SNP rs2200733

Basic Information
Name rs2200733
Chromosome 4
Position 110789013
Weight of evidence 84
Additional Information

Links to SNPedia

Title Summary
rs2200733 T/T 1.5x increased risk of atrial fibrillation and ischemic stroke.
rs2200733 C/C 0.86x decreased risk of atrial fibrillation
rs2200733 C/T 1.4x increased risk of atrial fibrillation and ischemic stroke.
Note: For some SNPs, testing providers detect the genotype from the opposite strand of DNA, so that the genotypes listed on openSNP don't appear here. In those cases, please replace "A" by "T" or "G" by "C" (and vice-versa).

Publications on this SNP on Mendeley

First Author Title Pub. Year # of Readers DOI
Adele H Goodloe Uncovering an intermediate phenotype associated with rs2200733 at 4q25 in lone atrial fibrillation. 2011 3 10.1016/j.amjcard.2011.02.326Oa logo
J Gulcher Common risk variants for atrial fibrillation on chromosomes 4q25 and 16q22 associate with non-cardiogenic stroke suggesting that AF is a greater cause of stroke than previously recognized 2010 1 -
S Gretarsdottir Risk variants for atrial fibrillation on chromosome 4q25 associate with ischemic stroke 2008 10 10.1002/ana.21480
Salim S Virani Usefulness of single nucleotide polymorphism in chromosome 4q25 to predict in-hospital and long-term development of atrial fibrillation and survival in patients undergoing coronary artery bypass grafting. 2011 6 10.1016/j.amjcard.2011.01.026Oa logo
Kristoffer M A Henningsen Association of rs2200733 at 4q25 with early onset of lone atrial fibrillation in young patients. 2011 0 10.3109/14017431.2011.594081
Babar Parvez Common genetic polymorphism at 4q25 locus predicts atrial fibrillation recurrence after successful cardioversion 2013 7 10.1016/j.hrthm.2013.02.018
Jason D Roberts Impact of a 4q25 Genetic Variant in Atrial Flutter and the Risk of Atrial Fibrillation after Cavotricuspid Isthmus Ablation. 2013 3 10.1111/jce.12317
C Viviani Anselmi Association of rs2200733 at 4q25 with atrial flutter/fibrillation diseases in an Italian population. 2008 4 -
M Benjamin Shoemaker Common atrial fibrillation risk alleles at 4q25 predict recurrence after catheter-based atrial fibrillation ablation. 2013 3 10.1016/j.hrthm.2012.11.012Oa logo
Marcin Wnuk The rs2200733 variant on chromosome 4q25 is a risk factor for cardioembolic stroke related to atrial fibrillation in Polish patients. 2011 2 -
Salim S Virani Usefulness of single nucleotide polymorphism in chromosome 4q25 to predict in-hospital and long-term development of atrial fibrillation and survival in patients undergoing coronary artery bypass grafting. 2011 0 -
Lisong Shi Assessment of association of rs2200733 on chromosome 4q25 with atrial fibrillation and ischemic stroke in a Chinese Han population. 2009 2 10.1007/s00439-009-0737-3Oa logo
Daniela Husser Chromosome 4q25 Variants and Atrial Fibrillation Recurrence After Catheter Ablation 2010 15 10.1016/j.jacc.2009.11.041
S C Body Variation in the 4q25 chromosomal locus predicts atrial fibrillation after coronary artery bypass graft surgery 2009 2 CIRCGENETICS.109.849075 [pii]\r10.1161/CIRCGENETICS.109.849075Oa logo
C Viviani Anselmi Association of rs2200733 at 4q25 with atrial flutter/fibrillation diseases in an Italian population. 2008 3 10.1136/hrt.2008.148544Oa logo
S S Virani Usefulness of Single Nucleotide Polymorphism in Chromosome 4q25 to Predict In-Hospital and Long-Term Development of Atrial Fibrillation and Survival in Patients Undergoing Coronary Artery Bypass Grafting 2011 1 -
Marco V. Perez African American race but not genome-wide ancestry is negatively associated with atrial fibrillation among postmenopausal women in the Women's Health Initiative 2013 3 10.1016/j.ahj.2013.05.024
Rosiak M. New single nucleotide polymorphisms associated with supraventricular arrythmias in patients with pacemaker implantation: Genome-wide association approach and pooled DNA strategy 2013 2 -
Marylyn D. Ritchie Chromosome 4q25 variants are genetic modifiers of rare ion channel mutations associated with familial atrial fibrillation 2012 6 10.1016/j.jacc.2012.04.030
Morten S. Olesen Association of rs2200733 at 4q25 with early onset of lone atrial fibrillation in young patients 2011 1 10.3109/14017431.2011.594081
Annukka M. Lahtinen Common genetic variants associated with Sudden cardiac death: The finscdgen study 2012 3 10.1371/journal.pone.0041675Oa logo
Lisong Shi Assessment of association of rs2200733 on chromosome 4q25 with atrial fibrillation and ischemic stroke in a Chinese Han population. 2009 2 -
M. Benjamin Shoemaker Common atrial fibrillation risk alleles at 4q25 predict recurrence after catheter-based atrial fibrillation ablation 2013 6 10.1016/j.hrthm.2012.11.012
