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SNP rs9923231
Basic Information
Name
rs9923231
Chromosome
16
Position
31096368
Weight of evidence
85
Genotype Frequency
Allele Frequency
Additional Information
SNPedia (3)
PLoS (20)
Mendeley (26)
Personal Genome Project (0)
Genome.gov (2)
Other users (1683)
Comments (0)
Links to SNPedia
Title
Summary
rs9923231 T/T
Reduced warfarin dose if treated for vte
rs9923231 C/C
Normal
rs9923231 C/T
Reduced warfarin dose if treated for vte
Note: For some SNPs, testing providers detect the genotype from the opposite strand of DNA, so that the genotypes listed on openSNP don't appear here. In those cases, please replace "A" by "T" or "G" by "C" (and vice-versa).
Publications on this SNP on the Public Library of Science:
First Author
Title
Year of Publication
# of readers
Blandine Patillon
Positive Selection in the Chromosome 16
VKORC1
Genomic Region Has Contributed to the Variability of Anticoagulant Response in Humans
2012
3779
Federico Innocenti
Identification, Replication, and Functional Fine-Mapping of Expression Quantitative Trait Loci in Primary Human Liver Tissue
2011
17426
Minami Ohara
Determinants of the Over-Anticoagulation Response during Warfarin Initiation Therapy in Asian Patients Based on Population Pharmacokinetic-Pharmacodynamic Analyses
2014
2334
Siyue Li
Warfarin Dosage Response Related Pharmacogenetics in Chinese Population
2015
4721
Inna Y. Gong
Clinical and Genetic Determinants of Warfarin Pharmacokinetics and Pharmacodynamics during Treatment Initiation
2011
12040
Frederick E. Dewey
Phased Whole-Genome Genetic Risk in a Family Quartet Using a Major Allele Reference Sequence
2011
30158
Fumihiko Takeuchi
A Genome-Wide Association Study Confirms
VKORC1
,
CYP2C9
, and
CYP4F2
as Principal Genetic Determinants of Warfarin Dose
2009
27946
Andrea L. Jorgensen
Influence of CYP2C9 and VKORC1 on Patient Response to Warfarin: A Systematic Review and Meta-Analysis
2012
13201
Jose Antonio Miñarro-Giménez
An Ontology-Based, Mobile-Optimized System for Pharmacogenomic Decision Support at the Point-of-Care
2014
4708
Alberto M. Borobia
An Acenocoumarol Dosing Algorithm Using Clinical and Pharmacogenetic Data in Spanish Patients with Thromboembolic Disease
2012
10767
Cristina Mazzaccara
Warfarin Anticoagulant Therapy: A Southern Italy Pharmacogenetics-Based Dosing Model
2013
3305
Vania Bonifaz-Peña
Exploring the Distribution of Genetic Markers of Pharmacogenomics Relevance in Brazilian and Mexican Populations
2014
5202
Ramasamy Saminathan
VKORC1
Pharmacogenetics and Pharmacoproteomics in Patients on Warfarin Anticoagulant Therapy: Transthyretin Precursor as a Potential Biomarker
2010
5419
Ana Isabel Anton
Novel Associations of
VKORC1
Variants with Higher Acenocoumarol Requirements
2013
3439
Zoraida Verde
A Novel, Single Algorithm Approach to Predict Acenocoumarol Dose Based on
CYP2C9
and
VKORC1
Allele Variants
2010
3881
Dana C. Crawford
VKORC1
Common Variation and Bone Mineral Density in the Third National Health and Nutrition Examination Survey
2010
2682
Konrad J. Karczewski
Chapter 7: Pharmacogenomics
2012
25648
Rong Liu
Comparison of Nine Statistical Model Based Warfarin Pharmacogenetic Dosing Algorithms Using the Racially Diverse International Warfarin Pharmacogenetic Consortium Cohort Database
2015
1037
Bora Yeon
Analysis of Pharmacogenomic Variants Associated with Population Differentiation
2015
1638
Hoi Y. Tong
A New Pharmacogenetic Algorithm to Predict the Most Appropriate Dosage of Acenocoumarol for Stable Anticoagulation in a Mixed Spanish Population
2016
2481
Publications on this SNP on Mendeley
First Author
Title
Pub. Year
# of Readers
DOI
D C Crawford
VKORC1 common variation and bone mineral density in the Third National Health and Nutrition Examination Survey
2010
1
10.1371/journal.pone.0015088
Dhakchinamoorthi Krishna Kumar
Effect of CYP2C9, VKORC1, CYP4F2 and GGCX genetic variants on warfarin maintenance dose and explicating a new pharmacogenetic algorithm in South Indian population.
