openSNP
Toggle
News
Data
SNPs
Genotypes
Phenotypes
Phenotypes Pictures
Open Humans Connections
Latest Data
About
About Us
Statistics
FAQ
Sign In
x
It seems like you have JavaScript disabled. This will make some features of openSNP.org, like the drop-down menus, break.
SNP rs10494366
Basic Information
Name
rs10494366
Chromosome
1
Position
162115895
Weight of evidence
58
Genotype Frequency
Allele Frequency
Additional Information
SNPedia (3)
PLoS (4)
Mendeley (31)
Personal Genome Project (0)
Genome.gov (2)
Other users (1691)
Comments (0)
Links to SNPedia
Title
Summary
rs10494366 T/T
Shorter qt interval
rs10494366 G/T
Average qt interval
rs10494366 G/G
Long qt interval
Note: For some SNPs, testing providers detect the genotype from the opposite strand of DNA, so that the genotypes listed on openSNP don't appear here. In those cases, please replace "A" by "T" or "G" by "C" (and vice-versa).
Publications on this SNP on the Public Library of Science:
First Author
Title
Year of Publication
# of readers
Dan E. Arking
Multiple Independent Genetic Factors at
NOS1AP
Modulate the QT Interval in a Multi-Ethnic Population
2009
3736
Christy L. Avery
Fine-Mapping and Initial Characterization of QT Interval Loci in African Americans
2012
3759
Ilja M. Nolte
Common Genetic Variation Near the
Phospholamban
Gene Is Associated with Cardiac Repolarisation: Meta-Analysis of Three Genome-Wide Association Studies
2009
6824
Boglárka Marcsa
A Common Polymorphism of the Human Cardiac Sodium Channel Alpha Subunit (SCN5A) Gene Is Associated with Sudden Cardiac Death in Chronic Ischemic Heart Disease
2015
1846
Publications on this SNP on Mendeley
First Author
Title
Pub. Year
# of Readers
DOI
Matthijs L Becker
Common variation in the NOS1AP gene is associated with reduced glucose-lowering effect and with increased mortality in users of sulfonylurea.
2008
5
-
Albert-Jan L H J Aarnoudse
Common NOS1AP variants are associated with a prolonged QTc interval in the Rotterdam Study.
2007
0
10.1161/CIRCULATIONAHA.106.676783
Kimmo Porthan
Relationship of common candidate gene variants to electrocardiographic T-wave peak to T-wave end interval and T-wave morphology parameters
2010
4
10.1016/j.hrthm.2010.03.002
Wendy Post
Associations between genetic variants in the NOS1AP (CAPON) gene and cardiac repolarization in the old order Amish.
2007
0
10.1159/000103630
Wen Qin
A variation in NOS1AP gene is associated with repaglinide efficacy on insulin resistance in type 2 diabetes of Chinese.
2010
0
10.1038/aps.2010.25
Wen Qin
A variation in NOS1AP gene is associated with repaglinide efficacy on insulin resistance in type 2 diabetes of Chinese.
2010
1
-
M L Becker
A common NOS1AP genetic polymorphism is associated with increased cardiovascular mortality in users of dihydropyridine calcium channel blockers
2009
1
-
Charlotte van Noord
Calcium channel blockers, NOS1AP, and heart-rate-corrected QT prolongation.
2009
0
10.1097/FPC.0b013e328324e556
Samir Saba
Cardiac levels of NOS1AP RNA from right ventricular tissue recovered during lead extraction
2012
9
10.1016/j.hrthm.2011.10.019
Wendy Post
Associations between genetic variants in the NOS1AP (CAPON) gene and cardiac repolarization in the Old Order Amish
2007
11
10.1159/000103630
M L Becker
A common NOS1AP genetic polymorphism is associated with increased cardiovascular mortality in users of dihydropyridine calcium channel blockers
2009
1
-
A Y Chu
NOS1AP variant associated with incidence of type 2 diabetes in calcium channel blocker users in the Atherosclerosis Risk in Communities (ARIC) study.
