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SNP rs1421085
Basic Information
Name
rs1421085
Chromosome
16
Position
53767042
Weight of evidence
108
Genotype Frequency
Allele Frequency
Additional Information
SNPedia (3)
PLoS (28)
Mendeley (35)
Personal Genome Project (0)
Genome.gov (1)
Other users (1686)
Comments (0)
Links to SNPedia
Title
Summary
rs1421085 C/T
~1.3x increased obesity risk
rs1421085 C/C
~1.7x increased obesity risk
rs1421085 T/T
Normal obesity risk
Note: For some SNPs, testing providers detect the genotype from the opposite strand of DNA, so that the genotypes listed on openSNP don't appear here. In those cases, please replace "A" by "T" or "G" by "C" (and vice-versa).
Publications on this SNP on the Public Library of Science:
First Author
Title
Year of Publication
# of readers
Bamidele O. Tayo
Genetic Background of Patients from a University Medical Center in Manhattan: Implications for Personalized Medicine
2011
4856
Timo D. Müller
Emerging Function of Fat Mass and Obesity-Associated Protein (Fto)
2013
9586
Koichi Akiyama
Systematic Fine-Mapping of Association with BMI and Type 2 Diabetes at the
FTO
Locus by Integrating Results from Multiple Ethnic Groups
2014
2526
Hui Cai
Prevalence and Determinants of Metabolic Syndrome among Women in Chinese Rural Areas
2012
5020
Ge Zhang
Common SNPs in FTO Gene Are Associated with Obesity Related Anthropometric Traits in an Island Population from the Eastern Adriatic Coast of Croatia
2010
4926
Benjamin W. Domingue
Polygenic Risk Predicts Obesity in Both White and Black Young Adults
2014
3261
Yuyang Xu
Rs7206790 and rs11644943 in
FTO
Gene Are Associated with Risk of Obesity in Chinese School-Age Population
2014
1704
Jan Bressler
Risk of Type 2 Diabetes and Obesity Is Differentially Associated with Variation in
FTO
in Whites and African-Americans in the ARIC Study
2010
6264
Tao Li
Common Variant rs9939609 in Gene FTO Confers Risk to Polycystic Ovary Syndrome
2013
2452
Anne Jääskeläinen
Meal Frequencies Modify the Effect of Common Genetic Variants on Body Mass Index in Adolescents of the Northern Finland Birth Cohort 1986
2013
6359
Cecilia M. Lindgren
Genome-Wide Association Scan Meta-Analysis Identifies Three Loci Influencing Adiposity and Fat Distribution
2009
24164
Anke Hinney
Genome Wide Association (GWA) Study for Early Onset Extreme Obesity Supports the Role of Fat Mass and Obesity Associated Gene
(FTO)
Variants
2007
24123
Li-Jun Tan
Replication of 6 Obesity Genes in a Meta-Analysis of Genome-Wide Association Studies from Diverse Ancestries
2014
4826
Angelo Scuteri
Genome-Wide Association Scan Shows Genetic Variants in the
FTO
Gene Are Associated with Obesity-Related Traits
2007
48418
Kathryn G. Ewens
FTO
and
MC4R
Gene Variants Are Associated with Obesity in Polycystic Ovary Syndrome
2011
7106
David Albuquerque
Association of
FTO
Polymorphisms with Obesity and Obesity-Related Outcomes in Portuguese Children
2013
3451
Christopher G. Bell
Integrated Genetic and Epigenetic Analysis Identifies Haplotype-Specific Methylation in the
FTO
Type 2 Diabetes and Obesity Susceptibility Locus
2010
20501
Xianli Cai
Association between Fat Mass- and Obesity- Associated (FTO) Gene Polymorphism and Polycystic Ovary Syndrome: A Meta-Analysis
2014
2879
Ulrike Peters
A Systematic Mapping Approach of 16q12.2/
FTO
and BMI in More Than 20,000 African Americans Narrows in on the Underlying Functional Variation: Results from the Population Architecture using Genomics and Epidemiology (PAGE) Study
2013
6943
Junqing Wu
