openSNP | rs7566605

Links to SNPedia

Title	Summary
rs7566605 C/C	Mixed evidence of increased obesity risk, may suppress excercise effects in men
rs7566605 C/G	?
rs7566605 G/G	Common

Note: For some SNPs, testing providers detect the genotype from the opposite strand of DNA, so that the genotypes listed on openSNP don't appear here. In those cases, please replace "A" by "T" or "G" by "C" (and vice-versa).

Publications on this SNP on the Public Library of Science:

First Author	Title	Year of Publication	# of readers
Sven Knüppel	Evaluation of 41 Candidate Gene Variants for Obesity in the EPIC-Potsdam Cohort by Multi-Locus Stepwise Regression	2013	3216
Kathryn G. Ewens	FTO and MC4R Gene Variants Are Associated with Obesity in Polycystic Ovary Syndrome	2011	7106
Iris M. Heid	Meta-Analysis of the INSIG2 Association with Obesity Including 74,345 Individuals: Does Heterogeneity of Estimates Relate to Study Design?	2009	8464
Gaurav Garg	Variation in the MC4R Gene Is Associated with Bone Phenotypes in Elderly Swedish Women	2014	1720
Anne-Marie Kaulfers	Association of INSIG2 Polymorphism with Overweight and LDL in Children	2015	1649
Jinghui Yang	Genetic Association Study with Metabolic Syndrome and Metabolic-Related Traits in a Cross-Sectional Sample and a 10-Year Longitudinal Sample of Chinese Elderly Population	2014	2701
Paola León-Mimila	Contribution of Common Genetic Variants to Obesity and Obesity-Related Traits in Mexican Children and Adults	2013	8826
Ming-Wei Su	Gene-Gene and Gene-Environmental Interactions of Childhood Asthma: A Multifactor Dimension Reduction Approach	2012	7101
Helen N Lyon	The Association of a SNP Upstream of INSIG2 with Body Mass Index is Reproduced in Several but Not All Cohorts	2007	7451
Camilla H. Andreasen	Non-Replication of Genome-Wide Based Associations between Common Variants in INSIG2 and PFKP and Obesity in Studies of 18,014 Danes	2008	3677

