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SNP rs1121980
Basic Information
Name
rs1121980
Chromosome
16
Position
53775335
Weight of evidence
80
Genotype Frequency
Allele Frequency
Additional Information
SNPedia (3)
PLoS (20)
Mendeley (25)
Personal Genome Project (0)
Genome.gov (0)
Other users (1686)
Comments (0)
Links to SNPedia
Title
Summary
rs1121980 T/T
2.76x risk for obesity
rs1121980 C/C
Average
rs1121980 C/T
1.67x risk for obesity
Note: For some SNPs, testing providers detect the genotype from the opposite strand of DNA, so that the genotypes listed on openSNP don't appear here. In those cases, please replace "A" by "T" or "G" by "C" (and vice-versa).
Publications on this SNP on the Public Library of Science:
First Author
Title
Year of Publication
# of readers
Bamidele O. Tayo
Genetic Background of Patients from a University Medical Center in Manhattan: Implications for Personalized Medicine
2011
4856
Koenraad Frans Cuypers
Obesity-Susceptibility Loci and Their Influence on Adiposity-Related Traits in Transition from Adolescence to Adulthood - The HUNT Study
2012
2248
Shafqat Ahmad
Gene × Physical Activity Interactions in Obesity: Combined Analysis of 111,421 Individuals of European Ancestry
2013
15014
Ge Zhang
Common SNPs in FTO Gene Are Associated with Obesity Related Anthropometric Traits in an Island Population from the Eastern Adriatic Coast of Croatia
2010
4926
Fuzhong Xue
A Latent Variable Partial Least Squares Path Modeling Approach to Regional Association and Polygenic Effect with Applications to a Human Obesity Study
2012
3808
Nicole M. Warrington
Modelling BMI Trajectories in Children for Genetic Association Studies
2013
4428
Hao Mei
Longitudinal Replication Studies of GWAS Risk SNPs Influencing Body Mass Index over the Course of Childhood and Adulthood
2012
5318
Anke Hinney
Genome Wide Association (GWA) Study for Early Onset Extreme Obesity Supports the Role of Fat Mass and Obesity Associated Gene
(FTO)
Variants
2007
24123
Gaurav Garg
Variation in the
MC4R
Gene Is Associated with Bone Phenotypes in Elderly Swedish Women
2014
1720
Li-Jun Tan
Replication of 6 Obesity Genes in a Meta-Analysis of Genome-Wide Association Studies from Diverse Ancestries
2014
4826
Zhixiang Zhu
Development of GMDR-GPU for Gene-Gene Interaction Analysis and Its Application to WTCCC GWAS Data for Type 2 Diabetes
2013
4435
Kai Wang
A Genome-Wide Association Study on Obesity and Obesity-Related Traits
2011
13518
Ulrike Peters
A Systematic Mapping Approach of 16q12.2/
FTO
and BMI in More Than 20,000 African Americans Narrows in on the Underlying Functional Variation: Results from the Population Architecture using Genomics and Epidemiology (PAGE) Study
2013
6943
Xuanshi Liu
Signatures of Natural Selection at the
FTO
(Fat Mass and Obesity Associated) Locus in Human Populations
2015
2319
Jianjin Guo
Fat Mass and Obesity Associated Gene (
FTO
) Expression Is Regulated Negatively by the Transcription Factor Foxa2
2012
4340
Tanica Lyngdoh
Serum Uric Acid and Adiposity: Deciphering Causality Using a Bidirectional Mendelian Randomization Approach
2012
2958
Shengxu Li
Physical Activity Attenuates the Genetic Predisposition to Obesity in 20,000 Men and Women from EPIC-Norfolk Prospective Population Study
2010
33172
Xuanshi Liu
Indications for Potential Parent-of-Origin Effects within the
FTO
Gene
2015
1706
Kirsti Kvaløy
Genetic Effects on Longitudinal Changes from Healthy to Adverse Weight and Metabolic Status — The HUNT Study
2015
1539
Yolanda Saldaña-Alvarez
Gender-Dependent Association of
FTO
Polymorphisms with Body Mass Index in Mexicans
2016
2882
Publications on this SNP on Mendeley
First Author
Title
Pub. Year
# of Readers
DOI
Marcel den Hoed
Genetic susceptibility to obesity and related traits in childhood and adolescence: influence of loci identified by genome-wide association studies.