Association of FTO Polymorphisms with Obesity and Metabolic Parameters in Han Chinese Adolescents
2014
2595
Jianjin Guo
Fat Mass and Obesity Associated Gene (
FTO
) Expression Is Regulated Negatively by the Transcription Factor Foxa2
2012
4340
Chibo Liu
FTO Gene Variant and Risk of Overweight and Obesity among Children and Adolescents: a Systematic Review and Meta-Analysis
2013
6121
Fleur P. Velders
FTO
at rs9939609, Food Responsiveness, Emotional Control and Symptoms of ADHD in Preschool Children
2012
2640
Peter Würtz
Metabolic Signatures of Adiposity in Young Adults: Mendelian Randomization Analysis and Effects of Weight Change
2014
18512
André Scherag
Two New Loci for Body-Weight Regulation Identified in a Joint Analysis of Genome-Wide Association Studies for Early-Onset Extreme Obesity in French and German Study Groups
2010
14060
Josefin A. Jacobsson
Detailed Analysis of Variants in FTO in Association with Body Composition in a Cohort of 70-Year-Olds Suggests a Weakened Effect among Elderly
2011
2282
Tove Fall
The Role of Adiposity in Cardiometabolic Traits: A Mendelian Randomization Analysis
2013
15673
Yolanda Saldaña-Alvarez
Gender-Dependent Association of
FTO
Polymorphisms with Body Mass Index in Mexicans
2016
2882
Publications on this SNP on Mendeley
First Author
Title
Pub. Year
# of Readers
DOI
N L Nock
Modeling Genetic and Environmental Factors in Biological Systems Using Structural Equation Modeling: An Application to Energy Balance
2009
0
Redha Attaoua
FTO gene associates to metabolic syndrome in women with polycystic ovary syndrome.
2008
0
10.1016/j.bbrc.2008.06.039
N L Nock
Modeling Genetic and Environmental Factors in Biological Systems Using Structural Equation Modeling: An Application to Energy Balance
2009
0
10.1109/OCCBIO.2009.18
R Arlen Price
FTO gene SNPs associated with extreme obesity in cases, controls and extremely discordant sister pairs
2008
15
10.1186/1471-2350-9-4
Toshiko Tanaka
Genome-wide meta-analysis of observational studies shows common genetic variants associated with macronutrient intake.
2013
23
10.3945/ajcn.112.052183
Toshiko Tanaka
Genome-wide meta-analysis of observational studies shows common genetic variants associated with macronutrient intake.
2013
15
10.3945/ajcn.112.052183
Redha Attaoua
FTO gene associates to metabolic syndrome in women with polycystic ovary syndrome
2008
6
10.1016/j.bbrc.2008.06.039
F Stutzmann
Common genetic variation near MC4R is associated with eating behaviour patterns in European populations.
2009
11
-
R Attaoua
FTO gene associates to metabolic syndrome in women with polycystic ovary syndrome
2008
0
T Wangensteen
FTO genotype and weight gain in obese and normal weight adults from a Norwegian population based cohort (the HUNT study).
2010
1
-
Nora L Nock
Modeling Genetic and Environmental Factors in Biological Systems Using Structural Equation Modeling: An Application to Energy Balance.
2009
0
10.1109/OCCBIO.2009.18
R. Attaoua
Association of the FTO gene with obesity and the metabolic syndrome is independent of the IRS-2 gene in the female population of Southern France
2009
9
10.1016/j.diabet.2009.07.002
Jan Bressler
Risk of Type 2 Diabetes and Obesity Is Differentially Associated with Variation in FTO in Whites and African-Americans in the ARIC Study
2010
18
10.1371/journal.pone.0010521
Mika Kivimäki
Examining overweight and obesity as risk factors for common mental disorders using fat mass and obesity-associated (FTO) genotype-instrumented analysis: The Whitehall II Study, 1985-2004.