2013
1
10.1007/s00228-013-1581-x
J Oldenburg
VKORC1: molecular target of coumarins.
2007
21
10.1111/j.1538-7836.2007.02549.x
L. R. Brandao
VKORC1 and CYP2C9 genotype and patient characteristics explain a large proportion of the variability in warfarin dose requirement among children
2012
8
10.1182/blood-2011-08-372722
M A Perera
Novel snps associated with warfarin dose in a large multicenter cohort of African Americans: Genome wide association study and Replication Results
2011
1
Hann-yeh Shyu
Clinica Chimica Acta Genotype polymorphisms of GGCX , NQO1 , and VKORC1 genes associated with risk susceptibility in patients with large-artery atherosclerotic stroke
2010
0
10.1016/j.cca.2010.02.071
V Perez-Andreu
Regulation of VKORC1 expression by micrornas and its potential effect on acenocoumarol requirements
2011
1
Jin Zhu
ARMS test for diagnosis of CYP2C9 and VKORC1 mutation in patients with pulmonary embolism in Han Chinese.
2010
1
Kendra A Ross
Worldwide allele frequency distribution of four polymorphisms associated with warfarin dose requirements.
2010
9
10.1038/jhg.2010.73
Guilherme Suarez-Kurtz
Pharmacogenomics of Warfarin in Populations of African Descent.
2012
3
10.1111/j.1365-2125.2012.04354.x
Center for History and New Media
Zotero Quick Start Guide
2011
1
10.3969/j.issn.1671-167X.2011.06.003
E Ramos
Pharmacogenomics, ancestry and clinical decision making for global populations.
2013
2
10.1038/tpj.2013.24
Jin Zhu
ARMS test for diagnosis of CYP2C9 and VKORC1 mutation in patients with pulmonary embolism in Han Chinese.
2010
1
-
Pei-Chieng Cha
Genome-wide association study identifies genetic determinants of warfarin responsiveness for Japanese.
2010
8
-
Kendra A Ross
Worldwide allele frequency distribution of four polymorphisms associated with warfarin dose requirements.
2010
6
-
J Oldenburg
VKORC1: molecular target of coumarins.
2007
7
-
John Mackay
A simulation of warfarin maintenance dose requirement using a pharmacogenetic algorithm in an ethnically diverse cohort
2010
1
10.2217/pme.10.24
Carlos Isaza
Factores genéticos y ambientales asociados con la respuestaa warfarina en pacientes colombianos
2010
4
Ivet M Suriapranata
Genetic factors associated with patient-specific warfarin dose in ethnic Indonesians
2011
4
10.1186/1471-2350-12-80
Hann Yeh Shyu
Genotype polymorphisms of GGCX, NQO1, and VKORC1 genes associated with risk susceptibility in patients with large-artery atherosclerotic stroke
2010
14
10.1016/j.cca.2010.02.071
Carlo Giansante
Oral anticoagulation and VKORC1 polymorphism in patients with a mechanical heart prosthesis: a 6-year follow-up
2012
1
10.1007/s11239-012-0740-8
Dana C Crawford
VKORC1 common variation and bone mineral density in the Third National Health and Nutrition Examination Survey.
2010
2
10.1371/journal.pone.0015088
Ting-Liang Wang
Genetic factors contribute to patient-specific warfarin dose for Han Chinese.
2008
4
10.1016/j.cca.2008.07.005
Pei-Chieng Cha
Genome-wide association study identifies genetic determinants of warfarin responsiveness for Japanese.
2010
7
10.1093/hmg/ddq389
E Ramos
Pharmacogenomics, ancestry and clinical decision making for global populations
2013
1
V Pérez-Andreu
Pharmacogenetics of acenocoumarol in patients with extreme dose requirements.
2010
4
10.1111/j.1538-7836.2010.03800.x
Evidence compiled by the
Personal Genome Project
There are no results from the
Personal Genome Project
yet. Please come back later.
Publications listed by
Genome.gov
First Author
Title
Journal
Publication Date
Trait
p-value
Confidence Interval
Cha PC
Genome-wide association study identifies genetic determinants of warfarin responsiveness for Japanese.
Hum Mol Genet
09/10/2010
Warfarin maintenance dose
9.0e-31
NR
Takeuchi F
A genome-wide association study confirms VKORC1, CYP2C9, and CYP4F2 as principal genetic determinants of warfarin dose.
PLoS Genet
03/20/2009
Warfarin maintenance dose
1.0e-100
[0.91-1.02] mg/week decrease
Users who share this SNP:
Genome Browser