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SNP rs4950928
Basic Information
Name
rs4950928
Chromosome
1
Position
203186754
Weight of evidence
65
Genotype Frequency
Allele Frequency
Additional Information
SNPedia (4)
PLoS (8)
Mendeley (27)
Personal Genome Project (0)
Genome.gov (1)
Other users (1535)
Comments (0)
Links to SNPedia
Title
Summary
rs4950928 G/G
Half the risk (maybe) of asthma.
rs4950928 G/C
Half the risk (maybe) of asthma.
rs4950928 C/G
Half the risk (maybe) of asthma.
rs4950928 C/C
Normal (higher) risk of asthma.
Note: For some SNPs, testing providers detect the genotype from the opposite strand of DNA, so that the genotypes listed on openSNP don't appear here. In those cases, please replace "A" by "T" or "G" by "C" (and vice-versa).
Publications on this SNP on the Public Library of Science:
First Author
Title
Year of Publication
# of readers
Camilla Noelle Rathcke
Variations of
CHI3L1
, Levels of the Encoded Glycoprotein YKL-40 and Prediction of Fatal and Non-fatal Ischemic Stroke
2012
1834
Yue-Shan Lin
Correlation of
Chitinase 3-Like 1
Single Nucleotide Polymorphisms and Haplotypes with Uterine Cervical Cancer in Taiwanese Women
2014
1566
Camilla Noelle Rathcke
Association of Polymorphisms of the
CHI3L1
Gene with Asthma and Atopy: A Populations-Based Study of 6514 Danish Adults
2009
4226
Stine Brinkløv Thomsen
The Association between Genetic Variations of
CHI3L1
, Levels of the Encoded Glycoprotein YKL-40 and the Lipid Profile in a Danish Population
2012
2241
Andreas Hector
The Chitinase-Like Protein YKL-40 Modulates Cystic Fibrosis Lung Disease
2011
7157
Camilla Noelle Rathcke
Variation in
CHI3LI
in Relation to Type 2 Diabetes and Related Quantitative Traits
2009
2824
Kaspar René Nielsen
Inherited Inflammatory Response Genes Are Associated with B-Cell Non-Hodgkin’s Lymphoma Risk and Survival
2015
1434
Simone Accordini
An Interleukin 13 Polymorphism Is Associated with Symptom Severity in Adult Subjects with Ever Asthma
2016
2175
Publications on this SNP on Mendeley
First Author
Title
Pub. Year
# of Readers
DOI
Sanjeev K Srivastava
Lack of evidence for association of two functional SNPs of CHI3L1 gene (HC-gp39) with rheumatoid arthritis.
2011
6
-
Hidenaga Yamamori
A promoter variant in the chitinase 3-like 1 gene is associated with serum YKL-40 level and personality trait
2012
8
10.1016/j.neulet.2012.02.039
Camilla Noelle Rathcke
Association of polymorphisms of the CHI3L1 gene with asthma and atopy: a populations-based study of 6514 Danish adults.
2009
11
10.1371/journal.pone.0006106
Jon R Konradsen
The chitinase-like protein YKL-40: A possible biomarker of inflammation and airway remodeling in severe pediatric asthma.
2013
3
10.1016/j.jaci.2013.03.003
Camilla Noelle Rathcke
Variation in CHI3LI in relation to type 2 diabetes and related quantitative traits.
2009
6
10.1371/journal.pone.0005469
Kazutaka Ohi
The chitinase 3-like 1 gene and schizophrenia: evidence from a multi-center case-control study and meta-analysis.
2010
6
10.1016/j.schres.2009.12.002
Camilla Noelle Rathcke
Variation in CHI3LI in Relation to Type 2 Diabetes and Related Quantitative Traits
2009
6
10.1371/journal.pone.0005469
Xinzhi Zhao
Functional Variants in the Promoter Region of Chitinase 3–Like 1 (CHI3L1) and Susceptibility to Schizophrenia
2007
11
-
Brian Kornblit
Plasma YKL-40 and CHI3L1 in systemic inflammation and sepsis-Experience from two prospective cohorts
2013
3
10.1016/j.imbio.2013.04.010
Xinzhi Zhao
Functional variants in the promoter region of Chitinase 3-like 1 (CHI3L1) and susceptibility to schizophrenia.