2011
0
10.1093/aje/kwq444
Toshiko Tanaka
Genome-wide meta-analysis of observational studies shows common genetic variants associated with macronutrient intake.
2013
0
10.3945/ajcn.112.052183
T. Wangensteen
FTO genotype and weight gain in obese and normal weight adults from a norwegian population based cohort (the HUNT study)
2010
1
10.1055/s-0030-1249636
Seong W Cha
Replication of genetic effects of FTO polymorphisms on BMI in a Korean population.
2008
10
-
Haina Wang
Genetic variants in FTO associated with metabolic syndrome: a meta- and gene-based analysis.
2011
3
10.1007/s11033-011-1377-y
Jan Bressler
Risk of type 2 diabetes and obesity is differentially associated with variation in FTO in whites and African-Americans in the ARIC study.
2010
0
10.1371/journal.pone.0010521
R Attaoua
FTO gene associates to metabolic syndrome in women with polycystic ovary syndrome
2008
0
S0006-291X(08)01145-5 [pii]\r10.1016/j.bbrc.2008.06.039 [doi]
Kikuko Hotta
Polymorphisms in NRXN3, TFAP2B, MSRA, LYPLAL1, FTO and MC4R and their effect on visceral fat area in the Japanese population.
2010
0
10.1038/jhg.2010.99
Toshiko Tanaka
Genome-wide meta-analysis of observational studies shows common genetic variants associated with macronutrient intake.
2013
5
10.3945/ajcn.112.052183
David Albuquerque
Association of FTO polymorphisms with obesity and obesity-related outcomes in Portuguese children.
2013
0
10.1371/journal.pone.0054370
Lina Wang
Variant rs1421085 in the FTO gene contribute childhood obesity in Chinese children aged 3-6 years
2013
3
10.1016/j.orcp.2011.12.007
S Cauchi
Combined effects of MC4R and FTO common genetic variants on obesity in European general populations.
2009
17
-
Redha Attaoua
FTO gene associates to metabolic syndrome in women with polycystic ovary syndrome.
2008
4
10.1016/j.bbrc.2008.06.039
J M McCaffery
Obesity susceptibility loci and dietary intake in the Look AHEAD Trial
2012
10
10.3945/ajcn.111.026955
M Kivimaki
Examining overweight and obesity as risk factors for common mental disorders using fat mass and obesity-associated (FTO) genotype-instrumented analysis: The Whitehall II Study, 1985-2004.
2011
14
10.1093/aje/kwq444
N.L. Nock
Modeling Genetic and Environmental Factors in Biological Systems Using Structural Equation Modeling: An Application to Energy Balance
2009
0
10.1109/OCCBIO.2009.18
Kikuko Hotta
Polymorphisms in NRXN3, TFAP2B, MSRA, LYPLAL1, FTO and MC4R and their effect on visceral fat area in the Japanese population.
2010
5
-
Armand Peeters
Variants in the FTO gene are associated with common obesity in the Belgian population.
2008
0
10.1016/j.ymgme.2007.10.011
Sihua Peng
FTO gene polymorphisms and obesity risk: a meta-analysis
2011
21
10.1186/1741-7015-9-71
N L Nock
Modeling Genetic and Environmental Factors in Biological Systems Using Structural Equation Modeling: An Application to Energy Balance
2009
0
T Wangensteen
FTO genotype and weight gain in obese and normal weight adults from a Norwegian population based cohort (the HUNT study).
2010
0
10.1055/s-0030-1249636
Jun Ohashi
FTO polymorphisms in oceanic populations.
2007
13
-
Evidence compiled by the
Personal Genome Project
There are no results from the
Personal Genome Project
yet. Please come back later.
Publications listed by
Genome.gov
First Author
Title
Journal
Publication Date
Trait
p-value
Confidence Interval
Meyre D
Genome-wide association study for early-onset and morbid adult obesity identifies three new risk loci in European populations.
Nat Genet
01/18/2009
Obesity
1.0e-28 (children)
[1.27-1.51]
Users who share this SNP:
Genome Browser