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SNP rs7754840
Basic Information
Name
rs7754840
Chromosome
6
Position
20661019
Weight of evidence
95
Genotype Frequency
Allele Frequency
Additional Information
SNPedia (3)
PLoS (29)
Mendeley (16)
Personal Genome Project (0)
Genome.gov (3)
Other users (1527)
Comments (0)
Links to SNPedia
Title
Summary
rs7754840 C/C
1.3x increased risk for type-2 diabetes
rs7754840 G/G
Normal
rs7754840 C/G
1.3x increased risk for type-2 diabetes
Note: For some SNPs, testing providers detect the genotype from the opposite strand of DNA, so that the genotypes listed on openSNP don't appear here. In those cases, please replace "A" by "T" or "G" by "C" (and vice-versa).
Publications on this SNP on the Public Library of Science:
First Author
Title
Year of Publication
# of readers
Stéphane Cauchi
Post Genome-Wide Association Studies of Novel Genes Associated with Type 2 Diabetes Show Gene-Gene Interaction and High Predictive Value
2008
12155
Chia Lin Chang
Adaptive Human
CDKAL1
Variants Underlie Hormonal Response Variations at the Enteroinsular Axis
2014
1448
Slavica Pecioska
Association between Type 2 Diabetes Loci and Measures of Fatness
2010
16908
John R. B. Perry
Stratifying Type 2 Diabetes Cases by BMI Identifies Genetic Risk Variants in
LAMA1
and Enrichment for Risk Variants in Lean Compared to Obese Cases
2012
19233
Harald Staiger
Polymorphisms within the Novel Type 2 Diabetes Risk Locus
MTNR1B
Determine β-Cell Function
2008
4738
Hongyan Mao
Meta-Analysis of the Relationship between Common Type 2 Diabetes Risk Gene Variants with Gestational Diabetes Mellitus
2012
7343
John P.A. Ioannidis
Heterogeneity in Meta-Analyses of Genome-Wide Association Investigations
2007
10623
Silke A. Herzberg-Schäfer
Evaluation of Fasting State-/Oral Glucose Tolerance Test-Derived Measures of Insulin Release for the Detection of Genetically Impaired β-Cell Function
2010
8521
Afaf Absood
Insulin Therapy for Pre-Hyperglycemic Beta-Cell Endoplasmic Reticulum Crowding
2013
2197
Trine Welløv Boesgaard
Variant near ADAMTS9 Known to Associate with Type 2 Diabetes Is Related to Insulin Resistance in Offspring of Type 2 Diabetes Patients—EUGENE2 Study
2009
4262
Kevin M. Waters
Consistent Association of Type 2 Diabetes Risk Variants Found in Europeans in Diverse Racial and Ethnic Groups
2010
10269
Steven Haney
RNAi Screening in Primary Human Hepatocytes of Genes Implicated in Genome-Wide Association Studies for Roles in Type 2 Diabetes Identifies Roles for CAMK1D and CDKAL1, among Others, in Hepatic Glucose Regulation
2013
4518
Harald Staiger
Polymorphisms within the Novel Type 2 Diabetes Risk Locus
MTNR1B
Determine β-Cell Function
2008
6672
Ying Wang
Association of Six Single Nucleotide Polymorphisms with Gestational Diabetes Mellitus in a Chinese Population
2011
5772
Mica Ohara-Imaizumi
Deletion of CDKAL1 Affects Mitochondrial ATP Generation and First-Phase Insulin Exocytosis
2010
3565
Xiaomu Kong
Association of Genetic Variants with Isolated Fasting Hyperglycaemia and Isolated Postprandial Hyperglycaemia in a Han Chinese Population
2013
3152
Jinghui Yang
Genetic Association Study with Metabolic Syndrome and Metabolic-Related Traits in a Cross-Sectional Sample and a 10-Year Longitudinal Sample of Chinese Elderly Population
2014
2701
Harald Staiger
Novel Meta-Analysis-Derived Type 2 Diabetes Risk Loci Do Not Determine Prediabetic Phenotypes
2008
3840
Yudi Pawitan
How Many Genetic Variants Remain to Be Discovered?
