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SNP rs5275
Basic Information
Name
rs5275
Chromosome
1
Position
186673926
Weight of evidence
73
Genotype Frequency
Allele Frequency
Additional Information
SNPedia (3)
PLoS (16)
Mendeley (26)
Personal Genome Project (0)
Genome.gov (0)
Other users (1674)
Comments (0)
Links to SNPedia
Title
Summary
rs5275 C/C
0.68x decreased risk for bladder cancer
rs5275 C/T
0.68x decreased risk for bladder cancer
rs5275 T/T
Normal
Note: For some SNPs, testing providers detect the genotype from the opposite strand of DNA, so that the genotypes listed on openSNP don't appear here. In those cases, please replace "A" by "T" or "G" by "C" (and vice-versa).
Publications on this SNP on the Public Library of Science:
First Author
Title
Year of Publication
# of readers
Shujie Guo
Synergistic Association of PTGS2 and CYP2E1 Genetic Polymorphisms with Lung Cancer Risk in Northeastern Chinese
2012
2056
Lotte K. Vogel
Intestinal
PTGS2
mRNA Levels,
PTGS2
Gene Polymorphisms, and Colorectal Carcinogenesis
2014
1657
Carina Pereira
Genetic Variability in Key Genes in Prostaglandin E
2
Pathway (
COX-2, HPGD, ABCC4
and
SLCO2A1
) and Their Involvement in Colorectal Cancer Development
2014
3288
Vibeke Andersen
Interactions between Diet, Lifestyle and
IL10, IL1B
, and
PTGS2/COX-2
Gene Polymorphisms in Relation to Risk of Colorectal Cancer in a Prospective Danish Case-Cohort Study
2013
2805
Xunsha Sun
The -7351C/T Polymorphism in the TPA Gene and Ischemic Stroke Risk: A Meta-Analysis
2013
2961
Qiliu Peng
Meta-Analysis of the Association between COX-2 Polymorphisms and Risk of Colorectal Cancer Based on Case–Control Studies
2014
2233
Michelle A. T. Hildebrandt
Genetic Variants in Inflammation-Related Genes Are Associated with Radiation-Induced Toxicity Following Treatment for Non-Small Cell Lung Cancer
2010
6708
Christopher N. Floyd
The PlA1/A2 Polymorphism of Glycoprotein IIIa as a Risk Factor for Stroke: A Systematic Review and Meta-Analysis
2014
2330
Lijun Jing
Ethnic Background and Genetic Variation in the Evaluation of Cancer Risk: A Systematic Review
2014
4020
Mai Nagao
A Meta-Analysis of
PTGS1
and
PTGS2
Polymorphisms and NSAID Intake on the Risk of Developing Cancer
2013
2231
María Asunción García-González
Prognostic Role of Host Cyclooxygenase and Cytokine Genotypes in a Caucasian Cohort of Patients with Gastric Adenocarcinoma
2012
3381
David Serre
Differential Allelic Expression in the Human Genome: A Robust Approach To Identify Genetic and Epigenetic
Cis
-Acting Mechanisms Regulating Gene Expression
2008
21602
Kshitij Srivastava
Gallbladder Cancer Predisposition: A Multigenic Approach to DNA-Repair, Apoptotic and Inflammatory Pathway Genes
2011
5270
Silvia von der Heyde
mRNA Profiling Reveals Determinants of Trastuzumab Efficiency in HER2-Positive Breast Cancer
2015
5469
Zhigang Chen
The Association between Three Cyclooxygenase-2 Polymorphisms and Hepatocellular Carcinoma Risk: A Meta-Analysis
2015
2049
Gui Yang
Cyclooxygenase-2 expression is positively associated with lymph node metastasis in nasopharyngeal carcinoma
2017
1349
Publications on this SNP on Mendeley
First Author
Title
Pub. Year
# of Readers
DOI
Wojciech Szczeklik
Common polymorphisms of cyclooxygenase-2 and prostaglandin E2 receptor and increased risk for acute coronary syndrome in coronary artery disease.
2008
1
10.1160/TH08-05-0282
Y S Chae
PTGs2/COX2 gene polymorphism associated with prognosis for patients with advanced colorectal cancer treated with capecitabine and oxaliplatin chemotherapy
2008
1
Galina Lurie
Pooled analysis of the association of PTGS2 rs5275 polymorphism and NSAID use with invasive ovarian carcinoma risk.