2010
0
10.1007/s00125-009-1608-0
Reem Mahjoub
Cardiac levels of NOS1AP RNA from right ventricular tissue recovered during lead extraction
2012
0
10.1016/j.hrthm.2011.10.019
Matthijs L Becker
A common NOS1AP genetic polymorphism is associated with increased cardiovascular mortality in users of dihydropyridine calcium channel blockers.
2009
0
10.1111/j.1365-2125.2008.03325.x
Marta Tom??s
Polymorphisms in the NOS1AP Gene Modulate QT Interval Duration and Risk of Arrhythmias in the Long QT Syndrome
2010
26
10.1016/j.jacc.2009.12.065
Motoki Osawa
SNP association and sequence analysis of the NOS1AP gene in SIDS.
2009
0
10.1016/j.legalmed.2009.01.065
Jenni Koskela
Allelic variant of NOS1AP effects on cardiac alternans of repolarization during exercise testing.
2011
7
10.3109/00365513.2011.638725
Motoki Osawa
SNP association and sequence analysis of the NOS1AP gene in SIDS.
2009
4
-
Martin D Tobin
Gender and effects of a common genetic variant in the NOS1 regulator NOS1AP on cardiac repolarization in 3761 individuals from two independent populations
2008
7
10.1093/ije/dyn091
Samir Saba
Cardiac Levels of NOS1AP RNA from Right Ventricular Tissue Recovered During Lead Extraction.
2011
5
10.1016/j.hrthm.2011.10.019
Martin D Tobin
Gender and effects of a common genetic variant in the NOS1 regulator NOS1AP on cardiac repolarization in 3761 individuals from two independent populations.
2008
0
10.1093/ije/dyn091
Sadeq A Quraishi
5 HT(3)-receptor antagonists and cardiac repolarization time in patients expressing a novel genetic target associated with baseline QTc interval abnormalities.
2011
0
10.1016/j.jclinane.2010.11.003
Albert-Jan L H J Aarnoudse
Letter by Herring and Paterson regarding article, "Common NOS1AP variants are associated with a prolonged QTc interval in the Rotterdam Study".
2007
3
-
Motoki Osawa
SNP association and sequence analysis of the NOS1AP gene in SIDS
2009
4
10.1016/j.legalmed.2009.01.065
Allison B Lehtinen
Association of NOS1AP genetic variants with QT interval duration in families from the Diabetes Heart Study.
2008
0
10.2337/db07-1365
M L Becker
A common NOS1AP genetic polymorphism is associated with increased cardiovascular mortality in users of dihydropyridine calcium channel blockers
2009
2
BCP3325 [pii]\r10.1111/j.1365-2125.2008.03325.x [doi]
Wendy Post
Associations between genetic variants in the NOS1AP (CAPON) gene and cardiac repolarization in the old order Amish.
2007
6
10.1159/000103630
Matthijs L Becker
Common variation in the NOS1AP gene is associated with reduced glucose-lowering effect and with increased mortality in users of sulfonylurea.
2008
0
10.1097/FPC.0b013e328300e8c5
Sadeq A Quraishi
5 HT(3)-receptor antagonists and cardiac repolarization time in patients expressing a novel genetic target associated with baseline QTc interval abnormalities.
2011
0
-
Olli T Raitakari
Common variation in NOS1AP and KCNH2 genes and QT interval duration in young adults. The Cardiovascular Risk in Young Finns Study.
2009
0
10.1080/07853890802392529
Matthijs L Becker
A common NOS1AP genetic polymorphism is associated with increased cardiovascular mortality in users of dihydropyridine calcium channel blockers.
2009
4
10.1111/j.1365-2125.2008.03325.x
Evidence compiled by the
Personal Genome Project
There are no results from the
Personal Genome Project
yet. Please come back later.
Publications listed by
Genome.gov
First Author
Title
Journal
Publication Date
Trait
p-value
Confidence Interval
Arking DE
A common genetic variant in the NOS1 regulator NOS1AP modulates cardiac repolarization.
Nat Genet
04/30/2006
QT interval
1.0e-10
- 7.90 [NR] msec difference between homozygotes
Holm H
Several common variants modulate heart rate, PR interval and QRS duration.
Nat Genet
01/10/2010
Electrocardiographic traits
5.0e-22 (QT interval)
[9.72-14.68] % s.d. increase
Users who share this SNP:
Genome Browser