Adele H. Goodloe Uncovering an intermediate phenotype associated with rs2200733 at 4q25 in lone atrial fibrillation 2011 5 10.1016/j.amjcard.2011.02.326
Babar Parvez Common genetic polymorphism at 4q25 locus predicts atrial fibrillation recurrence after successful cardioversion. 2013 3 10.1016/j.hrthm.2013.02.018Oa logo
Stefan Kääb Large scale replication and meta-analysis of variants on chromosome 4q25 associated with atrial fibrillation. 2009 13 10.1093/eurheartj/ehn578
Salim S. Virani Usefulness of single nucleotide polymorphism in chromosome 4q25 to predict in-hospital and long-term development of atrial fibrillation and survival in patients undergoing coronary artery bypass grafting 2011 7 10.1016/j.amjcard.2011.01.026
Jennifer L Hall Genetic mutations as risk predictors of atrial fibrillation recurrence after catheter ablation? 2010 10 -
Sanghamitra Mohanty Variant rs2200733 on Chromosome 4q25 Confers Increased Risk of Atrial Fibrillation: Evidence From a Meta-Analysis 2012 1 10.1111/jce.12017
Stefan Kääb Large scale replication and meta-analysis of variants on chromosome 4q25 associated with atrial fibrillation. 2009 15 10.1093/eurheartj/ehn578Oa logo
Adele H Goodloe Uncovering an intermediate phenotype associated with rs2200733 at 4q25 in lone atrial fibrillation. 2011 2 -
A M Lahtinen Common genetic variants associated with Sudden cardiac death: The finscdgen study 2012 1 Oa logo
Marek Kiliszek Association between Variants on Chromosome 4q25, 16q22 and 1q21 and Atrial Fibrillation in the Polish Population 2011 3 10.1371/journal.pone.0021790Oa logo
J Gustav Smith Genetic polymorphisms confer risk of atrial fibrillation in patients with heart failure: a population-based study. 2012 3 10.1093/eurjhf/hfs176
Matthew J. Kolek A common variant on chromosome 4q25 is associated with prolonged pr interval in subjects with and without atrial fibrillation 2014 3 10.1016/j.amjcard.2013.08.045
Kun-Tai Lee Association of RS2200733 but not RS10033464 on 4q25 with atrial fibrillation based on the recessive model in a Taiwanese population. 2010 3 10.1159/000318172
Sanghamitra Mohanty Variant rs2200733 on chromosome 4q25 confers increased risk of atrial fibrillation: evidence from a meta-analysis. 2013 3 10.1111/jce.12017
Solveig Gretarsdottir Risk variants for atrial fibrillation on chromosome 4q25 associate with ischemic stroke. 2008 2 -
Marylyn D Ritchie Chromosome 4q25 Variants Are Genetic Modifiers of Rare Ion Channel Mutations Associated With Familial Atrial Fibrillation. 2012 3 10.1016/j.jacc.2012.04.030
Charlotte van Noord Pharmacological and Biological Risk Factors for Cardiac Arrhythmias 2009 2 Oa logo
Daniela Husser Chromosome 4q25 variants and atrial fibrillation recurrence after catheter ablation. 2010 11 10.1016/j.jacc.2009.11.041Oa logo
Sanghamitra Mohanty Variant rs2200733 on chromosome 4q25 confers increased risk of atrial fibrillation: evidence from a meta-analysis. 2013 2 10.1111/jce.12017Oa logo
Kun-Tai Lee Association of RS2200733 but not RS10033464 on 4q25 with atrial fibrillation based on the recessive model in a Taiwanese population. 2010 3 10.1159/000318172Oa logo
J Gulcher Common risk variants for atrial fibrillation on chromosomes 4q25 and 16q22 associate with non-cardiogenic stroke suggesting that AF is a greater cause of stroke than previously recognized 2010 1 Oa logo
Kun-Tai Lee Association of RS2200733 but not RS10033464 on 4q25 with atrial fibrillation based on the recessive model in a Taiwanese population. 2010 0 -
Kun Tai Lee Association of RS2200733 but not RS10033464 on 4q25 with atrial fibrillation based on the recessive model in a Taiwanese population 2010 4 10.1159/000318172
Solveig Gretarsdottir Risk variants for atrial fibrillation on chromosome 4q25 associate with ischemic stroke. 2008 17 10.1002/ana.21480Oa logo

Evidence compiled by the Personal Genome Project

There are no results from the Personal Genome Project yet. Please come back later.

Publications listed by Genome.gov

First Author Title Journal Publication Date Trait p-value Confidence Interval
Gudbjartsson DF A sequence variant in ZFHX3 on 16q22 associates with atrial fibrillation and ischemic stroke. Nat Genet 07/13/2009 Atrial fibrillation 1.0e-14 [NR]
Gretarsdottir S Risk variants for atrial fibrillation on chromosome 4q25 associate with ischemic stroke. Ann Neurol 10/01/2008 Stroke (ischemic) 2.0e-10 [1.17-1.35]
Gudbjartsson DF Variants conferring risk of atrial fibrillation on chromosome 4q25. Nature 07/01/2007 Atrial fibrillation/atrial flutter 3.0e-41 [1.59-1.86]

Users who share this SNP:

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