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SNP rs2104286
Basic Information
Name
rs2104286
Chromosome
10
Position
6057082
Weight of evidence
83
Genotype Frequency
Allele Frequency
Additional Information
SNPedia (3)
PLoS (21)
Mendeley (26)
Personal Genome Project (0)
Genome.gov (0)
Other users (1683)
Comments (0)
Links to SNPedia
Title
Summary
rs2104286 A/A
1.7x risk for ra; 1.6x for t1d; also ms?
rs2104286 A/G
1.4x risk for ra; 1.3x for t1d; also ms?
rs2104286 G/G
Normal
Note: For some SNPs, testing providers detect the genotype from the opposite strand of DNA, so that the genotypes listed on openSNP don't appear here. In those cases, please replace "A" by "T" or "G" by "C" (and vice-versa).
Publications on this SNP on the Public Library of Science:
First Author
Title
Year of Publication
# of readers
Lisa M. Maier
IL2RA
Genetic Heterogeneity in Multiple Sclerosis and Type 1 Diabetes Susceptibility and Soluble Interleukin-2 Receptor Production
2009
8060
Isabela Goeldner
Mannose Binding Lectin and Susceptibility to Rheumatoid Arthritis in Brazilian Patients and Their Relatives
2014
1868
Antonio Alcina
IL2RA/CD25 Gene Polymorphisms: Uneven Association with Multiple Sclerosis (MS) and Type 1 Diabetes (T1D)
2009
6665
Falk Butter
Proteome-Wide Analysis of Disease-Associated SNPs That Show Allele-Specific Transcription Factor Binding
2012
15934
Gernot Steinwender
Association between Polymorphism of the Vitamin D Metabolism Gene CYP27B1 and HLA-B27-Associated Uveitis. Is a State of Relative Immunodeficiency Pathogenic in HLA B27-Positive Uveitis?
2013
3476
Ian C. Scott
Predicting the Risk of Rheumatoid Arthritis and Its Age of Onset through Modelling Genetic Risk Variants with Smoking
2013
11843
Naghmeh Jafari
Perspectives on the Use of Multiple Sclerosis Risk Genes for Prediction
2011
3961
Cathy J. Jensen
Multiple Sclerosis Susceptibility-Associated SNPs Do Not Influence Disease Severity Measures in a Cohort of Australian MS Patients
2010
5610
Peter Carbonetto
Integrated Enrichment Analysis of Variants and Pathways in Genome-Wide Association Studies Indicates Central Role for IL-2 Signaling Genes in Type 1 Diabetes, and Cytokine Signaling Genes in Crohn's Disease
2013
11672
Erich Dolejsi
Analyzing Genome-Wide Association Studies with an FDR Controlling Modification of the Bayesian Information Criterion
2014
1926
Adam E. Handel
The Effect of Single Nucleotide Polymorphisms from Genome Wide Association Studies in Multiple Sclerosis on Gene Expression
2010
5358
Wan-Yu Lin
Improving Power of Genome-Wide Association Studies with Weighted False Discovery Rate Control and Prioritized Subset Analysis
2012
4936
Chris Cotsapas
Pervasive Sharing of Genetic Effects in Autoimmune Disease
2011
21388
Ellen M. Mowry
Multiple Sclerosis Susceptibility Genes: Associations with Relapse Severity and Recovery
2013
2921
Marie-Pierre Belot
CpG Methylation Changes within the
IL2RA
Promoter in Type 1 Diabetes of Childhood Onset
2013
3155
Karen Cerosaletti
Multiple Autoimmune-Associated Variants Confer Decreased IL-2R Signaling in CD4
+
CD25
hi
T Cells of Type 1 Diabetic and Multiple Sclerosis Patients
2013
3418
Rohina Rubicz
A Genome-Wide Integrative Genomic Study Localizes Genetic Factors Influencing Antibodies against Epstein-Barr Virus Nuclear Antigen 1 (EBNA-1)
2013
9845
Pushplata Prasad
Caucasian and Asian Specific Rheumatoid Arthritis Risk Loci Reveal Limited Replication and Apparent Allelic Heterogeneity in North Indians
2012
5651
Ewald Lindner
Associations of Independent IL2RA Gene Variants with Intermediate Uveitis
2015
979
Chris Wallace
Dissection of a Complex Disease Susceptibility Region Using a Bayesian Stochastic Search Approach to Fine Mapping
2015
4044
Kaspar René Nielsen
Inherited Inflammatory Response Genes Are Associated with B-Cell Non-Hodgkin’s Lymphoma Risk and Survival
2015
1434
Publications on this SNP on Mendeley
First Author
Title
Pub. Year
# of Readers
DOI
R Knevel
Association of variants in IL2RA with progression of joint destruction in rheumatoid arthritis.
2013
5
10.1002/art.37938
Lisa M Maier
Effect of Soluble IL-2RA Levels in Multiple Sclerosis Subjects and the Effect of Soluble IL-2RA on Immune Responses
2011
3
-
Karen Cerosaletti
Multiple autoimmune-associated variants confer decreased IL-2R signaling in CD4+CD25hi T cells of type 1 diabetic and multiple sclerosis patients
2013
6
10.1371/journal.pone.0083811
Devindri Perera
Fine mapping of multiple sclerosis susceptibility genes provides evidence of allelic heterogeneity at the IL2RA locus.
2009
6
-
T Mihalova
PATU11 IL2RA and CD226 genotypes influence multiple sclerosis disease outcome.
2010
0
10.1136/jnnp.2010.226340.40
Lisa M Maier
Effect of Soluble IL-2RA on Immune Responses 1
2009
6
-
Tar Viturawong
Proteome-Wide Analysis of Disease-Associated SNPs That Show Allele-Specific Transcription Factor Binding
2012
65
10.1371/journal.pgen.1002982
Antonio Alcina
IL2RA/CD25 Gene Polymorphisms: Uneven Association with Multiple Sclerosis (MS) and Type 1 Diabetes (T1D)
2009
18
10.1371/journal.pone.0004137
Lisa M Maier
Effect of Soluble IL-2RA Levels in Multiple Sclerosis Subjects and the Effect of Soluble IL-2RA on Immune Responses
2011
1
-
A Hinks
Association of juvenile idiopathic arthritis (JIA) with the IL2RA gene
2009
2
-
E J Carr
Contrasting genetic association of IL2RA with SLE and ANCA-associated vasculitis
2009
1
10.1186/1471-2350-10-22;
Edward J Carr
Contrasting genetic association of IL2RA with SLE and ANCA – associated vasculitis
2009
9
10.1186/1471-2350-10-22
Devindri Perera
Fine mapping of multiple sclerosis susceptibility genes provides evidence of allelic heterogeneity at the IL2RA locus.
2009
6
10.1016/j.jneuroim.2009.03.010
Lisa M Maier
Soluble IL-2RA levels in multiple sclerosis subjects and the effect of soluble IL-2RA on immune responses.
2009
6
-
Antonio Alcina
IL2RA/CD25 gene polymorphisms: uneven association with multiple sclerosis (MS) and type 1 diabetes (T1D).
2009
19
10.1371/journal.pone.0004137
A Hinks
Association of the IL2RA/CD25 gene with juvenile idiopathic arthritis
2009
4
10.1002/art.24187;
D a Chistiakov
A variant of the Il2ra / Cd25 gene predisposing to graves' disease is associated with increased levels of soluble interleukin-2 receptor.
2011
3
10.1111/j.1365-3083.2011.02608.x
L-M Wang
Interleukin 2 receptor α gene polymorphism and risk of multiple sclerosis: a meta-analysis.
2011
2
Luis Rodríguez-Rodríguez
Influence of IL2RA rs2104286 polymorphism in the risk of biopsy-proven giant cell arteritis.
2010
0
10.3899/jrheum.100388
L-M L.-M. Wang
Interleukin 2 Receptor Gene Polymorphism and Risk of Multiple Sclerosis: A Meta-Analysis
2011
1
10.1177/147323001103900505
Luis Rodríguez-Rodríguez
Influence of IL2RA rs2104286 polymorphism in the risk of biopsy-proven giant cell arteritis.
2010
0
-
L-M Wang
Interleukin 2 Receptor α Gene Polymorphism and Risk of Multiple Sclerosis: a Meta-analysis.
2011
1
-
Lisa M Maier
Soluble IL-2RA levels in multiple sclerosis subjects and the effect of soluble IL-2RA on immune responses.
2009
16
Marcelo Matiello
Association of IL2RA polymorphisms with susceptibility to multiple sclerosis is not explained by missense mutations in IL2RA.
2011
3
10.1177/1352458510394703
L-M Wang
highly cis-selective wittig reations employing
2011
1
Mira M Wouters
Genetic variants in CDC42 and NXPH1 as susceptibility factors for constipation and diarrhoea predominant irritable bowel syndrome.
2013
3
10.1136/gutjnl-2013-304570
Evidence compiled by the
Personal Genome Project
There are no results from the
Personal Genome Project
yet. Please come back later.
Publications listed by
Genome.gov
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genome.gov
yet. Please come back later.
Users who share this SNP:
Genome Browser