2009
4574
Tadashi Okamura
Deletion of CDKAL1 Affects High-Fat Diet–Induced Fat Accumulation and Glucose-Stimulated Insulin Secretion in Mice, Indicating Relevance to Diabetes
2012
3778
André Gustavo P. Sousa
Genetic Variants of Diabetes Risk and Incident Cardiovascular Events in Chronic Coronary Artery Disease
2011
2482
Cheng Hu
PPARG
,
KCNJ11
,
CDKAL1
,
CDKN2A-CDKN2B
,
IDE-KIF11-HHEX
,
IGF2BP2
and
SLC30A8
Are Associated with Type 2 Diabetes in a Chinese Population
2009
8909
Samuel P. Dickson
Rare Variants Create Synthetic Genome-Wide Associations
2010
43735
Birgit-Christiane Zyriax
The Association of Genetic Markers for Type 2 Diabetes with Prediabetic Status - Cross-Sectional Data of a Diabetes Prevention Trial
2013
4027
Xueling Sim
Transferability of Type 2 Diabetes Implicated Loci in Multi-Ethnic Cohorts from Southeast Asia
2011
6832
Björn Friedrich
Variance of the SGK1 Gene Is Associated with Insulin Secretion in Different European Populations: Results from the TUEF, EUGENE2, and METSIM Studies
2008
4270
Alicia Huerta-Chagoya
Genetic Determinants for Gestational Diabetes Mellitus and Related Metabolic Traits in Mexican Women
2015
5509
Katherine Angela Benson
A HuGE Review and Meta-Analyses of Genetic Associations in New Onset Diabetes after Kidney Transplantation
2016
2223
Uru Nezu Osada
A Common Susceptibility Gene for Type 2 Diabetes Is Associated with Drug Response to a DPP-4 Inhibitor: Pharmacogenomic Cohort in Okinawa Japan
2016
2052
Publications on this SNP on Mendeley
First Author
Title
Pub. Year
# of Readers
DOI
Alena Stancáková
Single-nucleotide polymorphism rs7754840 of CDKAL1 is associated with impaired insulin secretion in nondiabetic offspring of type 2 diabetic subjects and in a large sample of men with normal glucose tolerance.
2008
3
-
Soo Heon Kwak
A Genome-Wide Association Study of Gestational Diabetes Mellitus in Korean Women.
2012
11
10.2337/db11-1034
Xiao Yun Bao
Replication study of novel risk variants in six genes with type 2 diabetes and related quantitative traits in the Han Chinese lean individuals.
2011
7
10.1007/s11033-011-0995-8
Michal Bronstein
Type 2 diabetes susceptibility loci in the Ashkenazi Jewish population.
2008
2
-
Mandy Van Hoek
Genetic Variant in the IGF2BP2 Gene May Interact With Fetal Malnutrition to Affect Glucose Metabolism
2009
11
10.2337/db08-1173
Michal Bronstein
Type 2 diabetes susceptibility loci in the Ashkenazi Jewish population.
2008
2
10.1007/s00439-008-0520-x
DA Chistiakov
of CDKAL1 impairs beta-cell function in both diabetic and non-diabetic patients and reduces response to non-sulfonylurea and sulfonylurea agonists of the pancreatic
2011
1
-
Alena Stancáková
CDKAL1 Is Associated with Impaired Insulin Secretion in Nondiabetic Offspring of Type 2 Diabetic Subjects and in a Large Sample of Men with Normal Glucose Tolerance
2008
7
10.1210/jc.2007-2218
Manickam Chidambaram
Replication of recently described type 2 diabetes gene variants in a South Indian population.
2010
6
10.1016/j.metabol.2010.04.024
Manickam Chidambaram
Replication of recently described type 2 diabetes gene variants in a South Indian population.
2010
5
-
K Kirchhoff
Polymorphisms in the TCF7L2, CDKAL1 and SLC30A8 genes are associated with impaired proinsulin conversion.
2008
9
-
Bin Peng
Replication study of novel risk variants in six genes with type 2 diabetes and related quantitative traits in the Han Chinese lean individuals
2012
8
10.1007/s11033-011-0995-8
M A S Dehwah
CDKAL1 and type 2 diabetes: a global meta-analysis.
2010
11
10.4238/vol9-2gmr802
Alena Stancáková
CDKAL1 Is Associated with Impaired Insulin Secretion in Nondiabetic Offspring of Type 2 Diabetic Subjects and in a Large Sample of Men with Normal Glucose Tolerance
2008
2
10.1210/jc.2007-2218
Srinath Sanda
A SNP in G6PC2 predicts insulin secretion in type 1 diabetes.
2012
3
10.1007/s00592-012-0389-y
Dharambir K Sanghera
Impact of nine common type 2 diabetes risk polymorphisms in Asian Indian Sikhs: PPARG2 (Pro12Ala), IGF2BP2, TCF7L2 and FTO variants confer a significant risk
2008
16
10.1186/1471-2350-9-59
Evidence compiled by the
Personal Genome Project
There are no results from the
Personal Genome Project
yet. Please come back later.
Publications listed by
Genome.gov
First Author
Title
Journal
Publication Date
Trait
p-value
Confidence Interval
Kwak SH
A genome-wide association study of gestational diabetes mellitus in Korean women.
Diabetes
01/10/2012
Diabetes (gestational)
7.0e-16
[1.372-1.680]
Saxena R
Genome-wide association analysis identifies loci for type 2 diabetes and triglyceride levels.
Science
04/26/2007
Type 2 diabetes
4.0e-11 (DGI+FUSION+WTCCC)
[1.08-1.16]
Scott LJ
A genome-wide association study of type 2 diabetes in Finns detects multiple susceptibility variants.
Science
04/26/2007
Type 2 diabetes
4.0e-11 (DGI+FUSION+WTCCC)
[1.08-1.16]
Users who share this SNP:
Genome Browser