Publications on this SNP on Mendeley

First Author	Title	Pub. Year	# of Readers	DOI
Karani S Vimaleswaran	Absence of association between the INSIG2 gene polymorphism (rs7566605) and obesity in the European Youth Heart Study (EYHS).	2009	3	-
Ron Do	Fine mapping of the insulin-induced gene 2 identifies a variant associated with LDL cholesterol and total apolipoprotein B levels.	2010	3	10.1161/CIRCGENETICS.109.917039
Funda E Orkunoglu-Suer	INSIG2 gene polymorphism is associated with increased subcutaneous fat in women and poor response to resistance training in men.	2008	6	10.1186/1471-2350-9-117
Seongwon Cha	Association analyses of the INSIG2 polymorphism in the obesity and cholesterol levels of Korean populations.	2009	3	10.1186/1471-2350-10-96
Seongwon Cha	Association analyses of the INSIG2 polymorphism in the obesity and cholesterol levels of Korean populations	2009	1	10.1186/1471-2350-10-96
Hai Jun Wang	Association of the common genetic variant upstream of INSIG2 gene with obesity related phenotypes in Chinese children and adolescents	2008	3	10.1016/S0895-3988(09)60013-1
A. Herbert	Response to Comments on "A Common Genetic Variant Is Associated with Adult and Childhood Obesity"	2007	5	10.1126/science.1129763
Helen N Lyon	The association of a SNP upstream of INSIG2 with body mass index is reproduced in several but not all cohorts.	2007	17	10.1371/journal.pgen.0030061
M Fornage	Common INSIG2 polymorphisms are associated with age-related changes in body size and high-density lipoprotein cholesterol from young adulthood to middle age	2010	1
J Harbron	Effect of eight polymorphisms on weight loss outcomes in overweight/obese caucasian adults	2010	2
Hai-Jun Wang	Association of the common genetic variant upstream of INSIG2 gene with obesity related phenotypes in Chinese children and adolescents.	2008	2	10.1016/S0895-3988(09)60013-1
Camilla H Andreasen	Non-Replication of Genome-Wide Based Associations between Common Variants in INSIG2 and PFKP and Obesity in Studies of 18,014 Danes	2008	9	10.1371/journal.pone.0002872
Dieter Rosskopf	Comment on "A common genetic variant is associated with adult and childhood obesity".	2007	15	-
A J P Smith	INSIG2 gene polymorphism is not associated with obesity in Caucasian, Afro-Caribbean and Indian subjects.	2007	3	-
Iris M Heid	Meta-Analysis of the INSIG2 Association with Obesity Including 74,345 Individuals: Does Heterogeneity of Estimates Relate to Study Design?	2009	17	10.1371/journal.pgen.1000694
Myriam Fornage	Common INSIG2 polymorphisms are associated with age-related changes in body size and high-density lipoprotein cholesterol from young adulthood to middle age.	2010	0
Jan Bressler	The INSIG2 rs7566605 genetic variant does not play a major role in obesity in a sample of 24,722 individuals from four cohorts	2009	1	10.1186/1471-2350-10-56
Kenji Oki	The single nucleotide polymorphism upstream of insulin-induced gene 2 ( INSIG2) is associated with the prevalence of hypercholesterolaemia, but not with obesity, in Japanese American women.	2009	0	10.1017/S0007114508006557
Kikuko Hotta	INSIG2 gene rs7566605 polymorphism is associated with severe obesity in Japanese.	2008	4	10.1007/s10038-008-0317-8
Daniele Campa	The INSIG2 rs7566605 polymorphism is not associated with body mass index and breast cancer risk	2010	5	10.1186/1471-2407-10-563
K Doudney	Upstream genetic variant near INSIG2 , influences response to carnitine supplementation in bipolar patients with valproate-induced weight gain	2009	3	10.1111/j.1601-5215.2009.00379.x
Kikuko Hotta	INSIG2 gene rs7566605 polymorphism is associated with severe obesity in Japanese	2008	2	10.1007/s10038-008-0317-8
J Kumar	The common genetic variant upstream of INSIG2 gene is not associated with obesity in Indian population.	2007	0
Daniele Campa	The INSIG2 rs7566605 polymorphism is not associated with body mass index and breast cancer risk.	2010	6	10.1186/1471-2407-10-563
T Reinehr	Aggravating effect of INSIG2 and FTO on overweight reduction in a one-year lifestyle intervention.	2009	4	10.1136/adc.2008.147652
Silke Wiedmann	Lack of association between a common polymorphism near the INSIG2 gene and BMI, myocardial infarction, and cardiovascular risk factors.	2009	2	-
Daniele Campa	The INSIG2 rs7566605 polymorphism is not associated with body mass index and breast cancer risk	2010	1	10.1186/1471-2407-10-563
E M Smith	INSIG1 influences obesity-related hypertriglyceridemia in humans.	2010	7	10.1194/jlr.M001404
Ling Yang	Potential association of INSIG2 rs7566605 polymorphism with body weight in a Chinese subpopulation.	2008	0	10.1038/ejhg.2008.8
Ron Do	Fine mapping of the insulin-induced gene 2 identifies a variant associated with LDL cholesterol and total apolipoprotein B levels.	2010	2	-
P W Franks	Assessing gene-treatment interactions at the FTO and INSIG2 loci on obesity-related traits in the Diabetes Prevention Program.	2008	20	10.1007/s00125-009-1389-5
J Zhang	A common polymorphism is associated with body mass index in Uyghur population	2008	2	10.1016/j.diabres.2008.03.022
Iris M Heid	Meta-analysis of the INSIG2 association with obesity including 74,345 individuals: does heterogeneity of estimates relate to study design?	2009	25	10.1371/journal.pgen.1000694
J Zhang	A common polymorphism is associated with body mass index in Uyghur population	2008	1	S0168-8227(08)00190-3 [pii]\r10.1016/j.diabres.2008.03.022 [doi]
Ranjan Deka	A tagging SNP in INSIG2 is associated with obesity-related phenotypes among Samoans.	2009	4	10.1186/1471-2350-10-143
Ruth J F Loos	Comment on “ A Common Genetic Childhood Obesity	2007	4	10.1126/science.1130012
Dieter Rosskopf	Comment on "A common genetic variant is associated with adult and childhood obesity".	2007	9	10.1126/science.1130571
Darroch H Hall	INSIG-2 promoter polymorphism and obesity related phenotypes: association study in 1428 members of 248 families.	2006	8	10.1186/1471-2350-7-83
Silke Wiedmann	Lack of association between a common polymorphism near the INSIG2 gene and BMI, myocardial infarction, and cardiovascular risk factors.	2009	2	10.1038/oby.2008.669
C Dina	Comment on "A common genetic variant is associated with adult and childhood obesity"	2007	1	10.1126/science.1129402
Thomas Reinehr	Evidence of an influence of a polymorphism near the INSIG2 on weight loss during a lifestyle intervention in obese children and adolescents.	2008	7	10.2337/db07-0408
Jun Zhang	A common polymorphism is associated with body mass index in Uyghur population.	2008	3	-
P W Franks	Assessing gene-treatment interactions at the FTO and INSIG2 loci on obesity-related traits in the Diabetes Prevention Program.	2008	15	-
J A Hubácek	INSIG2 promoter variant, obesity markers and lipid parameters - No association in a large Slavonic Caucasian population sample.	2010	3
Armand Peeters	Possible role for ENPP1 polymorphism in obesity but not for INSIG2 and PLIN variants.	2009	0	10.1007/s12020-009-9194-y
Eva Boes	INSIG2 polymorphism is neither associated with BMI nor with phenotypes of lipoprotein metabolism.	2008	7	10.1038/oby.2007.132
Yasuharu Tabara	No association between INSIG2 Gene rs7566605 polymorphism and being overweight in Japanese population.	2008	3	-
Thomas Reinehr	Evidence of an influence of a polymorphism near the INSIG2 on weight loss during a lifestyle intervention in obese children and adolescents.	2008	5	-
Yan Feng	Lack of association between rs7566605 and obesity in a Chinese population.	2007	0	-
A J P Smith	INSIG2 gene polymorphism is not associated with obesity in Caucasian, Afro-Caribbean and Indian subjects.	2007	4	10.1038/sj.ijo.0803645
Camilla H Andreasen	Non-replication of genome-wide based associations between common variants in INSIG2 and PFKP and obesity in studies of 18,014 Danes.	2008	10	10.1371/journal.pone.0002872
Helen N. Lyon	The association of a SNP upstream of INSIG2 with body mass index is reproduced in several but not all cohorts	2007	24	10.1371/journal.pgen.0030061
Dieter Rosskopf	Comment on “ A Common Genetic and Childhood Obesity	2007	6	10.1126/science.1130571
Christian Dina	Comment on "A common genetic variant is associated with adult and childhood obesity".	2007	1	10.1126/science.1129402
J Harbron	The interaction between BMI, lifestyle factors and seven obesity related polymorphisms in Caucasian adults	2010	2
Marina Ciullo	Identification and replication of a novel obesity locus on chromosome 1q24 in isolated populations of Cilento.	2008	6	10.2337/db07-0970
Kenji Oki	The single nucleotide polymorphism upstream of insulin-induced gene 2 ( INSIG2) is associated with the prevalence of hypercholesterolaemia, but not with obesity, in Japanese American women.	2009	0	-
Ling Yang	Potential association of INSIG2 rs7566605 polymorphism with body weight in a Chinese subpopulation.	2008	0	-
K Kvaløy	Sex-specific effects of weight-affecting gene variants in a life course perspective-The HUNT Study, Norway.	2013	6	10.1038/ijo.2012.220
Jun Zhang	A common polymorphism is associated with body mass index in Uyghur population	2008	3	10.1016/j.diabres.2008.03.022
Cláudia B Angeli	Multilocus analyses of seven candidate genes suggest interacting pathways for obesity-related traits in Brazilian populations.	2011	5	10.1038/oby.2010.325
J A Hubacek	INSIG2 Promoter Variant, Obesity Markers and Lipid Parameters - No Association in a Large Slavonic Caucasian Population Sample	2010	2	-
Marina Ciullo	Mitochondrial diabetes: investigation and identification of a novel mutation.	2008	5	-
Yuka Takahama	Association of a genetic polymorphism in ectonucleotide pyrophosphatase/phosphodiesterase 1 with hepatitis C virus infection and hepatitis C virus core antigen levels in subjects in a hyperendemic area of Japan.	2008	0	-
R J Loos	Comment on "A common genetic variant is associated with adult and childhood obesity"	2007	1	10.1126/science.1130012
F E Orkunoglu-Suer	INSIG2 gene polymorphism is associated with increased subcutaneous fat in women and poor response to resistance training in men	2008	2	1471-2350-9-117 [pii]\r10.1186/1471-2350-9-117
J Z Popadic Gacesa	Association between intramuscular fat in the arm following arm training and INSIG2.	2013	1	10.1111/sms.12102
Funda E Orkunoglu-Suer	INSIG2 gene polymorphism is associated with increased subcutaneous fat in women and poor response to resistance training in men	2008	3	10.1186/1471-2350-9-117