2007
16
10.1086/510438
Hidenaga Yamamori
A promoter variant in the chitinase 3-like 1 gene is associated with serum YKL-40 level and personality trait.
2012
5
10.1016/j.neulet.2012.02.039
Brian Kornblit
Plasma YKL-40 and CHI3L1 in systemic inflammation and sepsis-Experience from two prospective cohorts.
2013
4
10.1016/j.imbio.2013.04.010
Jason Cunningham
The CHI3L1 rs4950928 polymorphism is associated with asthma-related hospital admissions in children and young adults.
2011
4
10.1016/j.anai.2011.01.030
Jon R. Konradsen
The chitinase-like protein YKL-40: A possible biomarker of inflammation and airway remodeling in severe pediatric asthma
2013
4
10.1016/j.jaci.2013.03.003
Eurich D.
YKL-40-gene polymorphism affects acute cellular rejection and fibrosis progression after transplantation for hepatitis C virus-induced liver disease
2013
5
10.1111/j.1440-1746.2012.07270.x
Xinzhi Zhao
Functional variants in the promoter region of Chitinase 3-like 1 (CHI3L1) and susceptibility to schizophrenia.
2007
1
10.1086/510438
J Cunningham
The Chitinase 3-like-1 rs4950928 polymorphism is associated with asthma related hospital admissions in children and young adults attending secondary care clinics
2010
1
Sanjeev K Srivastava
Lack of evidence for association of two functional SNPs of CHI3L1 gene (HC-gp39) with rheumatoid arthritis.
2011
6
10.1007/s00296-010-1396-3
Kazutaka Ohi
The chitinase 3-like 1 gene and schizophrenia: Evidence from a multi-center case-control study and meta-analysis
2010
7
10.1016/j.schres.2009.12.002
Kazuo Yamada
Failure to confirm genetic association of the CHI3L1 gene with schizophrenia in Japanese and Chinese populations.
2009
1
10.1002/ajmg.b.30847
R J Fontana
YKL-40 genetic polymorphisms and the risk of liver disease progression in patients with advanced fibrosis due to chronic hepatitis C
2011
1
10.1111/j.1478-3231.2011.02686.x; 10.1111/j.1478-3231.2011.02686.x
Jason Cunningham
The CHI3L1 rs4950928 polymorphism is associated with asthma-related hospital admissions in children and young adults.
2011
4
-
Atsuo Sekiyama
A promoter variant in the chitinase 3-like 1 gene is associated with serum YKL-40 level and personality trait
2012
8
10.1016/j.neulet.2012.02.039
E Cantó
Chitinase 3-like 1 plasma levels are increased in patients with progressive forms of multiple sclerosis.
2011
6
-
Kazutaka Ohi
The chitinase 3-like 1 gene and schizophrenia: evidence from a multi-center case-control study and meta-analysis.
2010
7
-
Jason Cunningham
The CHI3L1 rs4950928 polymorphism is associated with asthma-related hospital admissions in children and young adults
2011
4
10.1016/j.anai.2011.01.030
Robert J Fontana
YKL-40 genetic polymorphisms and the risk of liver disease progression in patients with advanced fibrosis due to chronic hepatitis C.
2012
2
10.1111/j.1478-3231.2011.02686.x
Evidence compiled by the
Personal Genome Project
There are no results from the
Personal Genome Project
yet. Please come back later.
Publications listed by
Genome.gov
First Author
Title
Journal
Publication Date
Trait
p-value
Confidence Interval
Ober C
Effect of variation in CHI3L1 on serum YKL-40 level, risk of asthma, and lung function.
N Engl J Med
04/09/2008
YKL-40 levels
1.0e-13
[NR] ng/ml decrease
Users who share this SNP:
Genome Browser