2010
2
-
Galina Lurie
Pooled analysis of the association of PTGS2 rs5275 polymorphism and NSAID use with invasive ovarian carcinoma risk.
2010
3
10.1007/s10552-010-9602-x
S M Rausch
SNPs in PTGS2 and LTA predict pain and quality of life in long term lung cancer survivors
2012
2
-
Wojciech Szczeklik
Common polymorphisms of cyclooxygenase-2 and prostaglandin E2 receptor and increased risk for acute coronary syndrome in coronary artery disease.
2008
1
-
Jong Gwang Kim
Prostaglandin synthase 2/cyclooxygenase 2 (PTGS2/COX2) 8473T>C polymorphism associated with prognosis for patients with colorectal cancer treated with capecitabine and oxaliplatin.
2009
6
-
Raju K Mandal
Polymorphisms in COX-2 Gene Influence Prostate Cancer Susceptibility in a Northern Indian Cohort.
2011
0
10.1016/j.arcmed.2011.10.005
Jin Hyang Jung
TNF superfamily gene polymorphism as prognostic factor in early breast cancer.
2010
2
-
Hushan Yang
Profiling of genetic variations in inflammation pathway genes in relation to bladder cancer predisposition.
2008
5
10.1158/1078-0432.CCR-07-1670
Huizhang Li
A genetic variant in 3'-untranslated region of cyclooxygenases-2 gene is associated with risk of gastric cancer in a chinese population.
2012
3
10.1089/dna.2012.1615
Maria Hedelin
Association of frequent consumption of fatty fish with prostate cancer risk is modified by COX-2 polymorphism.
2007
0
Jason Ross
An association between the PTGS2 rs5275 polymorphism and colorectal cancer risk in families with inherited non-syndromic predisposition.
2013
1
10.1038/ejhg.2013.53
Gül Ozhan
The effect of genetic polymorphisms of cyclooxygenase 2 on acute pancreatitis in Turkey.
2010
1
-
David G Cox
A polymorphism in the 3' untranslated region of the gene encoding prostaglandin endoperoxide synthase 2 is not associated with an increase in breast cancer risk: a nested case-control study
2007
2
10.1186/bcr1635
Jane Maguire
Impact of COX-2 rs5275 and rs20417 and GPIIIa rs5918 polymorphisms on 90-day ischemic stroke functional outcome: a novel finding.
2010
9
-
Jong Gwang Kim
Prostaglandin synthase 2/cyclooxygenase 2 (PTGS2/COX2) 8473T>C polymorphism associated with prognosis for patients with colorectal cancer treated with capecitabine and oxaliplatin.
2009
8
10.1007/s00280-009-0947-3
Jason Ross
An association between the PTGS2 rs5275 polymorphism and colorectal cancer risk in families with inherited non-syndromic predisposition.
2013
1
10.1038/ejhg.2013.53
Hushan Yang
Profiling of genetic variations in inflammation pathway genes in relation to bladder cancer predisposition.
2008
-
Gül Ozhan
Cyclooxygenase-2 polymorphisms and pancreatic cancer susceptibility.
2011
5
10.1097/MPA.0b013e31821fcc3b
Jane Maguire
Impact of COX-2 rs5275 and rs20417 and GPIIIa rs5918 polymorphisms on 90-day ischemic stroke functional outcome: A novel finding
2011
19
10.1016/j.jstrokecerebrovasdis.2009.10.011
Maria Hedelin
Association of frequent consumption of fatty fish with prostate cancer risk is modified by COX-2 polymorphism.
2007
9
10.1002/ijc.22319
Saumya Pandey
Association of TNFA (-308G>A) and IL-10 (-819C>T) promoter polymorphisms with risk of cervical cancer.
2010
0
Huizhang Li
A genetic variant in 3'-untranslated region of cyclooxygenases-2 gene is associated with risk of gastric cancer in a Chinese population.
2012
4
10.1089/dna.2012.1615
Taek Sang Lee
Lack of association of the cyclooxygenase-2 and inducible nitric oxide synthase gene polymorphism with risk of cervical cancer in Korean population.
2007
1
10.1196/annals.1397.017
Kim N Danforth
Polymorphic variants in PTGS2 and prostate cancer risk: results from two large nested case-control studies.
2008
3
-
Evidence compiled by the
Personal Genome Project
There are no results from the
Personal Genome Project
yet. Please come back later.
Publications listed by
Genome.gov
There are no results from
genome.gov
yet. Please come back later.
Users who share this SNP:
Genome Browser