Links to SNPedia
Title |
Summary |
rs3798220 C/T
|
2-3x higher risk for cardiovascular events, which can be lowered by aspirin |
rs3798220 C/C
|
2-3x higher risk for cardiovascular events, which can be lowered by aspirin |
rs3798220 T/T
|
Normal |
Note: For some SNPs, testing providers detect the genotype from the opposite strand of DNA, so that the genotypes listed on openSNP don't appear here. In those cases, please replace "A" by "T" or "G" by "C" (and vice-versa).
Publications on this SNP on the Public Library of Science:
Publications on this SNP on Mendeley
First Author |
Title |
Pub. Year |
# of Readers |
DOI |
Hironobu Akao |
KIF6, LPA, TAS2R50, and VAMP8 genetic variation, low density lipoprotein cholesterol lowering response to pravastatin, and heart disease risk reduction in the elderly |
2012 |
7 |
10.1016/j.atherosclerosis.2011.11.037 |
Dov Shiffman |
Single variants can explain the association between coronary heart disease and haplotypes in the apolipoprotein(a) locus |
2010 |
8 |
10.1016/j.atherosclerosis.2010.05.009 |
Pia R. Kamstrup |
Extreme lipoprotein(a) levels and improved cardiovascular risk prediction |
2013 |
16 |
10.1016/j.jacc.2012.12.023 |
Pia R. Kamstrup |
Elevated lipoprotein(a) and risk of aortic valve stenosis in the general population |
2014 |
8 |
10.1016/j.jacc.2013.09.038 |
A Helgadottir |
Apolipoprotein(a) genetic sequence variants associated with systemic atherosclerosis and coronary atherosclerotic burden but not with venous thromboembolism |
2012 |
0 |
10.1016/j.jacc.2012.01.078 |
May M Luke |
A polymorphism in the protease-like domain of apolipoprotein(a) is associated with severe coronary artery disease. |
2007 |
10 |
10.1161/ATVBAHA.107.141291 |
Jeffrey L. Anderson |
Validation and quantification of genetic determinants of lipoprotein-a levels and predictive value for angiographic coronary artery disease |
2013 |
4 |
10.1016/j.amjcard.2013.05.009 |
Yongqin Wang |
Genetic variants associated with myocardial infarction and the risk factors in chinese population. |
2014 |
3 |
10.1371/journal.pone.0086332 |
Kiyohito Arai |
The I4399M variant of apolipoprotein(a) is associated with increased oxidized phospholipids on apolipoprotein B-100 particles. |
2010 |
4 |
10.1016/j.atherosclerosis.2009.09.077 |
Kiyohito Arai |
The I4399M variant of apolipoprotein(a) is associated with increased oxidized phospholipids on apolipoprotein B-100 particles |
2010 |
5 |
10.1016/j.atherosclerosis.2009.09.077 |
May M Luke |
A polymorphism in the protease-like domain of apolipoprotein(a) is associated with severe coronary artery disease. |
2007 |
7 |
- |
Daniel I Chasman |
Polymorphism in the apolipoprotein(a) gene, plasma lipoprotein(a), cardiovascular disease, and low-dose aspirin therapy. |
2009 |
12 |
10.1016/j.atherosclerosis.2008.07.019 |
Dov Shiffman |
Single variants can explain the association between coronary heart disease and haplotypes in the apolipoprotein(a) locus. |
2010 |
4 |
- |
Daniel I Chasman |
Polymorphism in the apolipoprotein(a) gene, plasma lipoprotein(a), cardiovascular disease, and low-dose aspirin therapy. |
2009 |
6 |
- |
Dov Shiffman |
Cost-Effectiveness Model of Use of Genetic Testing as an Aid in Assessing the Likely Benefit of Aspirin Therapy for Primary Prevention of Cardiovascular Disease |
2012 |
7 |
10.1016/j.clinthera.2012.04.004 |
Kiyohito Arai |
The I4399M variant of apolipoprotein(a) is associated with increased oxidized phospholipids on apolipoprotein B-100 particles. |
2010 |
4 |
- |
Anna Helgadottir |
Apolipoprotein(a) genetic sequence variants associated with systemic atherosclerosis and coronary atherosclerotic burden but not with venous thromboembolism |
2012 |
20 |
10.1016/j.jacc.2012.01.078 |
Dov Shiffman |
Single variants can explain the association between coronary heart disease and haplotypes in the apolipoprotein(a) locus. |
2010 |
6 |
10.1016/j.atherosclerosis.2010.05.009 |
Daniel I. Chasman |
Polymorphism in the apolipoprotein(a) gene, plasma lipoprotein(a), cardiovascular disease, and low-dose aspirin therapy |
2009 |
19 |
10.1016/j.atherosclerosis.2008.07.019 |
Evidence compiled by the Personal Genome Project
Gene |
Impact |
Trait |
Summary |
Inheritance |
LPA |
Insufficiently evaluated pathogenic |
|
This variant strongly associated with an increase in Lp(a) lipoprotein levels, associated with an increased risk of coronary disease in a dominant or incomplete dominant manner. This variant is also referred to as I4399M in literature; this discrepancy is due to a highly variable number of kringle repeats in the protein (2-43), our version for inferring amino acid changes from genetic variants uses an assembly with 15 copies. |
unknown |
Publications listed by Genome.gov
Users who share this SNP: