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SNP rs12970134
Basic Information
Name
rs12970134
Chromosome
18
Position
60217517
Weight of evidence
68
Genotype Frequency
Allele Frequency
Additional Information
SNPedia (3)
PLoS (16)
Mendeley (17)
Personal Genome Project (0)
Genome.gov (2)
Other users (1689)
Comments (0)
Links to SNPedia
Title
Summary
rs12970134 A/G
Adult waist 0.9cm larger on average
rs12970134 G/G
Normal
rs12970134 A/A
Adult waist 1.8cm larger on average
Note: For some SNPs, testing providers detect the genotype from the opposite strand of DNA, so that the genotypes listed on openSNP don't appear here. In those cases, please replace "A" by "T" or "G" by "C" (and vice-versa).
Publications on this SNP on the Public Library of Science:
First Author
Title
Year of Publication
# of readers
Claudia Langenberg
Gene-Lifestyle Interaction and Type 2 Diabetes: The EPIC InterAct Case-Cohort Study
2014
20508
Delilah Zabaneh
A Genome-Wide Association Study of the Metabolic Syndrome in Indian Asian Men
2010
7605
Bo Xi
Association between Common Polymorphism near the
MC4R
Gene and Obesity Risk: A Systematic Review and Meta-Analysis
2012
6144
Nicole M. Warrington
Association of a Body Mass Index Genetic Risk Score with Growth throughout Childhood and Adolescence
2013
3006
Xiaomu Kong
Obesity-Related Genomic Loci Are Associated with Type 2 Diabetes in a Han Chinese Population
2014
4022
Hao Mei
Longitudinal Replication Studies of GWAS Risk SNPs Influencing Body Mass Index over the Course of Childhood and Adulthood
2012
5318
Daniel S. Evans
Genetic Association Study of Adiposity and Melanocortin-4 Receptor (
MC4R
) Common Variants: Replication and Functional Characterization of Non-Coding Regions
2014
2800
Annette Horstmann
Common Genetic Variation near MC4R Has a Sex-Specific Impact on Human Brain Structure and Eating Behavior
2013
4179
Bamidele O. Tayo
Genetic Background of Patients from a University Medical Center in Manhattan: Implications for Personalized Medicine
2011
4856
Ehm A. Andersson
Do Gene Variants Influencing Adult Adiposity Affect Birth Weight? A Population-Based Study of 24 Loci in 4,744 Danish Individuals
2010
2549
Tadashi Okamura
Deletion of CDKAL1 Affects High-Fat Diet–Induced Fat Accumulation and Glucose-Stimulated Insulin Secretion in Mice, Indicating Relevance to Diabetes
2012
3778
André Scherag
Investigation of a Genome Wide Association Signal for Obesity: Synthetic Association and Haplotype Analyses at the Melanocortin 4 Receptor Gene Locus
2010
3704
Kathryn G. Ewens
FTO
and
MC4R
Gene Variants Are Associated with Obesity in Polycystic Ovary Syndrome
2011
7106
Xueyao Han
Rs4074134 Near BDNF Gene Is Associated with Type 2 Diabetes Mellitus in Chinese Han Population Independently of Body Mass Index
2013
3032
Ren Matsuba
Replication Study in a Japanese Population to Evaluate the Association between 10 SNP Loci, Identified in European Genome-Wide Association Studies, and Type 2 Diabetes
2015
2402
M. Loredana Marcovecchio
Low
AMY1
Gene Copy Number Is Associated with Increased Body Mass Index in Prepubertal Boys
2016
672
Publications on this SNP on Mendeley
First Author
Title
Pub. Year
# of Readers
DOI
Carla I G Vogel
Common variants near MC4R: Exploring gender effects in overweight and obese children and adolescents participating in a lifestyle intervention
2011
4
10.1159/000324557
Dorit P Zobel
Variants Near MC4R Are Associated With Obesity and Influence Obesity-Related Quantitative Traits in a Population of Middle-Aged People: Studies of 14,940 Danes
2009
1
-
JC Chambers
Common genetic variation near MC4R is associated with waist circumference and insulin resistance
2008
42
-
John C Chambers
Common genetic variation near MC4R is associated with waist circumference and insulin resistance.
2008
53
10.1038/ng.156
Ann L Hasselbalch
A variant in the fat mass and obesity-associated gene (FTO) and variants near the melanocortin-4 receptor gene (MC4R) do not influence dietary intake.
2010
10
-
Dorit P Zobel
Variants Near MC4R Are Associated With Obesity and Influence Obesity-Related Quantitative Traits in a Population of Middle-Aged People: Studies of 14,940 Danes
2009
1
-
Dorit P Zobel
Variants Near MC4R Are Associated With Obesity and Influence Obesity-Related Quantitative Traits in a Population of Middle-Aged People: Studies of 14,940 Danes
2009
1
-
Bo Xi
Association between Common Polymorphism near the MC4R Gene and Obesity Risk: A Systematic Review and Meta-Analysis
2012
14
10.1371/journal.pone.0045731
Pablo Perez-Martinez
A variant near the melanocortin-4 receptor gene regulates postprandial lipid metabolism in a healthy Caucasian population.
2011
6
-
Ehm A Andersson
Do gene variants influencing adult adiposity affect birth weight? A population-based study of 24 loci in 4,744 Danish individuals.
2010
11
10.1371/journal.pone.0014190
Dorit P Zobel
Variants Near MC4R Are Associated With Obesity and Influence Obesity-Related Quantitative Traits in a Population of Middle-Aged People: Studies of 14,940 Danes
2009
1
-
Maggie C Y Ng
Implication of genetic variants near NEGR1, SEC16B, TMEM18, ETV5/DGKG, GNPDA2, LIN7C/BDNF, MTCH2, BCDIN3D/FAIM2, SH2B1, FTO, MC4R, and KCTD15 with obesity and type 2 diabetes in 7705 Chinese.
2010
17
10.1210/jc.2009-2077
Andr?? Scherag
Investigation of a genome wide association signal for obesity: Synthetic association and haplotype analyses at the melanocortin 4 receptor gene locus
2010
10
10.1371/journal.pone.0013967
Pablo Perez-Martinez
A variant near the melanocortin-4 receptor gene regulates postprandial lipid metabolism in a healthy Caucasian population.
2011
7
10.1017/S0007114511002212
Rui Liu
Implication of genetic variants near TMEM18, BCDIN3D/FAIM2, and MC4R with coronary artery disease and obesity in Chinese: a angiography-based study
2012
4
10.1007/s11033-011-0914-z
Om Prakash Dwivedi
Strong influence of variants near MC4R on adiposity in children and adults: a cross-sectional study in Indian population.
2013
5
10.1038/jhg.2012.129
André Scherag
Investigation of a Genome Wide Association Signal for Obesity: Synthetic Association and Haplotype Analyses at the Melanocortin 4 Receptor Gene Locus
2010
8
10.1371/journal.pone.0013967
Evidence compiled by the
Personal Genome Project
There are no results from the
Personal Genome Project
yet. Please come back later.
Publications listed by
Genome.gov
First Author
Title
Journal
Publication Date
Trait
p-value
Confidence Interval
Chambers JC
Common genetic variation near MC4R is associated with waist circumference and insulin resistance.
Nat Genet
05/04/2008
Waist circumference and related phenotypes
2.0e-09 (waist circumference)
[0.59-1.17] cm increase
Thorleifsson G
Genome-wide association yields new sequence variants at seven loci that associate with measures of obesity.
Nat Genet
12/14/2008
Weight
5.0e-13
[3.41-5.91] % SD
Users who share this SNP:
Genome Browser