarction in an extended genomic region including the apolipoprotein(a) gene	2013	2	10.1111/j.1469-1809.2012.00739.x
Q Qi	Genetic variants, plasma lipoprotein(a) levels, and risk of cardiovascular morbidity and mortality among two prospective cohorts of type 2 diabetes	2012	1	ehr350 [pii]\r10.1093/eurheartj/ehr350
Werner Koch	Two rare variants explain association with acute myocardial infarction in an extended genomic region including the apolipoprotein(A) gene.	2013	4	10.1111/j.1469-1809.2012.00739.x
H. A. Deshmukh	Genome-wide association study of genetic determinants of LDL-c response to atorvastatin therapy: importance of Lp(a)	2012	7	10.1194/jlr.P021113
Qibin Qi	Genetic variants, plasma lipoprotein(a) levels, and risk of cardiovascular morbidity and mortality among two prospective cohorts of type 2 diabetes.	2011	4	10.1093/eurheartj/ehr350
Pia R Kamstrup	Extreme lipoprotein(a) levels and improved cardiovascular risk prediction.	2013	6	10.1016/j.jacc.2012.12.023
R Clarke	Genetic Variants Associated with Lp(a) Lipoprotein Level and Coronary Disease	2009	63	10.1056/NEJMoa0902604
Harshal A Deshmukh	Genome-wide association study of genetic determinants of LDL-c response to atorvastatin therapy: Importance of Lp(a).	2012	5	10.1194/jlr.P021113
Benoit J Arsenault	Lipoprotein(a) Levels, Genotype and Incident Aortic Valve Stenosis: A Prospective Mendelian Randomization Study and Replication in a Case-Control Cohort.	2014	1	10.1161/CIRCGENETICS.113.000400

Evidence compiled by the Personal Genome Project

There are no results from the Personal Genome Project yet. Please come back later.

Publications listed by Genome.gov

First Author	Title	Journal	Publication Date	Trait	p-value	Confidence Interval
Chasman DI	Genetic determinants of statin-induced low-density lipoprotein cholesterol reduction: the Justification for the Use of Statins in Prevention: an Intervention Trial Evaluating Rosuvastatin (JUPITER) trial.	Circ Cardiovasc Genet	02/13/2012	Response to statin therapy (LDL-C)	5.0e-15 (fractional LDL-C reduction)	[4.45-9.15] % increase
Deshmukh HA	Genome-wide association study of genetic determinants of LDL-c response to atorvastatin therapy: importance of Lp(a).	J Lipid Res	02/24/2012	Response to statin therapy	1.0e-09	[0.20-0.36] mmol/L decrease
Qi Q	Genetic variants, plasma lipoprotein(a) levels, and risk of cardiovascular morbidity and mortality among two prospective cohorts of type 2 diabetes.	Eur Heart J	09/06/2011	Lp (a) levels	5.0e-39	[1.08-1.48] mg/dL increase

Name	rs10455872
Chromosome	6
Position	160589086
Weight of evidence	68

SNP rs10455872

Basic Information

Genotype Frequency

Allele Frequency

Additional Information

Links to SNPedia

Publications on this SNP on the Public Library of Science:

Publications on this SNP on Mendeley

Evidence compiled by the Personal Genome Project

Publications listed by Genome.gov

Users who share this SNP:

Genome Browser

Contacts