Kumar J.	The common genetic variant upstream of INSIG2 gene is not associated with obesity in Indian population	2007	1	-
J Kumar	The common genetic variant upstream of INSIG2 gene is not associated with obesity in Indian population.	2007	1	-
Gaifen Liu	Influence of common variants in FTO and near INSIG2 and MC4R on growth curves for adiposity in African- and European-American youth.	2011	12	10.1007/s10654-011-9583-4
J Kumar	The common genetic variant upstream of INSIG2 gene is not associated with obesity in Indian population	2007	1	-
R Deka	INSIG2 variants, dietary patterns and metabolic risk in Samoa	2012	2	10.1038/ejcn.2012.124
E M Smith	INSIG1 influences obesity-related hypertriglyceridemia in humans	2010	6	10.1194/jlr.M001404
C Dina	Comment on "A common genetic variant is associated with adult and childhood obesity"	2007	1	10.1126/science.1129402
Christian Dina	Comment on "A common genetic variant is associated with adult and childhood obesity".	2007	10	10.1126/science.1129402
Ruth J F Loos	Comment on "A common genetic variant is associated with adult and childhood obesity".	2007	1	10.1126/science.1130012
Dieter Rosskopf	Comment on "A common genetic variant is associated with adult and childhood obesity".	2007	1	10.1126/science.1130571
Karani S Vimaleswaran	Absence of association between the INSIG2 gene polymorphism (rs7566605) and obesity in the European Youth Heart Study (EYHS).	2009	5	10.1038/oby.2008.650
Masafumi Kuzuya	No association between rs7566605 variant and being overweight in Japanese.	2007	0	10.1038/oby.2007.301
Darroch H Hall	INSIG-2 promoter polymorphism and obesity related phenotypes: association study in 1428 members of 248 families	2006	4	10.1186/1471-2350-7-83
Hai-Jun Wang	Association of the common genetic variant upstream of INSIG2 gene with obesity related phenotypes in Chinese children and adolescents.	2008	0	-
H N Lyon	The association of a SNP upstream of INSIG2 with body mass index is reproduced in several but not all cohorts	2007	7
Jun Zhang	A common polymorphism is associated with body mass index in Uyghur population.	2008	3	10.1016/j.diabres.2008.03.022
Patrizia Zavattari	An INSIG2 polymorphism affects glucose homeostasis in Sardinian obese children and adolescents.	2010	1	10.1111/j.1469-1809.2010.00590.x
Rebecca L Pollex	Association between the -455T>C promoter polymorphism of the APOC3 gene and the metabolic syndrome in a multi-ethnic sample	2007	6	10.1186/1471-2350-8-80
Patrizia Zavattari	An INSIG2 polymorphism affects glucose homeostasis in Sardinian obese children and adolescents.	2010	1	-
Rebecca L Pollex	Association between the -455T>C promoter polymorphism of the APOC3 gene and the metabolic syndrome in a multi-ethnic sample.	2007	7	10.1186/1471-2350-8-80
Alan Herbert	Response to Comments on "A Common Genetic Variant Is Associated with Adult and Childhood Obesity"	2007	1
Masafumi Kuzuya	No association between rs7566605 variant and being overweight in Japanese.	2007	0	-
Yasuharu Tabara	No association between INSIG2 Gene rs7566605 polymorphism and being overweight in Japanese population.	2008	2	10.1038/oby.2007.25
Jan Bressler	The INSIG2 rs7566605 genetic variant does not play a major role in obesity in a sample of 24,722 individuals from four cohorts.	2009	2	10.1186/1471-2350-10-56
Iris M. Heid	Meta-analysis of the INSIG2 association with obesity including 74,345 individuals: Does heterogeneity of estimates relate to study design?	2009	27	10.1371/journal.pgen.1000694
Kimberly A Skelding	Association of an INSIG2 obesity allele with cardiovascular phenotypes is gender and age dependent	2010	3	10.1186/1471-2261-10-46
R J Loos	Comment on "A common genetic variant is associated with adult and childhood obesity"	2007	1
Ranjan Deka	A tagging SNP in INSIG2 is associated with obesity-related phenotypes among Samoans	2009	4	10.1186/1471-2350-10-143
Cláudia B Angeli	Multilocus analyses of seven candidate genes suggest interacting pathways for obesity-related traits in Brazilian populations.	2011	4	-
Eva Boes	INSIG2 polymorphism is neither associated with BMI nor with phenotypes of lipoprotein metabolism.	2008	5	-
All Snps	Is rs7566605 , a SNP near INSIG2 , associated with body mass in a randomized clinical trial of antipsychotics in schizophrenia ? Catechol-O- methyltransferase gene regulation in rat frontal cortex	2007	1	10.1038/sj.mp.4001956
Ruth J F Loos	Comment on "A common genetic variant is associated with adult and childhood obesity".	2007	7	10.1126/science.1130012

Evidence compiled by the Personal Genome Project

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Publications listed by Genome.gov

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Users who share this SNP:

Nash Parovoz

correct frequencies

01.10.2011 11:02

CC 0.12
CG 0.45
GG 0.43

Bastian Greshake Tzovaras

02.10.2011 17:18 @Nash Parovoz

Thanks, the frequencies here get calculated by the genotypes that are currently entered in the openSNP-database. So the frequencies displayed here should come down to the numbers you posted if enough users share their data. :)

Name	rs7566605
Chromosome	2
Position	118078449
Weight of evidence	135

SNP rs7566605

Basic Information

Genotype Frequency

Allele Frequency

Additional Information