2010
18
10.2337/db10-0370
Izumi Shimaoka
Association of gene polymorphism of the fat-mass and obesity-associated gene with insulin resistance in Japanese.
2010
7
10.1038/hr.2009.215
Ohishi M Et Al Shimaoka I Kamide K
Association of gene polymorphism of the fat-mass and obesity-associated gene with insulin resistance in Japanese.
2010
1
-
A Hinney
Genome Wide Association (GWA) Study for Early Onset Extreme Obesity Supports the Role of Fat Mass and Obesity Associated Gene (FTO) Variants
2007
0
-
Anke Hinney
Genome Wide Association (GWA) Study for Early Onset Extreme Obesity Supports the Role of Fat Mass and Obesity Associated Gene (FTO) Variants
2007
41
10.1371/journal.pone.0001361
Izumi Shimaoka
Association of gene polymorphism of the fat-mass and obesity-associated gene with insulin resistance in Japanese.
2010
6
-
Anke Hinney
Genome Wide Association (GWA) study for early onset extreme obesity supports the role of fat mass and obesity associated gene (FTO) variants
2007
56
10.1371/journal.pone.0001361
Tuomas O Kilpelainen
Obesity-susceptibility loci have a limited influence on birth weight: a meta-analysis of up to 28,219 individuals
2011
5
-
Shafqat Ahmad
Gene ?? Physical Activity Interactions in Obesity: Combined Analysis of 111,421 Individuals of European Ancestry
2013
24
10.1371/journal.pgen.1003607
Adebowale Adeyemo
FTO Genetic Variation and Association With Obesity in West Africans and African Americans
2010
2
10.2337/db09-1252
Shengxu Li
Physical activity attenuates the genetic predisposition to obesity in 20,000 men and women from EPIC-Norfolk prospective population study.
2010
60
10.1371/journal.pmed.1000332
Karani S Vimaleswaran
Physical activity attenuates the body mass index-increasing influence of genetic variation in the FTO gene.
2009
16
-
Kikuko Hotta
Variations in the FTO gene are associated with severe obesity in the Japanese.
2008
28
10.1007/s10038-008-0283-1
Adebowale Adeyemo
FTO Genetic Variation and Association With Obesity in West Africans and African Americans — Diabetes
2010
6
10.2337/db09-1252.
Shengxu Li
Cumulative effects and predictive value of common obesity-susceptibility variants identified by genome-wide association studies.
2010
21
-
Dolores Corella
A high intake of saturated fatty acids strengthens the association between the fat mass and obesity-associated gene and BMI.
2011
15
10.3945/jn.111.143826.level
C.-Q. Lai
A High Intake of Saturated Fatty Acids Strengthens the Association between the Fat Mass and Obesity-Associated Gene and BMI
2011
16
10.3945/jn.111.143826
Shengxu Li
Physical activity attenuates the genetic predisposition to obesity in 20,000 men and women from EPIC-Norfolk prospective population study
2010
71
10.1371/journal.pmed.1000332
T Kawajiri
Association of gene polymorphism of the fat mass and obesity associated gene with metabolic syndrome: A retrospective cohort study in Japanese workers
2012
4
S Li
Genetic predisposition to obesity leads to increased risk of type 2 diabetes.
2011
11
10.1007/s00125-011-2044-5
Shafqat Ahmad
Gene × physical activity interactions in obesity: combined analysis of 111,421 individuals of European ancestry.
2013
10
10.1371/journal.pgen.1003607
Anke Hinney
Genome wide association (GWA) study for early onset extreme obesity supports the role of fat mass and obesity associated gene (FTO) variants.
2007
46
10.1371/journal.pone.0001361
Frida Renström
Replication and extension of genome-wide association study results for obesity in 4923 adults from northern Sweden
2009
24
10.1093/hmg/ddp041
Jian'an Luan
A multilevel linear mixed model of the association between candidate genes and weight and body mass index using the Framingham longitudinal family data
2009
3
-
Karani S Vimaleswaran
Physical activity attenuates the body mass index-increasing influence of genetic variation in the FTO gene.
2009
10
10.3945/ajcn.2009.27652
Evidence compiled by the
Personal Genome Project
There are no results from the
Personal Genome Project
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Publications listed by
Genome.gov
There are no results from
genome.gov
yet. Please come back later.
Users who share this SNP:
Genome Browser